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61. 发明授权

US5767064A Soluble type II interleukin-1 receptors and methods 失效
标题翻译：可溶性II型白细胞介素-1受体和方法
公开(公告)号：US5767064A
公开(公告)日：1998-06-16
申请号：US442043
申请日：1995-05-16
申请人： John E. Sims , David J. Cosman , Stephen D. Lupton , Bruce A. Mosley , Steven K. Dower
发明人： John E. Sims , David J. Cosman , Stephen D. Lupton , Bruce A. Mosley , Steven K. Dower
IPC分类号： A61K38/00 , C07K14/715 , C12N15/06 , C12N15/12 , A01N37/18
CPC分类号： C07K14/7155 , A61K38/00
摘要： Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed. Also disclosed are compositions and methods for regulating an IL-1 mediated immune or inflammatory response in a mammal.
摘要翻译：公开了II型IL-1受体（II型IL-1R）蛋白，编码II型IL-1R的DNA和表达载体，以及作为重组细胞培养产物的产生II型IL-1R的方法。还公开了用于调节哺乳动物中IL-1介导的免疫或炎症反应的组合物和方法。

62. 发明授权

US5762908A Process for detecting potential carcinogens 失效
标题翻译：检测潜在致癌物质的过程
公开(公告)号：US5762908A
公开(公告)日：1998-06-09
申请号：US266014
申请日：1994-06-27
申请人： Robert H. Schiestl
发明人： Robert H. Schiestl
IPC分类号： C12Q1/68 , G01N33/50 , A61K49/00 , C12N15/06
CPC分类号： G01N33/5017 , C12Q1/68
摘要： A process is described for the screening of an agent to determine its effect on the frequency of genome rearrangement in mammals. In particular, mice harboring a p.sup.un mutation are exposed to an agent of interest and the frequency of genome rearrangement relative to that observed in an unexposed mouse is determined. The relative frequency of rearrangement represents a measure of the effect of the agent on the host animal.
摘要翻译：描述了用于筛选试剂以确定其对哺乳动物中基因组重排频率的影响的方法。特别地，携带双突变的小鼠暴露于感兴趣的试剂，并且确定相对于未暴露小鼠中观察到的基因组重排的频率。重排的相对频率表示药剂对宿主动物的影响的量度。

63. 发明授权

US5721115A DNA encoding a novel Haemophilus influenzae protein 失效
标题翻译：编码新型流感嗜血杆菌蛋白的DNA
公开(公告)号：US5721115A
公开(公告)日：1998-02-24
申请号：US480993
申请日：1995-06-07
申请人： Howard C. Krivan , James E. Samuel
发明人： Howard C. Krivan , James E. Samuel
IPC分类号： A61K39/102 , C07H3/06 , C07H15/04 , C07H15/08 , C07H15/18 , C07K14/285 , C12P21/06 , C07H21/02 , C12N15/06
CPC分类号： C07H15/04 , A61K39/102 , C07H15/08 , C07H15/18 , C07H3/06 , C07K14/285 , A61K2039/6068 , A61K2039/627 , C07K2319/00
摘要： Disclosed herein are an immunogenic Haemophilus influenzae outer membrane protein of 49 kDa as well as a mature outer membrane protein of 47 kDa protein, DNA and vector useful for producing the outer membrane protein, host cell containing said DNA, and a method for producing the outer membrane protein. Also disclosed are methods for producing these materials which can be beneficially used in the production of vaccines against H. influenzae.
摘要翻译：本文公开了49kDa的免疫原性流感嗜血杆菌外膜蛋白以及47kDa蛋白质的成熟外膜蛋白，可用于产生外膜蛋白的DNA和载体，含有所述DNA的宿主细胞，以及用于生产外部的方法膜蛋白。还公开了可用于生产针对流感嗜血杆菌疫苗的这些材料的生产方法。

