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61. 发明授权

US07378276B2 Method of inducing memory B cell development and terminal differentiation 有权
标题翻译：诱导记忆B细胞发育和终末分化的方法
公开(公告)号：US07378276B2
公开(公告)日：2008-05-27
申请号：US11197221
申请日：2005-08-03
申请人： Catherine Rachel Ettinger , Peter E. Lipsky , Warren J. Leonard , Rosanne Spolski , Herbert C. Morse, III
发明人： Catherine Rachel Ettinger , Peter E. Lipsky , Warren J. Leonard , Rosanne Spolski , Herbert C. Morse, III
IPC分类号： C12N5/02 , C12N5/08 , A01N37/18 , C07K1/00
CPC分类号： G01N33/5052 , A61K35/17 , A61K38/20 , A61K2035/124 , A61K2039/5158 , C12N5/0635 , C12N2501/052 , C12N2501/23 , C12N2501/50 , C12N2501/52 , G01N2333/54
摘要： A method is disclosed herein for inducing differentiation of a B cell progenitor into a memory B cells and/or a plasma cell. The method includes contacting a population of cells including a mature B cell or a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. In one embodiment, the B cell progenitor is an immature B cell. A method is also disclosed for enhancing an immune response. The method includes contacting a population of cells including a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. The memory B cells and/or the plasma cell are then introduced into the subject to enhance the immune response. A method is also disclosed for treating a subject with a condition comprising a specific deficiency of at least one of memory B cells and plasma cells. A method is disclosed for identifying an agent with a physiological effect on one or more of a memory B cell and a plasma cell differentiation. A method is also disclosed for identifying agents that inhibit an activity of IL-21. Methods are also disclosed for inducing apoptosis of a B cell and for decreasing the number of B cells. A method is also described for producing a B cell hybridoma.
摘要翻译：本文公开了一种用于诱导B细胞祖细胞分化为记忆B细胞和/或浆细胞的方法。该方法包括使包含成熟B细胞或B细胞祖细胞的细胞群与有效量的IL-21接触，并分离记忆B细胞或浆细胞。在一个实施方案中，B细胞祖细胞是未成熟的B细胞。还公开了一种用于增强免疫应答的方法。该方法包括使包含B细胞祖细胞的细胞群与有效量的IL-21接触，并分离记忆B细胞或浆细胞。然后将记忆B细胞和/或浆细胞引入受试者以增强免疫应答。还公开了一种用于治疗患有包含存储B细胞和浆细胞中的至少一种的特定缺陷的病症的受试者的方法。公开了用于鉴定对存储B细胞和浆细胞分化中的一种或多种具有生理作用的药剂的方法。还公开了用于鉴定抑制IL-21活性的试剂的方法。还公开了诱导B细胞凋亡和减少B细胞数量的方法。还描述了用于产生B细胞杂交瘤的方法。

62. 发明申请

US20070014798A1 Antibodies to dendritc cells and human dendritic cell populations and uses thereof 审中-公开
公开(公告)号：US20070014798A1
公开(公告)日：2007-01-18
申请号：US11524875
申请日：2006-09-22
申请人： Ernst Rieber
发明人： Ernst Rieber
IPC分类号： A61K39/395 , C12P21/06 , C07H21/04 , C12N5/06 , C07K16/28
CPC分类号： C12N5/0639 , A01K2217/05 , A61K38/00 , A61K39/0011 , A61K39/08 , A61K2039/5154 , A61K2039/5158 , C07K14/70596 , C07K16/28 , C12N2501/052 , C12N2501/22 , C12N2501/23 , C12N2501/59 , A61K2300/00
摘要： Described are novel antibodies specifically recognizing a distinct population of human dendritic cells (DCs) and methods of isolating said DCs using said antibodies. Furthermore, antigens and epitopes recognized by the above-described antibodies as well as polynucleotides encoding said antibodies are provided. Also provided are vectors comprising said polynucleotides as well as host cells transformed therewith and their use in the production of said antibodies. Additionally, polypeptides comprising a domain of the binding site of the aforementioned antibodies, or an antigen or epitope described above and at least one further, preferably functional domain as well as polynucleotides encoding such polypeptides are described. Furthermore, vectors comprising said polynucleotides, host cells transfected with said polynucleotide or vector and their use for the preparation of the above-described polypeptides are provided. Described is further a method for isolating or identifying DCs as defined above as well as DCs obtainable by said method and/or characterized by recognition of the above-described antibody, and/or containing the aforementioned antigen or epitope. Moreover, a method for preparing or identifying T cells in a certain status as well as methods for identifying compounds which interfere with T cell mediated activation of immune responses are described. In addition kits, and compositions, preferably pharmaceutical and diagnostic compositions are provided comprising any of the aforedescribed antibodies, antigens, epitopes, polypeptides, polynucleotides, vectors, dendritc cells or T cells or compounds obtainable by the aforementioned method. Further described are vaccines comprising antigens exposed to dendritic cells, antigen expressing DCs or comprising an antigen or epitope mentioned before. Furthermore, dendritc cells for immunopotentiating compositions are provided. Moreover, the use of T cells obtainable by the above-described method, the aforementioned DCs, antibodies, nucleotides and vectors in adoptive immunotherapy, preferably against cancer and infectious diseases and for the identification of new antigenic targets for immunotherapy is described.

