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61. 发明申请

US20110312085A1 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 有权
标题翻译：在原发热诱导的抗原恢复和染色设备和方法
公开(公告)号：US20110312085A1
公开(公告)日：2011-12-22
申请号：US13220438
申请日：2011-08-29
申请人： Lee Angros
发明人： Lee Angros
IPC分类号： C12M1/26
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”.
摘要翻译：一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。在相同的装置中进行热诱导的抗原恢复过程和在显微镜载玻片上染色生物样品的过程，其中显微镜幻灯片不需要从一个装置物理移除到另一个装置。每个处理步骤发生在相同的反应室内。用于处理载玻片的每个反应室的反应条件可以独立地进行控制，包括各载玻片的各种试剂的应用以及各载玻片的个体化处理。试剂优选保持在类似于“泡罩包装”的试剂分配条中。

62. 发明授权

US08071023B2 In situ heat induced antigen recovery and staining apparatus and method 有权
标题翻译：原位热诱导抗原回收染色装置及方法
公开(公告)号：US08071023B2
公开(公告)日：2011-12-06
申请号：US12624120
申请日：2009-11-23
申请人： Lee Angros
发明人： Lee Angros
IPC分类号： G01N1/36 , G01N33/543
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
摘要翻译：一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。在相同的装置中进行热诱导的抗原恢复过程和在显微镜载玻片上染色生物样品的过程，其中显微镜幻灯片不需要从一个装置物理移除到另一个装置。每个处理步骤发生在相同的反应室内。用于处理载玻片的每个反应室的反应条件可以独立地进行控制，包括各载玻片的各种试剂的应用以及各载玻片的个体化处理。

63. 发明申请

US20110150725A1 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 有权
标题翻译：在原发热诱导的抗原恢复和染色设备和方法
公开(公告)号：US20110150725A1
公开(公告)日：2011-06-23
申请号：US13036873
申请日：2011-02-28
申请人： Lee Angros , Thomas Lee Byers
发明人： Lee Angros , Thomas Lee Byers
IPC分类号： G01N1/28 , G01N1/31
CPC分类号： G01N1/30 , A61F7/0085 , A61F7/12 , A61F2007/0063 , A61F2007/126 , B01L7/00 , B01L7/52 , B01L2200/16 , B01L2300/0822 , B01L2300/14 , B01L2400/0478 , G01N1/28 , G01N1/312 , G01N1/44 , G01N35/00029 , G01N35/026 , G01N2035/00138 , G01N2035/0412 , Y10T436/25
摘要： Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element preferably supports a single microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins. Because of the ability to pressurize and regulate pressure within the reaction compartment, and to individually heat each slide, each slide and a liquid solution or reagent thereon can be heated to temperatures that could not be obtained without the enclosed pressurized environment of the reaction compartment. A reagent dispensing strip having a plurality of reconfigurable reagent modules may also be used.
摘要翻译：本文考虑的是自动显微镜载玻片抗原恢复和染色装置和方法，其特征在于具有多个单独可操作的小型可加压反应室，用于单独和独立地处理多个单独的显微镜载玻片。该装置优选地具有各自具有可单独加热的加热板的可独立移动的滑动支撑元件。每个滑动支撑元件优选地支撑单个显微镜载玻片。每个显微镜载玻片可以封闭在单独的可加压反应室内。超过1 atm或低于1 atm的压力可以在滑块开始加热之前，期间或之后产生并保持在反应室中。由于能够对反应室内的压力进行加压和调节，并且单独地加热每个载玻片，所以每个载玻片及其上的液体溶液或试剂可以被加热到在没有反应室的封闭的加压环境的情况下不能获得的温度。还可以使用具有多个可重新配置的试剂模块的试剂分配条。

64. 发明申请

US20100284602A1 METHOD FOR DETERMINING A COMPLETE BLOOD COUNT ON A WHITE BLOOD CELL DIFFERENTIAL COUNT 有权
标题翻译：白血病细胞差异数确定完全血液计数的方法
公开(公告)号：US20100284602A1
公开(公告)日：2010-11-11
申请号：US12785314
申请日：2010-05-21
申请人： James WINKELMAN , Milenko TANASIJEVIC , David ZAHNISER
发明人： James WINKELMAN , Milenko TANASIJEVIC , David ZAHNISER
IPC分类号： G06K9/00
CPC分类号： G01N15/1475 , G01N1/2813 , G01N1/312 , G01N21/255 , G01N33/49 , G01N35/00029 , G01N35/00871 , G01N35/1016 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1472 , G01N2015/1486 , G01N2015/1497 , G01N2035/00138 , G01N2035/00465 , G01N2035/0091 , G01N2201/062 , G01N2201/126 , G01N2333/805 , G06K9/4652 , G06K9/6267 , G06T7/0012 , H04N5/2256 , H04N5/23293 , H04N5/265
摘要： Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
摘要翻译：公开了分析体液如血液和骨髓的系统和方法。系统和方法可以利用改进的技术将单层细胞施加到载玻片上以在载玻片上产生基本均匀的细胞分布。本发明的另外方面还涉及用于利用多色显微镜来提高由光接收装置捕获的图像的质量的系统和方法。

