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61. 发明授权

US5434264A .alpha.,.alpha.-disubstituted aromatics and heteroaromatics as cognition enhancers 失效
标题翻译： α，α-二取代的芳族化合物和杂芳族化合物作为认知增强剂
公开(公告)号：US5434264A
公开(公告)日：1995-07-18
申请号：US953273
申请日：1992-09-30
申请人： Richard A. Earl , Melvyn J. Myers , Victor J. Nickolson
发明人： Richard A. Earl , Melvyn J. Myers , Victor J. Nickolson
IPC分类号： C07D213/16 , C07D213/26 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/53 , C07D213/57 , C07D239/26 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D471/04 , C07D471/02 , A61K31/44 , C07D471/06
CPC分类号： C07D213/06 , C07D213/26 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/53 , C07D213/57 , C07D239/26 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D471/04
摘要： Cognitive defeciencies or neurological dysfunction in mammals are treated with .alpha.,.alpha.-disubstituted aromatic or heteroaromatic compounds. The compounds have the formula: ##STR1## or a salt thereof wherein X and Y are taken together to form a saturated or unsaturated carbocyclic or heterocyclic first ring and the shown carbon in said ring is .alpha. to at least one additional aromatic ring or heteroaromatic ring fused to the first ring;one of Het.sup.1 or Het.sup.2 is 2, 3, or 4-pyridyl or 2, 4, or 5-pyrimidinyl and the other is selected from(a) 2, 3, or 4-pyridyl,(b) 2, 4, or 5-pyrimidinyl,(c) 2-pyrazinyl,(d) 3, or 4-pyridazinyl,(e) 3, or 4-pyrazolyl,(f) 2, or 3-tetrahydrofuranyl, and(g) 3-thienyl.
摘要翻译：哺乳动物的认知缺陷或神经功能障碍用α，α-二取代芳族或杂芳族化合物处理。化合物具有下式：其中X和Y一起形成饱和或不饱和的碳环或杂环第一环，所述环中所示的碳是至少一个另外的芳环的α 或与第一环稠合的杂芳环; Het1或Het2之一是2,3或4-吡啶基或2,4或5-嘧啶基，另一个选自（a）2,3或4-吡啶基，（b）2,4或5 （c）2-吡嗪基，（d）3或4-哒嗪基，（e）3或4-吡唑基，（f）2或3-四氢呋喃基和（g）3-噻吩基。

62. 发明授权

US4981861A Tricyclic imidazole derivatives 失效
标题翻译：三环咪唑衍生物
公开(公告)号：US4981861A
公开(公告)日：1991-01-01
申请号：US463879
申请日：1990-01-05
申请人： Albert Fischli , Anna Krasso , Henri Ramuz , Andre Szente
发明人： Albert Fischli , Anna Krasso , Henri Ramuz , Andre Szente
IPC分类号： A61K31/4184 , A61K31/44 , A61K31/4427 , A61P1/04 , C07D213/06 , C07D213/127 , C07D213/26 , C07D213/68 , C07D213/89 , C07D317/00 , C07D401/12 , C07D491/04 , C07D491/056
CPC分类号： C07D213/06 , C07D213/26 , C07D213/68 , C07D213/89 , C07D401/12 , C07D491/04
摘要： Tricyclic imidazole derivatives of formula I ##STR1## wherein one of R.sup.1 and R.sup.3 is lower alkyl and the other is hydrogen or lower alkyl, R.sup.2 is lower alkyl, n is the number 0 or 1, A is ##STR2## R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each is lower alkyl land R.sup.8 is hydrogen nor lower alkyl,and their acid addition salts are described. These compounds are useful as agents for control or prevention of ulcers and of increaased gastric acid secretion.

