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61. 发明授权

US4522493A Partial injection apparatus 失效
标题翻译：局部注射装置
公开(公告)号：US4522493A
公开(公告)日：1985-06-11
申请号：US436662
申请日：1982-10-26
申请人： Akira Tamagawa , Tokio Kano
发明人： Akira Tamagawa , Tokio Kano
IPC分类号： G01N35/10 , G01N1/38 , G01N15/12 , G01N1/14 , G01N33/48
CPC分类号： G01N1/38 , G01N15/1209
摘要： A partial injection apparatus is adapted to partially inject a required amount of a sample and to control an amount of a diluent to be added therein by partially injecting while detecting concentration of a test fluid which contains the required amount of the sample and the diluent added in the sample so that a desired concentration of the test fluid can be obtained.
摘要翻译：部分注射装置适于部分地注入所需量的样品并且通过部分注射来控制待添加的稀释剂的量，同时检测包含所需量的样品和添加的稀释剂的测试流体的浓度样品，使得可以获得所需浓度的测试流体。

62. 发明授权

US4503385A Apparatus and method for regulating sheath fluid flow in a hydrodynamically focused fluid flow system 失效
标题翻译：用于调节流体动力学聚焦流体流动系统中护套流体流动的装置和方法
公开(公告)号：US4503385A
公开(公告)日：1985-03-05
申请号：US512267
申请日：1983-07-11
申请人： John L. Haynes
发明人： John L. Haynes
IPC分类号： G01N1/00 , G01N15/10 , G01N15/12 , G01N15/14 , G01N27/00
CPC分类号： G01N15/1209 , G01N2015/1037 , G01N2015/1062 , G01N2015/1081 , G01N2015/1409 , G01N2015/1486 , G01N2015/149
摘要： An apparatus for analyzing particles, adapted to operate continuously even in the absence of particles contained in a sample medium, includes a sensing region and a particle analyzer associated therewith. A fluid flow path, preferably air flow, causes a sample medium with particles therein to flow through the sensing region. Another fluid flow path ensheathes the sample medium with a flowing sheath fluid for hydrodynamically focusing the particles as they pass through the sensing region. The sheath fluid is adapted to flow at a first flow rate compatible with the flow rate of flowing particles. When the apparatus is operating in the absence of a sample medium, the sheath fluid is controlled to flow at a second flow rate, slower than the first flow rate, for collection thereof.
摘要翻译：用于分析适于即使在样品介质中包含的颗粒不存在的情况下连续操作的颗粒的装置包括感测区域和与其相关联的颗粒分析仪。流体流动路径，优选空气流，使其中具有颗粒的样品介质流过感测区域。另一个流体流动通道用流动的护套流体包裹样品介质，用于当颗粒通过感测区域时进行流体动力聚焦。鞘液适于以与流动颗粒的流速相容的第一流速流动。当设备在不存在样品介质的情况下操作时，护套流体被控制为以比第一流速慢的第二流量流动以进行收集。

63. 发明授权

US4434398A Porous passage means and method for particle analyzing systems 失效
标题翻译：多孔通道用于粒子分析系统的方法和方法
公开(公告)号：US4434398A
公开(公告)日：1984-02-28
申请号：US264199
申请日：1981-05-15
申请人： Robert H. Berg , Richard F. Karuhn
发明人： Robert H. Berg , Richard F. Karuhn
IPC分类号： G01N15/12 , G01N27/00
CPC分类号： G01N15/12 , G01N15/1209
摘要： A method of and means for controlling orientation of particles through a sensing zone in a particle analyzing system, which facilitates particle shape determination, comprises laminar flow orientation of the particles in a stream moving through an elongate straight passage coaxially aligned with an elongate sensing zone longer than the longest particle to be sensed and analyzed. The particles are carried through the sensing zone in an isokinetic laminar flow sheath of fluid.
摘要翻译：用于控制颗粒通过颗粒分析系统中的感测区域的取向的方法和装置，其有利于颗粒形状确定，包括颗粒在流过细长直线通道的流中的层流取向，该细长直线通道与细长的感测区域同轴对准更长比要被感测和分析的最长的粒子。颗粒通过流体的等动力层流鞘被传送通过传感区域。

