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61. 发明申请

US20100113288A1 Modular System for Performing Laboratory Protocols and Associated Methods 有权
标题翻译：用于执行实验室协议和相关方法的模块化系统
公开(公告)号：US20100113288A1
公开(公告)日：2010-05-06
申请号：US12606083
申请日：2009-10-26
申请人： Nils Adey , Rob Parry
发明人： Nils Adey , Rob Parry
IPC分类号： C40B30/00 , G05D9/00 , C40B60/00 , C12M1/36 , C12Q1/68
CPC分类号： G01N1/312 , B01F11/0008 , B01F11/0017 , B01L3/502715 , B01L7/52 , B01L2300/1822 , G01N35/00029 , G01N2001/315 , G01N2035/00039 , G01N2035/00089 , G01N2035/00138 , G01N2035/00326
摘要： Systems, devices, and methods for automating laboratory protocols utilizing modular processing components to allow systems to be reconfigured for processing a wide variety of disparate laboratory protocols are provided. In one aspect, a sample processing module is provided, including a housing configured to accommodate a pre-identified sample process, a standardized temperature input capable of interfacing with a temperature controller, a standardized fluid input capable of interfacing with an input fluid controller, and a standardized agitation connector capable of interfacing with an agitator. These standardized components provide interchangeability of the module with a module having a housing configured to accommodate a different pre-identified sample process in a sample processing system.
摘要翻译：提供了使用模块化处理组件自动化实验室协议以允许系统重新配置以处理各种不同实验室协议的系统，设备和方法。在一个方面，提供了一种样品处理模块，其包括构造成容纳预先识别的样品过程的壳体，能够与温度控制器接口的标准化温度输入，能够与输入流体控制器接口的标准化流体输入，以及能够与搅拌器连接的标准化搅拌连接器。这些标准化组件提供了模块与具有壳体的模块的可互换性，该壳体被配置为在样本处理系统中适应不同的预先识别的样本过程。

62. 发明申请

US20100068757A1 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 有权
标题翻译：在原发热诱导的抗原恢复和染色设备和方法
公开(公告)号：US20100068757A1
公开(公告)日：2010-03-18
申请号：US12550296
申请日：2009-08-28
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： G01N1/31 , G01N1/30
CPC分类号： G01N1/312 , B01J2219/0036 , B01J2219/00477 , B01J2219/00495 , B01J2219/00533 , B01J2219/00659 , B01L3/0293 , B01L7/54 , B01L2200/04 , B01L2200/16 , B01L2300/0822 , B01L2300/14 , B01L2400/0478 , G01N1/44 , G01N35/00029 , G01N2035/00039 , G01N2035/00138 , G01N2035/00168 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165
摘要： An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element.
摘要翻译：一种自动显微镜载玻片染色系统和染色装置和方法，其特征在于具有多个独立可操作的小型可加压反应室或用于单独和独立地处理多个显微镜载玻片的可加压公共室。该装置优选地具有各自具有可单独操作的加热元件的可独立移动的滑动支撑元件。

63. 发明申请

US20100009429A1 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 有权
标题翻译：在原发热诱导的抗原恢复和染色设备和方法
公开(公告)号：US20100009429A1
公开(公告)日：2010-01-14
申请号：US12561568
申请日：2009-09-17
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： C12M1/00
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
摘要翻译：一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。在相同的装置中进行热诱导的抗原恢复过程和在显微镜载玻片上染色生物样品的过程，其中显微镜幻灯片不需要从一个装置物理移除到另一个装置。用于处理载玻片的反应条件可以独立地进行控制，包括将试剂单独施加到每个载玻片上，以及每个载玻片的个体化处理。

