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71. 发明申请

US20080242603A1 Novel Apo2L and IL-24 Polypeptides, Polynucleotides, and Methods of Their Use 审中-公开
标题翻译：新型Apo2L和IL-24多肽，多核苷酸及其使用方法
公开(公告)号：US20080242603A1
公开(公告)日：2008-10-02
申请号：US10589561
申请日：2005-02-18
申请人： Yan Wang , Amy L. Tsui Collins , Kevin Hestir , Ernestine Lee , Forgan Robert Halenbeck , Elizabeth Bosch , Thomas Linnemann , Lewis Thomas Williams
发明人： Yan Wang , Amy L. Tsui Collins , Kevin Hestir , Ernestine Lee , Forgan Robert Halenbeck , Elizabeth Bosch , Thomas Linnemann , Lewis Thomas Williams
IPC分类号： A61K38/17 , C07H21/00 , C07K14/00 , C12N5/06 , C12N15/09 , A61P35/00
CPC分类号： C07K14/70575 , C07K14/54
摘要： Disclosed are newly identified Interleukin 24 and APO2L splice variant molecules, their polypeptide sequences, and the polynucleotides encoding the polypeptide sequences. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells, and, for example, heterologous secretory leader sequences. Also disclosed are methods for using such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
摘要翻译：公开了新鉴定的白细胞介素24和APO2L剪接变体分子，其多肽序列和编码多肽序列的多核苷酸。还提供了通过使用例如载体和宿主细胞以及例如异源分泌前导序列的重组技术产生此类多肽的方法。还公开了使用这些多肽及其调节剂用于治疗包括癌症，免疫疾病，感染性疾病和缺血性疾病在内的疾病的方法。

72. 发明授权

US07415950B2 Engine valve control system and method 有权
标题翻译：发动机气门控制系统及方法
公开(公告)号：US07415950B2
公开(公告)日：2008-08-26
申请号：US11627316
申请日：2007-01-25
申请人： James Ervin , Yan Wang , Thomas Megll
发明人： James Ervin , Yan Wang , Thomas Megll
IPC分类号： F01L9/04
CPC分类号： F02D13/0253 , F01L9/04 , F01L2009/0436 , Y02T10/18
摘要： A method of operating an engine having at least one cylinder, said cylinder including at least one electric valve actuator, said actuator including at least a coil and an armature moveable thereto, the method comprising during a non-firing state of the cylinder: holding the armature of the actuator at a first position away from an equilibrium position by supplying a first amount of current to a first coil of the actuator; and reducing current supplied to the first coil from said first amount to a lower second amount to cause the armature to begin moving toward the equilibrium position; and during a subsequent firing state of the cylinder, varying an amount of holding current supplied to the first coil for holding the armature away from the equilibrium position based on at least said second amount of current.
摘要翻译：一种操作具有至少一个气缸的发动机的方法，所述气缸包括至少一个电动阀致动器，所述致动器包括至少一个线圈和可移动到其上的衔铁，该方法包括在气缸的非点火状态期间：通过向致动器的第一线圈提供第一量的电流，致动器的电枢位于离开平衡位置的第一位置处; 以及将从所述第一量提供给所述第一线圈的电流减小到较低的第二量，以使所述电枢开始朝向所述平衡位置移动; 并且在所述气缸的随后的点火状态期间，基于至少所述第二电流量，改变提供给所述第一线圈的保持电流的量以保持所述电枢远离所述平衡位置。

73. 发明授权

US07405299B2 Compounds as pharmaceutical agents 失效
标题翻译：化合物作为药剂
公开(公告)号：US07405299B2
公开(公告)日：2008-07-29
申请号：US10535381
申请日：2003-11-24
申请人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
发明人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
IPC分类号： C07D241/36 , C07D217/00 , C07D401/00
CPC分类号： C07D487/04
摘要： The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
摘要翻译：本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。