63. 发明申请

US20040214333A1 Loading of cells with antigens by electroporation 审中-公开
标题翻译：通过电穿孔加载抗原细胞
公开(公告)号：US20040214333A1
公开(公告)日：2004-10-28
申请号：US10781440
申请日：2004-02-18
申请人： MaxCyte, Inc.
发明人： Linda N. Liu , Jonathan M. Weiss
IPC分类号： C12Q001/68 , C12N015/87
CPC分类号： C12N5/0639 , A61K39/0011 , A61K2039/5154 , C12N2501/02 , C12N2501/052 , C12N2501/23 , C12N2501/25
摘要： Methods for loading an antigen-presenting cell with one ore more antigens are disclosed. Methods for the treatment and prevention of a disease in a subject using an antigen-presenting cell that has been electroporated with a composition of one or more antigens. Composition of one or more antigens comprises one or more antigens of a hyperproliferative cell, a microorganism or a microorganism-infected cell are also disclosed. In addition, compositions of antigen-presenting cells that have been loaded with one or more antigens of a hyperproliferative cell, a microorganism-infected cell or a microorganism using electroporation are disclosed.
摘要翻译：公开了加载具有一个或多个抗原的抗原呈递细胞的方法。使用已经用一种或多种抗原的组合物电穿孔的抗原呈递细胞治疗和预防受试者的疾病的方法。一种或多种抗原的组成包括一种或多种过度增殖细胞的抗原，微生物或微生物感染的细胞。此外，公开了已经装载过度增殖细胞，微生物感染细胞或使用电穿孔的微生物的一种或多种抗原的抗原呈递细胞的组合物。

64. 发明授权

US6165785A Bone marrow cultures for developing suppressor and stimulator cells for research and therapeutic applications 失效
标题翻译：用于研究和治疗应用的用于开发抑制因子和刺激细胞的骨髓培养物
公开(公告)号：US6165785A
公开(公告)日：2000-12-26
申请号：US178045
申请日：1998-10-23
申请人： Cora K. Ogle , John F. Valente , J. Wesley Alexander
发明人： Cora K. Ogle , John F. Valente , J. Wesley Alexander
IPC分类号： A61K35/12 , A61K39/00 , C12N5/071 , C12N5/078 , C12N5/0784 , A61K35/18 , A61K35/26 , A61K35/28
CPC分类号： C12N5/064 , A61K2035/122 , A61K2035/124 , A61K2039/55572 , C12N5/0634 , C12N5/0639 , C12N5/0648 , C12N2501/052 , C12N2501/22 , C12N2501/999 , C12N2502/11
摘要： A method of treatment using immune system suppressor cells and immune system stimulator cells comprises providing stem cells; combining the stem cells with lymphoid-derived cells to produce a co-culture; adding lipopolysaccharide and a factor selected from the group consisting of granulocyte macrophage-colony stimulating factor, macrophage colony stimulating factor, granulocyte-colony stimulating factor and mixtures thereof to the co-culture; obtaining immune system suppressor cells and immune system stimulator cells from the co-culture; and introducing and the cells into a host.
摘要翻译：使用免疫系统抑制细胞和免疫系统刺激细胞的治疗方法包括提供干细胞; 将干细胞与淋巴样衍生的细胞结合以产生共培养物; 添加脂多糖和选自粒细胞巨噬细胞集落刺激因子，巨噬细胞集落刺激因子，粒细胞集落刺激因子及其混合物的组合的因子与共培养物; 从共培养获得免疫系统抑制细胞和免疫系统刺激细胞; 并将细胞引入宿主。

