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71. 发明授权

US07833189B2 Controlled needle-free transport 有权
标题翻译：受控无针运输
公开(公告)号：US07833189B2
公开(公告)日：2010-11-16
申请号：US11354279
申请日：2006-02-13
申请人： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
发明人： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
IPC分类号： A61M5/30
CPC分类号： H02K41/02 , A61B17/20 , A61B17/205 , A61D7/00 , A61M5/19 , A61M5/30 , A61M2205/50 , A61M2205/6009 , A61M2205/825 , A61M2250/00
摘要： A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
摘要翻译：用于将物质转移到生物体的表面上的无针透皮传送装置包括用于储存物质的储存器，与储存器流体连通的喷嘴和与储存器连通的可控电磁致动器。称为洛伦兹力致动器的致动器包括固定磁体组件和移动线圈组件。线圈组件移动具有位于储存器内的端部的活塞。致动器接收电输入并且响应于相应的力产生作用在活塞上的相应的力并导致物质在储存器和生物体之间的无针转移。力的大小，方向和持续时间由电输入动态控制（例如，伺服控制），并且可以在致动循环的过程中改变。有利地，致动器可以根据电气输入沿不同方向移动。

72. 发明授权

US07818065B2 Conducting polymer nanowire brain-machine interface systems and methods 有权
公开(公告)号：US07818065B2
公开(公告)日：2010-10-19
申请号：US11396340
申请日：2006-03-31
申请人： Rodolfo R. Llinas , Ian W. Hunter , Bryan P. Ruddy
发明人： Rodolfo R. Llinas , Ian W. Hunter , Bryan P. Ruddy
IPC分类号： A61N1/00
CPC分类号： A61B5/04001 , A61B5/4041 , B82Y10/00 , Y10S977/762 , Y10S977/925
摘要： The present invention relates to conducting polymer nanowires and their use in a brain-machine interface which is secure, robust and minimally invasive. In accordance with a first aspect of the present invention, a vascular-based brain-machine interface comprising conducting polymer nanowires is disclosed.

73. 发明申请

US20080117416A1 USE OF COHERENT RAMAN TECHNIQUES FOR MEDICAL DIAGNOSTIC AND THERAPEUTIC PURPOSES, AND CALIBRATION TECHNIQUES FOR SAME 审中-公开
标题翻译：用于医学诊断和治疗目的的相关拉曼技术的使用以及相同的校准技术
公开(公告)号：US20080117416A1
公开(公告)日：2008-05-22
申请号：US11927557
申请日：2007-10-29
申请人： Ian W. Hunter , Shyamal Somaroo , Serge Lafontaine , Patrick A. Anquetil , Ching-Hua Tseng
发明人： Ian W. Hunter , Shyamal Somaroo , Serge Lafontaine , Patrick A. Anquetil , Ching-Hua Tseng
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , A61B5/0059 , A61B5/0066 , A61B5/0075 , A61B5/14546 , A61B5/412 , A61B5/415 , A61B5/418 , A61B5/444 , A61B5/445 , G01N21/276 , G01N2021/653
摘要： System and methods are provided to perform non-invasive, real-time, continuous molecular detection and quantification of molecular species in a sample or animal subject using Raman spectroscopy. Such systems and methods may be applied to identify and quantify molecular species found in the body, which may be useful for prenatal diagnosis, detecting deep skin infections, performing cerebral spinal fluid assessment, measuring arterial blood gases, blood glucose, cardiac biomarkers, creatinine flow rates. The non-invasive, quantification of such molecular species continuously in real time enables a significantly more attractive course of therapy than existing protocols.
摘要翻译：提供系统和方法以使用拉曼光谱法来对样品或动物受试者中的分子物质进行非侵入性，实时的，连续的分子检测和定量。这样的系统和方法可以用于鉴定和定量在体内发现的分子种类，其可用于产前诊断，检测深层皮肤感染，进行脑脊髓液评估，测量动脉血气，血糖，心脏生物标志物，肌酐流价格。这种分子物质的非侵入性定量实时连续地实现了比现有方案显着更有吸引力的治疗过程。

