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61. 发明申请

US20100248234A1 CANCER DIAGNOSTIC KIT AND CANCER DIAGNOSTIC METHOD 有权
标题翻译：癌症诊断套件和癌症诊断方法
公开(公告)号：US20100248234A1
公开(公告)日：2010-09-30
申请号：US12677755
申请日：2008-07-18
申请人： Toshiro Ono , Eiichi Nakayama
发明人： Toshiro Ono , Eiichi Nakayama
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/00 , G01N33/53 , G01N33/574 , C07K16/18
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158 , G01N33/57419 , G01N33/57423 , G01N33/5743 , G01N33/57446 , G01N33/57484 , G01N33/6872
摘要： The present invention provides a kit and method for diagnosing a cancer using a polynucleotide including a nucleotide sequence of SEQ ID No: 1 or 3 or a partial sequence thereof, a polypeptide consisting of an amino acid sequence of SEQ ID No: 2 or 4 or a partial sequence thereof, or an antibody binding specifically to a polypeptide consisting of an amino acid sequence of SEQ ID No: 2 or 4 or a partial sequence thereof. This makes it possible to find a CT antigen useful for testing, diagnosis, or treatment of a digestive system cancer and to develop a novel cancer diagnostic technique using the CT antigen.
摘要翻译：本发明提供使用包含SEQ ID No：1或3的核苷酸序列或其部分序列的多核苷酸诊断癌症的试剂盒和方法，由SEQ ID No：2或4的氨基酸序列组成的多肽或或其特异性结合于由SEQ ID No：2或4的氨基酸序列或其部分序列组成的多肽的抗体。这使得可以找到可用于测试，诊断或治疗消化系统癌症的CT抗原，并开发使用CT抗原的新型癌症诊断技术。

62. 发明申请

US20100247432A1 MARKER FOR THE DIAGNOSIS OF CANCER 有权
标题翻译：癌症诊断标记
公开(公告)号：US20100247432A1
公开(公告)日：2010-09-30
申请号：US12753686
申请日：2010-04-02
申请人： DEREK ZIEKER
发明人： DEREK ZIEKER
IPC分类号： A61K51/10 , G01N33/53 , G01N33/574 , C12Q1/68 , A61K39/395 , A61K31/7105 , A61P35/00
CPC分类号： G01N33/57446 , A61K31/713 , A61K45/06 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention relates to a method for diagnosing peritoneal carcinoses or metastatic primary tumors in a subject, as well as to a method for providing a prognosis to a subject diagnosed with a primary tumor to develop metastases, in particular peritoneal carcinosis, comprising the step of determining the level of expression of at least phosphoglycerate kinase 1 (PGK1) gene. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the activity and/or expression of phosphoglycerate kinase 1 (PGK1) and/or β-catenin, either alone or in combination with the detection of CXCR4 and/or CXCL12, for the diagnosis or prognosis of peritoneal carcinoses and/or metastatic primary tumors. Also, a method for the preventive treatment of peritoneal carcinoses and/or metastatic primary tumors in a subject in need thereof is disclosed, wherein the method comprises the step of administering to the subject at least a pharmaceutically effective amount of a substance inhibiting the activity and/or expression of phosphoglycerate kinase 1 (PGK1).
摘要翻译：本发明涉及一种用于诊断受试者腹膜癌或转移性原发性肿瘤的方法，以及用于向被诊断患有原发性肿瘤的受试者提供预后以产生转移，特别是腹膜癌的方法，该方法包括以下步骤：确定至少磷酸甘油酸激酶1（PGK1）基因的表达水平。此外，本发明涉及一种诊断试剂盒，其包含至少一种用于检测磷酸甘油酸激酶1（PGK1）和/或β-联蛋白的活性和/或表达的物质，或单独或结合检测CXCR4和 /或CXCL12，用于诊断或预后腹膜癌和/或转移性原发性肿瘤。另外，公开了一种在有需要的受试者中预防治疗腹膜癌和/或转移性原发性肿瘤的方法，其中所述方法包括以下步骤：向受试者施用至少一种药学有效量的抑制该活性的物质，以及 /或磷酸甘油酸激酶1（PGK1）的表达。

