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61. 发明授权

US08409109B2 Rectal probe with disposable balloon assembly 有权
标题翻译：带一次性气囊组件的直肠探头
公开(公告)号：US08409109B2
公开(公告)日：2013-04-02
申请号：US11091107
申请日：2005-03-28
申请人： Scott R. Tiesma , David A. Montecalvo
发明人： Scott R. Tiesma , David A. Montecalvo
IPC分类号： A61B5/00 , A61B1/04 , A61B1/00 , A61M29/00
CPC分类号： A61B5/01 , A61B5/4381
摘要： A reusable temperature sensing probe assembly comprises a temperature sensor strip extending from one end of a handle. The temperature sensor strip carries at least one temperature sensor for measuring temperature within a body cavity of a person, such as the rectum. The handle/temperature sensor strip is reversibly positionable within a unitary balloon/sleeve assembly comprised of a balloon portion and a sleeve portion. The balloon portion is comprised of a first interior space configured to hold the temperature sensor stip and a second interior space separate from the first interior space that is configured for inflation. An inflation tube has one portion sealed within the second interior space of the balloon portion and a second portion which extends through the sleeve portion for connection to a fluid source.
摘要翻译：可重复使用的温度感测探头组件包括从手柄的一端延伸的温度传感器条。温度传感器带带有至少一个温度传感器，用于测量人体的体腔内的温度，例如直肠。手柄/温度传感器条可逆地定位在由球囊部分和套筒部分组成的整体球囊/套筒组件内。球囊部分包括构造成保持温度传感器的第一内部空间和与构造成用于充气的第一内部空间分开的第二内部空间。充气管具有密封在球囊部分的第二内部空间内的一个部分和延伸穿过套筒部分以连接到流体源的第二部分。

62. 发明申请

US20130053728A1 SYSTEMS AND METHODS RELATED TO WASTE DISCHARGING FOR AIDING PATIENTS CONCERNING PROSTATE IRREGULARITIES 审中-公开
标题翻译：与前瞻性不良相关的吸烟患者废物排放相关系统和方法
公开(公告)号：US20130053728A1
公开(公告)日：2013-02-28
申请号：US13217661
申请日：2011-08-25
申请人： MAN LOK
发明人： MAN LOK
IPC分类号： A61B5/20
CPC分类号： A61B5/208 , A61B5/4381 , A61B10/007 , E03D11/025
摘要： Systems and methods are provided concerning waste discharging for aiding patients concerning prostate irregularities. According to one embodiment, this invention includes a waste discharging system for aiding patients concerning prostate irregularities comprising a toilet shared by many persons, a detector detecting that urination occurs, a RFID reader attached to the toilet, a RFID tag associated with a person with prostate concerns, a urine collector attached to the toilet, a pressure sensor associated with the toilet, a timer associated with the toilet, an IR transceiver associated with the toilet, an IR transceiver associated with the door; and a camera outside a door of a room containing the toilet, wherein the camera is used to capture identities of persons detected with prostate irregularities but without associating with RFID tag.
摘要翻译：提供了关于帮助患者关于前列腺不规则的废物排放的系统和方法。根据一个实施例，本发明包括一种用于帮助患者涉及前列腺不规则的废物排放系统，其包括由许多人共享的厕所，检测器发现排尿的检测器，连接到马桶的RFID读取器，与前列腺者相关联的RFID标签关心，连接到马桶的尿液收集器，与马桶相关联的压力传感器，与马桶相关联的定时器，与马桶相关联的IR收发器，与门相关联的IR收发器; 以及包含马桶的房间的门外的照相机，其中所述相机用于捕获用前列腺不规则检测到的但不与RFID标签相关联的人的身份。

63. 发明授权

US08386012B2 Screening test for recognizing prostate diseases and apparatus and diagnosis substance for carrying out the test 失效
标题翻译：识别前列腺疾病筛查试验及检测仪器及诊断物质
公开(公告)号：US08386012B2
公开(公告)日：2013-02-26
申请号：US12671643
申请日：2008-07-31
申请人： Jens Fehre , Ralf Nanke , Martin Stetter
发明人： Jens Fehre , Ralf Nanke , Martin Stetter
IPC分类号： A61B5/05
CPC分类号： G01R33/1269 , A61B5/06 , A61B5/4381 , A61K49/00 , A61K49/0004
摘要： In a screening test method, and a device for implementing the screening test method, a diagnostic substance is provided that contains at least one biomarker connected with at least one ferromagnetic particle, the biomarker binding specifically to a target molecule that is formed by specific pathological prostrate tissue. The diagnostic substance is administered to the blood stream of a patient. A magnetometer is used to detect enrichment of the ferromagnetic particle in the prostrate, as an indicator of a level of the specific pathological prostrate tissue.
摘要翻译：在筛选试验方法以及实施筛选试验方法的装置中，提供了含有至少一种与至少一个铁磁性粒子连接的生物标志物的诊断物质，特异性结合由特异性病理性前列腺素形成的靶分子的生物标志物组织。将诊断物质施用于患者的血液流。磁力计用于检测前列腺中铁磁颗粒的富集，作为特定病理性pro层组织水平的指标。

