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61. 发明申请

US20040180393A1 Chromogenic substrates of sialidase of bacterial, viral, protozoa and vertebrate origin and methods of making and using the same 审中-公开
标题翻译：细菌，病毒，原生动物和脊椎动物起源的唾液酸酶的显色底物及其制备和使用方法
公开(公告)号：US20040180393A1
公开(公告)日：2004-09-16
申请号：US10679663
申请日：2003-10-06
发明人： Stephen C. Johnson , Ming Luo , Shijia Yan
IPC分类号： C12Q001/48 , C12Q001/34
CPC分类号： C07H15/203 , C07H7/027 , C07H15/24 , C07H15/26 , C07H17/02 , C07H17/075 , C12Q1/34
摘要： The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
摘要翻译：本发明涉及用于细菌，病毒，原生动物和脊椎动物（包括人）来源的唾液酸酶的显色底物化合物的设计，合成和生物化学评估。特别地，本发明提供了一种新型的有效化合物作为这些唾液酸酶的显色底物，其在由唾液酸酶催化的反应发生后产生显色产物。还提供了使用这些底物化合物制备这些底物化合物的方法，唾液酸酶相关疾病的诊断和预后的方法。

62. 发明授权

US06667161B1 Chromogenic substrates of sialidase of bacterial, viral, protozoa, and vertebrate origin and methods of making and using the same 有权
标题翻译：细菌，病毒，原生动物和脊椎动物起源的唾液酸酶的显色底物及其制备和使用方法
公开(公告)号：US06667161B1
公开(公告)日：2003-12-23
申请号：US09412896
申请日：1999-10-05
申请人： Stephen C. Johnson , Ming Lou , Shijia Yan
发明人： Stephen C. Johnson , Ming Lou , Shijia Yan
IPC分类号： C12Q134
CPC分类号： C07H15/203 , C07H7/027 , C07H15/24 , C07H15/26 , C07H17/02 , C07H17/075 , C12Q1/34
摘要： The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
摘要翻译：本发明涉及用于细菌，病毒，原生动物和脊椎动物（包括人）来源的唾液酸酶的显色底物化合物的设计，合成和生物化学评估。特别地，本发明提供了一种新型的有效化合物作为这些唾液酸酶的显色底物，其在由唾液酸酶催化的反应发生后产生显色产物。还提供了使用这些底物化合物制备这些底物化合物的方法，唾液酸酶相关疾病的诊断和预后的方法。

63. 发明申请

US20030162240A1 Chromogenic substrates of sialidase and methods of making and using the same 有权
公开(公告)号：US20030162240A1
公开(公告)日：2003-08-28
申请号：US10348668
申请日：2003-01-21
发明人： Stephen C. Johnson , Ashraf Saeed , Ming Luo
IPC分类号： C12Q001/34 , C07H017/02
CPC分类号： C07H15/203 , C07H7/027 , C07H15/24 , C07H17/02 , C07H17/075
摘要： The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

64. 发明申请

US20030139594A1 Catalytic process for the modification of carbohydrates, alcohols, aldehydes or polyhydroxy compounds 有权
标题翻译：用于碳水化合物，醇，醛或多羟基化合物改性的催化方法
公开(公告)号：US20030139594A1
公开(公告)日：2003-07-24
申请号：US10340913
申请日：2003-01-10
申请人： SUDZUCKER AKTIENGESELLSCHAFT
发明人： Emine Capan , Marc Sascha Hahnlein , Ulf Prusse , Klaus-Dieter Vorlop , Alireza Haji Begli
IPC分类号： C07H005/04 , C07C29/26 , C07C029/14
CPC分类号： C07H7/033 , C07H7/027
摘要： The invention relates to the industrial conversion of carbohydrates, alcohols, aldehydes or polyhydroxy compounds in aqueous phase. According to the invention a catalytic method is used for the conversion, using a metal catalyst consisting of polymer-stabilized nanoparticles. A catalyst of this type is not deactivated by the conversion reaction as long as the stabilizing interaction between the polymer and the nanoparticles is maintained.
摘要翻译：本发明涉及碳水化合物，醇，醛或多羟基化合物在水相中的工业转化。根据本发明，使用由聚合物稳定的纳米颗粒组成的金属催化剂进行转化的催化方法。只要维持聚合物和纳米颗粒之间的稳定相互作用，这种类型的催化剂就不会通过转化反应失活。

