专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US4820758A Novel [5.5]-spiroketals 失效
标题翻译：新型[5.5] - 螺缩酮
公开(公告)号：US4820758A
公开(公告)日：1989-04-11
申请号：US47364
申请日：1987-05-06
申请人： Stephen J. Nelson
发明人： Stephen J. Nelson
IPC分类号： A23K1/16 , C07D493/10 , C07F7/18 , C07D311/00
CPC分类号： C07D493/10 , A23K20/121 , C07F7/1856
摘要： This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.
摘要翻译：本发明涉及用于杀死和控制蠕虫（蠕虫）的新方法，用于杀死和控制动物蠕虫的新配方，新的化合物和用于合成米尔倍霉素和阿维菌素大环内酯的北半球中间体的新合成。

62. 发明授权

US4764508A Complexes of flavanolignans with phospholipids, preparation thereof and associated pharmaceutical compositions 失效
标题翻译：黄烷醇胺与磷脂的配合物，其制备和相关的药物组合物
公开(公告)号：US4764508A
公开(公告)日：1988-08-16
申请号：US882608
申请日：1986-07-07
申请人： Bruno Gabetta , Ezio Bombardelli , Giorgio Pifferi
发明人： Bruno Gabetta , Ezio Bombardelli , Giorgio Pifferi
IPC分类号： C07D311/22 , A61K31/35 , A61K31/357 , A61K31/685 , A61P1/16 , C07D319/00 , C07D407/04 , C07F9/10 , C07D311/00 , C07D311/32 , C07D319/20
CPC分类号： C07D407/04 , C07F9/106
摘要： The invention relates to novel compounds comprising lipophilic complexes of silybin, silidianin, and silicristin with phospholipids, and the preparation of these complexes by non-conventional methods. Absorption of the novel compounds in the gastrointestinal tract is appreciably greater, resulting in higher plasma levels than for the individual flavanolignans. The resulting improvement in the pharmacokinetic and pharmacological parameters is such that the substances can advantageously be used in the treatment of acute and chronic liver disease of toxic, metabolic or infective origin or of degenerative nature.
摘要翻译：本发明涉及包含水飞蓟宾，硅藻土和硅藻土与磷脂的亲脂性复合物的新化合物，以及通过非常规方法制备这些络合物。新型化合物在胃肠道中的吸收明显更大，导致比单独的黄烷醇胺类药物更高的血浆水平。所得到的药代动力学和药理学参数的改善使得该物质可有利地用于治疗有毒，代谢或感染起源或退行性质的急性和慢性肝脏疾病。

63. 发明授权

US4677212A Intermediate 1,2-benzoxathiin derivatives 失效
标题翻译：中间体1,2-苯并恶嗪衍生物
公开(公告)号：US4677212A
公开(公告)日：1987-06-30
申请号：US658003
申请日：1984-10-04
申请人： Josef Ehrenfreund , Werner Fory , Willy Meyer , Werner Topfl
发明人： Josef Ehrenfreund , Werner Fory , Willy Meyer , Werner Topfl
IPC分类号： A01N47/36 , C07D209/08 , C07D215/00 , C07D215/36 , C07D239/00 , C07D251/00 , C07D307/00 , C07D307/79 , C07D307/82 , C07D307/83 , C07D307/88 , C07D311/00 , C07D311/18 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/70 , C07D311/76 , C07D317/00 , C07D317/46 , C07D317/62 , C07D319/00 , C07D319/18 , C07D327/00 , C07D327/04 , C07D327/06 , C07D333/00 , C07D333/54 , C07D333/62 , C07D335/00 , C07D335/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D411/12 , C07D417/12 , C07D521/00
CPC分类号： C07D307/79 , A01N47/36 , C07D209/08 , C07D215/36 , C07D307/83 , C07D307/88 , C07D311/18 , C07D311/22 , C07D311/58 , C07D311/70 , C07D311/76 , C07D317/46 , C07D317/62 , C07D319/18 , C07D327/06 , C07D333/54 , C07D335/06 , C07D521/00
摘要： The invention relates to N-phenylsulfonyl-N'-pyrimidinylureas and N-phenylsulfonyl-N-triazinylureas of the general formula ##STR1## wherein Q is selected from a radical ##STR2## Z is oxygen or sulfur, E is nitrogen or .dbd.CH--,R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.3 alkoxy, andR.sub.3 and R.sub.4, each independently of the other, are hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylthio, halogen, C.sub.2 -C.sub.5 alkoxyalkyl, C.sub.2 -C.sub.5 alkoxyalkoxy or --NR.sub.5 R.sub.6, wherein R.sub.5 and R.sub.6 are hydrogen or C.sub.1 -C.sub.4 alkyl,and to the salts of these compounds with amines, alkali metal bases or alkaline earth metal bases or with quaternary ammonium bases. These compounds have good pre- and postemergence selective herbicidal and growth regulating properties.
摘要翻译：本发明涉及通式为（I）的N-苯基磺酰基-N'-嘧啶基脲和N-苯基磺酰基-N-三嗪基脲，其中Q选自基团Z是氧或硫，E是氮或= CH-，R 2是氢，C 1 -C 4烷基或C 1 -C 3烷氧基，R 3和R 4各自独立地是氢，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4 卤代烷氧基，C 1 -C 4卤代烷硫基，C 1 -C 4烷硫基，卤素，C 2 -C 5烷氧基烷基，C 2 -C 5烷氧基烷氧基或-NR 5 R 6，其中R 5和R 6是氢或C 1 -C 4烷基，以及这些化合物与胺，碱金属碱或碱土金属碱或季铵碱。这些化合物具有良好的芽前和芽后选择性除草和生长调节性质。

