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61. 发明授权

US07807113B2 Microchannel compression reactor assembly 有权
标题翻译：微通道压缩反应器总成
公开(公告)号：US07807113B2
公开(公告)日：2010-10-05
申请号：US12386256
申请日：2009-04-15
申请人： William Allen Rogers , Paul William Neagle , Michael Alan Marchiando , Christopher Paul Weil , Robert Dwayne Litt , Ronald Chester Pasadyn , G. Bradley Smith , Charles Robert Miele , Thomas Peter Forte , Jimmy Glen Pelham
发明人： William Allen Rogers , Paul William Neagle , Michael Alan Marchiando , Christopher Paul Weil , Robert Dwayne Litt , Ronald Chester Pasadyn , G. Bradley Smith , Charles Robert Miele , Thomas Peter Forte , Jimmy Glen Pelham
IPC分类号： B01J10/00 , B01J8/04 , B01J3/00
CPC分类号： B01J19/0093 , B01J3/046 , B01J2219/0081 , B01J2219/00817 , B01J2219/00835 , B01J2219/00867 , B01J2219/00869 , B01J2219/00873 , B01J2219/00891 , B01J2219/00957 , B01J2219/00961 , B01J2219/00963 , B01J2219/00986 , C01B3/382 , C01B3/384 , C01B2203/0227 , C01B2203/0283 , C01B2203/0811 , C01B2203/1604 , C07C1/0475 , C07C1/0485 , C10G2/00 , C10G2300/4031 , Y02P20/52 , Y10T29/49345 , Y10T29/49815 , Y10T29/49826 , Y10T29/49948 , Y10T137/0335
摘要： The present invention includes a removable microchannel unit including an inlet orifice and an outlet orifice in fluid communication with a plurality of microchannels distributed throughout the removable microchannel unit, and a pressurized vessel adapted have the removable microchannel unit mounted thereto, the pressurized vessel adapted to contain a pressurized fluid exerting a positive gauge pressure upon at least a portion of the exterior of the removable microchannel unit. The invention also includes a microchannel unit assembly comprising a microchannel unit operation carried out within a pressurized vessel, where pressurized vessel includes a pressurized fluid exerting a positive gauge pressure upon an exterior of the microchannel unit operation, and where the microchannel unit operation includes an outlet orifice in fluid communication with an interior of the pressurized vessel.
摘要翻译：本发明包括可拆卸微通道单元，其包括入口孔和与遍布可移除微通道单元分布的多个微通道流体连通的出口孔，以及适于具有安装在其上的可移除微通道单元的加压容器，该加压容器适于容纳加压流体在可移除的微通道单元的外部的至少一部分上施加正的表压。本发明还包括微通道单元组件，其包括在加压容器内执行的微通道单元操作，其中加压容器包括在微通道单元操作的外部施加正表压的加压流体，并且其中微通道单元操作包括出口孔与压力容器的内部流体连通。

62. 发明申请

US20100233042A1 FLUID PORTING ASSEMBLY AND MICROREACTOR INCORPORATING THE SAME 有权
标题翻译：流体成型装置和与其同时进行的微型反应器
公开(公告)号：US20100233042A1
公开(公告)日：2010-09-16
申请号：US12744608
申请日：2008-11-25
申请人： Olivier Lobet
发明人： Olivier Lobet
IPC分类号： B01J19/00
CPC分类号： B01L3/565 , B01J19/0093 , B01J2219/0081 , B01J2219/00891 , B01L3/502707 , B01L2300/1894
摘要： A fluid porting assembly for a microreactor comprising a process fluid passageway, a pliable seal, and a cooling fluid passageway is provided. The pliable seal is positioned in the vicinity of the process fluid outlet and is configured to define a sealing interface between the process fluid outlet and a fluid port of a microreactor. The cooling fluid passageway terminates at a cooling fluid interface and defines a dispensing gap between the cooling fluid interface and the sealing interface. The cooling fluid outlet is configured to distribute cooling fluid about a periphery of the pliable seal and to direct cooling fluid away from the periphery of the pliable seal through the dispensing gap when the pliable seal of the fluid porting assembly engages a fluid port of a microreactor. The cooling fluid removes heat from areas of the microreactor in the vicinity of the fluid port and pliable seal.
摘要翻译：提供了一种用于微反应器的流体移植组件，其包括过程流体通道，柔性密封件和冷却流体通道。柔性密封件位于过程流体出口附近，并且构造成限定过程流体出口和微反应器的流体端口之间的密封界面。冷却流体通道终止于冷却流体界面并且限定冷却流体界面和密封界面之间的分配间隙。冷却流体出口构造成在柔性密封件的周边分布冷却流体，并且当流体移动组件的柔性密封件接合微反应器的流体端口时，将冷却流体引导通过分配间隙远离柔性密封件的周边。冷却流体从流体端口附近的微反应器区域和柔性密封件移除热量。