64. 发明授权

US5712122A Carboxy terminal peptide-extended proteins 失效
标题翻译：羧基末端肽延伸蛋白
公开(公告)号：US5712122A
公开(公告)日：1998-01-27
申请号：US483023
申请日：1995-06-07
申请人： Irving Boime , Martin M. Matzuk , Jeffrey L. Keene
发明人： Irving Boime , Martin M. Matzuk , Jeffrey L. Keene
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/24 , A61K38/27 , A61P13/02 , A61P15/00 , C07K14/00 , C07K14/575 , C07K14/59 , C07K19/00 , C12N5/10 , C12N15/06 , C12N15/16 , C12P21/02 , C12R1/91 , A61K38/17 , C07K14/435 , C12N15/12
CPC分类号： C07K14/59 , A61K38/00 , C07K2319/00 , C07K2319/75 , C07K2319/91
摘要： Modified protein pharmaceuticals extended with a CTP unit retain their biological activity and they had extended biological half-lives. The CTP extension represents an amino acid sequence derived from that of positions 112-118 to 145 of human chorionic gonadotropin.
摘要翻译：用CTP单元延伸的改性蛋白质药物保持其生物活性，并且延长了生物半衰期。 CTP延伸代表衍生自人绒毛膜促性腺激素的位置112-118至145的氨基酸序列。

65. 发明授权

US5667839A Human recombinant collagen in the milk of transgenic animals 失效
标题翻译：转基因动物乳中人重组胶原蛋白
公开(公告)号：US5667839A
公开(公告)日：1997-09-16
申请号：US183648
申请日：1994-01-18
申请人： Richard A. Berg
发明人： Richard A. Berg
IPC分类号： A01K67/027 , A23C9/152 , A23C9/20 , A23J1/00 , A23J1/20 , A23J3/06 , C07H21/04 , C07K14/78 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C07K1/00 , C12N15/06
CPC分类号： C12N15/8509 , A01K67/0278 , A23C9/20 , A23J1/20 , A23J3/06 , C07K14/78 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/01 , A23C2230/05 , Y10S119/01 , Y10S514/801 , Y10S530/832
摘要： Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mammals. For example, expression systems can be microinjected into fertilized oocytes and reimplanted in foster mothers and carried to term in order to obtain transgenic non-human mammals capable of producing milk containing recombinant human procollagen or collagen. Human procollagen or collagen produced in this manner can be made of a single collagen type uncontaminated by other human or non-human collagens.
摘要翻译：通常不产生这些分子的细胞中人原胶原或胶原的生产通过构建与非人哺乳动物的乳腺相容的表达系统来实现。例如，表达系统可以被显微注射到受精的卵母细胞中并重新植入寄养母亲中并进行术语以获得能够产生含有重组人前胶原或胶原蛋白的乳的转基因非人哺乳动物。以这种方式产生的人前胶原或胶原蛋白可以由未被其他人或非人胶原蛋白污染的单一胶原型制成。

66. 发明授权

US5645997A Assay and treatment for demyelinating diseases such as multiple sclerosis, related hybridomas and monoclonal antibodies 失效
标题翻译：脱髓鞘疾病如多发性硬化，相关杂交瘤和单克隆抗体的测定和治疗
公开(公告)号：US5645997A
公开(公告)日：1997-07-08
申请号：US487066
申请日：1995-06-07
申请人： Ellis L. Kline , Daniel H. Zimmerman
发明人： Ellis L. Kline , Daniel H. Zimmerman
IPC分类号： G01N33/53 , A61K38/00 , A61K38/17 , A61K39/00 , C07K14/435 , C07K14/47 , C07K16/18 , C12N5/071 , C12N15/06 , C12P21/08 , C12N5/20
CPC分类号： C07K14/4713 , C07K16/18 , A61K38/00 , Y10S530/829 , Y10S530/837 , Y10S530/838 , Y10S530/839
摘要： The present invention relates to the diagnosis of multiple sclerosis. More specifically, this invention relates to an assay for detecting antigen(s) associated with multiple sclerosis. The present invention also relates to the generation of hybridomas which produce monoclonal antibodies which are specific for the multiple sclerosis-associated antigens. The present invention's use is in diagnosing multiple sclerosis and in routine follow-up monitoring of multiple sclerosis patients as to disease progression or response to therapy.
摘要翻译：本发明涉及多发性硬化症的诊断。更具体地，本发明涉及用于检测与多发性硬化相关的抗原的测定法。本发明还涉及产生对多发性硬化相关抗原具有特异性的单克隆抗体的杂交瘤的产生。本发明的用途是诊断多发性硬化和多发性硬化症患者关于疾病进展或对治疗的反应的常规随访监测。