64. 发明授权

US07572638B2 Automated system and method for processing multiple liquid-based specimens 有权
标题翻译：用于处理多种液体样品的自动化系统和方法
公开(公告)号：US07572638B2
公开(公告)日：2009-08-11
申请号：US10274366
申请日：2002-10-21
申请人： Norman J. Pressman , William J. Mayer
发明人： Norman J. Pressman , William J. Mayer
IPC分类号： G01N35/02
CPC分类号： G01N1/4077 , B01D61/18 , B01D61/22 , B01D63/08 , B01D65/08 , B01D2321/02 , B01D2321/10 , B01D2321/16 , B01D2321/2008 , B01D2321/2016 , B01D2321/2066 , B01F7/00583 , B01F7/1695 , B01F13/002 , B01F13/04 , B01F13/045 , B01L3/502 , B01L3/508 , B01L3/50825 , B01L9/06 , B01L9/52 , B01L2200/025 , B01L2300/042 , B01L2300/044 , B01L2300/046 , B01L2300/0681 , B01L2300/0822 , B01L2300/0851 , B65B7/161 , B65B69/00 , G01N1/2813 , G01N27/22 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/021 , G01N35/04 , G01N35/1016 , G01N2001/1025 , G01N2001/2826 , G01N2035/00089 , G01N2035/00138 , G01N2035/0405 , G01N2035/0427 , G01N2035/0441 , G01N2035/0443 , G01N2035/0458 , G01N2035/0462 , Y10T29/49822 , Y10T29/53039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/12 , Y10T436/25375 , Y10T436/255
摘要： An automated system and method for individually processing multiple specimens of particulate matter-containing liquid in respective containers. The containers are transported seriatim along a processing path to present them to, at least, a preprocessing apparatus (e.g., a mixing head), and then to a specimen acquisition apparatus, which removes preprocessed specimen fluid from the container for subsequent analytical testing or evaluation. Each apparatus is actuated in response to presentation of a container thereto so as to carry out its respective operation independently. An exemplary system can include, in sequential order, stations for container loading and unloading, container uncapping and cap disposal, specimen mixing, filter loading, specimen acquisition (e.g., by aspiration, and then slide printing), filter disposal, and container resealing. The system is capable of unattended operation for many hours at a time, and can interface with an integrated data management system to provide fully integrated specimen and information management in a complete diagnostic laboratory system.
摘要翻译：一种用于在相应容器中单独处理含有颗粒物质的液体的多个样品的自动化系统和方法。容器沿着处理路径串联输送，至少提供给预处理设备（例如，混合头），然后到样品采集设备，其从容器中除去预处理的样品流体用于随后的分析测试或评价。每个装置响应于容器的呈现被致动，以便独立地执行其各自的操作。示例性系统可以按顺序包括用于容器装载和卸载，容器开盖和盖处理，样品混合，过滤器装载，样品采集（例如通过抽吸，然后滑动打印），过滤器处理和容器再密封的站。该系统能够一次无人值守的操作，并可与一个综合的数据管理系统进行接口，在完整的诊断实验室系统中提供完全集成的标本和信息管理。

65. 发明授权

US07508583B2 Configurable cytological imaging system 失效
标题翻译：可配置细胞学成像系统
公开(公告)号：US07508583B2
公开(公告)日：2009-03-24
申请号：US11227017
申请日：2005-09-14
申请人： Steven A. Scampini
发明人： Steven A. Scampini
IPC分类号： G02B21/26
CPC分类号： G01N1/312 , G01N35/04 , G01N2035/00138
摘要： A configurable slide imaging system includes a plurality of slide cassettes, each cassette configured for accessibly storing a plurality of specimen slides, a plurality of imagers, each operatively coupled with one or more processors for processing images obtained of respective specimen slides retrieved from the storage cassettes, and a slide transport system including a movable arm having a slide engagement mechanism, the slide transport system configured for retrieving slides from the slide cassettes and positioning them on a slide stage of a respective imager, and for retrieving slides from a slide stage of an imager and transporting them to a respective storage cassette. The number of imagers may be selected, and their operation synchronized, so as to minimize down time of the extendable arm 204.
摘要翻译：可配置的幻灯片成像系统包括多个滑动盒，每个盒被配置用于可容纳地存储多个标本片，多个成像器，每个成像器可操作地与一个或多个处理器耦合，用于处理从存储盒取回的各个标本片的图像以及滑动运输系统，其包括具有滑动接合机构的可动臂，所述滑动运输系统构造成用于从滑动盒中检索滑块并将其定位在相应成像器的滑台上，并用于从滑动台并将其运送到相应的存储盒。可以选择成像器的数量，并且它们的操作同步，以便最小化可延伸臂204的停机时间。

