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71. 发明授权

US08854739B2 Electrowetting device 有权
标题翻译：电动搅拌装置
公开(公告)号：US08854739B2
公开(公告)日：2014-10-07
申请号：US13499918
申请日：2010-09-29
申请人： Stein Kuiper , Johannes Wilhelmus Weekamp
发明人： Stein Kuiper , Johannes Wilhelmus Weekamp
IPC分类号： G02B1/06 , G02B26/00 , G02B3/14
CPC分类号： G02B3/14 , G02B26/005
摘要： The invention relates to an electrowetting-on-dielectric device (200). This is an electro wetting device comprising one or more cells, wherein each cell comprises an electrowetting composition of first and second immiscible fluids, the first fluid being an electrolytic solution (240), a first electrode (230), separated from the electrowetting composition by a dielectric (231), and a voltage source (260) for applying an operating voltage difference between the first electrode (230) and the electrolytic solution to operate the electrowetting device. According to the invention, the first electrode (230) of the electrowetting-on-dielectric device (200) comprises a valve metal, and the electrolytic solution (240) is capable of anodizing the valve metal to form a metal oxide at the operating voltage difference. This provides the electrowetting-on-dielectric device (200) with self-repairing properties thereby preventing breakdown of the dielectric. As a result, the electrowetting device can be operated at a low voltage, and it has an improved reliability.
摘要翻译：本发明涉及一种电润湿介电装置（200）。这是一种包含一个或多个电池的电润湿装置，其中每个电池包括第一和第二不混溶流体的电润湿组合物，第一流体是电解溶液（240），第一电极（230），其与电润湿组合物分离，电介质（231）和用于在第一电极（230）和电解液之间施加工作电压差以操作电润湿装置的电压源（260）。根据本发明，电介质电介质器件（200）的第一电极（230）包括阀金属，并且电解溶液（240）能够在操作电压下阳极氧化阀金属以形成金属氧化物区别。这提供了具有自修复性能的电介质电介质器件（200），从而防止电介质的破坏。结果，电润湿装置可以在低电压下操作，并且其可靠性提高。

72. 发明申请

US20120034623A1 UP-CONCENTRATION OF ORGANIZ MICROOBJECTS FOR MICROSCOPIC IMAGING 有权
标题翻译：用于微观成像的组织微结构的上调
公开(公告)号：US20120034623A1
公开(公告)日：2012-02-09
申请号：US13263997
申请日：2010-04-14
申请人： Bas Hulsken , Stein Kuiper , Sjoerd Stallinga , Bo Joakim Isaksson , Mark W.G. Ponjee , Bart E.G.J. Van Meerbergen , Zeynep S. Unay
发明人： Bas Hulsken , Stein Kuiper , Sjoerd Stallinga , Bo Joakim Isaksson , Mark W.G. Ponjee , Bart E.G.J. Van Meerbergen , Zeynep S. Unay
IPC分类号： G01N33/566 , C12M1/34 , C12Q1/02
CPC分类号： G01N1/4077 , G01N1/4005 , G01N15/0625 , G01N15/0631
摘要： A method of analyzing a sample fluid containing organic microobjects is proposed. The method comprises the steps of: up-concentrating (S1) the microobjects by removing, in a total time T1, a volume V1 of the sample fluid from the upconcentrate sample microobjects; immersing (S2) the microobjects in a transfer fluid, or leaving the microobjects in a remaining portion of the sample fluid, the remaining portion of the sample fluid then providing the transfer fluid; filtering (S3), in a total time T3, a volume V3 of the transfer fluid by a filter, thereby accumulating the microobjects on the filter; and generating (S4) an image of the microobjects accumulated on the filter; wherein the throughput V1/T1 of the step of up-concentrating (S1) is greater than the throughput V1/T1, of the step of filtering (S3). The filter may be a second filter, and the step of up-concentrating (S1) may involve: filtering the sample fluid by a first filter, thereby accumulating the microobjects on the first filter. An apparatus or system for analyzing a sample fluid containing organic microobjects is also disclosed.
摘要翻译：提出了一种分析含有机微物体样品液的方法。该方法包括以下步骤：通过在总时间T1中去除来自上升浓度样品微物体的样品流体的体积V1来上升（S1）微观对象; 将微量物体浸入（S2）到转移流体中，或将微量物体留在样品流体的剩余部分中，然后将样品流体的剩余部分提供转移流体; 在总时间T3中过滤（S3）通过过滤器传送流体的体积V3，从而将微物体累积在过滤器上; 以及生成（S4）累积在所述过滤器上的所述微物体的图像; 其特征在于，上述浓缩步骤（S1）的吞吐量V1 / T1大于滤波步骤的吞吐量V1 / T1（S3）。过滤器可以是第二过滤器，并且上集中（S1）的步骤可以包括：通过第一过滤器过滤样品流体，从而将微物体累积在第一过滤器上。还公开了一种用于分析含有机微物体的样品流体的装置或系统。