67. 发明授权

US5620890A Monoclonal antibodies to hygromycin B and the method of making the same 失效
标题翻译：潮霉素B的单克隆抗体及其制备方法
公开(公告)号：US5620890A
公开(公告)日：1997-04-15
申请号：US404007
申请日：1995-03-14
申请人： Carol Kamps-Holtzapple , Larry H. Stanker , John R. DeLoach
发明人： Carol Kamps-Holtzapple , Larry H. Stanker , John R. DeLoach
IPC分类号： C07K16/44 , C12N5/12 , C12N15/06
CPC分类号： C07K16/44 , Y10S435/975
摘要： Hybridoma cell lines have been produced which secrete monoclonal antibodies that bind hygromycin B and are effective to detect hygromycin B levels as low as about 0.7 ppm. These monoclonal antibodies may be used for the detection and quantitative determination of trace amounts of hygromycin B in samples, especially in animal tissue and feed material.
摘要翻译：已经产生了分泌结合潮霉素B的单克隆抗体并有效检测低至约0.7ppm的潮霉素B水平的杂交瘤细胞系。这些单克隆抗体可用于检测和定量测定样品中痕量的潮霉素B，特别是在动物组织和饲料中。

68. 发明授权

US5589174A Anti-human influenza virus antibody 失效
标题翻译：抗人流感病毒抗体
公开(公告)号：US5589174A
公开(公告)日：1996-12-31
申请号：US229781
申请日：1994-04-19
申请人： Yoshinobu Okuno , Yuji Isegawa , Fuyoko Sasao , Shigeharu Ueda
发明人： Yoshinobu Okuno , Yuji Isegawa , Fuyoko Sasao , Shigeharu Ueda
IPC分类号： A61K38/00 , A61K39/00 , C07K14/11 , C07K16/10 , A61K39/395 , C07K16/08 , C12N5/20 , C12N15/06
CPC分类号： C07K14/005 , C07K16/1018 , A61K38/00 , A61K39/00 , C12N2760/16122 , C12N2760/16222
摘要： An anti-human influenza virus antibody is provided which recognizes the stem regions of haemagglutinin molecules of the H1N1 and H2N2 subtypes and has a neutralization activity, but does not recognize the stem region of the H3N2 subtype and has no neutralization activity. Also provided is an immunogenic artificial polypeptide having an antigenicity substantially the same as the stem regions of haemagglutinin molecules. Provided further is an immunogenic artificial polypeptide having an antigenicity substantially the same as the stem regions of haemagglutinin molecule and lacking the globular head region of haemagglutinin molecules. The antibody is useful in the diagnosis and treatment of influenza A virus, while the polypeptides are useful as a vaccine.
摘要翻译：提供抗人流感病毒抗体，其识别H1N1和H2N2亚型的血细胞凝集素分子的茎区，并具有中和活性，但不识别H3N2亚型的茎区并且没有中和活性。还提供了具有与血细胞凝集素分子的茎区域基本相同的抗原性的免疫原性人造多肽。还提供了具有与血细胞凝集素分子的茎区域基本相同的抗原性并且缺少血细胞凝集素分子的球形头部区域的免疫原性人造多肽。该抗体可用于甲型流感病毒的诊断和治疗，而多肽可用作疫苗。

