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    • 66. 发明授权
    • Diacetylenics containing adjacent triple bonds
    • 含有相邻三键的二乙酰基
    • US06440056B1
    • 2002-08-27
    • US09845106
    • 2001-04-27
    • Alok SinghPaul SchoenDan ZabetakisJoel M. Schnur
    • Alok SinghPaul SchoenDan ZabetakisJoel M. Schnur
    • C11B300
    • C07C51/373C07C51/353C07C57/24C07C59/76C07C59/84
    • This invention pertains to a process for preparing diacetylenics, to diacetylenic compounds and to reduced diacetylenic compounds. The process includes the steps of reacting coupling an acetylenic acid in presence of cupric chloride in Ethylamine and hydroxylamine hydrochloride to form a diacetylenic diacid; reacting the diacetylenic diacid with a lithium compound, trimethylsilyl chloride and hydrochloric acid to form a diacetylenic compound; and reducing the diacetylenic compound to a reduced diacetylenic compound. The diacetylenic compounds have the formula COOH—(CH2)m—C≡C—C≡C—(CH2)m—C(═O)—R or R—C(═O)—(CH2)m—C≡C—C≡C—(CH2)m—C(═O)—R and the reduced cyclic diacetylenic compounds have the formula COOH—(CH2)m—C≡C—C≡C—(CH2)m—CH2—R or R—CH2—(CH2)m—C≡C—C≡C—(CH2)m—CH2—R, where m is 1-18 and R is selected from alkyl groups of 1-10 and cyclic groups containing 6-35 carbon atoms and aryl moieties
    • 本发明涉及制备二乙炔基化合物,二乙炔化合物和还原二炔化合物的方法。 该方法包括使乙酸氯化物在乙胺和盐酸羟胺存在下偶联乙酸以形成二乙炔二酸的步骤; 使二乙炔二酸与锂化合物,三甲基甲硅烷基氯和盐酸反应,形成二乙炔化合物; 并将二乙炔化合物还原成还原的二乙炔化合物。 二乙炔化合物具有式COOH-(CH2)mC = CC = C-(CH2)mC(= O)-R或RC(= O) - (CH2)mC = CC = C-(CH2)mC(= O )-R并且还原的环状二炔化合物具有式COOH-(CH 2)m C = CC = C-(CH 2)m -CH 2 -R或R-CH 2 - (CH 2)m C = CC = C-(CH 2)m - CH2-R,其中m为1-18,R选自1-10的烷基和含有6-35个碳原子的环状基团和芳基部分
    • 68. 发明授权
    • Processes for producing aldehyde acids or salts
    • 生产醛酸或盐的方法
    • US5919978A
    • 1999-07-06
    • US839579
    • 1997-04-15
    • Diane Lee PackettThomas Carl EisenschmidMichael Allen BrammerJohn Michael Maher
    • Diane Lee PackettThomas Carl EisenschmidMichael Allen BrammerJohn Michael Maher
    • C07C51/14C07C51/373
    • C07C51/14C07C51/373Y02P20/582
    • This invention relates in part to processes for producing one or more substituted or unsubstituted aldehyde acids or salts, e.g., 5-formylvaleric acid or salt, which comprises subjecting one or more substituted or unsubstituted alkadienes, e.g., butadiene, to hydroxycarbonylation in the presence of a hydroxycarbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, and optionally neutralization with a base to produce one or more substituted or unsubstituted unsaturated acids or salts, e.g., pentenoic acid or salt, and subjecting said one or more substituted or unsubstituted unsaturated acids or salts to hydroformylation in the presence of a hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce said one or more substituted or unsubstituted aldehyde acids or salts and/or one or more substituted or unsubstituted epsilon caprolactam precursors. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted aldehyde acids or salts as the principal product(s) of reaction.
    • 本发明部分地涉及生产一种或多种取代或未取代的醛酸或其盐的方法,例如5-甲酰基戊酸或其盐,其包括使一种或多种取代或未取代的二烯烃如丁二烯在存在下进行羟基羰基化反应 羟基羰基化催化剂,例如金属 - 有机磷配体配合物催化剂,并且任选地用碱中和以产生一种或多种取代或未取代的不饱和酸或盐,例如戊烯酸或盐,并使所述一种或多种取代或未取代的不饱和 在加氢甲酰化催化剂(例如金属 - 有机磷配体配合物催化剂)的存在下加氢甲酰化,以产生所述一种或多种取代或未取代的醛酸或其盐和/或一种或多种取代或未取代的ε己内酰胺前体。 本发明还部分涉及含有一种或多种取代或未取代的醛酸或盐作为主要反应产物的反应混合物。