64. 发明授权

US4420720A Field focused particle sensing zone 失效
标题翻译：场聚焦粒子感应区
公开(公告)号：US4420720A
公开(公告)日：1983-12-13
申请号：US279920
申请日：1981-06-29
申请人： William A. Newton , Marshall D. Graham
发明人： William A. Newton , Marshall D. Graham
IPC分类号： G01N15/12 , G01N27/00
CPC分类号： G01N15/1218 , G01N15/1209
摘要： A particle analyzer wherein a flow of liquid suspension, having individually entrained particles, flows along a predetermined path; a center pair of electrodes are positioned on opposed sides of the predetermined path: the center electrodes are energized to provide an electrical sensing field therebetween, two pairs of outer electrodes are positioned so that one pair is on each side of the center electrodes; the outer electrodes are oriented and/or energized so that their electrical fields bulge outward in the direction of the sensing field of the center plates to narrow the width of the sensing field along the predetermined path. Additionally, the field between the center plates can be focused in additional directions and the sensing electrode arrangement can be implemented in a flow cell, with or without an aperture, or on the surface of a substrate.
摘要翻译：一种颗粒分析仪，其中具有单独夹带的颗粒的液体悬浮液流沿预定路径流动; 中心对电极位于预定路径的相对侧上：中心电极通电以在其间提供电感测场，两对外电极定位成使得一对位于中心电极的每一侧; 外电极被定向和/或通电，使得它们的电场沿着中心板的感测场的方向向外凸出，以沿着预定路径使感测场的宽度变窄。此外，中心板之间的场可以在附加方向上聚焦，并且感测电极装置可以在具有或不具有孔的流动池中或在基板的表面上实现。

65. 发明授权

US4350292A Centrifugal feeder 失效
标题翻译：离心式给料机
公开(公告)号：US4350292A
公开(公告)日：1982-09-21
申请号：US107704
申请日：1979-12-27
申请人： Ian D. Gilbert , Michael T. Halloran , Ermi Roos
发明人： Ian D. Gilbert , Michael T. Halloran , Ermi Roos
IPC分类号： B01J8/00 , B65G31/04 , G01N15/12 , B05B17/04
CPC分类号： B65G31/04 , B01J8/002 , G01N15/1209
摘要： A centrifugal feeder includes a cylindrical feeder disc having an upwardly inclined uniform surface which is designed to expel particles placed thereon in a predetermined fashion by centrifugal force. The upwardly inclined surface of the disc may be designed to have a first predetermined expulsion rate which is the initial speed at which the disc must be rotated to expel any of the particles from the surface thereof. The disc also may be designed to have a final expulsion rate at which all particles placed on the surface thereof are expelled. The disc is rotated at a controlled rate of speed and at a controlled rate of change of speed to expel the particles in the manner desired in a linear or non linear fashion. The feed or expulsion rate of the particles is determined by the design of the disc and the rotation speed of the disc and essentially is independent of the size and density of the particles and the viscosity of the surrounding fluid in which the disc is rotated.
摘要翻译：离心给料器包括具有向上倾斜的均匀表面的圆柱形进料盘，其设计成通过离心力以预定方式排放放置在其上的颗粒。盘的向上倾斜表面可以被设计成具有第一预定排出速率，其是盘必须旋转的初始速度，以从其表面排出任何颗粒。盘也可以被设计成具有放置在其表面上的所有颗粒的最终排出速率。盘以受控的速度旋转并且以受控的速度变化的速度旋转，以按线性或非线性方式将粒子排出。颗粒的进料或排出速率通过盘的设计和盘的旋转速度来确定，并且基本上与颗粒的尺寸和密度以及盘旋转的周围流体的粘度无关。

66. 发明授权

US4290011A Particle length and volume comeasurement with controlled orientation 失效
标题翻译：颗粒长度和体积测量与受控方向
公开(公告)号：US4290011A
公开(公告)日：1981-09-15
申请号：US907010
申请日：1978-05-18
申请人： Robert H. Berg , Richard F. Karuhn
发明人： Robert H. Berg , Richard F. Karuhn
IPC分类号： G01N15/12 , G01N27/00
CPC分类号： G01N15/12 , G01N15/1209
摘要： A method of and means for controlling orientation of particles through a sensing zone in a particle analyzing system, which facilitates particle shape determination, comprises laminar flow orientation of the particles in a stream moving through an elongate straight passage coaxially aligned with an elongate sensing zone longer than the longest particle to be sensed and analyzed. The particles are carried through the sensing zone in an isokinetic laminar flow sheath of fluid.
摘要翻译：用于控制颗粒通过颗粒分析系统中的感测区域的取向的方法和装置，其有利于颗粒形状确定，包括颗粒在流过细长直线通道的流中的层流取向，该细长直线通道与细长的感测区域同轴对准更长比要被感测和分析的最长的粒子。颗粒通过流体的等动力层流鞘被传送通过传感区域。