66. 发明申请

US20090073418A1 CELL COUNTING BOARD 失效
标题翻译：细胞计数板
公开(公告)号：US20090073418A1
公开(公告)日：2009-03-19
申请号：US12300269
申请日：2007-05-09
申请人： Hisashi Fukushima , Kazuki Sugiyama
发明人： Hisashi Fukushima , Kazuki Sugiyama
IPC分类号： G01N33/48
CPC分类号： G01N1/312 , G01N2035/00138
摘要： [Problems] A disposable cell counting board in which a space formed by a counting board body and an upper plate is fixed in advance, and which does not require assembling by a cell counting worker, and which can be mass-produced at low costs, is provided.[Means for Solving Problems] The cell counting board comprises a main body and a cover plate attached to the main body. The main body comprises a planar lands positioned at a lower position by a predetermined distance with respect to the top face of the other part than the lands, a counting sections provided at the lands, and four projection sections in the vicinity of the lands for positioning and fixing the cover plate above the lands. The cover plate has engagement holes formed at locations corresponding to the projection sections. A space of the predetermined distance, 0.1 mm, is generated between the top face of the lands and the bottom face of the cover plate, when the cover plate is attached to the main body by engaging each of the projection sections with the corresponding engagement hole.
摘要翻译： [问题]一种一次性电池计数板，其中由计数板主体和上板形成的空间预先固定，并且不需要由电池计数器组装，并且可以以低成本批量生产，被提供。解决问题的手段电池计数板包括主体和安装在主体上的盖板。主体包括相对于另一部分的上表面相对于平台的下表面位于相对于另一部分的顶面预定距离的平坦平台，设置在平台处的计数部分和用于定位的凸台附近的四个突出部分并将盖板固定在平台上。盖板具有形成在与突出部对应的位置处的接合孔。当盖板通过将每个突出部分与相应的接合孔接合而将盖板安装到主体上时，在凸台的顶面和盖板的底面之间产生预定距离为0.1mm的空间。

67. 发明授权

US07476362B2 In situ heat induced antigen recovery and staining apparatus and method 有权
标题翻译：原位热诱导抗原回收染色装置及方法
公开(公告)号：US07476362B2
公开(公告)日：2009-01-13
申请号：US10943546
申请日：2004-09-17
申请人： Lee Angros
发明人： Lee Angros
IPC分类号： B01L3/02 , G01N21/01
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”.
摘要翻译：一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。在相同的装置中进行热诱导的抗原恢复过程和在显微镜载玻片上染色生物样品的过程，其中显微镜幻灯片不需要从一个装置物理移除到另一个装置。每个处理步骤发生在相同的反应室内。用于处理载玻片的每个反应室的反应条件可以独立地进行控制，包括各载玻片的各种试剂的应用以及各载玻片的个体化处理。试剂优选保持在类似于“泡罩包装”的试剂分配条中。

68. 发明申请

US20080318305A1 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 有权
标题翻译：在原发热诱导的抗原恢复和染色设备和方法
公开(公告)号：US20080318305A1
公开(公告)日：2008-12-25
申请号：US12198692
申请日：2008-08-26
申请人： Lee Angros
发明人： Lee Angros
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”.
摘要翻译：一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。在相同的装置中进行热诱导的抗原恢复过程和在显微镜载玻片上染色生物样品的过程，其中显微镜幻灯片不需要从一个装置物理移除到另一个装置。每个处理步骤发生在相同的反应室内。用于处理载玻片的每个反应室的反应条件可以独立地进行控制，包括各载玻片的各种试剂的应用以及各载玻片的个体化处理。试剂优选保持在类似于“泡罩包装”的试剂分配条中。