65. 发明授权

US07760428B2 Specimen slide unit for holding a specimen that is to be examined under a microscope or analyzed with a laboratory analysis system 有权
标题翻译：用于在显微镜下保持要检查的样品或用实验室分析系统分析的样品滑块单元
公开(公告)号：US07760428B2
公开(公告)日：2010-07-20
申请号：US11570488
申请日：2005-06-10
申请人： Frank Sieckmann
发明人： Frank Sieckmann
IPC分类号： G02B21/26
CPC分类号： G01N35/00029 , G01N35/00732 , G01N35/00871 , G01N2035/00138 , G01N2035/00782
摘要： A specimen slide unit for holding a specimen that is to be examined under a microscope or analyzed with a laboratory analysis system includes a specimen slide, a data carrier device and a signal element. The data carrier device has a radio frequency identification tag that can be read out and/or written on using Phase Jitter Modulation so as to switch a communication carrier frequency between two predefinable communication carrier frequencies. The signal element can be activated so as to assist an operator in following a predefinable processing sequence including a second specimen slide unit when the RFID tag is in a range of action of the read/write device. The signal element can be a visual or an acoustic signal element.
摘要翻译：用于在显微镜下保持要检查的样本或用实验室分析系统分析的样本滑块单元包括样本滑块，数据载体装置和信号元件。数据载体装置具有能够使用相位抖动调制读出和/或写入的射频识别标签，以便在两个可预定的通信载波频率之间切换通信载波频率。信号元件可以被激活，以便当RFID标签处于读/写设备的动作范围内时，帮助操作者遵循包括第二标本滑动单元的可预定的处理顺序。信号元件可以是视觉或声学信号元件。

66. 发明申请

US20100178711A1 VIAL SYSTEM AND METHOD FOR PROCESSING LIQUID-BASED SPECIMENS 有权
标题翻译： VIAL系统和处理基于液体样本的方法
公开(公告)号：US20100178711A1
公开(公告)日：2010-07-15
申请号：US12732078
申请日：2010-03-25
申请人： Norman J. PRESSMAN , William J. MAYER
发明人： Norman J. PRESSMAN , William J. MAYER
IPC分类号： G01N1/18
CPC分类号： B01D61/18 , B01D61/22 , B01D63/08 , B01D65/08 , B01D2321/2041 , B01F7/00583 , B01F7/1695 , B01F13/002 , B01F13/04 , B01F13/045 , B01L3/502 , B01L3/50825 , B01L2300/042 , B01L2300/046 , B01L2300/0681 , B01L2400/049 , B65B7/161 , G01N1/2813 , G01N1/4077 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/021 , G01N35/1016 , G01N2001/1025 , G01N2001/2826 , G01N2035/00089 , G01N2035/00138 , G01N2035/0405 , G01N2035/0427 , G01N2035/0441 , G01N2035/0443 , G01N2035/0458 , G01N2035/0462 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： A vial-based system and method for handling and processing specimens of particulate matter-containing liquid directly in the vial. A processing assembly, which includes a stirrer and a particulate matter separation chamber, is releasably coupled to the inside of the vial cover. The processing assembly remains with the cover when the vial is opened to insert a specimen therein. Application of a particular external force to the closed vial detaches the processing assembly from the cover so that it remains in the vial, for access by automated or manual laboratory equipment, when the cover is subsequently removed.
摘要翻译：一种基于小瓶的系统和方法，用于直接在小瓶中处理和处理含颗粒物质的液体样品。包括搅拌器和颗粒物分离室的处理组件可释放地联接到小瓶盖的内部。当小瓶打开以将样品插入其中时，加工组件保留在盖子上。将特定外力施加到封闭的小瓶将处理组件从盖子上分离，使得当盖子随后被移除时，处理组件保留在小瓶中，以便通过自动或手动的实验室设备进入。