67. 发明授权

US4102810A Stabilized hematological reagent solutions 失效
标题翻译：稳定的血液试剂溶液
公开(公告)号：US4102810A
公开(公告)日：1978-07-25
申请号：US670924
申请日：1976-03-26
申请人： Douglas Armstrong
发明人： Douglas Armstrong
IPC分类号： G01N33/49 , G01N15/12 , G01N33/483 , G01N33/50 , G01N33/96 , C09K3/00 , G01N33/16
CPC分类号： G01N33/96 , G01N15/12 , G01N15/1209 , G01N33/5094 , G01N2496/05 , Y10T436/101666 , Y10T436/105831 , Y10T436/106664 , Y10T436/107497 , Y10T436/108331
摘要： The conjoint use of an ethoxylated phenol such as 2-phenoxyethanol, as a bacteriostatic and fungistatic agent and an alkali metal fluoride such as sodium fluoride as a stabilizer in a system used for specified hemotological reagents. Sodium fluoride is added as a counterbalancing agent to the action of 2-phenoxyethanol. A cleaning solution for electronic particle counting apparatus, a lysing reagent and an artificial plasma which can be used as a control in blood sample analysis are disclosed.

68. 发明授权

US4007013A Holder device for sample vials or the like for an analysis apparatus 失效
标题翻译：用于分析装置的样品瓶等的保持器装置
公开(公告)号：US4007013A
公开(公告)日：1977-02-08
申请号：US703844
申请日：1976-07-09
申请人： Karl Kotacka
发明人： Karl Kotacka
IPC分类号： A61B5/15 , B01L7/00 , B01L9/06 , G01N15/12 , G01N33/48 , G01N33/49 , G01N35/04 , G01N33/16
CPC分类号： B01L9/06 , G01N15/1209
摘要： A holder device for sample vials or the like for an analysis apparatus, especially a blood cell counter, equipped with a suction tube immersible in a sample vial filled with liquid and standing upon an appropriately arranged support surface in order to remove sample from the sample vial. The holder device has a recess or cavity formed by a rear wall extending approximately parallel to the central axis of the recess and two side walls extending between the lower edge and the upper edge of the holder device and tapering upwardly with respect to the rear wall between the lower edge and the upper edge. The recess is bounded by a standing surface arranged transversely with respect to the rear wall.
摘要翻译：用于分析装置，特别是血细胞计数器的样品瓶等的保持器装置，其配备有吸入管，该抽吸管浸入装有液体的样品瓶中并站立在适当布置的支撑表面上，以从样品瓶中移除样品。保持器装置具有由大致平行于凹部的中心轴线延伸的后壁形成的凹部或空腔，在保持器装置的下边缘和上边缘之间延伸的两个侧壁相对于后壁向上逐渐变细下边缘和上边缘。该凹部由相对于后壁横向排列的立面界定。

69. 发明授权

US3389334A Particle analyzing apparatus having means for observing a scanning aperture 失效
标题翻译：具有观察扫描孔径的装置的粒子分析装置
公开(公告)号：US3389334A
公开(公告)日：1968-06-18
申请号：US38256064
申请日：1964-07-14
申请人： COULTER ELECTRONICS
发明人： COULTER WALLACE H , HOGG WALTER R
IPC分类号： G01N15/12
CPC分类号： G01N15/12 , G01N15/1209

70. 发明申请

US20190234930A1 Controlling Translocation Through Nanopores With Fluid Walls 审中-公开
公开(公告)号：US20190234930A1
公开(公告)日：2019-08-01
申请号：US16377970
申请日：2019-04-08
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Michael MAYER , Erik YUSKO , Jerry YANG
IPC分类号： G01N33/487 , C12Q1/6869 , G01N15/12 , B82Y30/00
CPC分类号： G01N33/48721 , B82Y30/00 , C12Q1/6869 , G01N15/1209 , G01N2015/0038 , C12Q2563/131 , C12Q2565/631
摘要： Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid coatings such as lipid walls. Fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.

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