63. 发明申请

US20100190173A1 Gene Expression Markers For Colorectal Cancer Prognosis 有权
标题翻译：基因表达标记用于结肠直肠癌预后
公开(公告)号：US20100190173A1
公开(公告)日：2010-07-29
申请号：US12696934
申请日：2010-01-29
申请人： Wayne Cowens , Joffre B. Baker , Kim Clark , James Hackett , Drew Watson , Soonmyung Paik
发明人： Wayne Cowens , Joffre B. Baker , Kim Clark , James Hackett , Drew Watson , Soonmyung Paik
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.
摘要翻译：一种预测患有结肠直肠癌的受试者的临床结果的方法，包括确定从受试者获得的癌细胞的生物样品中一种或多种预测性RNA转录物或其表达产物的表达的证据。

64. 发明授权

US07608403B2 Method for cancer detection, progression analysis and malign tumour prognosis based on the study of metabolic markers of the cell 失效
标题翻译：基于细胞代谢标志物研究的癌症检测，进展分析和恶性肿瘤预后的方法
公开(公告)号：US07608403B2
公开(公告)日：2009-10-27
申请号：US10514771
申请日：2003-05-20
申请人： Jose Manuel Cuezva Marcos
发明人： Jose Manuel Cuezva Marcos
IPC分类号： G01N33/53
CPC分类号： C12N9/14 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57438 , G01N33/57446 , G01N33/57484 , G01N2333/914
摘要： Described is a method for cancer detection, progression analysis and malign tumor prognosis based on the study of metabolic markers of the cell. The method consists in using the study of the protein expression of the bioenergetic function of the mitochondrion, such as the beta-catalytic subunit of the H-ATP synthase, in relation to structural proteins and mitochondrial respiration, such as hsp 60 and cytochrome oxidase subunits I and IV respectively, and said mitochondrial bioenergetic index, (ratio of beta-ATPasa/hsp60; beta-ATPasa/COX I; beta-ATPasa/COX IV) which relates to the cellular protein expression of the glycolytic pathway, such as glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase M, in order to generate the bioenergetic index of the cell.
摘要翻译：描述了一种基于细胞代谢标记研究的癌症检测，进展分析和恶性肿瘤预后的方法。该方法包括使用线粒体的生物能量功能的蛋白质表达研究，如H-ATP合酶的β-催化亚基，与结构蛋白和线粒体呼吸相关，如hsp 60和细胞色素氧化酶亚基 I和IV分别表示线粒体生物能量指数（β-ATPasa / hsp60;β-ATPasa / COX I;β-ATPasa / COX IV的比例），其与糖酵解途径的细胞蛋白质表达有关， 3-磷酸脱氢酶和丙酮酸激酶M，以产生细胞的生物能量指数。

