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61. 发明申请

US20130125621A1 SYSTEM FOR ANALYZING A GAS MIXTURE INCLUDING AT LEAST ONE CHROMATOGRAPHY COLUMN 有权
公开(公告)号：US20130125621A1
公开(公告)日：2013-05-23
申请号：US13702727
申请日：2011-06-06
申请人： Pierre Puget , Edward B. Myers , Michael L. Roukes
发明人： Pierre Puget , Edward B. Myers , Michael L. Roukes
IPC分类号： G01N30/78
CPC分类号： G01N30/78 , G01N30/463 , G01N30/60 , G01N30/6039 , G01N30/6052 , G01N30/6095 , G01N30/8693
摘要： A system for analyzing a gas mixture, including at least one chromatography column, a mechanism injecting the mixture into the column, and a mechanism detecting compound(s) forming the gas mixture, the detection mechanism including at least one detector of nanosensor type of an outlet of the column and a detector of nanosensor type in the column, capable of detecting passage of the compounds. It is then possible to determine the velocity of each of the compounds within the system.

62. 发明授权

US08438903B2 Molecule detection device formed in a semiconductor structure 有权
标题翻译：形成在半导体结构中的分子检测装置
公开(公告)号：US08438903B2
公开(公告)日：2013-05-14
申请号：US12694712
申请日：2010-01-27
申请人： Stanislav Polonsky , Frank Suits
发明人： Stanislav Polonsky , Frank Suits
IPC分类号： G01N30/02 , G01N30/26 , C12M1/34
CPC分类号： B82Y15/00 , G01N30/6095
摘要： Semiconductor devices, chromatography devices and integrated circuits for detecting one or more molecules and methods for forming a semiconductor device for detecting one or more molecules are presented. For example, a semiconductor device for detecting one or more molecules includes a channel formed within a semiconductor structure, and at least one detector formed within the semiconductor structure. The at least one detector detects the one or more molecules in the channel. The semiconductor device may optionally comprise one or more additional channels formed within the semiconductor structure. The semiconductor device may, for example, be operative to detect a single molecule.
摘要翻译：提供用于检测一个或多个分子的半导体器件，色谱装置和集成电路以及用于形成用于检测一个或多个分子的半导体器件的方法。例如，用于检测一个或多个分子的半导体器件包括形成在半导体结构内的沟道和形成在半导体结构内的至少一个检测器。至少一个检测器检测通道中的一个或多个分子。半导体器件可以可选地包括在半导体结构内形成的一个或多个附加通道。例如，半导体器件可以用于检测单个分子。

63. 发明申请

US20130014567A1 CHROMATOGRAPHY APPARATUS HAVING DIFFUSION-BONDED AND SURFACE-MODIFIED COMPONENTS 有权
标题翻译：具有扩散键合和表面改性成分的色谱装置
公开(公告)号：US20130014567A1
公开(公告)日：2013-01-17
申请号：US13637273
申请日：2011-03-25
申请人： Bernard Bunner , Theodore A. Dourdeville
发明人： Bernard Bunner , Theodore A. Dourdeville
IPC分类号： G01N30/84 , B23K20/00
CPC分类号： G01N30/7266 , B01L3/502707 , B01L3/502753 , B01L2200/0689 , B01L2300/0816 , B01L2300/0887 , B01L2400/0487 , B23B35/00 , B23H9/12 , B23H9/14 , B23K20/023 , B23K20/233 , B23K26/382 , B23K2101/18 , B23K2103/14 , C23C16/44 , C23C26/00 , C23F1/14 , G01N30/6095 , H01J49/0018 , H01J49/167
摘要： A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet. The separation channel is packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation. Wetted surfaces of the separation channel include a coating of an organic material at least one monolayer thick.
摘要翻译：用于通过色谱分离样品的微流体装置包括连接在一起的扩散接合的金属片，以在每个相邻的金属片之间形成气密密封的界面，而不引入次级材料。封隔在扩散接合片内的是可由入口或出口中的至少一个接近的分离通道。分离通道用色谱分离中用作固定相的微米级颗粒填充。分离通道的接液表面包括至少一层单层厚的有机材料的涂层。