74. 发明授权

US06249076B1 Conducting polymer actuator 有权
标题翻译：导电聚合物致动器
公开(公告)号：US06249076B1
公开(公告)日：2001-06-19
申请号：US09292041
申请日：1999-04-14
申请人： John D. Madden , Tanya S. Kanigan , Serge Lafontaine , Ian W. Hunter
发明人： John D. Madden , Tanya S. Kanigan , Serge Lafontaine , Ian W. Hunter
IPC分类号： H01L4104
CPC分类号： F03G7/005 , A61B2017/00871 , Y10S310/80
摘要： Embodiments of actuators having an active member including a polymer having a surface, an electrolyte coupled to the surface, and an electrolyte are provided. Actuators which, when an electrical potential is applied across the electrolyte between the active member and the counter electrode, exert force per unit area of at least 10 MPa are described. Particular designs utilizing stretch aligned conducting polymers as active members are discussed.
摘要翻译：提供具有包括具有表面的聚合物的活性构件，耦合到表面的电解质和电解质的致动器的实施方案。当在有源构件和对电极之间跨越电解质施加电位时施加至少10MPa的每单位面积的力的致动器。讨论了使用拉伸对齐的导电聚合物作为活性成员的特殊设计。

75. 发明授权

US6059546A Contractile actuated bellows pump 失效
标题翻译：收缩式致动波纹管泵
公开(公告)号：US6059546A
公开(公告)日：2000-05-09
申请号：US237465
申请日：1999-01-26
申请人： Colin J. H. Brenan , Serge R. Lafontaine , Ian W. Hunter
发明人： Colin J. H. Brenan , Serge R. Lafontaine , Ian W. Hunter
IPC分类号： F03G7/06 , F04B43/04 , F04B43/06
CPC分类号： F04B43/046 , F03G7/065 , F05C2251/08
摘要： A pump for impelling a fluid includes a first variable volume, the first variable volume having a first inlet for allowing the influx of the fluid into the first variable volume and a first outlet for allowing the efflux of the fluid out of the first variable volume and a first membrane defining at least a portion of the first variable volume. The pump also includes a first contractile actuator, for displacing the first membrane from a first position to a second position in such a manner as to vary the first variable volume and a second contractile actuator, for restoring the first membrane from the second position to the first position in such a manner as to vary the first variable volume. A first check valve is coupled to the first inlet for regulating the influx of fluid into the first variable volume through the first inlet and a second check valve is coupled to the first outlet for regulating the efflux of the fluid out of the first variable volume through the first outlet. In a preferred embodiment, at least one of the first and second contractile actuators is a linear actuator.
摘要翻译：用于推动流体的泵包括第一可变容积，第一可变容积具有用于允许流体流入第一可变容积的第一入口和用于允许流体从第一可变容积流出的第一出口，以及限定所述第一可变体积的至少一部分的第一膜。泵还包括第一收缩致动器，用于将第一膜从第一位置移动到第二位置，以便改变第一可变容积和第二收缩致动器，用于将第一膜从第二位置恢复到第二位置第一位置以改变第一可变容积的方式。第一止回阀联接到第一入口，用于通过第一入口调节流体流入第一可变容积，并且第二止回阀联接到第一出口，用于调节流体流出第一可变容积的流出第一个出口。在优选实施例中，第一和第二收缩致动器中的至少一个是线性致动器。

76. 发明授权

US5887165A Dynamically reconfigurable hardware system for real-time control of processes 失效
标题翻译：动态可重构硬件系统，用于实时控制过程
公开(公告)号：US5887165A
公开(公告)日：1999-03-23
申请号：US879923
申请日：1997-06-20
申请人： Sylvain Martel , Serge R. Lafontaine , Ian W. Hunter
发明人： Sylvain Martel , Serge R. Lafontaine , Ian W. Hunter
IPC分类号： G06F9/38 , G06F15/78 , G06F13/00
CPC分类号： G06F15/7867 , G06F9/3879
摘要： A dynanically reconfigurable hardware system for real-time control of ,an external device. Configuration of a dynamically reconfigurable logic module is provided on the basis of a hardware configuration established in a local configuration memory by a configuration signal received over a data bus from a host processor, thereby enabling an external device to be controlled in real-time independently of the host processor.
摘要翻译：用于实时控制外部设备的动态可重构硬件系统。基于通过数据总线从主处理器接收的配置信号在本地配置存储器中建立的硬件配置来提供动态可重配置逻辑模块的配置，从而使外部设备能够独立于主机处理器。