73. 发明申请

US20110309241A1 INTERVENTIONAL INSTRUMENT WITH ILLUMINATION MEANS 审中-公开
标题翻译：具有照明手段的传统仪器
公开(公告)号：US20110309241A1
公开(公告)日：2011-12-22
申请号：US13201078
申请日：2010-02-08
申请人： Cristina Tanase , Herbert Lifka , Stein Kuiper
发明人： Cristina Tanase , Herbert Lifka , Stein Kuiper
IPC分类号： H01J40/14 , H01L31/12
CPC分类号： A61B1/0676 , A61B1/0607 , A61B1/0638 , A61B1/0684 , G02B23/2461
摘要： The invention relates to an instrument (100) that can at least partially be inserted into an internal cavity (2) of an object (1), particularly a catheter or an endoscope. The instrument (100) comprises an optical system (OS) for collecting light coming from external objects through a viewing corridor (VC). The optical system comprises an OLED (110) for illuminating said external objects which is disposed in the viewing corridor (VC). In a particular embodiment, the OLED (110) may at least partially be transparent. By arranging the OLED (110) in the light corridor, an optimal illumination can be achieved together with a compact design of the whole instrument (100).
摘要翻译：本发明涉及一种能够至少部分地插入到物体（1）的内腔（2）中，特别是导管或内窥镜的器械（100）。仪器（100）包括用于通过观察走廊（VC）收集来自外部物体的光的光学系统（OS）。光学系统包括用于照亮设置在观察走廊（VC）中的所述外部物体的OLED（110）。在特定实施例中，OLED（110）可以至少部分地是透明的。通过将OLED（110）布置在光走廊中，可以与整个仪器（100）的紧凑设计一起实现最佳照明。

74. 发明授权

US07982963B2 Liquid-based optical device and electronic device 有权
标题翻译：液基光学器件和电子器件
公开(公告)号：US07982963B2
公开(公告)日：2011-07-19
申请号：US12405639
申请日：2009-03-17
申请人： Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks
发明人： Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks
IPC分类号： G02B1/06
CPC分类号： G02B26/005 , G02B3/14
摘要： The present invention discloses an optical device comprising a container enclosing an insulating liquid (A) and a liquid responsive to an electric field (B), the insulating liquid (A) and the liquid responsive to an electric field (B) being immiscible and being in contact with each other via an interface (14), at least one of the liquids (A; B) being at least partially placed in a light path through the container. The optical device further comprises an electrode arrangement (2; 12) for controlling the shape of the interface (14) by means of a voltage; and means (100) for preventing the interface from an exposure to an external electric field. Consequently, the build-up of electrostatic charge on a surface of the optical device is avoided, which prevents the unwanted distortion of the interface (14) caused by the interaction of the liquid responsive to an electric field (B) and the electrostatic charge.
摘要翻译：本发明公开了一种光学装置，其包括容纳绝缘液体（A）的容器和响应于电场（B）的液体，所述绝缘液体（A）和响应于电场（B）的液体不混溶，通过接口（14）彼此接触，至少一个液体（A; B）至少部分地放置在通过容器的光路中。光学装置还包括用于通过电压控制接口（14）的形状的电极装置（2; 12）以及用于防止接口暴露于外部电场的装置（100）。因此，避免了在光学器件的表面上积聚静电电荷，这防止了由于响应于电场（B）的液体与静电电荷的相互作用而引起的界面（14）的不期望的失真。

75. 发明授权

US07957219B2 Method and apparatus for elevation focus control of acoustic waves 有权
标题翻译：用于声波高程聚焦控制的方法和装置
公开(公告)号：US07957219B2
公开(公告)日：2011-06-07
申请号：US12297902
申请日：2007-04-27
申请人： Christopher S. Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher S. Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： G03B42/06
CPC分类号： G10K11/30
摘要： An acoustic probe includes an acoustic transducer having acoustic transducer elements arranged in a one-dimensional array; and a variably-refracting acoustic lens coupled to the acoustic transducer. The variably-refracting acoustic lens has a pair of electrodes configured to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探头包括具有以一维阵列布置的声换能器元件的声换能器; 以及耦合到声换能器的可变折射声透镜。可变折射声透镜具有一对电极，其被配置为响应于跨过电极施加的选定电压来调节可变折射声透镜的焦点。在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