63. 发明申请

US20100233026A1 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION 审中-公开
标题翻译：用于压力驱动输送和反应的装置和方法
公开(公告)号：US20100233026A1
公开(公告)日：2010-09-16
申请号：US12777099
申请日：2010-05-10
申请人： Rustem F. Ismagliov , Joshua David Tice , Cory John Gerdts , Bo Zheng
发明人： Rustem F. Ismagliov , Joshua David Tice , Cory John Gerdts , Bo Zheng
IPC分类号： G01N33/68
CPC分类号： B01L3/502784 , B01D9/0072 , B01D2009/0086 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01J14/00 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00894 , B01J2219/00903 , B01J2219/00975 , B01J2219/00977 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2200/12 , B01L2300/0867 , B01L2400/0487 , B82Y30/00 , C07K14/43 , C12N9/2462 , C12Q1/6806 , C12Y302/01017 , C30B7/14 , C30B29/54 , C30B29/58 , G01N1/28 , G01N35/08 , Y10T117/10 , Y10T137/0318 , Y10T436/117497 , Y10T436/143333 , Y10T436/25
摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
摘要翻译：本发明提供微制造的底物和在这些底物内进行反应的方法。反应发生在在载体流体流中输送的塞子中。

64. 发明授权

US07780944B2 Multi-stream microchannel device 有权
标题翻译：多流微通道设备
公开(公告)号：US07780944B2
公开(公告)日：2010-08-24
申请号：US11300914
申请日：2005-12-15
申请人： James A. Mathias , G. Bradley Chadwell , Dongming Qiu , Annalee Y. Tonkovich , Steven T. Perry , Matthew B. Schmidt , Sean P. Fitzgerald , David J. Hesse , Thomas D. Yuschak , Bin Yang
发明人： James A. Mathias , G. Bradley Chadwell , Dongming Qiu , Annalee Y. Tonkovich , Steven T. Perry , Matthew B. Schmidt , Sean P. Fitzgerald , David J. Hesse , Thomas D. Yuschak , Bin Yang
IPC分类号： C01B3/24 , C01B3/26
CPC分类号： F16L41/02 , B01J19/0093 , B01J35/04 , B01J2219/00869 , B01J2219/00891 , C01B3/384 , C01B2203/0233 , C01B2203/0811 , C01B2203/0822 , F28D7/0066 , F28D9/0093 , F28F3/12 , F28F7/02 , F28F2260/02 , Y02P20/128 , Y02P20/52 , Y10T137/0318 , Y10T137/6579 , Y10T137/87153 , Y10T137/87249
摘要： The invention is a process and device for exchanging heat energy between three or more streams in a microchannel heat exchanger which can be integrated with a microchannel reactor to form an integrated microchannel processing unit. The invention enables the combining of a plurality of integrated microchannel devices to provide the benefits of large-scale operation. In particular, the microchannel heat exchanger of the present invention enables flexible heat transfer between multiple streams and total heat transfer rates of about 1 Watt or more per core unit volume expressed as W/cc.
摘要翻译：本发明是一种用于在微通道热交换器中的三个或更多个流之间交换热能的方法和装置，其可以与微通道反应器集成以形成集成的微通道处理单元。本发明使得能够组合多个集成微通道装置以提供大规模操作的优点。特别地，本发明的微通道热交换器能够在多个流之间实现柔性热传递，并且以W / cc表示的每单位体积的约1瓦特或更高的总传热速率。