74. 发明授权

US07368445B2 Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms 失效
标题翻译：融合的吡唑衍生物作为TGF-β信号转导抑制剂用于治疗纤维化和肿瘤
公开(公告)号：US07368445B2
公开(公告)日：2008-05-06
申请号：US10597979
申请日：2005-02-16
申请人： Hong-Yu Li , William Thomas McMillen , Yan Wang
发明人： Hong-Yu Li , William Thomas McMillen , Yan Wang
IPC分类号： C07D487/04 , A61K31/517
CPC分类号： C07D413/14 , C07D401/14 , C07D487/04
摘要： The disclosed invention is directed to compounds of the formula: Formula (I) and methods of using these compounds.
摘要翻译：所公开的发明涉及下式的化合物：式（I）和使用这些化合物的方法。

75. 发明授权

US07359577B2 Differential method for layer-to-layer registration 失效
标题翻译：层间注册的差分方法
公开(公告)号：US07359577B2
公开(公告)日：2008-04-15
申请号：US10889038
申请日：2004-07-13
申请人： Yan Wang , Youling Lin
发明人： Yan Wang , Youling Lin
IPC分类号： G06K9/32
CPC分类号： G03F7/70633 , G03F9/7076
摘要： A system for precisely measuring layer-to-layer mis-registration is provided. The system includes a new type of mark and a comparison system, which compare the right and left signals from the mark to eliminate non-alignment noise, to enlarge the alignment information hundreds times then the actual shiftiness between two layers and to measure the mis-registration.
摘要翻译：提供了一种用于精确测量层间错配的系统。该系统包括一种新型的标记和比较系统，比较来自标记的左右信号以消除不对准噪声，将对准信息放大数百倍，然后实现两层之间的实际漂移，注册。

76. 发明授权

US07344431B2 Pad assembly for electrochemical mechanical processing 失效
标题翻译：焊接组件用于电化学机械加工
公开(公告)号：US07344431B2
公开(公告)日：2008-03-18
申请号：US11458356
申请日：2006-07-18
申请人： Yongqi Hu , Stan D. Tsai , Yan Wang , Feng Q. Liu , Shou-Sung Chang , Liang-Yuh Chen
发明人： Yongqi Hu , Stan D. Tsai , Yan Wang , Feng Q. Liu , Shou-Sung Chang , Liang-Yuh Chen
IPC分类号： B24D11/02 , C25D17/00 , C25F3/00 , C25C7/04
CPC分类号： B24B37/26 , B23H5/06 , B23H5/08 , B23H5/10 , B24B37/042 , B24B37/046 , B24B37/22 , B24B37/24 , B24B49/16 , B24B53/017 , C25D17/14 , H01L21/32125
摘要： Embodiments of a processing pad assembly for processing a substrate are provided. The processing pad assembly includes an upper layer having a processing surface and an electrode having a top side coupled to the upper layer and a bottom side opposite the top side. A first set of holes is formed through the upper layer for exposing the electrode to the processing surface. At least one aperture is formed through the upper layer and the electrode.
摘要翻译：提供了用于处理衬底的处理衬垫组件的实施例。处理垫组件包括具有处理表面的上层和具有联接到上层的顶侧和与顶侧相对的底侧的电极。通过上层形成第一组孔，用于将电极暴露于处理表面。通过上层和电极形成至少一个孔。

77. 发明申请

US20080059772A1 Method and system for increasing decoder throughput 有权
标题翻译：提高解码器吞吐量的方法和系统
公开(公告)号：US20080059772A1
公开(公告)日：2008-03-06
申请号：US11712653
申请日：2007-03-01
申请人： Eran Pisek , Yan Wang
发明人： Eran Pisek , Yan Wang
IPC分类号： G06F9/44
CPC分类号： H03M13/6525 , H03M13/09 , H03M13/23 , H03M13/2957 , H03M13/3961 , H03M13/3972 , H03M13/6511 , H03M13/6519 , H03M13/6527 , H03M13/653 , H03M13/6544
摘要： A method for increasing decoder throughput is provided that includes dividing a data block into a plurality of segments. For each of the segments, the segment is decoded by performing a plurality of processes for the segment. At least one process for a current segment is performed while at least one process for a preceding segment is performed. Also, at least one process for the current segment is performed while at least one process for a subsequent segment is performed.
摘要翻译：提供了一种用于增加解码器吞吐量的方法，其包括将数据块划分成多个段。对于每个段，通过对段进行多个处理来解码段。在执行用于前一段的至少一个进程时，执行用于当前段的至少一个进程。此外，当执行用于后续段的至少一个进程时，执行用于当前段的至少一个进程。