76. 发明申请

US20100277809A1 FLUID LENS WITH PRESSURE RELEASE SYSTEM 有权
标题翻译：带压力释放系统的流体镜
公开(公告)号：US20100277809A1
公开(公告)日：2010-11-04
申请号：US12811831
申请日：2009-01-12
申请人： Jan Frederik Suijver , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Antonius Johannes Josephus Rademakers , Cornelius Antonius Micolaas Maria Van Der Vleuten , Johannes Wilhelmus Weekamp , Waltherus Cornelis Jozef Bierhoff
发明人： Jan Frederik Suijver , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Antonius Johannes Josephus Rademakers , Cornelius Antonius Micolaas Maria Van Der Vleuten , Johannes Wilhelmus Weekamp , Waltherus Cornelis Jozef Bierhoff
IPC分类号： G02B3/14 , A61B1/06
CPC分类号： G02B7/008 , A61B1/0019 , G02B3/14 , G02B23/2407
摘要： Fluid lens system, e.g. for medical imaging or medical treatment, with a container enclosing a fluid arranged to refract incoming waves. A pressure release mechanism is in contact with the fluid so as to compensate changes in its volume due to thermal variations, e.g. during high temperature medical cleaning. This pressure release mechanism is positioned within a pathway of incoming waves. In preferred embodiments a fluid container connected via a tube to the fluid as a reservoir, is arranged within or outside the container, e.g. beyond an image sensor. Alternatively, an easily compressible body, e.g. a small closed metal bellows enclosing a gas, is positioned inside the fluid to absorb volume changes by compression. In both embodiments, the pressure release elements are preferably positioned in a peripheral part of the pathway of incoming waves to not affect performance of the lens. In another aspect, a fluid lens includes a container with an inner container part that fits inside an outer container part, wherein the inner container part is in rigid connection to at least a one boundary arranged for penetration of incoming waves. The pressure release mechanism is positioned within the outer container part, and it is in contact with the fluid so as to compensate changes in volume of the fluid due to thermal variations. In one embodiment the inner and outer container parts are arranged for relative one-dimensional movement and fluid tight interconnected. In another embodiment, a fluid filled cavity is formed between the inner and outer container parts, and this cavity houses a compressible body. The lens systems are suited for applications such as medical endoscopes, catheters and needles, optically as well as acoustically based.
摘要翻译：流体透镜系统，例如用于医疗成像或医疗处理，容器包围布置成折射入射波的流体。压力释放机构与流体接触，以便补偿由于热变化引起的体积变化，例如，在高温医疗清洗过程中。该压力释放机构位于入射波的通路内。在优选实施例中，经由管连接到作为储存器的流体的流体容器设置在容器内或外部，例如，超越图像传感器。或者，容易压缩的主体，例如，围绕气体的小封闭金属波纹管位于流体内部以通过压缩吸收体积变化。在两个实施例中，压力释放元件优选地定位在入射波通路的周边部分中，从而不影响透镜的性能。在另一方面，一种流体透镜包括具有内部容器部分的容器，该内部容器部分装配在外部容器部分内部，其中内部容器部分刚好连接至布置成用于穿透入射波的至少一个边界。压力释放机构定位在外部容器部分内，并且与流体接触，以补偿由于热变化引起的流体体积的变化。在一个实施例中，内部和外部容器部件布置用于相对一维运动并且流体密封互连。在另一个实施例中，在内部和外部容器部分之间形成流体填充空腔，并且该空腔容纳可压缩体。透镜系统适用于诸如医用内窥镜，导管和针的应用，光学和声学基础。

77. 发明申请

US20100171820A1 LENS SYSTEM 审中-公开
标题翻译：镜头系统
公开(公告)号：US20100171820A1
公开(公告)日：2010-07-08
申请号：US12666545
申请日：2008-06-25
申请人： Bernardus Hendrikus Wihelmu Hendriks , Jeff Shimizu , Stein Kuiper
发明人： Bernardus Hendrikus Wihelmu Hendriks , Jeff Shimizu , Stein Kuiper
IPC分类号： H04N7/18 , G02B15/00 , G02B21/02 , G02B23/24
CPC分类号： G02B23/243 , G02B26/103
摘要： A lens system comprises a first lens group and a second lens group, and is configured to form an image at a first magnification and at a second magnification. The lens system has a common optical axis in both magnifications. The lens system is further configured to form an intermediate image between the first lens group and the second lens group at the first magnification. The intermediate image formed in the first magnification is further imaged onto an optical detector. In the first magnification, the second lens group acts as a relay lens imaging the intermediate image onto the optical detector. In the second magnification, the first and second lens groups together form an image on the optical detector without forming an intermediate image.
摘要翻译：透镜系统包括第一透镜组和第二透镜组，并且被配置为以第一放大率和第二放大率形成图像。透镜系统具有两个放大倍率的共同光轴。透镜系统还被配置为在第一放大率下在第一透镜组和第二透镜组之间形成中间图像。在第一放大率中形成的中间图像进一步成像到光学检测器上。在第一放大率中，第二透镜组用作将中间图像成像到中间透镜到光学检测器。在第二放大倍数中，第一和第二透镜组一起在光学检测器上形成图像，而不形成中间图像。