65. 发明授权

US07767155B2 Microreactor apparatus having integral connectors 有权
标题翻译：具有整体连接器的微反应器装置
公开(公告)号：US07767155B2
公开(公告)日：2010-08-03
申请号：US11706368
申请日：2007-02-15
申请人： Tetsuo Ohta , Seiichi Takagi
发明人： Tetsuo Ohta , Seiichi Takagi
IPC分类号： B01L99/00 , G01N33/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00804 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/5027 , B01L3/565
摘要： A microreactor apparatus includes; a microreactor body that includes first and second substrates; a microchannel that is formed inside the microreactor body; and integral connectors that are disposed detachably on the microreactor body, and through which supply/discharge pipes are to be connected to end portions of the microchannel, respectively.
摘要翻译：微反应器装置包括：微反应器主体，其包括第一和第二基板; 在微反应器体内形成的微通道; 以及整体连接器，其可拆卸地设置在微反应器主体上，并且分别将供给/排出管连接到微通道的端部。

66. 发明申请

US20100182868A1 Microfluidic Self-Sustaining Oscillating Mixers and Devices and Methods Utilizing Same 审中-公开
标题翻译：微流体自维持振荡器及其使用方法
公开(公告)号：US20100182868A1
公开(公告)日：2010-07-22
申请号：US12600322
申请日：2008-05-15
申请人： Pierre Woehl
发明人： Pierre Woehl
IPC分类号： B01F15/02 , B81B1/00 , B01J19/00 , B01J19/08
CPC分类号： B01F5/02 , B01F5/0602 , B01F5/0603 , B01F5/0647 , B01F13/0059 , B01F13/0094 , B01F13/1013 , B01F13/1016 , B01F15/06 , B01F2215/0431 , B01J19/0093 , B01J2219/00824 , B01J2219/00831 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00932 , B01J2219/00934 , B01J2219/00952 , B01J2219/00975
摘要： A microfluidic device (10) for performing chemical or biological reactions comprises a chamber (20) for use as a self-sustaining oscillating jet mixing chamber and two or more separate feed channels (22, 24, 40) separated by one or more inter-channel walls (25), the two or more channels (22,24,40) terminating at a common side (18) of the chamber (20), the two or more channels (22,24,40) having a total channel width (28) comprising the widths of the two or more channels (22,24,40) and all inter-channel walls (25) taken together, the chamber (20) having a width (26) in a direction perpendicular to the channels (22,24,40) and a length (32) in a direction parallel to the channels, the width (26) being at least two times the total channel width (28), the chamber (20) having two opposing major surfaces (56) defining a height (30) thereof, the chamber (20) having a major-surface-area to volume ratio of at least 10 cm2/cm3. A method of microfluidic fluid mixing using a self-sustaining oscillating jet mixing chamber is also disclosed.
摘要翻译：用于进行化学或生物反应的微流体装置（10）包括用作自持式振荡喷射混合室的两个或多个分离的进料通道（22,24,40）的腔室（20）通道壁（25），两个或多个通道（22,24,40）终止于腔室（20）的共同侧（18）处，两个或多个通道（22,24,40）具有总通道宽度（28），包括两个或多个通道（22,24,40）的宽度和所有通道间壁（25）组合在一起，所述室（20）在垂直于通道的方向上具有宽度（26） 22,24,40）和在与所述通道平行的方向上的长度（32），所述宽度（26）是所述总通道宽度（28）的至少两倍，所述腔室（20）具有两个相对的主表面（56 ）限定其高度（30），所述腔室（20）的主表面积与体积比至少为10cm 2 / cm 3。还公开了使用自持式振荡喷射混合室的微流体混合的方法。