65. 发明授权

US07569352B2 Method for identifying modulators of the dioxin/aryl hydrocarbon receptor (AHR) 失效
标题翻译：识别二恶英/芳烃受体（AHR）调节剂的方法
公开(公告)号：US07569352B2
公开(公告)日：2009-08-04
申请号：US10556857
申请日：2004-05-13
申请人： Petra Von Stein , Patrik Andersson , Nikolai Kouznetsov , Lorenz Poellinger
发明人： Petra Von Stein , Patrik Andersson , Nikolai Kouznetsov , Lorenz Poellinger
IPC分类号： G01N33/52 , G01N33/567 , C07H21/04
CPC分类号： G01N33/566 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A61K48/005 , C07K14/705 , C12N15/8509 , G01N33/57446 , G01N2500/04
摘要： Agents useful for modulating the dioxin/aryl hydrocarbon receptor (AhR) can now be identified by determining the binding to said receptor and whether said agent suppresses or inhibits the expression of a gene substantially consisting of a sequence according to one of SEQ. ID. NO. 1 and SEQ. ID. NO. 2; a nucleotide sequence functionally homologous, or substantially homologous, or at least 90% identical to one of SEQ. ID. NO. 1 and SEQ. ID. NO. 2; and a nucleotide sequence complementary to the nucleotide sequence of SEQ. ID. NO. 1 or SEQ. ID. NO. 2. Such agents find utility in pharmaceutical compositions and methods for the prevention, alleviation or treatment of diseases involving gastrointestinal hyperplasia, such as gastrointestinal cancer or gastric cancer.
摘要翻译：现在可以通过确定与所述受体的结合来确定可用于调节二恶英/芳烃受体（AhR）的药剂，以及所述药物是否抑制或抑制基本上由SEQ ID NO：1之一的序列组成的基因的表达。 ID。没有。 1和SEQ。 ID。没有。 2; 与SEQ ID NO：1中的一个功能同源或基本同源或至少90％相同的核苷酸序列。 ID。没有。 1和SEQ。 ID。没有。 2; 和与SEQ ID NO：1的核苷酸序列互补的核苷酸序列。 ID。没有。 1或SEQ。 ID。没有。这样的试剂可用于预防，缓解或治疗涉及胃肠道增生的疾病如胃肠癌或胃癌的药物组合物和方法。

66. 发明申请

US20090170216A1 Selection of colorectal cancer patients for treatment with drugs targeting EGFR pathway 有权
标题翻译：选择结直肠癌患者治疗靶向EGFR途径的药物
公开(公告)号：US20090170216A1
公开(公告)日：2009-07-02
申请号：US12321394
申请日：2009-01-20
申请人： Heinrich Roder , Maxim Tsypin , Julia Grigorieva
发明人： Heinrich Roder , Maxim Tsypin , Julia Grigorieva
IPC分类号： G01N24/00
CPC分类号： G01N33/57446 , G01N33/6848 , G01N2800/52 , G06F19/707 , Y02A90/26 , Y10T436/24
摘要： Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a colorectal cancer (CRC) patient is likely to benefit from a drug targeting an epidermal growth factor receptor pathway, such as monoclonal antibody EGFR inhibitors.
摘要翻译：使用质谱数据分析和分类算法的方法提供了确定结肠直肠癌（CRC）患者是否可能受益于靶向表皮生长因子受体途径的药物，例如单克隆抗体EGFR抑制剂的能力。

67. 发明申请

US20090136508A1 METHOD OF DIAGNOSING COLON AND GASTRIC CANCERS 审中-公开
标题翻译：诊断结肠癌和胃癌的方法
公开(公告)号：US20090136508A1
公开(公告)日：2009-05-28
申请号：US12250419
申请日：2008-10-13
申请人： Yusuke NAKAMURA , Yoichi Furukawa
发明人： Yusuke NAKAMURA , Yoichi Furukawa
IPC分类号： A61K39/395 , C07K14/435 , C07H21/04 , C12N15/63 , C12N5/00 , C12P21/06 , A61K39/00 , A61K38/17 , C12N5/02 , C07K16/18 , C07H21/02 , C12Q1/68 , G01N33/53 , A61K31/7088
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4748 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12Q1/6886 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N33/57419 , G01N33/57446 , G01N2500/00
摘要： Objective methods for detecting and diagnosing Colorectal and gastric carcinomas are described herein. In one embodiment, the diagnostic method involves the determining a expression level of colon or gastric cancer-associated gene that discriminate between colon or gastric cancer and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of colonic cancer and method of vaccinating a subject against colon or gastric cancer.
摘要翻译：本文描述了用于检测和诊断结肠直肠癌和胃癌的客观方法。在一个实施方案中，诊断方法涉及确定区分结肠癌或胃癌和正常细胞的结肠癌或胃癌相关基因的表达水平。本发明进一步提供筛选用于治疗结肠癌的治疗剂的方法以及接种对抗结肠癌或胃癌的方法。