77. 发明授权

US09333060B2 Plaque removal and differentiation of tooth and gum 有权
标题翻译：牙齿和牙龈的牙齿去除和分化
公开(公告)号：US09333060B2
公开(公告)日：2016-05-10
申请号：US12969111
申请日：2010-12-15
申请人： Ian W. Hunter
发明人： Ian W. Hunter
IPC分类号： A61C17/02 , A61C19/06
CPC分类号： A61C17/02 , A61C19/063
摘要： A method of tooth treatment includes sensing a surface condition of tooth or gum and controlling ejection of a fluid jet against the tooth based on the sensed condition. The fluid may be a liquid and may be carried in a self-contained reservoir in a handle of a fluid ejection device. The liquid can be a cleansing solution and may contain cleaning particles. The ejection can be controlled to clean teeth at high pressure and to reduce pressure applied to gum, for example, to clean plaque. In some embodiments, the method may be used to remove soft tooth. The method may further include automatically scanning the fluid jet relative to a handle of an injection device. In an embodiment, the fluid is ejected by means of a fluid ejector comprising a stationary magnet assembly providing a magnetic field and a coil assembly, slidably disposed with respect to the magnet assembly, the coil assembly driving ejection of the fluid jet. Sensing the surface condition can include measuring a response of tissue to a mechanical perturbation and may include sensing an acoustic signal reflected from tissue. The mechanical perturbation can include applied force and the measured response can include deformation of the tissue. The method may further include mechanically disturbing the tissue with the fluid jet. A tooth treatment device includes a fluid ejector that ejects fluid against teeth and a servo controller controlling pressure of ejected fluid in response to a sensed surface condition. The fluid jet can have a diameter of less than 500 microns, a peak relative pressure of at least 1 kilopascal and velocity of at least 1 meter per second.
摘要翻译：牙齿治疗的方法包括感测牙齿或牙龈的表面状况，并根据检测到的状况控制针对牙齿的流体射流的喷射。流体可以是液体，并且可以在流体喷射装置的手柄中的独立储存器中携带。液体可以是清洁溶液并且可以含有清洁颗粒。可以控制喷射以在高压下清洁牙齿并减少施加到牙龈上的压力，例如清洁斑块。在一些实施例中，该方法可用于去除软齿。该方法还可以包括相对于注射装置的手柄自动扫描流体射流。在一个实施例中，通过包括提供磁场的固定磁体组件和相对于磁体组件可滑动地设置的线圈组件的流体喷射器喷射流体，线圈组件驱动喷射流体射流。感测表面状况可以包括测量组织对机械扰动的响应，并且可以包括感测从组织反射的声信号。机械扰动可以包括施加的力，并且测量的响应可以包括组织的变形。该方法还可以包括用流体射流机械地干扰组织。牙齿治疗装置包括喷射流体抵抗牙齿的流体喷射器和响应于检测到的表面状况控制喷射流体的压力的伺服控制器。流体射流可以具有小于500微米的直径，至少1千帕斯卡的峰值相对压力和至少1米/秒的速度。