64. 发明申请

US20120273350A1 Chip Produced at Wafer Level for Liquid Chromatography and Method for the Production Thereof 有权
标题翻译：用于液相色谱的晶圆级产生的芯片及其制造方法
公开(公告)号：US20120273350A1
公开(公告)日：2012-11-01
申请号：US13508196
申请日：2010-11-05
申请人： Gundula Piechotta , Hans-Joachim Quenzer
发明人： Gundula Piechotta , Hans-Joachim Quenzer
IPC分类号： B01D15/22 , B05D3/10 , B05D5/00 , G01N30/60 , G01N27/30 , B82Y99/00
CPC分类号： G01N30/6095 , G01N2030/528
摘要： The present invention relates to a method for producing a miniaturized separation column for chromatographic purposes including a porous stationary phase anchored in the column, including the following steps: (a) preparing a fiat substrate of silicon, glass, glass ceramic or ceramic; (b) etching at least one channel structure into the fiat substrate; (c) introducing a non-porous precursor material for the porous stationary phase into at least one portion of the channel structure(s); (d) forming a porous, three-dimensional network from the precursor material; and (e) fluid-tight covering of the channel structure(s) on the top side of the flat substrate.
摘要翻译：本发明涉及一种用于制备用于色谱目的的小型化分离塔的方法，其包括锚定在柱中的多孔固定相，其包括以下步骤：（a）制备硅，玻璃，玻璃陶瓷或陶瓷的平板基材; （b）将至少一个通道结构蚀刻到平坦基底中; （c）将用于所述多孔固定相的无孔前体材料引入所述通道结构的至少一部分中; （d）从前体材料形成多孔的三维网络; 和（e）在平坦基底的顶侧上的通道结构的流体密封的覆盖物。

65. 发明申请

US20120263626A1 Miniature Chemical Analysis System 审中-公开
标题翻译：微型化学分析系统
公开(公告)号：US20120263626A1
公开(公告)日：2012-10-18
申请号：US13464847
申请日：2012-05-04
申请人： Li-Peng Wang , Qing Ma
发明人： Li-Peng Wang , Qing Ma
IPC分类号： G01N27/00 , B23P15/00 , C30B33/08
CPC分类号： G01N30/6095 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N2030/025 , G01N2291/0224 , G01N2291/0255 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , Y10T29/49117
摘要： An apparatus, according to one aspect, may include a chromatograph and a bulk acoustic resonator. The chromatograph may include a channel that is defined at least partially in a monolithic substrate. The channel may have an inlet to receive a sample and an outlet. A chromatography material may be included in the channel. The bulk acoustic resonator may have a first electrode and a second electrode that has a chemically functionalized surface. The chemically functionalized surface may be included in a chamber that is defined at least partially in the monolithic substrate and that is coupled with the outlet of the channel. Methods of making and using such apparatus, and systems including such apparatus, are also disclosed.
摘要翻译：根据一个方面的装置可以包括色谱仪和体声波谐振器。色谱仪可以包括至少部分地限定在整体式衬底中的通道。通道可以具有用于接收样品和出口的入口。色谱材料可以包括在通道中。体声波谐振器可以具有第一电极和具有化学官能化表面的第二电极。化学官能化的表面可以包括在至少部分地限定在整体式衬底中并且与通道的出口耦合的室中。还公开了制造和使用这种装置的方法，以及包括这种装置的系统。

66. 发明授权

US08272249B1 Axial-geometry micro-discharge detector 有权
标题翻译：轴向几何微量放电检测器
公开(公告)号：US08272249B1
公开(公告)日：2012-09-25
申请号：US12220730
申请日：2008-07-28
申请人： Cyrus M. Herring
发明人： Cyrus M. Herring
IPC分类号： G01N30/64 , G01N30/72
CPC分类号： G01N30/74 , G01N21/67 , G01N30/6095 , G01N30/64
摘要： A detection device capable of giving atomic and molecular compositions of gases made of concentric tubes and a fiber optic. The body of the detector holds these constituents in their relative positions. A micro-discharge is created between two of the concentric tubes at the tip of the device. The small size of the tubes allows a stable discharge to be achieved. The light from this discharge is delivered from the discharge area to an optical sensing device through the fiber optic. The optical sensing device, along with a computer, analyzes the light to determine the composition of the gas in the discharge. Gas and vacuum are applied through the tubes as needed to aid operation. The detector can be battery powered and used in both hot and toxic environments. Alternatively, a voltmeter can be used to measure impedance across the discharge thus providing another means to determine relative changes in gas composition.
摘要翻译：能够提供由同心管和光纤制成的气体的原子和分子组成的检测装置。检测器的主体将这些成分保持在相对位置。在设备尖端的两个同心管之间产生微放电。管的小尺寸允许实现稳定的放电。来自该放电的光通过光纤从放电区域传送到光学感测装置。光学传感装置与计算机一起分析光线以确定放电中气体的组成。根据需要通过管道施加气体和真空以帮助操作。检测器可以由电池供电并用于热和有毒环境。或者，可以使用电压表来测量放电上的阻抗，从而提供另一种确定气体成分相对变化的方法。