65. 发明授权

US06423834B1 KDO aldolase and condensation reactions employed therewith 失效
标题翻译： KDO醛缩酶和与其一起使用的缩合反应
公开(公告)号：US06423834B1
公开(公告)日：2002-07-23
申请号：US09247164
申请日：1999-02-09
申请人： Chi-Huey Wong , Takeshi Sugai , Gwo-Jenn Shen
发明人： Chi-Huey Wong , Takeshi Sugai , Gwo-Jenn Shen
IPC分类号： C07H1500
CPC分类号： C12P19/02 , C07H7/027 , C12N9/88 , C12P7/58 , C12P9/00 , Y10S435/822
摘要： Aureobacterium barkerei strain KDO-37-2 (ATCC 49977) and KDO aldolase (EC 4.1.2.23) isolated therefrom are disclosed. The KDO aldolase is further disclosed to have a broad substrate specificity with respect to its reverse reaction, i.e. the condensation of aldoses with pyruvate to form a wide range of 2-keto-3-deoxy-onic acids, including 2-keto-3-deoxy-nonulosonic acid, 2-keto-3-deoxy-octulosonic acid, 2-keto-3-deoxy-heptulosonic acid, and 2-keto-3-deoxy-hexulosonic acid. In particular, 3-deoxy-D-manno-2-octulosonic acid (D-KDO), a vital component of lipopolysaccharides found in the bacterial outer membrane may be synthesized from D-arabinose and pyruvate in 67% yield. Additionally, protected forms of the KDO aldolase products, e.g. hexaacetyl 2-keto-3-deoxy-nonulosonic acid and pentaacetyl 2-keto-3-deoxy-octulosonic acid, may be decarboxylated to form the corresponding 2-deoxy-aldoses, e.g. 2-deoxy-octulose and 2-deoxy-heptulose respectively.
摘要翻译：公开了从其分离的巴氏杆菌菌株KDO-37-2（ATCC 49977）和KDO醛缩酶（EC 4.1.2.23）。进一步公开KDO醛缩酶相对于其逆反应具有广泛的底物特异性，即醛糖与丙酮酸的缩合形成宽范围的2-酮-3-脱氧ic酸，包括2-酮-3- 脱氧 - 非酮酸，2-酮-3-脱氧 - 八环酮酸，2-酮-3-脱氧 - 庚酮酸和2-酮-3-脱氧 - 己酸。特别地，在D-细菌外膜中发现的脂多糖的重要组分3-脱氧-D-壬烯-2-辛酮酸（D-KDO）可由D-阿拉伯糖和丙酮酸合成，产率67％。另外，保护形式的KDO醛缩酶产物，例如，六乙酰基2-酮-3-脱氧 - 非酮酸和五乙酰基2-酮-3-脱氧 - 八环酸可以脱羧以形成相应的2-脱氧醛糖，例如， 2-脱氧 - 八酮糖和2-脱氧 - 七氟醚。

66. 发明授权

US6083931A Method of inhibiting cancer metastasis 失效
标题翻译：抑制癌症转移的方法
公开(公告)号：US6083931A
公开(公告)日：2000-07-04
申请号：US930680
申请日：1997-12-09
申请人： Takaaki Hasegawa , Kenichi Miyamoto , Mitsuo Kawase , Yasuko Yoshida , Tadahiko Inukai
发明人： Takaaki Hasegawa , Kenichi Miyamoto , Mitsuo Kawase , Yasuko Yoshida , Tadahiko Inukai
IPC分类号： A61K31/726 , A61P35/00 , C07H7/027 , A61K31/715
CPC分类号： A61K31/7012 , A61K31/726 , C07H7/027
摘要： The present invention is aimed at providing an anticancer agent which can inhibit the metastasis of cancer cells when used alone. In addition, the present invention is also aimed at providing an anticancer agent which can inhibit the metastasis of cancer cells while causing a small side effect and very small toxicity even for an extended time of administration. The cancer metastasis-inhibiting anticancer agent according to the present invention is characterized by containing sialic acid, its salt, a polymer of sialic acid or a salt of the polymer as an effective ingredient.
摘要翻译： PCT No.PCT / JP96 / 00268 Sec。 371日期1997年12月9日第 102（e）日期1997年12月9日PCT提交1996年2月8日PCT公布。公开号WO97 / 28807 日期：1997年8月14日本发明旨在提供一种当单独使用时能抑制癌细胞转移的抗癌剂。另外，本发明的目的还在于提供一种能够抑制癌细胞的转移，同时引起副作用小，毒性甚至延长施用时的毒性也非常小的抗癌剂。根据本发明的癌转移抑制抗癌剂的特征在于含有唾液酸，其盐，唾液酸的聚合物或聚合物的盐作为有效成分。