63. 发明授权

US4948912A Alkylating agents and method of use thereof 失效
标题翻译：烷基化剂及其使用方法
公开(公告)号：US4948912A
公开(公告)日：1990-08-14
申请号：US904884
申请日：1986-09-08
申请人： Robert E. Lyle, Jr. , Donald J. Mangold , Nollie F. Swynnerton
发明人： Robert E. Lyle, Jr. , Donald J. Mangold , Nollie F. Swynnerton
IPC分类号： C07C205/57 , C07D213/16 , C07D213/20 , C07D213/50 , C07D213/53 , C07D213/81
CPC分类号： C07D213/06 , C07C205/57 , C07D213/20 , C07D213/50 , C07D213/53 , C07D213/81
摘要： The present invention comprises a haloacetoxyalkyl ether having the formula: ##STR1## wherein R is H or a C.sub.1 -C.sub.4 substituted or unsubstituted alkyl group, R' is H or a C.sub.1 -C.sub.3 group, and X is chlorine or fluorine; aroyloxymethyl ethers having the formula:R--COOCH.sub.2 --O--CH.sub.2 --OOC--Rwherein the R is p-NO.sub.2 C.sub.6 H.sub.4, halogen substituted C.sub.6 H.sub.4, or other aromatics; the method of making such ethers and monoquaternary salts; and the method of alkylating amines, pyridines, or acetals or pyridine derivatives with such ethers to form quaternary ammonium salts; particularly HI-6, HGG-12, Toxogonin, and SAS-128.
摘要翻译：本发明包括具有下式的卤代烷氧基烷基醚：其中R是H或C1-C4取代或未取代的烷基，R'是H或C1-C3基，X是氯或氟; 具有下式的芳酰基甲基醚：R-COOCH2-O-CH2-OOC-R，其中R是p-NO2C6H4，卤素取代的C6H4或其它芳族化合物; 制备这种醚和单季盐的方法; 以及用这种醚烷基化胺，吡啶或缩醛或吡啶衍生物以形成季铵盐的方法; 特别是HI-6，HGG-12，Toxogonin和SAS-128。

64. 发明授权

US4824955A Selenium oxy chloride-pyridine or bipyridine complexes 失效
标题翻译：氯氧化硒 - 吡啶或联吡啶配合物
公开(公告)号：US4824955A
公开(公告)日：1989-04-25
申请号：US928551
申请日：1986-11-10
申请人： Hisao Ekimoto , Masanobu Suzuki , Takao Izawa , Katsutoshi Takahashi , Tokuji Nakatani , Akio Fujii
发明人： Hisao Ekimoto , Masanobu Suzuki , Takao Izawa , Katsutoshi Takahashi , Tokuji Nakatani , Akio Fujii
IPC分类号： C07D207/20 , C07D213/06 , C07D213/22 , C07D213/61 , C07D213/64 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D213/89 , C07D215/06 , C07D215/18 , C07D215/22 , C07D215/233 , C07D215/24 , C07D217/02 , C07D233/68 , C07D235/06 , C07D235/08 , C07D471/04 , C07D473/08 , C07D473/10 , C07D473/12 , C07D521/00 , C07F9/11 , C07D401/04 , C07D213/65
CPC分类号： C07D213/06 , C07D207/20 , C07D213/22 , C07D213/61 , C07D213/64 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D213/89 , C07D215/06 , C07D215/18 , C07D215/233 , C07D215/24 , C07D217/02 , C07D231/12 , C07D233/56 , C07D233/68 , C07D235/06 , C07D235/08 , C07D249/08 , C07D471/04 , C07D473/08 , C07D473/10 , C07D473/12 , C07F9/11
摘要： This invention relates to the novel selenium compounds which are useful as an antineoplastic agent. The compounds are represented by the general formula (I):Se(O).sub.a (R).sub.b (X).sub.c (A).sub.n (Y).sub.m (I)wherein R, X, A and Y represent the groups specified below, a represents a number of 0 or 1, b represents a number of 0, 1 or 2, and (1) when a is 0 and b is also 0, c is 4, n is 1 or 2 and m is 0, (2) when a is 1 and b is 0, c is 2, n is 1 or 2 and m is 0 or 1, and (3) when b is 1 or 2, c, n and m are all 0;(i) when b is 2, R represents (1) a C.sub.4-10 alkoxy group substituted with a halogen atom, (2) a lower alkoxyl group substituted with a halogen atom and a phenyl group, or (3) a cycloalkyloxy group substituted with a halogen atom, and (ii) when b is 1, R represents a group represented by the formula ##STR1## (wherein R.sub.0 is a C.sub.2-6 alkyl group); X represents a halogen atom;A represents a compound represented by the formula ##STR2## (wherein R.sub.1 and R.sub.2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkyl group, a halogen atom, a phenyl group, a cyano group, a lower alkoxycarbonly group, a phenoxycarbonyl group, an amino group (to which a lower alkyl, lower alkylaminocarbonyl, lower halogenoalkylaminocarbonyl or lower alkoxycarbonyl group may be bonded), a benzoyl group, a loweralkoxyl group, a carbamyl group or an allyloxycarbonyl group; R.sub.7 represents a hydrogen atom, a lower alkyl group or a group represented by the formula ##STR3## (wherein R.sub.9 represents an amino group or a lowr alkoxyl group); Y represents H.sub.2 O.
摘要翻译：本发明涉及可用作抗肿瘤剂的新型硒化合物。这些化合物由通式（I）表示：Se（O）a（R）b（X）c（A）n（Y）m（I）其中R，X，A和Y表示下面规定的基团， a表示0或1的数，b表示0,1或2的数，以及（1）当a为0且b为0时，c为4，n为1或2，m为0，（2））当a为1且b为0时，c为2，n为1或2，m为0或1，（3）当b为1或2时，c，n和m均为0; （i）当b为2时，R表示（1）被卤素原子取代的C 4-10烷氧基，（2）被卤素原子和苯基取代的低级烷氧基，或（3）环烷氧基取代和（ii）当b为1时，R表示由式“IMAGE”表示的基团（其中R 0为C 2-6烷基）; X表示卤原子; A表示由式“IMAGE”表示的化合物（其中R 1和R 2可以相同或不同，表示氢原子，羟基，低级烷基，卤原子，苯基，氰基，苯氧基羰基，氨基（可以键合有低级烷基，低级烷基氨基羰基，低级卤代烷基氨基羰基或低级烷氧基羰基），苯甲酰基，低级烷氧基，氨基甲酰基或烯丙氧基羰基; R7表示氢原子，低级烷基或下式表示的基团（其中R9表示氨基或低级烷氧基）; Y表示H 2 O。

