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    • 75. 发明授权
    • Intensity-modulated proton therapy
    • 强度调制质子治疗
    • US08644571B1
    • 2014-02-04
    • US13705903
    • 2012-12-05
    • Loma Linda University Medical CenterUniveristy of South Australia
    • Reinhard W. SchulteRegina BurachikYalcin Kaya
    • G06K9/00
    • A61N5/1039A61N5/1031A61N5/1077A61N2005/1087
    • The therapeutic treatment of a patient using intensity-modulated proton therapy is described. In one example, a method of creating a proton treatment plan is presented that divides volumes of interest into sub-volumes, applies dose constraints to the sub-volumes, finds one or more feasible configurations of a proton therapy system, and selects a proton beam configuration that improves or optimizes one or more aspects of proton therapy. In some implementations, the method of dividing volumes into sub-volumes includes creating fractional sub-volumes based at least in part on proximity to a target volume boundary. In some implementations, the method of finding an improved or optimal proton beam configuration from a set of feasible configurations includes finding a minimum of a cost function that utilizes weighting factors associated with treatment sites.
    • 描述了使用强度调制质子治疗的患者的治疗方法。 在一个示例中,提出了一种创建质子治疗计划的方法,其将感兴趣的体积分成子体积,对子体积施加剂量约束,找到质子治疗系统的一个或多个可行配置,并选择质子束 改善或优化质子治疗的一个或多个方面的配置。 在一些实现中,将卷分割成子卷的方法包括至少部分地基于与目标卷边界的接近度来创建分数子卷。 在一些实施方式中,从一组可行配置中找到改进或最佳质子束配置的方法包括找到利用与治疗部位相关联的加权因子的成本函数的最小值。