67. 发明授权

US6080563A Method for synthesizing 2-ketoaldonic acids 失效
标题翻译：合成2-酮戊二酸的方法
公开(公告)号：US6080563A
公开(公告)日：2000-06-27
申请号：US88941
申请日：1998-06-02
申请人： Chi-Huey Wong
发明人： Chi-Huey Wong
IPC分类号： C07H1/08 , C07H7/027 , C07H7/033 , C12N9/88 , C12P7/58 , C12P9/00 , C12P19/02 , C12P7/40 , C07H1/00 , C12P9/88
CPC分类号： C12N9/88 , C07H1/08 , C07H7/027 , C07H7/033 , C12P19/02 , C12P7/58 , C12P9/00
摘要： 2-Ketoaldonic acid is synthesized by aldolase condensation reaction involving pyruvate and an aldose acceptor in the presence of excess pyruvate. After the reaction is substantially complete, the excess pyruvate is removed from the reaction mixture by treatment with pyruvate decarboxylase.
摘要翻译：在过量的丙酮酸存在下，2-酮糖醛酸通过醛缩酶缩合反应合成，涉及丙酮酸和醛糖受体。反应基本完成后，通过用丙酮酸脱羧酶处理从反应混合物中除去过量的丙酮酸。

68. 发明授权

US5872096A Modified sialyl Lewis.sup.a compounds 失效
公开(公告)号：US5872096A
公开(公告)日：1999-02-16
申请号：US325139
申请日：1994-10-20
申请人： Andre P. Venot , Pandurang V. Nikrad , Mohammed A. Kashem
发明人： Andre P. Venot , Pandurang V. Nikrad , Mohammed A. Kashem
IPC分类号： A61K31/70 , A61K31/702 , A61K31/7028 , A61K38/00 , A61K39/00 , A61K39/385 , A61K39/39 , A61P37/00 , C07H3/06 , C07H7/027 , C07H15/04 , C07H19/10 , C07H19/20 , C12P19/26 , A61K38/16 , C07K9/00 , C07M15/00
CPC分类号： C12P19/26 , A61K31/70 , A61K39/39 , C07H15/04 , C07H19/10 , C07H19/20 , C07H3/06 , C07H7/027 , A61K2039/55583 , A61K39/00
摘要： The present invention is drawn to methods for the synthesis of Lewis.sup.a derivatives modified at the C-2 and/or C-6 position of GlcNAc employing chemo-enzymatic synthesis. The derivatives find use in the treatment and prevention of diseases.