65. 发明授权

US4658032A Process for producing 2,3,5-collidine and/or 2,3,5,6-tetramethylpyridine 失效
标题翻译：制备2,3,5-可力丁和/或2,3,5,6-四甲基吡啶的方法
公开(公告)号：US4658032A
公开(公告)日：1987-04-14
申请号：US753533
申请日：1985-07-10
申请人： Mitsuharu Yamaji
发明人： Mitsuharu Yamaji
IPC分类号： B01J25/00 , C07B61/00 , C07D213/06 , C07D213/127
CPC分类号： C07D213/06
摘要： Process for producing 2,3,5-collidine and/or 2,3,5,6-tetramethylpyridine which is characterized by reacting 3,5-lutidine as the starting material with an aliphatic alcohol having 1 to 4 carbon atoms, in the presence of a catalyst for hydrogenation at a temperature of 200.degree. C. or higher.The above-mentioned 2,3,5-collidine and/or 2,3,5,6-tetramethylpyridine are important compounds as intermediates for synthesizing various pharmaceutical chemicals.
摘要翻译：在制备2,3,5-可力丁和/或2,3,5,6-四甲基吡啶的方法中，其特征在于使3,5-二甲基吡啶作为起始原料与具有1至4个碳原子的脂族醇反应，在200℃以上的温度下进行氢化的催化剂。上述2,3,5-可力丁和/或2,3,5,6-四甲基吡啶是用于合成各种药物化学品的中间体的重要化合物。

66. 发明授权

US4523016A Process for the catalytic dehydrogenation of piperidine 失效
标题翻译：哌啶催化脱氢方法
公开(公告)号：US4523016A
公开(公告)日：1985-06-11
申请号：US513197
申请日：1983-07-13
申请人： Georg Grigoleit , Rudolf Oberkobusch , Jurgen Stadelhofer , Kurt Matern
发明人： Georg Grigoleit , Rudolf Oberkobusch , Jurgen Stadelhofer , Kurt Matern
IPC分类号： C07D213/06 , C07D213/133 , C07D213/02
CPC分类号： C07D213/06
摘要： The catalytic dehydrogenation of piperidine to pyridine in the gas phase using hydrogen as the carrier gas is carried out with a silicon dioxide carrier activated with copper, nickel and chromium as the catalyst, the metals copper, nickel and chromium being present in an amount of 5-12:1-5:0.1-
摘要翻译：使用氢气作为载气，在气相中哌啶到吡啶的催化脱氢是用以铜，镍和铬为催化剂活化的二氧化硅载体进行的，金属铜，镍和铬的存在量为5 -12：1-5：每100重量份催化剂0.1-0.7重量份。最佳氢/哌啶摩尔比为5:1，脱氢反应的纯化和干燥的转化气优选循环使用，作为氢。