78. 发明申请

US20080051009A1 ENDPOINT FOR ELECTROPROCESSING 失效
标题翻译：电子终端
公开(公告)号：US20080051009A1
公开(公告)日：2008-02-28
申请号：US11930495
申请日：2007-10-31
申请人： Yan Wang , Antoine Manens , Siew Neo , Alain Duboust , Liang-Yuh Chen
发明人： Yan Wang , Antoine Manens , Siew Neo , Alain Duboust , Liang-Yuh Chen
IPC分类号： B24B49/00
CPC分类号： H01L21/32134 , B23H5/06 , B23H5/08 , B24B37/013 , B24B37/042 , B24B37/046 , B24B49/04 , B24B49/10 , B24B49/16 , G01N1/32 , H01L21/32125 , H04N1/00
摘要： Method for process control of electro-processes is provided. In one embodiment, the method includes processing a conductive layer formed on a wafer using a target endpoint, detecting breakthrough of the conductive layer to expose portions of an underlying layer, and adjusting the target endpoint in response to the detected breakthrough. In another embodiment, the target endpoint is adjusted relative to an amount of underlying layer exposed through the conductive layer.
摘要翻译：提供了电工艺过程控制方法。在一个实施例中，该方法包括使用目标端点处理在晶片上形成的导电层，检测导电层的穿透以暴露下层的部分，以及响应于检测到的突破来调整目标端点。在另一个实施例中，相对于通过导电层暴露的下层的量来调整目标端点。

79. 发明申请

US20080014197A1 NEUTRALIZING HUMAN ANTI-IGFR ANTIBODY 有权
标题翻译：中性人抗原抗体抗体
公开(公告)号：US20080014197A1
公开(公告)日：2008-01-17
申请号：US11835791
申请日：2007-08-08
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： A61K39/395 , A61P35/00 , A61P9/10 , C07K16/22
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
摘要翻译：本发明包括针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体。抗体可用于治疗或预防受试者的癌症。还包括使用和产生本发明的抗体的方法。

80. 发明授权

US07311592B2 Conductive polishing article for electrochemical mechanical polishing 有权
标题翻译：电化学机械抛光用导电抛光制品
公开(公告)号：US07311592B2
公开(公告)日：2007-12-25
申请号：US11556011
申请日：2006-11-02
申请人： Liang-Yuh Chen , Yuchun Wang , Yan Wang , Alain Duboust , Daniel A. Carl , Ralph Wadensweiler , Manoocher Birang , Paul D. Butterfield , Rashid Mavliev , Stan D. Tsai
发明人： Liang-Yuh Chen , Yuchun Wang , Yan Wang , Alain Duboust , Daniel A. Carl , Ralph Wadensweiler , Manoocher Birang , Paul D. Butterfield , Rashid Mavliev , Stan D. Tsai
IPC分类号： B24D3/34 , B24D11/00 , B24D17/00
CPC分类号： B82Y30/00 , B24B37/046 , B24B37/24 , B24B37/26 , B24D3/34
摘要： An article of manufacture and apparatus are provided for planarizing a substrate surface. In one aspect, an article of manufacture is provided for polishing a substrate including polishing article comprising a body having at least a partially conductive surface adapted to polish the substrate. A plurality of perforations may be formed in the polishing article for flow of material therethrough. An electrode is also exposed to the polishing surface by at least a portion of the plurality of perforations. The article of manufacture may also include a polishing surface having a plurality of grooves, wherein a portion of the plurality of grooves intersect with a portion of the plurality of perforations.
摘要翻译：提供了一种用于平坦化基板表面的制造和设备。在一个方面，提供了一种用于抛光衬底的制品，所述衬底包括抛光制品，所述抛光制品包括具有适于抛光所述衬底的至少部分导电表面的主体。可以在抛光制品中形成多个穿孔，以使材料流过其中。电极还通过多个穿孔的至少一部分暴露于抛光表面。制品还可以包括具有多个凹槽的抛光表面，其中多个凹槽的一部分与多个穿孔的一部分相交。

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