67. 发明授权

US08187442B2 Microchip processing method and apparatus 有权
标题翻译： Microchip的加工方法和装置
公开(公告)号：US08187442B2
公开(公告)日：2012-05-29
申请号：US12347387
申请日：2008-12-31
申请人： Nobuhiro Hanafusa , Akihiro Arai , Koji Tanimizu
发明人： Nobuhiro Hanafusa , Akihiro Arai , Koji Tanimizu
IPC分类号： G01N27/453
CPC分类号： G01N27/44743 , G01N30/24 , G01N30/6095 , G01N30/88 , G01N2030/8827 , Y10T436/25 , Y10T436/25375
摘要： The processing apparatus for microchips, each at least having a main flow path performing migration of a sample for analysis inside a sheet-like member, comprises a holding part holding microchips so that the multiple main flow paths are provided; a pretreatment part common to the multiple main flow paths for performing a pretreatment step prior to an analysis step in each of the multiple main flow paths; a processing part for performing analysis in each of the main flow paths independently of the others; and a control part controlling an operation in the pretreatment part so that when a pretreatment step for one main flow path ends, a pretreatment for a next main flow path starts and further controlling an operation in the processing part so that an analysis is subsequently performed for the main flow path where the pretreatment step has ended.
摘要翻译：用于微芯片的处理装置，每个至少具有在片状构件内执行用于分析的样品的迁移的主流路，包括保持微型芯片以使得设置多个主流路的保持部; 用于在多个主流路中的每一个中执行分析步骤之前的预处理步骤的多个主流路通用的预处理部分; 处理部，用于独立于其他主流路进行分析; 以及控制部，其控制所述预处理部的操作，使得当一个主流路的预处理步骤结束时，开始对下一主流路进行预处理，并且进一步控制所述处理部中的操作，以便随后进行分析预处理步骤结束的主流路。

68. 发明申请

US20120118049A1 FLUIDIC DEVICES AND METHODS USING THEM 有权
标题翻译：流体装置及其使用方法
公开(公告)号：US20120118049A1
公开(公告)日：2012-05-17
申请号：US13158953
申请日：2011-06-13
申请人： Andrew Tipler
发明人： Andrew Tipler
IPC分类号： G01N30/00
CPC分类号： B01D53/0446 , G01N30/463 , G01N30/465 , G01N30/6095 , G01N30/62 , G01N30/72 , G01N2030/328 , Y10T137/877
摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device configured to provide three-way switching or switching between three or more inputs or outputs. The microfluidic device can be fluidically coupled to one or more switching valves to provide for selective control of fluid flow in the chromatography system.
摘要翻译：本文描述的某些实施例涉及包括配置成在三个或更多个输入或输出之间提供三路切换或切换的微流体装置的色谱系统。微流体装置可以流体耦合到一个或多个切换阀，以提供色谱系统中流体流动的选择性控制。

69. 发明授权

US08163177B2 Delivery and assessment system for the automated manufacturing of high performance nanofluidic separation devices 有权
标题翻译：高性能纳米流体分离装置的自动化生产交付和评估系统
公开(公告)号：US08163177B2
公开(公告)日：2012-04-24
申请号：US12275335
申请日：2008-11-21
申请人： Colleen K. Van Pelt
发明人： Colleen K. Van Pelt
IPC分类号： B01D15/08
CPC分类号： G01N30/56 , G01N30/6095
摘要： A multi-column packing system and packed bed assessment system for producing small bore LC columns of superior quality, improved column-to-column reproducibility, and lower cost than current commercially available columns. The process utilizes an automated multi-column packing system with an integrated sensor that detects when the slurry-packed bed has reached the desired length. The optical packed bed assessment system examines the packed bed within the column and detects any packing inconsistencies or voids within the column. The multi-column packing system makes automated connections to tubes via an automated compression mechanism.
摘要翻译：一种多柱填料系统和填充床评估系统，用于生产质量较好，柱对柱重现性好且成本低于现有市售柱的小孔LC柱。该过程利用具有集成传感器的自动多柱填料系统，其检测浆料填充床何时已经达到所需长度。光学填充床评估系统检查柱内的填充床，并检测柱内的任何包装不一致或空隙。多列包装系统通过自动压缩机构自动连接到管道。

70. 发明申请

US20120085422A1 CONTINUOUSLY REGULATED PRECISION PRESSURE FLUID DELIVERY SYSTEM 有权
标题翻译：连续精密压力流体输送系统
公开(公告)号：US20120085422A1
公开(公告)日：2012-04-12
申请号：US13376144
申请日：2010-06-03
申请人： Thomas Boyd Gilligan
发明人： Thomas Boyd Gilligan
IPC分类号： F15D1/00
CPC分类号： C12Q1/24 , B01L3/0289 , B01L2200/026 , B01L2400/082 , G01N30/32 , G01N30/6095 , Y10T137/0324 , Y10T137/85978 , Y10T436/11 , Y10T436/2575
摘要： A fluid flow characteristic regulator (58) which provides a variable volume flow path in which a fluid flow can be continuously adjusted by a control fluid (57) to regulate at least one fluid flow characteristic of the fluid flow (11) within the variable volume flow path.
摘要翻译：一种流体流动特性调节器（58），其提供可变体积流动路径，其中可以通过控制流体（57）连续地调节流体流动，以调节可变体积内的流体流动（11）的至少一个流体流动特性流路。

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