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    • 62. 发明授权
    • Clear aqueous antacid solution containing a polymeric meglumine-hexitol-aluminum hydroxide complex and preparation thereof
    • 含有聚合葡甲胺 - 己糖醇 - 氢氧化铝配合物的清水含水抗酸溶液及其制备方法
    • US3892851A
    • 1975-07-01
    • US37634973
    • 1973-07-05
    • STERLING DRUG INC
    • HINKEL JR EMIL T
    • A61K31/13C08G79/10A61K27/00
    • A61K31/13C08G79/10A61K31/045
    • Aqueous antacid solution comprising water and an effective amount of a polymeric meglumine-hexitol-aluminum hydroxide complex having mole ratios of Al:hexitol:meglumine of about 1:at least 0.333:0.12-0.50, preferably 1:0.667-1.333:0.20-0.333, is prepared by reacting aluminum tri(lower-alkoxide) in a non-polar solvent with an aqueous solution of meglumine and hexitol, removing the solvent and lower-alkanol formed by the reaction, and diluting the remaining aqueous solution with water to the desired concentration. A preferred modification having up to about 27 percent by weight of the aluminum hydroxide replaced by magnesium hydroxide is prepared as above by replacing a portion of the aluminum tri-(lower-alkoxide) by magnesium di-(loweralkoxide) or by magnesium di-aluminum octa-(lower-alkoxide).
    • 包含水和有效量的聚合葡甲胺 - 己糖醇 - 氢氧化铝配合物的水性抗酸溶液,其摩尔比为Al:己糖醇:葡甲胺约1:至少0.333:0.12-0.50,优选1:0.667-1.333:0.20-0.333 通过使非极性溶剂中的三(低级醇盐)铝与葡甲胺和己糖醇的水溶液反应制备,除去通过反应形成的溶剂和低级链烷醇,并将剩余的水溶液用水稀释至所需的 浓度。 如上制备具有高达约27重量%氢氧化铝被氢氧化镁取代的优选改性剂,通过用二 - (低级醇盐)镁或二碘化镁代替一部分三(低级醇盐)三 (低级醇盐)。