67. 发明授权

US07759067B2 Method for determining the amount of an analyte with a disc-shaped microfluidic device 有权
标题翻译：用圆盘形微流体装置确定分析物的量的方法
公开(公告)号：US07759067B2
公开(公告)日：2010-07-20
申请号：US10472421
申请日：2002-03-19
申请人： Per Andersson , Mats Inganas , Gunnar Thorsen , Gunnar Kylberg
发明人： Per Andersson , Mats Inganas , Gunnar Thorsen , Gunnar Kylberg
IPC分类号： C12M1/34 , C12M3/00 , C12Q1/00 , G01N9/30 , G01N15/06 , G01N21/00 , G01N31/00 , G01N31/22 , G01N33/00 , G01N33/48 , G01N33/53
CPC分类号： G01N33/54306 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01J19/0093 , B01J2219/00788 , B01J2219/00833 , B01J2219/0086 , B01J2219/00862 , B01J2219/00891 , B01L3/5025 , B01L3/5027 , B01L3/502738 , B01L3/502746 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2200/142 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/14 , B01L2300/16 , B01L2400/0406 , B01L2400/0409 , B01L2400/0633 , B01L2400/0688 , B01L2400/086 , G01N30/6095 , G01N30/7266 , G01N33/54366 , G01N35/00069 , G01N2035/00504 , H01J49/04 , Y10S435/973
摘要： A microscale method for the characterization of one or more reaction variables that influence the formation or dissociation of an affinity complex comprising a ligand and a binder, which have mutual affinity for each other. The method is characterized in comprising the steps of: (i) providing a microfluidic device comprising a microchannel structures that are under a common flow control, each microchannel structure comprising a reaction microactivity; (ii) performing essentially in parallel an experiment in each of two or more of the plurality of microchannel structures, the experiment in these two or more microchannel structures comprising either a) formation of an immobilized form of the complex and retaining under flow conditions said form within the reaction microactivity, or b) dissociating, preferably under flow condition, an immobilized form of the complex which has been included in the microfluidic device provided in step (i), at least one reaction variable varies or is uncharacterized for said two or more microchannel structures while the remaining reaction variables are kept essentially constant; (iii) measuring the presentation of the complex in said reaction microactivity in said two or more microchannel structures; and (iv) characterizing said one or more reaction variables based on the values for presentation obtained in step (iii).
摘要翻译：用于表征影响包含配体和粘合剂的亲和络合物的形成或解离的一个或多个反应变量的微观方法，其彼此具有相互亲和力。该方法的特征在于包括以下步骤：（i）提供包含处于共同流量控制下的微通道结构的微流体装置，每个微通道结构包含反应微活性; （ii）在两个或多个多个微通道结构的每一个中基本上并行地进行实验，这两个或更多个微通道结构中的实验包括a）形成复合物的固定形式并在流动条件下保持所述形式或者b）优选在流动条件下解离包含在步骤（i）中提供的微流体装置中的复合物的固定化形式，至少一个反应变量对于所述两个或更多个变化是变化的或没有表征的微通道结构，而剩余的反应变量保持基本恒定; （iii）测量所述两个或多个微通道结构中所述反应微活性物中复合物的表现; 和（iv）基于在步骤（iii）中获得的呈现值来表征所述一个或多个反应变量。