69. 发明授权

US5576182A Anti-mucus glycoprotein monoclonal antibody 失效
标题翻译：抗粘蛋白糖蛋白单克隆抗体
公开(公告)号：US5576182A
公开(公告)日：1996-11-19
申请号：US373220
申请日：1995-01-18
申请人： Makoto Kurihara , Kazuhiko Ishihara , Kyoko Hotta , Hiromi Tanaka , Shiro Shimauchi
发明人： Makoto Kurihara , Kazuhiko Ishihara , Kyoko Hotta , Hiromi Tanaka , Shiro Shimauchi
IPC分类号： C07K16/18 , C12N5/10 , C12N5/20 , C12N15/06 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/18 , Y10S435/96
摘要： An IgM class monoclonal antibody which specifically reacts with mucus glycoproteins produced by human gastric gland-type mucous cells is provided. By performing immunohistochemical staining using a labeled derivative of the monoclonal antibody, human gastric gland-type mucous cells as well as mucus secreted by these cells can be specifically stained. The monoclonal antibody can also be used for the analysis of gastric gland-type mucous cell-derived mucus glycoproteins in human body fluids as well as for the examination or diagnosis of cancer.
摘要翻译： PCT No.PCT / JP94 / 00838 Sec。 371日期1995年1月19日 102（e）1995年1月19日PCT PCT 1994年5月26日PCT公布。公开号WO94 / 28158 PCT 日期1994年12月8日提供了与人胃腺型粘液细胞产生的粘液糖蛋白特异性反应的IgM类单克隆抗体。通过使用单克隆抗体的标记衍生物进行免疫组织化学染色，可以特异性地染色人胃腺型粘液细胞以及由这些细胞分泌的粘液。单克隆抗体也可用于分析人体液中的胃腺粘液细胞来源的粘液糖蛋白以及癌症的检查或诊断。

70. 发明授权

US5563120A Cytokine preparation for immunotherapy 失效
标题翻译：免疫治疗的细胞因子制剂
公开(公告)号：US5563120A
公开(公告)日：1996-10-08
申请号：US244401
申请日：1994-08-23
申请人： Vladimir P. Kuznetsov
发明人： Vladimir P. Kuznetsov
IPC分类号： A61K38/00 , A61K38/16 , A61P31/04 , A61P31/12 , A61P35/00 , C07K1/18 , C07K14/47 , C07K14/52 , C07K14/81 , C12N15/06 , A61K37/02 , A61K35/16 , C12P21/04 , C07K3/12
CPC分类号： C07K14/47 , C07K14/52 , C07K14/8107 , A61K38/00
摘要： A cytokine composition is prepared for use in immunotherapy of various diseases. The composition is prepared by culturing leucocytes previously infected with a virus in a culture medium containing a transal composition isolated from plasma and a complex of proteinase inhibitors composition isolated from plasma, separating leucocytes from the medium, removing impurities from the medium, and recovering a cytokine composition containing the transal composition and the complex of protease inhibitors composition. The transal composition contains transferrin, albumin and a 40 kDa protein and the complex of protease inhibitors composition contains .alpha..sub.2 -macroglobulin, a 160 kDa protein, an 80-60 kDa protein and a 20 kDa protein. The transal composition is prepared by mixing plasma with chloroform and recovering an aqueous phase, precipitating gamma globulins from the aqueous phase with polyethylene glycol to recover another aqueous phase, passing this aqueous phase through an anion exchange column and recovering proteins that bind to the column. The complex of protease inhibitors composition is prepared using steps for preparing the transal composition except that additional steps are used of collecting eluate from the anion exchange column, passing the eluate through a Cu.sup.++ chelate anion exchange column and recovering proteins that bind to the column.
摘要翻译： PCT No.PCT / CA93 / 00381 Sec。 371日期：1994年8月23日 102（e）日期1994年8月23日PCT提交1993年9月20日PCT公布。出版物WO94 / 06820 日期1994年3月31日一种准备用于各种疾病的免疫治疗的细胞因子组成。通过将培养含有从血浆中分离出的转运组合物的培养基和从血浆中分离的蛋白酶抑制剂组合物的复合物培养预先感染病毒的白细胞，从培养基中分离白细胞，从培养基中除去杂质，并回收细胞因子含有transal组合物的组合物和蛋白酶抑制剂组合物的复合物。 transal组合物含有转铁蛋白，白蛋白和40kDa蛋白，蛋白酶抑制剂组合物的复合物含有α2-巨球蛋白，160kDa蛋白，80-60kDa蛋白和20kDa蛋白。通过将等离子体与氯仿混合并回收水相，将聚氨基甲酸酯从水相中沉淀出来，以回收另一个水相，使该水相通过阴离子交换柱并回收与柱结合的蛋白质来制备转运组合物。蛋白酶抑制剂组合物的复合物是使用制备转运组合物的步骤制备的，除了使用附加步骤从阴离子交换柱收集洗脱液，使洗脱液通过Cu ++螯合物阴离子交换柱并回收与柱结合的蛋白质。

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