67. 发明授权

US4401819A Process for the preparation of pyridine and substituted pyridines 失效
标题翻译：制备吡啶和取代吡啶的方法
公开(公告)号：US4401819A
公开(公告)日：1983-08-30
申请号：US360567
申请日：1982-03-22
申请人： Georges Cordier , Patrick Leroux
发明人： Georges Cordier , Patrick Leroux
IPC分类号： C07D211/12 , C07D213/06 , C07D213/08 , C07D213/09 , C07D213/133
CPC分类号： C07D213/06 , C07D213/08 , C07D213/133
摘要： The present invention relates to a process for the preparation of pyridine and substituted pyridines, in the vapor phase. These compounds are obtained by heating, at a temperature of 200.degree. to 500.degree. C., in the vapor phase:piperidine or piperidine substituted by one or more lower alkyl radicals;1,5-diaminopentane;1,5-diaminopentane containing, in its hydrocarbon part, from 1 to 3 linear or branched alkyl radicals having from 1 to 4 carbon atoms; orcompounds such as: N,N'-bis-(piperidin-2-yl)hydrazines,in the presence of a catalyst consisting of palladium, platinum or ruthenium deposited on a macroporous solid.The products obtained by the process according to the invention have various uses. Pyridine is used in particular as a solvent. .beta.-Picoline (or 3-methylpyridine) is used for the preparation of nicotinic acid or nicotinamide, used in pharmacy and in nutrition.
摘要翻译：本发明涉及一种在气相中制备吡啶和取代吡啶的方法。这些化合物通过在气相中在200〜500℃的温度下加热得到：哌啶或被一个或多个低级烷基取代的哌啶; 1,5-二氨基戊烷; 在其烃部分含有1至3个具有1至4个碳原子的直链或支链烷基的1,5-二氨基戊烷; 或诸如：N，N'-双（哌啶-2-基）肼的化合物在沉积在大孔固体上的由钯，铂或钌组成的催化剂存在下进行。通过本发明方法获得的产品具有各种用途。特别是作为溶剂使用吡啶。 β-哌啶（或3-甲基吡啶）用于制备用于制药和营养的烟酸或烟酰胺。

68. 发明授权

US4395554A Process for producing alpha-picoline 失效
标题翻译：生产α-甲基吡啶的方法
公开(公告)号：US4395554A
公开(公告)日：1983-07-26
申请号：US369296
申请日：1982-04-16
申请人： Clarence D. Chang , Patrick D. Perkins
发明人： Clarence D. Chang , Patrick D. Perkins
IPC分类号： C07D213/06 , C07D213/08 , C07D213/09 , C07D213/16
CPC分类号： C07D213/06 , C07D213/08 , Y02P20/582
摘要： Alpha-picolines are produced by containing aniline or substituted anilines, such as alkyl-, cyclo alkyl-, halo- ; alkoxy- or substituted alkyl-anilines with a crystalline zeolite catalyst having a silica:alumina ratio of at least 12 and a constraint index of 1 to 12. ZSM-5 type catalysts are contacted at elevated temperature to yield alpha-picolines selectively.
摘要翻译：通过含有苯胺或取代的苯胺如烷基 - ，环烷基 - ，卤代 - 烷氧基或取代的烷基苯胺与具有至少12的二氧化硅：氧化铝比的结晶沸石催化剂和1至12的约束指数。ZSM-5型催化剂在升高的温度下接触以选择性地产生α-吡啶甲酸。