68. 发明申请

US20090130694A1 MAC-2BP as a Marker for the Diagnosis of Gastric Cancer 审中-公开
标题翻译： MAC-2BP作为胃癌诊断的标志物
公开(公告)号：US20090130694A1
公开(公告)日：2009-05-21
申请号：US12087224
申请日：2006-09-25
申请人： Hee Gu Lee , Yuk Pheel Park , Jae Wha Kim , Eun Young Song , Do Young Yoon , Young Il Yeom , Seung-Chul Choi
发明人： Hee Gu Lee , Yuk Pheel Park , Jae Wha Kim , Eun Young Song , Do Young Yoon , Young Il Yeom , Seung-Chul Choi
IPC分类号： G01N33/574
CPC分类号： G01N33/57446
摘要： Disclosed is a diagnostic kit for gastric cancer. It comprises an agent capable of detecting and quantitatively assaying the gastric cancer marker Mac-2BP (Mac-2 binding protein). Also, a method for detecting the gastric cancer marker using the kit is disclosed.
摘要翻译：公开了一种胃癌诊断试剂盒。它包括能够检测和定量测定胃癌标记物Mac-2BP（Mac-2结合蛋白）的试剂。另外，公开了使用该试剂盒检测胃癌标记物的方法。

69. 发明授权

US07485422B2 Detection of CDX2 expression 失效
标题翻译：检测CDX2表达
公开(公告)号：US07485422B2
公开(公告)日：2009-02-03
申请号：US11058778
申请日：2005-02-16
申请人： Scott A. Waldman , Jason Park , Stephanie Schulz
发明人： Scott A. Waldman , Jason Park , Stephanie Schulz
IPC分类号： C12Q1/70
CPC分类号： A61K39/0011 , A61K9/127 , A61K31/7034 , A61K31/7048 , A61K47/6871 , A61K51/1075 , C07K16/3046 , C07K16/40 , C12N15/113 , C12Q1/6886 , C12Q2600/158 , G01N33/57407 , G01N33/57419 , G01N33/57446 , G01N2333/988
摘要： Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of for treating and preventing metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed.
摘要翻译：公开了用于转移性结直肠癌或原发性和/或转移性胃或食管癌的筛选和诊断试剂，试剂盒和方法。公开了用于治疗和预防转移性结肠直肠癌或原发性和/或转移性胃或食管癌的疫苗组合物和方法。

70. 发明申请

US20080311131A1 Human Mob-5 (IL-24) receptors and uses thereof 审中-公开
标题翻译：人类Mob-5（IL-24）受体及其用途
公开(公告)号：US20080311131A1
公开(公告)日：2008-12-18
申请号：US11892613
申请日：2007-08-24
申请人： Peng Liang
发明人： Peng Liang
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： G01N33/57419 , C07K14/54 , C07K14/7155 , C07K16/244 , G01N33/5011 , G01N33/574 , G01N33/57446 , G01N2333/715
摘要： The present invention provides the receptors for Mob-5 (IL-24). One of the Mob-5 receptors comprises IL-22R1 and IL-20R2. Another Mob-5 receptor comprises IL-20R1 and IL-22R2. The invention also provides methods of inhibiting the Mob-5 receptor as well as methods of detecting cancer by detecting the presence of the Mob-5 receptor.
摘要翻译：本发明提供了用于Mob-5（IL-24）的受体。 Mob-5受体之一包含IL-22R1和IL-20R2。另一种Mob-5受体包含IL-20R1和IL-22R2。本发明还提供了通过检测Mob-5受体的存在来抑制Mob-5受体的方法以及检测癌症的方法。

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