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    • 61. 发明授权
    • Direct sensing of molecular species by polyfluors on a DNA backbone
    • 通过DNA骨架上的多聚体直接检测分子种类
    • US09416155B2
    • 2016-08-16
    • US13515481
    • 2010-12-14
    • Eric Todd Kool
    • Eric Todd Kool
    • C07H19/04C12Q1/68C07H21/00G01N31/22G01N33/58
    • C07H21/00G01N31/22G01N33/582
    • Nucleoside analogs are provided; and fluorescent sensors comprising the nucleoside analogs. The sensors comprise multiple chromophores built on a DNA backbone, in which all the natural DNA bases are replaced by excimeric or exciplex-forming fluorophores, ligands, quenchers and spacers in thousands of combinations. The sensors find use in the detection and identification of target analytes by fluorescence, e.g., detection of metal ions, neutral organic compounds and anions. The sensors find use in the detection and identification of molecular species in the vapor or gaseous phase, or the liquid phase. The sensors find use in qualitative and quantitative screening and detection methods.
    • 提供核苷类似物; 和包含核苷类似物的荧光传感器。 传感器包括建立在DNA骨架上的多个发色团,其中所有天然DNA碱基被成千上万种组合中的被形成磷酸复合物或激肽复合物的荧光团,配体,猝灭剂和间隔物代替。 这些传感器可用于通过荧光检测和鉴定目标分析物,例如检测金属离子,中性有机化合物和阴离子。 传感器可用于检测和鉴定蒸气或气相或液相中的分子物质。 传感器用于定性和定量筛选和检测方法。