64. 发明授权

US4647670A Trans-3,4-dihydro-2,2-dimethyl-6-nitro-4-(2-oxo-pyrrolidinyl)2H-1-ben zopyran-3-ol 失效
标题翻译：反式-3,4-二氢-2,2-二甲基-6-硝基-4-（2-氧代 - 吡咯烷基）-2H- 1,1-苯并吡喃-3-醇
公开(公告)号：US4647670A
公开(公告)日：1987-03-03
申请号：US679685
申请日：1984-12-10
申请人： John M. Evans , Robin E. Buckingham , Kenneth Willcocks
发明人： John M. Evans , Robin E. Buckingham , Kenneth Willcocks
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/443 , A61K31/445 , A61P9/12 , C07D207/00 , C07D211/00 , C07D311/00 , C07D311/68 , C07D311/70 , C07D405/04 , C07D405/12
CPC分类号： C07D405/04 , C07D311/68 , C07D311/70
摘要： Compounds of formula (I): ##STR1## wherein the various substituents are defined hereinbelow, having anti-hypertensive activity.

65. 发明授权

US4602934A Anilide herbicides 失效
标题翻译：苯胺类除草剂
公开(公告)号：US4602934A
公开(公告)日：1986-07-29
申请号：US670252
申请日：1984-11-13
申请人： Kurt H. Pilgram
发明人： Kurt H. Pilgram
IPC分类号： A01N43/08 , A01N43/12 , A01N43/90 , A01N53/00 , A01N53/12 , C07D307/94 , C07D311/00 , C07D493/06 , C07D493/10 , C07D493/08
CPC分类号： C07D311/00 , A01N43/08 , A01N43/12 , A01N43/90 , A01N53/00 , C07D307/94 , C07D493/06 , C07D493/10
摘要： Novel compounds of the formula ##STR1## wherein D is hydrogen, halogen, (halo)alkyl or (halo)alkoxy; R is alkyl or is cycloalkyl optionally 1-substituted by alkyl or halogen and R.sup.1 is the hydrocarbyl residue of a saturated oxygen-heterocyclic alcohol, are useful as herbicides.
摘要翻译：新颖的式（VI）化合物，其中D是氢，卤素，（卤素）烷基或（卤代）烷氧基; R是烷基或是被烷基或卤素任意1-取代的环烷基，R 1是饱和的氧杂环醇的烃基残基，可用作除草剂。