69. 发明授权

US5869316A Biologically pure culture of aureobacterium barkeri KDO-37-2 失效
标题翻译：生物纯培养的巴氏杆菌KDO-37-2
公开(公告)号：US5869316A
公开(公告)日：1999-02-09
申请号：US767182
申请日：1996-12-16
申请人： Chi-Huey Wong , Takeshi Sugai , Gwo-Jenn Shen
发明人： Chi-Huey Wong , Takeshi Sugai , Gwo-Jenn Shen
IPC分类号： C07H7/027 , C12N9/88 , C12P7/58 , C12P9/00 , C12P19/02 , C12N1/20
CPC分类号： C12P19/02 , C07H7/027 , C12N9/88 , C12P7/58 , C12P9/00 , Y10S435/822
摘要： Aureobacterium barkeri strain KDO-37-2 (ATCC 49977) and KDO aldolase (EC 4.1.2.23) isolated therefrom are disclosed. The KDO aldolase is further disclosed to have a broad substrate specificity with respect to its reverse reaction, i.e. the condensation of aldoses with pyruvate to form a wide range of 2-keto-3-deoxy-onic acids, including 2-keto-3-deoxy-nonulosonic acid, 2-keto-3-deoxy-octulosonic acid, 2-keto-3-deoxy-heptulosonic acid, and 2-keto-3-deoxy-hexulosonic acid. In particular, 3-deoxy-D-manno-2-octulosonic acid (D-KDO), a vital component of lipopolysaccharides found in the bacterial outer membrane may be synthesized from D-arabinose and pyruvate in 67% yield. Additionally, protected forms of the KDO aldolase products, e.g. hexaacetyl 2-keto-3-deoxy-nonulosonic acid and pentaacetyl 2-keto-3-deoxy-octulosonic acid, may be decarboxylated to form the corresponding 2-deoxy-aldoses, e.g. 2-deoxy-octulose and 2-deoxy-heptulose respectively.
摘要翻译：公开了分离自巴斯德氏菌杆菌菌株KDO-37-2（ATCC 49977）和KDO醛缩酶（EC 4.1.2.23）。进一步公开KDO醛缩酶相对于其逆反应具有广泛的底物特异性，即醛糖与丙酮酸的缩合形成宽范围的2-酮-3-脱氧ic酸，包括2-酮-3- 脱氧 - 非酮酸，2-酮-3-脱氧 - 八环酮酸，2-酮-3-脱氧 - 庚酮酸和2-酮-3-脱氧 - 己酸。特别地，在D-细菌外膜中发现的脂多糖的重要组分3-脱氧-D-壬烯-2-辛酮酸（D-KDO）可由D-阿拉伯糖和丙酮酸合成，产率67％。另外，保护形式的KDO醛缩酶产物，例如，六乙酰基2-酮-3-脱氧 - 非酮酸和五乙酰基2-酮-3-脱氧 - 八环酸可以脱羧以形成相应的2-脱氧醛糖，例如， 2-脱氧 - 八酮糖和2-脱氧 - 七氟醚。

70. 发明授权

US5719020A 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens 失效
标题翻译： 4,7-二烷氧基N-乙酰神经氨酸衍生物和临床标本中A型和B型流感病毒检测方法
公开(公告)号：US5719020A
公开(公告)日：1998-02-17
申请号：US718666
申请日：1996-09-25
申请人： Avraham Liav , Joyce Anne Hansjergen , Craig David Shimasaki
发明人： Avraham Liav , Joyce Anne Hansjergen , Craig David Shimasaki
IPC分类号： C12Q1/04 , C07H7/027 , C07H15/04 , C07H15/203 , C07H17/02 , C07H17/075 , C12Q1/34 , C12R1/92 , G01N33/569 , C12Q1/70 , C07H1/00 , C07H15/00 , C12N9/26
CPC分类号： C07H7/027 , C12Q1/34 , G01N33/56983 , C12Q2334/50 , G01N2333/924
摘要： Chromogenic and fluorogenic 4,7-dialkoxy-N-acetylneuraminic acid substrates of the general formula ##STR1## are provided wherein R.sub.1 and R.sub.2 are alkyl groups containing 1 to 4 carbon atoms and R.sub.3 is a chromogenic or fluorogenic group. These substrates can be used to detect influenza types A and B in clinical samples or specimens. More particularly, these 4,7-dialkoxy-N-acetylneuraminic acid substrates can be used to distinguish between various viruses having neuraminidase reactivity. Thus, influenza type A and B viruses can be distinguished from parainfluenza type 1, 2, 3, and 4, and mumps using the 4,7-dialkoxy-N-acetylneuraminic acid derivatives of this invention. Diagnostic methods employing these substrates are provided to identify influenza type A and B viruses in clinical specimens and to distinguish from other viruses having neuraminidase reactivity.
摘要翻译：具有1至4个碳原子的通式1基团的显色和荧光4,7-二烷氧基-N-乙酰神经氨酸底物是显色或荧光基团。这些底物可用于检测临床样本或标本中的A型和B型流感。更具体地，这些4,7-二烷氧基-N-乙酰神经氨酸底物可用于区分具有神经氨酸酶反应性的各种病毒。因此，使用本发明的4,7-二烷氧基-N-乙酰神经氨酸衍生物可以将A型和B型流感病毒与1型，2型，3型和4型副流感病毒和腮腺炎进行区分。提供使用这些底物的诊断方法来鉴定临床标本中的A型和B型流感病毒，并区别于具有神经氨酸酶反应性的其他病毒。

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