68. 发明授权

US07759013B2 Fuel delivery apparatus of direct liquid feed fuel cell 失效
标题翻译：直接液体进料燃料电池的燃油输送装置
公开(公告)号：US07759013B2
公开(公告)日：2010-07-20
申请号：US11287376
申请日：2005-11-28
申请人： Jae-yong Lee , Hye-jung Cho
发明人： Jae-yong Lee , Hye-jung Cho
IPC分类号： H01M2/00 , H01M2/02 , F22B37/18
CPC分类号： H01M8/04201 , B01B1/005 , B01J2219/00783 , B01J2219/00828 , B01J2219/00844 , B01J2219/00873 , B01J2219/00891 , H01M8/04037 , H01M8/04186 , H01M8/06 , H01M8/1011 , Y02E60/523
摘要： A fuel delivery apparatus for a direct liquid feed fuel cell is provided. The fuel delivery apparatus includes a plate stack formed by a one or more double-sided plates positioned between opposing end plates. Both sides of the one or more double-sided plates, and the interior side of each end plate, may include one or more microchannels that extend between, and link, an inlet port with an outlet port. The length of the microchannels is chosen to be less than the height of a predetermined meniscus so that liquid fuel propelled by capillary force forms a meniscus that stands proximate the interface between the ends of the microchannels and the outlet port. A heater may be located at the upper ends of the microchannels around the plate stack, to vaporize the liquid fuel at the meniscus.
摘要翻译：提供一种用于直接液体进料燃料电池的燃料输送装置。燃料输送装置包括由位于相对端板之间的一个或多个双面板形成的板堆叠。一个或多个双面板的两侧和每个端板的内侧可以包括一个或多个微通道，其在具有出口的入口之间延伸并连接。微通道的长度被选择为小于预定弯液面的高度，使得由毛细管力推动的液体燃料形成靠近微通道的端部与出口之间的界面的弯液面。加热器可以位于板堆叠周围的微通道的上端，以便在弯液面处蒸发液体燃料。

69. 发明授权

US07744822B2 Microchip reactor 失效
标题翻译： Microchip反应堆
公开(公告)号：US07744822B2
公开(公告)日：2010-06-29
申请号：US11770420
申请日：2007-06-28
申请人： Satoshi Sakurai
发明人： Satoshi Sakurai
IPC分类号： G01N30/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00858 , B01J2219/00862 , B01J2219/00889 , B01J2219/00891 , B01J2219/00952 , B01L3/502707 , B01L2200/025 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2400/0487 , G01R33/302 , G01R33/307 , H01J49/0018 , H01J49/165
摘要： There is disclosed a microchip reactor capable of being used in research on reaction kinetics. With this microchip reactor, the time (reaction time) elapsed until a measurement is made since mixing of two liquids is variable. The microchip reactor comprises a base portion and a movable portion which have sliding contact surfaces that are in contact with each other. The base portion and movable portion have their respective downstream flow channel portions which meet at an intersection. Different reagents are introduced at the intersection, mixed, and reacted. An opening is formed in the movable portion. A slot is formed in the base portion. The major axis of the slot is in the direction of sliding motion of the movable portion. The position of the intersection where the reagents are mixed is determined by the intersection of the opening and the slot.
摘要翻译：公开了一种可用于研究反应动力学的微芯片反应器。利用该微芯片反应器，从两种液体的混合开始到测量之前经过的时间（反应时间）是可变的。微芯片反应器包括具有彼此接触的滑动接触表面的基部和可动部。底座部分和可移动部分具有在相交处相交的各自的下游流动通道部分。在交叉点引入不同的试剂，混合并反应。在可动部形成开口部。在基部形成槽。槽的长轴在可动部的滑动方向上。试剂混合的交点的位置由开口和槽的交点确定。

70. 发明授权

US07731918B2 Catalyst incorporation in a microreactor 有权
标题翻译：催化剂掺入微反应器
公开(公告)号：US07731918B2
公开(公告)日：2010-06-08
申请号：US11749097
申请日：2007-05-15
申请人： Anand Chellappa
发明人： Anand Chellappa
IPC分类号： B01J8/02 , B01J19/00 , B01J7/00 , C01B3/02
CPC分类号： B01J35/04 , B01J19/0053 , B01J19/0093 , B01J37/0225 , B01J2219/00783 , B01J2219/00804 , B01J2219/00835 , B01J2219/00891 , C01B3/38 , C01B3/384 , C01B3/40 , C01B3/501 , C01B2203/0233 , C01B2203/041 , C01B2203/047 , C01B2203/0811 , C01B2203/1035 , C01B2203/1205 , Y02P20/52
摘要： A method and device for loading a catalyst into a chamber. The catalyst loading is well suited for production of hydrogen producing microreactors. The catalyst is coated onto a strip which is mountable within the chamber.
摘要翻译：一种用于将催化剂装载到室中的方法和装置。催化剂负载非常适合生产生产氢的微反应器。将催化剂涂覆到可安装在室内的条上。

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