65. 发明授权

US11788044B2 Rheologically biomimetic fluid surrogate 有权
公开(公告)号：US11788044B2
公开(公告)日：2023-10-17
申请号：US16820530
申请日：2020-03-16
申请人： EMULATE, INC.
发明人： Antonio Varone , Magdalena Kasendra , Carolina Lucchesi , S. Jordan Kerns , Riccardo Barrile , Sonalee Barthakur
IPC分类号： C12M3/06 , B01L3/00 , C12M1/12 , C12N5/071 , G01N33/50 , C12M1/00
CPC分类号： C12M23/16 , B01L3/502715 , B01L3/502761 , C12M23/26 , C12M25/02 , C12N5/069 , G01N33/5047 , G01N33/5064 , B01L2200/16 , B01L2300/123 , B01L2300/16 , C12N2500/00 , C12N2501/052 , C12N2501/2301 , C12N2501/2306 , C12N2501/25
摘要： The present invention contemplates compositions, devices and methods of simulating biological fluids in a fluidic device, including but not limited to a microfluidic chip. In one embodiment, fluid comprising a colloid under flow in a microfluidic chip has a fluid density or viscosity similar to a bodily fluid, e.g. blood, lymph, lung fluid, or the like. In one embodiment, a fluid is provided as a Theologically biomimetic blood surrogate or substitute for simulating physiological shear stress and cell dynamics in fluidic device, including but not limited to immune cells.

66. 发明申请

US20190249892A1 INTEGRATED SENSOR AND SERVICE PORT FOR HVAC EQUIPMENT OR HVAC SYSTEM 审中-公开
公开(公告)号：US20190249892A1
公开(公告)日：2019-08-15
申请号：US16273205
申请日：2019-02-12
申请人： Watsco Ventures LLC
发明人： Mario A. Cruz , Charles Peter Harland , Christopher Todd Kirby
IPC分类号： F24F11/30 , F24F11/50
CPC分类号： C12N5/0645 , C12N5/0656 , C12N5/0663 , C12N2501/052 , F24F11/30 , F24F11/50 , F24F2110/10 , F24F2110/40
摘要： An integrated sensor and service port for HVAC (heating, ventilating, and air conditioning) equipment or an HVAC system.

67. 发明申请

US20180202104A1 STANDARDIZED EX VIVO PLATFORMS FOR THE ANTIGEN-SPECIFIC EXPANSION OF CD4+ T CELL POPULATIONS 审中-公开
公开(公告)号：US20180202104A1
公开(公告)日：2018-07-19
申请号：US15895734
申请日：2018-02-13
申请人： Western University of Health Sciences
发明人： Douglas Wayne Ethell
IPC分类号： D21H17/63 , D21H21/36 , D06M23/12 , D06M11/83 , D06M11/46 , D06M11/45 , D06M16/00 , D06M11/38 , D06M23/08 , D06M10/08 , D06M10/06 , D06M10/02 , D06M11/44
CPC分类号： D21H17/63 , A61K39/0007 , A61K2039/5158 , A61K2039/57 , C07K2319/00 , C07K2319/03 , C12N5/0636 , C12N5/0639 , C12N2500/44 , C12N2501/052 , C12N2501/22 , C12N2501/2304 , C12N2501/25 , C12N2501/50 , C12N2501/998 , C12N2502/1121 , C12N2502/1394 , C12N2506/02 , C12N2510/00 , D06M10/02 , D06M10/06 , D06M10/08 , D06M11/38 , D06M11/44 , D06M11/45 , D06M11/46 , D06M11/83 , D06M16/00 , D06M23/08 , D06M23/12 , D21H21/36
摘要： This invention relates to methods, peptides, nucleic acids and cells for use in isolating and expanding human T cell populations in an antigen-specific manner for immunodiagnostic or therapeutic purposes. The invention also relates to professional antigen presenting cells derived from pluripotent human stem cells, and to customizable antigen presentation by the antigen presenting cells.