69. 发明授权

US07425306B1 Slide heater 有权
标题翻译：滑动加热器
公开(公告)号：US07425306B1
公开(公告)日：2008-09-16
申请号：US09953417
申请日：2001-09-11
申请人： Brian H. Kram
发明人： Brian H. Kram
IPC分类号： G01N25/00
CPC分类号： B01L9/52 , B01L7/00 , B01L2300/0822 , G01N1/312 , G01N2035/00138 , G01N2035/00386 , G02B21/30 , Y10T436/111666
摘要： A slide heater for use in a slide processing apparatus in which an interface surface between the slide heater and the slide has a plurality of slots or channels terminating in an edge thereof, for gathering and venting gas bubbles.
摘要翻译：一种用于滑动处理装置的滑动加热器，其中，滑动加热器和滑块之间的界面具有终止于其边缘的多个狭槽或通道，用于收集和排出气泡。

70. 发明申请

US20080209709A1 Container uncapping mechanism and method 审中-公开
标题翻译：集装箱起吊机制和方法
公开(公告)号：US20080209709A1
公开(公告)日：2008-09-04
申请号：US12073427
申请日：2008-03-05
申请人： William J. Mayer
发明人： William J. Mayer
IPC分类号： B23P17/00
CPC分类号： G01N1/4077 , B01D61/18 , B01D61/22 , B01D63/08 , B01D65/08 , B01D2321/02 , B01D2321/10 , B01D2321/16 , B01D2321/2008 , B01D2321/2016 , B01D2321/2066 , B01F7/00583 , B01F7/1695 , B01F13/002 , B01F13/04 , B01F13/045 , B01L3/502 , B01L3/508 , B01L3/50825 , B01L9/06 , B01L9/52 , B01L2200/025 , B01L2300/042 , B01L2300/044 , B01L2300/046 , B01L2300/0681 , B01L2300/0822 , B01L2300/0851 , B65B7/161 , B65B69/00 , G01N1/2813 , G01N27/22 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/021 , G01N35/04 , G01N35/1016 , G01N2001/1025 , G01N2001/2826 , G01N2035/00089 , G01N2035/00138 , G01N2035/0405 , G01N2035/0427 , G01N2035/0441 , G01N2035/0443 , G01N2035/0458 , G01N2035/0462 , Y10T29/49822 , Y10T29/53039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/12 , Y10T436/25375 , Y10T436/255
摘要： Apparatus and method for handling a container having a removable cover, e.g., a vial for holding a biological fluid specimen. The container may have therein an internal element that is releasably coupled to the cover, such as an assembly for processing the specimen in the container. The method involves applying an external force to the covered container sufficient to release the internal element from the cover, and then dislodging the cover from the container. The external force may be an acceleration force applied to the container, such as an impact force to the bottom of the container, or direct contact with the cover with sufficient force to deflect the cover inwardly. A vertically mounted pressing member and a movably mounted gripper can be used. The pressing member may act to eject the cover from the gripper after the container is clear of the gripper. The apparatus may be part of an automated system for processing multiple liquid-based specimens.
摘要翻译：用于处理具有可移除盖的容器的装置和方法，例如用于保持生物流体样本的小瓶。容器可以具有可释放地联接到盖的内部元件，例如用于处理容器中的样本的组件。该方法包括向被覆盖的容器施加足以将内部元件从盖上释放的外力，然后将盖从容器中移出。外力可以是施加到容器的加速力，例如到容器底部的冲击力，或者用足够的力直接与盖接触以使盖向内偏转。可以使用垂直安装的按压构件和可移动安装的夹具。在容器离开夹具之后，按压构件可以起作用以将夹子从夹具中弹出。该设备可以是用于处理多个基于液体的样品的自动化系统的一部分。

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