66. 发明授权

US4532248A Method of combatting coronary and vascular diseases 失效
标题翻译：打击冠心病和血管疾病的方法
公开(公告)号：US4532248A
公开(公告)日：1985-07-30
申请号：US398034
申请日：1982-07-14
申请人： Gerhard Franckowiak , Horst Boshagen , Friedrich Bossert , Siegfried Goldmann , Horst Meyer , Egbert Wehinger , Jurgen Stoltefuss , Matthias Schramm , Gunter Thomas , Robertson Towart
发明人： Gerhard Franckowiak , Horst Boshagen , Friedrich Bossert , Siegfried Goldmann , Horst Meyer , Egbert Wehinger , Jurgen Stoltefuss , Matthias Schramm , Gunter Thomas , Robertson Towart
IPC分类号： A61K31/435 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/451 , A61K31/455 , A61K31/47 , A61K31/495 , A61K31/535 , A61P3/00 , A61P3/08 , A61P7/10 , A61P9/02 , A61P9/04 , A61P29/00 , C07D211/00 , C07D211/82 , C07D211/84 , C07D211/90 , C07D213/00 , C07D221/00 , C07D307/00 , C07D311/00 , C07D333/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D491/052 , C07D491/10 , C07D491/107 , C07D498/04 , A61K31/44
CPC分类号： C07D401/04 , C07D211/84 , C07D211/90 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/10
摘要： 1,4-Dihydropyridines of the formula ##STR1## in which n is 0,1 or 2, andR.sup.1 to R.sup.7 can have a wide variety of meanings, which possess inotropic action, and many of which are new, are useful in increasing the influx of Ca.sup.++ into cells, particularly in combatting coronary and vascular diseases, hypertension swelling in the mucous membranes and diseases involving increased blood sugar or an incorrect salt and fluid balance.
摘要翻译：其中n为0,1或2，且R1至R7可以具有多种含义，其具有各向异性作用，并且其中许多是新的，可用于增加其中n为0,1或2的1,4-二氢吡啶 Ca ++进入细胞，特别是与冠状动脉和血管疾病的对抗，粘膜中的高血压肿胀和血糖升高或不正确的盐和液体平衡的疾病。

67. 发明授权

US4427614A 3-Hydroxybutyric acid polymers 失效
标题翻译： 3-羟基丁酸聚合物
公开(公告)号：US4427614A
公开(公告)日：1984-01-24
申请号：US434229
申请日：1982-10-14
申请人： Peter J. Barham , Paul A. Holmes
发明人： Peter J. Barham , Paul A. Holmes
IPC分类号： C07C17/16 , C07C29/147 , C07C45/30 , C07C405/00 , C07D267/10 , C07D295/096 , C07D295/112 , C07D295/155 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/12 , C07D333/16 , C07D333/22 , C07D333/24 , D01F6/62 , D01D5/12
CPC分类号： C07D295/096 , C07C17/16 , C07C29/147 , C07C405/00 , C07C405/0033 , C07C405/0041 , C07C45/30 , C07D267/10 , C07D295/112 , C07D295/155 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/12 , C07D333/16 , C07D333/22 , C07D333/24 , D01F6/625 , Y10S428/91
摘要： A solvent-free preform of a 3-hydroxybutyric acid polymer is subjected to a compression step to reduce its thickness by at least 5% and the compressed preform is then drawn uni- or bi- axially to induce orientation.
摘要翻译：将不含溶剂的3-羟基丁酸聚合物的预成型体进行压缩步骤以将其厚度减小至少5％，然后将压缩的预成型件单向或双向拉伸以诱导取向。

68. 发明授权

US4413133A Process for manufacturing chlorolactones from unsaturated carboxylic acids 失效
标题翻译：从不饱和羧酸生产氯内酯的方法
公开(公告)号：US4413133A
公开(公告)日：1983-11-01
申请号：US321145
申请日：1981-11-13
申请人： Bernard Damin , Alain Forestiere , Bernard Sillion
发明人： Bernard Damin , Alain Forestiere , Bernard Sillion
IPC分类号： C07D307/00 , C07D307/33 , C07D307/77 , C07D309/30 , C07D311/00 , C07D493/10 , C07D307/32
CPC分类号： C07D307/00 , C07D307/33 , C07D307/77 , C07D309/30 , C07D311/00 , C07D493/10
摘要： Process for manufacturing chlorolactones by reacting, within an ahydrous organic solvent, a metal N-chlorosulfonamidate of the formula ##STR1## wherein R is a hydrogen or halogen atom or an alkyl radical, Ar is a mono- or polycyclic divalent aromatic radical and M is an alkali metal, with a substantially stoichiometrical proportion of an aliphatic or alicyclic carboxylic acid having at least one double bond separated from the COOH group by at least 2 carbon atoms, in the presence of a substantially stoichiometrical amount of a strong acid whose conjugate base is weakly nucleophilic.
摘要翻译：在无水有机溶剂中使下式的化合物的N-氯磺酰氨基化物，其中R是氢或卤原子或烷基，Ar是单环或多环二价芳基，M是碱金属，具有基本上化学计量比例的具有至少一个双键的脂族或脂环族羧酸，其具有至少2个碳原子的COOH基团，在基本上化学计量的强酸的存在下，其共轭碱为弱亲核。