68. 发明授权

US09855330B2 Granulysin in immunotherapy 有权
公开(公告)号：US09855330B2
公开(公告)日：2018-01-02
申请号：US15174402
申请日：2016-06-06
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Alan M. Krensky , Carol Clayberger
IPC分类号： A61K35/00 , A61K39/39 , A61K31/727 , A61K35/15 , A61K35/17 , A61K38/19 , C12N5/0784 , A61K38/17 , A61K45/06 , A61K38/20 , A61K9/00 , A61K39/00
CPC分类号： A61K39/39 , A61K9/0014 , A61K31/727 , A61K35/15 , A61K35/17 , A61K38/1729 , A61K38/19 , A61K38/2026 , A61K45/06 , A61K2039/55516 , A61K2039/55522 , A61K2039/55527 , C12N5/0639 , C12N5/064 , C12N2501/052 , C12N2501/23 , C12N2501/998 , C12N2506/11 , A61K2300/00
摘要： Methods of stimulating or enhancing an immune response in a host are disclosed. The methods include contacting a monocyte with 15 kD granulysin thereby producing a monocyte-derived dendritic cell. In one example, the method further includes contacting the monocyte or monocyte-derived dendritic cell with a target antigen, such as a tumor antigen or an autoimmune antigen. In another embodiment, the method includes contacting the monocyte with an additional agent that enhances maturation of dendritic cells or induces immunological tolerance. The methods are of use in vivo, in vitro and ex vivo. In another aspect, the disclosure relates to compositions and methods for the treatment of tumors.

69. 发明申请

US20170267974A1 EX VIVO DEVELOPMENT, EXPANSION AND IN VIVO ANALYSIS OF A NOVEL LINEAGE OF DENDRITIC CELLS 审中-公开
公开(公告)号：US20170267974A1
公开(公告)日：2017-09-21
申请号：US15332301
申请日：2016-10-24
申请人： Lung-Ji Chang
发明人： Lung-Ji Chang
IPC分类号： C12N5/0784 , A61K35/15 , A61K39/00
CPC分类号： C12N5/0639 , A61K35/15 , A61K39/0011 , A61K2039/5154 , A61K2039/5156 , C12N2501/052 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/2302 , C12N2501/2304 , C12N2501/2307 , C12N2501/2315 , C12N2501/25 , C12N2501/26 , C12N2510/00
摘要： Disclosed herein are new methods of producing a novel line of dendritic cells. The method comprises subjecting a sample of hematopoietic stem/precursor cells to a first feeder culture system that is supplemented with a first set of factors and a second feeder culture system supplemented with a second group of factors. The disclosure also pertains to new cell types that may be used as cancer immunotherapy.

70. 发明申请

US20170100424A1 BETA-GLUCAN METHODS AND COMPOSITIONS THAT AFFECT THE TUMOR MICROENVIRONMENT 审中-公开
公开(公告)号：US20170100424A1
公开(公告)日：2017-04-13
申请号：US15386781
申请日：2016-12-21
申请人： Biothera, Inc.
发明人： Nandita BOSE , Keith GORDEN , Anissa SH. CHAN , Steven LEONARDO , Jeremy GRAFF , Xiaohong QIU , Takashi KANGAS , Kathryn A. FRASER , Adria BYKOWSKI JONAS , Nadine OTTOSON
IPC分类号： A61K31/716 , C07K16/30 , A61K39/395 , C07K16/28
CPC分类号： A61K31/716 , A61K39/3955 , A61K2039/505 , C07K16/2818 , C07K16/2827 , C07K16/2863 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3061 , C07K2317/24 , C07K2317/76 , C12N5/0636 , C12N5/0639 , C12N5/0645 , C12N2500/34 , C12N2501/052 , C12N2501/22 , C12N2501/2304 , C12N2501/24 , C12N2501/51 , C12N2502/1114 , A61K2300/00
摘要： This disclosure relates to the combination of soluble β-glucan and immune suppression-relieving agents that affect the tumor microenvironment. Soluble β-glucan promotes an immunostimulatory environment, which allows enhanced effectiveness of anti-angiogenics, checkpoint inhibitors including non-tumor targeting antibodies.

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