67. 发明申请

US20100150781A1 Optical sensor and methods for measuring molecular binding interactions 审中-公开
标题翻译：光学传感器和测量分子结合相互作用的方法
公开(公告)号：US20100150781A1
公开(公告)日：2010-06-17
申请号：US12221119
申请日：2008-07-30
申请人： John Lawrence Ervin , Hus Tigli
发明人： John Lawrence Ervin , Hus Tigli
IPC分类号： G01N21/25
CPC分类号： G01N35/08 , B01L3/502715 , G01N21/774 , G01N2035/00138 , G01N2035/0097
摘要： Optical sensor for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.
摘要翻译：用于测量分子结合相互作用的光学传感器。优选的实施方案提供动力学结合和分离的实时测量，包括蛋白质分子与其它蛋白质分子和其它分子的结合和解离。在优选的实施方案中，将配体固定在硅衬底中产生的多孔硅相互作用区域的孔内，之后悬浮在流体中的分析物流过多孔硅区域。结合反应发生在分析物分子向配体扩散得足够接近以成为结合物时。在优选实施方案中，配体和分析物通过计算机控制的机器人流体控制技术通过微流体流动通道传递到多孔硅相互作用区域。

68. 发明申请

US20100113288A1 Modular System for Performing Laboratory Protocols and Associated Methods 有权
标题翻译：用于执行实验室协议和相关方法的模块化系统
公开(公告)号：US20100113288A1
公开(公告)日：2010-05-06
申请号：US12606083
申请日：2009-10-26
申请人： Nils Adey , Rob Parry
发明人： Nils Adey , Rob Parry
IPC分类号： C40B30/00 , G05D9/00 , C40B60/00 , C12M1/36 , C12Q1/68
CPC分类号： G01N1/312 , B01F11/0008 , B01F11/0017 , B01L3/502715 , B01L7/52 , B01L2300/1822 , G01N35/00029 , G01N2001/315 , G01N2035/00039 , G01N2035/00089 , G01N2035/00138 , G01N2035/00326
摘要： Systems, devices, and methods for automating laboratory protocols utilizing modular processing components to allow systems to be reconfigured for processing a wide variety of disparate laboratory protocols are provided. In one aspect, a sample processing module is provided, including a housing configured to accommodate a pre-identified sample process, a standardized temperature input capable of interfacing with a temperature controller, a standardized fluid input capable of interfacing with an input fluid controller, and a standardized agitation connector capable of interfacing with an agitator. These standardized components provide interchangeability of the module with a module having a housing configured to accommodate a different pre-identified sample process in a sample processing system.
摘要翻译：提供了使用模块化处理组件自动化实验室协议以允许系统重新配置以处理各种不同实验室协议的系统，设备和方法。在一个方面，提供了一种样品处理模块，其包括构造成容纳预先识别的样品过程的壳体，能够与温度控制器接口的标准化温度输入，能够与输入流体控制器接口的标准化流体输入，以及能够与搅拌器连接的标准化搅拌连接器。这些标准化组件提供了模块与具有壳体的模块的可互换性，该壳体被配置为在样本处理系统中适应不同的预先识别的样本过程。

69. 发明申请

US20100068757A1 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 有权
标题翻译：在原发热诱导的抗原恢复和染色设备和方法
公开(公告)号：US20100068757A1
公开(公告)日：2010-03-18
申请号：US12550296
申请日：2009-08-28
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： G01N1/31 , G01N1/30
CPC分类号： G01N1/312 , B01J2219/0036 , B01J2219/00477 , B01J2219/00495 , B01J2219/00533 , B01J2219/00659 , B01L3/0293 , B01L7/54 , B01L2200/04 , B01L2200/16 , B01L2300/0822 , B01L2300/14 , B01L2400/0478 , G01N1/44 , G01N35/00029 , G01N2035/00039 , G01N2035/00138 , G01N2035/00168 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165
摘要： An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element.
摘要翻译：一种自动显微镜载玻片染色系统和染色装置和方法，其特征在于具有多个独立可操作的小型可加压反应室或用于单独和独立地处理多个显微镜载玻片的可加压公共室。该装置优选地具有各自具有可单独操作的加热元件的可独立移动的滑动支撑元件。

70. 发明申请

US20100009429A1 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 有权
标题翻译：在原发热诱导的抗原恢复和染色设备和方法
公开(公告)号：US20100009429A1
公开(公告)日：2010-01-14
申请号：US12561568
申请日：2009-09-17
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： C12M1/00
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
摘要翻译：一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。在相同的装置中进行热诱导的抗原恢复过程和在显微镜载玻片上染色生物样品的过程，其中显微镜幻灯片不需要从一个装置物理移除到另一个装置。用于处理载玻片的反应条件可以独立地进行控制，包括将试剂单独施加到每个载玻片上，以及每个载玻片的个体化处理。

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