69. 发明授权

US4390721A 3-Endo-protected hydroxyl-tricyclo[3,2,0,0.sup.2,7 ]heptan-6-ones 失效
标题翻译： 3-内酯保护的羟基 - 三环[3,2,0,0,2,7]庚-6-酮
公开(公告)号：US4390721A
公开(公告)日：1983-06-28
申请号：US956676
申请日：1978-11-01
申请人： Stanley M. Roberts
发明人： Stanley M. Roberts
IPC分类号： C07C69/734 , A61K31/045 , A61K31/20 , A61K31/23 , A61K31/275 , A61P43/00 , C07C41/00 , C07C43/178 , C07C45/00 , C07C45/67 , C07C49/517 , C07C49/753 , C07C51/00 , C07C51/367 , C07C59/62 , C07C67/00 , C07C69/013 , C07C253/00 , C07C255/46 , C07C401/00 , C07C405/00 , C07D309/12 , C07D311/00 , C07F7/18 , C07C69/14
CPC分类号： C07F7/1856 , C07C405/00 , C07C49/753 , C07C51/367 , C07D309/12 , C07D311/00 , Y02P20/55
摘要： A novel 3-endo-protected hydroxyl-tricyclo[3,2,0,0.sup.2,7 ]heptan-6-one is described which can be alkylated stereospecifically to give a 5-endo-protected hydroxyl-bicyclo[2,2,1]heptan-2-one which may then be converted via a sequence of reactions into prostaglandins of the F-series having a protecting group at the 9-position. The synthesis of the tricyclo[3,2,0,0.sup.2,7 ]heptan-6-one is also described.
摘要翻译：描述了一种新的3-内切保护的羟基 - 三环[3,2,0,0,2,7]庚-6-酮，其可以通过立体特异性烷基化得到5-端保护的羟基 - 双环[2,2,1 ]庚-2-酮，其然后可以经由一系列反应转化成在9-位具有保护基的F-系列的前列腺素。还描述了三环[3,2,0,2,7]庚-6-酮的合成。

70. 发明授权

US4381399A Purification of tetrahydrodibenzo[b,d]pyrans from crude synthetic mixtures 失效
标题翻译：从粗制合成混合物中纯化四氢二苯并[b，d]吡喃
公开(公告)号：US4381399A
公开(公告)日：1983-04-26
申请号：US332644
申请日：1981-12-21
申请人： Robert E. Olsen , Stephen J. Backlund
发明人： Robert E. Olsen , Stephen J. Backlund
IPC分类号： C07D311/00 , C07D20060101 , C07D311/80
CPC分类号： C07D311/80
摘要： (-)-6a,10a-Trans-1-hydroxy-3-n-pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydrodibenzo[b,d]pyran or any of its related pyrans in which the n-pentyl group is replaced by hydrogen or C.sub.1 -C.sub.10 alkyl is isolated from a crude synthetic mixture by a process which comprises esterifying the mixture to form perfluorinated alkanoic acid esters, removing low-boiling and non-volatile components, passing the mixture through a first gas chromatographic column with a packing whose liquid phase consists of a slightly polar phenyl-substituted silicone oil and recovering a fraction rich in the desired component, passing the recovered fraction through a second gas chromatographic column with a packing whose liquid phase consists of a non-phenyl-substituted silicone oil and recovering a fraction rich in the desired component, hydrolyzing the fraction recovered from the second stage, and recovering the desired product from the hydrolysis mixture.
摘要翻译：（ - ） - 6a，10a-反式-1-羟基-3-正戊基-6,6,9-三甲基-6a，7,8,10a-四氢二苯并[b，d]吡喃或其相关的吡喃其中正戊基被氢代替或C1-C10烷基通过包括将混合物酯化形成全氟化的链烷酸酯的方法从粗合成混合物中分离出来，除去低沸点和非挥发性组分，将混合物通过具有填料的第一气相色谱柱，其液相由稍微极性的苯基取代的硅油组成并回收富含所需组分的级分，使回收的级分通过第二气相色谱柱，其中液相包含的非苯基取代的硅油，并回收富含所需组分的级分，水解从第二级回收的级分，并从水解混合物中回收所需产物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式