78. 发明申请

US20090311738A1 METHOD AND SYSTEM FOR DETERMINING PROPERTIES OF BIOLOGICAL CELLS 审中-公开
标题翻译：用于确定生物细胞特性的方法和系统
公开(公告)号：US20090311738A1
公开(公告)日：2009-12-17
申请号：US12438178
申请日：2007-08-17
申请人： Stein Kuiper , Jacob MARINUS JAN Den Toonder
发明人： Stein Kuiper , Jacob MARINUS JAN Den Toonder
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： G01N33/5026 , C12Q1/04 , C12Q1/24 , G01N15/0227
摘要： A system (100) for determining properties of particles is described, wherein elastic properties of particles can be studied. The system (100) typically comprises a microporous structure (110) having a first side and a second side, the microporous structure comprising a plurality of micropores extending from the first side to the second side. Using a means (120) for generating a pressure difference over the microporous structure, particles provided to the first side of the micropores (113) are passed at least partially into the micropores and deformed. A detector (130) is provided for qualitatively and/or quantitatively detecting presence of particles having passed at least partially into the micropores (113), thus allowing to obtain information about the deformation of the particles.
摘要翻译：描述了用于确定颗粒性质的系统（100），其中可以研究颗粒的弹性特性。系统（100）通常包括具有第一侧和第二侧的微孔结构（110），所述微孔结构包括从第一侧延伸到第二侧的多个微孔。使用用于在微孔结构上产生压力差的装置（120），提供到微孔（113）的第一侧的颗粒至少部分地进入微孔并变形。提供了一种检测器（130），用于定性和/或定量地检测已经至少部分地进入微孔（113）的颗粒的存在，从而允许获得关于颗粒变形的信息。

79. 发明申请

US20090197272A1 VITRO METHOD OF DETECTING AND/OR DIAGNOSING CANCER USING UV LIGHT BASED DNA IMAGE CYTOMETRY 有权
标题翻译：使用基于紫外线的DNA图像细胞计数检测和/或诊断癌症的VITRO方法
公开(公告)号：US20090197272A1
公开(公告)日：2009-08-06
申请号：US12305399
申请日：2007-05-14
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Erik Robbert Vossenaar , Gerhard Spekowius , Nijs Cornelis Van Der Vaart , Stein Kuiper
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Erik Robbert Vossenaar , Gerhard Spekowius , Nijs Cornelis Van Der Vaart , Stein Kuiper
IPC分类号： C12Q1/68
CPC分类号： G01N33/582 , C12Q1/68 , G01N15/147 , G01N21/33 , G01N33/5035 , G01N33/5076 , G01N33/5308 , G01N33/574 , G06K9/00134 , G06T7/0012 , G06T7/41 , G06T2207/10056 , G06T2207/30024 , C12Q2523/313
摘要： The invention relates to a method of determining in vitro the amount of nuclear DNA within a human or animal cell using UV absorption measurement with UV light. The invention also relates to a method for detecting in vitro cancerous cells in a biological sample relying on the aforementioned principles. The invention also relates to an in vitro method of diagnosing or predicting the likely occurrence of cancer in a human or animal subject.
摘要翻译：本发明涉及使用UV光的紫外吸收测量体外测定人或动物细胞内核DNA的量的方法。本发明还涉及一种用于根据上述原理检测生物样品中的体外癌细胞的方法。本发明还涉及诊断或预测人或动物受试者中癌症可能发生的体外方法。

80. 发明申请

US20090122639A1 METHOD AND APPARATUS FOR ELEVATION FOCUS CONTROL OF ACOUSTIC WAVES 有权
标题翻译：用于高音重点控制声波的方法和装置
公开(公告)号：US20090122639A1
公开(公告)日：2009-05-14
申请号：US12297902
申请日：2007-04-27
申请人： Christopher Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： G03B42/06
CPC分类号： G10K11/30
摘要： An acoustic probe (100) includes an acoustic transducer (20) including a plurality of acoustic transducer elements arranged in a one-dimensional array; and a variably- refracting acoustic lens (10) coupled to the acoustic transducer. The variably-refracting acoustic lens has at least a pair of electrodes (150, 160) adapted to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100）包括声换能器（20），其包括以一维阵列排列的多个声换能器元件; 以及耦合到声换能器的可变折射声透镜（10）。可变折射声透镜具有至少一对电极（150,160），其适于响应于施加在电极上的选定电压来调节可变折射声透镜的焦点。在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

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