78. 发明授权

US09306252B2 Dynamic pressure control in a battery assembly 有权
标题翻译：电池组件中的动态压力控制
公开(公告)号：US09306252B2
公开(公告)日：2016-04-05
申请号：US13493592
申请日：2012-06-11
申请人： Grant W. Kristofek , Serge R. Lafontaine , Ian W. Hunter
发明人： Grant W. Kristofek , Serge R. Lafontaine , Ian W. Hunter
IPC分类号： H01M10/48 , H01M10/44 , H02J7/00 , H01M10/6557 , H01M2/10 , H01M10/42 , H01M10/625 , H01M10/647 , H01M10/6568 , H01M10/052
CPC分类号： H01M10/63 , H01M2/1077 , H01M10/052 , H01M10/0525 , H01M10/4207 , H01M10/441 , H01M10/445 , H01M10/482 , H01M10/486 , H01M10/613 , H01M10/625 , H01M10/647 , H01M10/6557 , H01M10/6568 , H01M2220/20 , Y02E60/122
摘要： Operating a battery assembly that includes one or more rechargeable battery cells includes: monitoring one or more operational parameters of the battery cells; and dynamically controlling pressure applied to the one or more battery cells based at least in part on one or more of the monitored operational parameters.
摘要翻译：操作包括一个或多个可充电电池单元的电池组件包括：监测电池单元的一个或多个操作参数; 以及至少部分地基于所监视的操作参数中的一个或多个来动态地控制施加到所述一个或多个电池单元的压力。

79. 发明授权

US09075011B2 Irregular excitation of optical sensors 有权
标题翻译：光学传感器的不规则激励
公开(公告)号：US09075011B2
公开(公告)日：2015-07-07
申请号：US14118303
申请日：2012-05-18
申请人： Samuel Walker Inman , Ian W. Hunter
发明人： Samuel Walker Inman , Ian W. Hunter
IPC分类号： G01N21/64 , G01J3/02 , G01J3/44 , G01N21/77
CPC分类号： G01N21/64 , G01J3/0218 , G01J3/4406 , G01N21/6408 , G01N21/7703 , G01N2021/6432 , G01N2021/6484 , G01N2021/772 , G01N2021/7786 , G01N2201/0691
摘要： A material is excited with light whose intensity is modulated according to a modulation signal. The modulation signal includes multiple transitions between at least two intensity levels, with times of at least a first contiguous sequence of the transitions being selected according to an irregular pattern. A response of the material to the excitation is detected.
摘要翻译：材料被激发，其光强度根据调制信号被调制。所述调制信号包括至少两个强度级之间的多个转换，根据不规则图案选择所述转换的至少第一连续序列的时间。检测材料对激发的响应。

80. 发明授权

US08821434B2 Delivery of a solid body and/or a fluid using a linear Lorentz-force actuated needle-free jet injection system 有权
标题翻译：使用线性洛伦兹强力无针喷射系统输送固体和/或流体
公开(公告)号：US08821434B2
公开(公告)日：2014-09-02
申请号：US13269322
申请日：2011-10-07
申请人： Ian W. Hunter , Andrew J. Taberner , N. Catherine Hogan
发明人： Ian W. Hunter , Andrew J. Taberner , N. Catherine Hogan
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/19 , A61M5/3015 , A61M5/427 , A61M37/0069 , A61M2205/332 , A61M2205/3331 , A61M2205/3561 , A61M2205/3584 , A61M2205/583
摘要： A method for transferring a solid body across a surface of a biological body includes (i) applying an electrical input to a controllable electromagnetic actuator; (ii) producing with the electromagnetic actuator a mechanical force corresponding to the electrical input; and (iii) applying the mechanical force to a reservoir coupled at one end to a nozzle, the mechanical force producing a pressure within the reservoir, a magnitude of the pressure varying with the mechanical force and causing ejection of a fluid from the reservoir to drive the solid body into the biological body. A method for delivering a substance to a target body includes (i) positioning a needle-free injector proximate to a surface of the target body; (ii) injecting the substance into the target body; and (iii) while injecting, moving the needle-free injector along the surface, thereby sweeping the surface.
摘要翻译：用于将固体转移到生物体的表面上的方法包括（i）将电输入施加到可控制的电磁致动器; （ii）用电磁致动器产生对应于电输入的机械力; 并且（iii）将机械力施加到在一端连接到喷嘴的储存器，所述机械力产生储存器内的压力，所述压力的大小随着机械力而变化并且使流体从储存器喷射到驱动固体进入生物体。将物质输送到目标体的方法包括：（i）将无针注射器定位在目标体的表面附近; （ii）将物质注入目标体内; 和（iii）在注射的同时沿着表面移动无针注射器，从而扫掠表面。

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