69. 发明授权

US4158099A Production of aromatic compounds containing ethylene double bonds 失效
标题翻译：生产含乙烯双键的芳香族化合物
公开(公告)号：US4158099A
公开(公告)日：1979-06-12
申请号：US673317
申请日：1976-04-05
申请人： Adolf E. Siegrist , Peter Liechti , Hans R. Meyer , Kurt Weber
发明人： Adolf E. Siegrist , Peter Liechti , Hans R. Meyer , Kurt Weber
IPC分类号： C07C2/86 , C07C17/26 , C07C41/30 , C07C43/215 , C07D213/06 , C07D213/16 , C07D213/30 , C07D317/50 , C07D317/54 , C07D333/08 , C07D333/16 , C07C41/06
CPC分类号： C07D213/16 , C07C17/263 , C07C2/86 , C07C41/30 , C07D213/06 , C07D213/30 , C07D317/50 , C07D317/54 , C07D333/08 , C07D333/16 , C07C2103/24 , C07C2103/26 , C07C2103/50
摘要： The invention provides a new process for the manufacture of aromatic compounds which at least once contain a benzene ring of an aromatic carbocyclic ring system bonded by an ethylene double bond in conjugation with a further aromatic ring system, i.e. contain the stilbene skeleton or stilbene analogon as central structural element, as well as certain classes of new compounds of this type. The process is characterized by the reaction of a Schiff base of an aromatic aldehyde with an aromatic carbocyclic six-membered ring compound which contains one to four methyl groups bonded to ring carbon atoms of a benzene ring, which furthermore contains aromatic rings which are exclusively six-membered carbocyclic rings, and wherein those benzene rings whose methyl groups are to be caused to react are free of other substituents which contain atoms wich are replaceable by alkali metal. The reaction is carried out in the presence of (a) a strongly basic alkali compound and (b) an N-dialkyl-acylamide as solvent. The compounds obtainable according to this process show a marked fluorescence emission and therefore are suitable for all purposes where fluorescence properties are used, as for instance optical brighteners, scintillators fluorescence dyes, etc.
摘要翻译：本发明提供了一种制备芳族化合物的新方法，所述芳族化合物至少一次含有通过乙烯双键与另外的芳族环系统共轭的芳族碳环系统的苯环，即含有二苯乙烯骨架或1,2-二苯乙烯类似物作为中心结构元素，以及某些类型的这类新化合物。该方法的特征在于芳族醛的席夫碱与芳族碳环六元环化合物的反应，所述芳族碳环六元环化合物含有与苯环的环碳原子键合的一至四个甲基，其还包含仅六个芳环的芳环并且其中将要使甲基反应的那些苯环不含可被碱金属替代的原子的其它取代基。反应在（a）强碱性碱性化合物和（b）N-二烷基 - 酰基酰胺作为溶剂的存在下进行。根据该方法可获得的化合物显示出显着的荧光发射，因此适用于所有使用荧光性质的目的，例如荧光增白剂，闪烁体荧光染料等。

70. 发明授权

US4118388A Process for producing pyridine 失效
标题翻译：制备吡啶的方法
公开(公告)号：US4118388A
公开(公告)日：1978-10-03
申请号：US823477
申请日：1977-08-10
申请人： Takushi Yokoyama , Hidetaka Kojima , Masaharu Uragami , Kathuyoshi Miwa
发明人： Takushi Yokoyama , Hidetaka Kojima , Masaharu Uragami , Kathuyoshi Miwa
IPC分类号： B01J23/00 , B01J23/68 , C07B61/00 , C07D213/06 , C07D213/127 , C07D213/16
CPC分类号： C07D213/06 , B01J23/683
摘要： A process for producing pyridine which comprises oxidatively dealkylating an alkylpyridine, an alkenylpyridine or a mixture thereof in the gaseous phase with molecular oxygen and steam in the presence of a catalyst comprising active components with a general composition of the formulav.sub.a X.sub.b Ag.sub.c O.sub.wherein a, c, and d respectively represent the atomic proportions of vanadium, silver and oxygen; X represents at least one element selected from the group consisting of chromium, molybdenum and tungsten; b represents the atomic proportion of X; and when a is 1, b is about 0.1 to about 1.5, c is about 0.005 to about 1.0, and d represents the atomic proportion of oxygen, is a value determined by the atomic valences of the individual V, X and Ag elements and is about 2.6 to about 7.5; and separating pyridine from the reaction product.
摘要翻译：一种制备吡啶的方法，其包括在包含活性组分与通式VAXbAgcO的一般组合物的催化剂存在下，将气态的烷基吡啶，烯基吡啶或其混合物与分子氧和蒸汽进行氧化脱烷基化，其中a，c和 d分别代表钒，银和氧的原子比例; X表示选自铬，钼和钨中的至少一种元素; b表示X的原子比例; 当a为1时，b为约0.1至约1.5，c为约0.005至约1.0，d表示氧的原子比例，是由各V，X和Ag元素的原子价决定的值，为约2.6至约7.5; 并从反应产物中分离出吡啶。

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