64. 发明申请

US20120010495A1 Method For Generating MR Images And An Appropriately Designed Magnetic Resonance System 有权
标题翻译：用于生成MR图像和适当设计的磁共振系统的方法
公开(公告)号：US20120010495A1
公开(公告)日：2012-01-12
申请号：US13176010
申请日：2011-07-05
申请人： Andre de Oliveira , Matthias Fenchel , Wilhelm Horger
发明人： Andre de Oliveira , Matthias Fenchel , Wilhelm Horger
IPC分类号： A61B5/055
CPC分类号： G01R33/5608 , A61B5/055 , A61B5/201 , A61B5/4064 , A61B5/4244 , A61B5/4381 , G01R33/543
摘要： An embodiment of the invention relates to the generation of MR images of a volume section within an examination object by way of a magnetic resonance scanner. In at least one embodiment, the following steps are performed: generating at least one of the MR images; automatically performing a number of quality inspections on the at least one MR image; and, should one of these quality inspections fail, an action is automatically performed in order to improve a quality when generating more of the MR images.
摘要翻译：本发明的实施例涉及通过磁共振扫描仪生成检查对象内的体积部分的MR图像。在至少一个实施例中，执行以下步骤：产生MR图像中的至少一个; 在所述至少一个MR图像上自动执行多个质量检查; 并且如果这些质量检查之一失败，则自动执行动作以便在生成更多的MR图像时提高质量。

65. 发明授权

US07947001B1 Methods and devices for measuring structural and elastic properties of a hollow organ 有权
标题翻译：用于测量中空器官的结构和弹性性能的方法和装置
公开(公告)号：US07947001B1
公开(公告)日：2011-05-24
申请号：US12794955
申请日：2010-06-07
申请人： Armen P. Sarvazyan
发明人： Armen P. Sarvazyan
IPC分类号： A61B5/117 , A61B5/103
CPC分类号： A61B5/03 , A61B5/037 , A61B5/205 , A61B5/42 , A61B5/4381
摘要： A spatial profile of structural and elastic parameters along a lumen of a hollow organ is determined based on obtaining the functional dataset of pressure P, balloon volume V, and balloon linear coordinate X while continuously moving the balloon along the lumen. A comprehensive characterization of elastic properties of the tissue and geometrical parameters of the lumen are then determined using a previously obtained calibration curve of balloon pressure vs. balloon volume when the balloon is expanded freely. As opposed to prior art devices for measuring tissues elasticity at one or several distinct locations by having deploying a balloon locally, the present invention describes a device in which the balloon is continuously moved through the lumen of the hollow organ whereby allowing elasticity determination over a significant portion or the entire length of the organ. The relationship between P, V, and X is then described by a family of constant pressure curves F(Pi=const,V,X), in the constant pressure method; or by family of constant volume curves F(P,Vi=const,X), in the constant volume method. The handheld device of the invention supports evaluation using either method. Repeating the test at different levels of balloon pressure or volume allows obtaining of a family of curves characterizing linear distribution of wall compliance along the lumen. Methods and devices of the invention can be used to evaluate cervix, urethra, esophagus, intestines, blood vessels, and other organs.
摘要翻译：基于获得压力P，球囊体积V和气球线性坐标X的功能数据集，同时沿着内腔连续移动球囊，来确定沿着中空器官的腔的结构和弹性参数的空间分布。然后使用先前获得的球囊压力对气囊体积的校准曲线来确定组织的弹性性质和几何参数的综合表征，当气囊自由膨胀时。与现有技术的装置相比，通过局部展开球囊来测量一个或几个不同位置的组织弹性，本发明描述了一种装置，其中球囊连续移动通过中空器官的内腔，从而允许在显着的器官的部分或整个长度。然后通过恒压法中的一系列恒定压力曲线F（Pi = const，V，X）来描述P，V和X之间的关系; 或恒定体积曲线F（P，Vi = const，X）的系列。本发明的手持设备支持使用任一方法进行评估。在不同级别的球囊压力或体积上重复测试允许获得一系列曲线，其表征沿内腔的壁顺应性的线性分布。本发明的方法和装置可用于评估子宫颈，尿道，食管，肠，血管和其他器官。

66. 发明申请

US20110015547A1 METHOD AND A DUAL-ARRAY TRANSDUCER PROBE FOR REAL TIME MECHANICAL IMAGING OF PROSTATE 审中-公开
标题翻译：用于实时机械成像的方法和双阵列传感器探测
公开(公告)号：US20110015547A1
公开(公告)日：2011-01-20
申请号：US12885688
申请日：2010-09-20
申请人： Armen P. Sarvazyan , Vladimir Egorov , Suren Ayrapetyan
发明人： Armen P. Sarvazyan , Vladimir Egorov , Suren Ayrapetyan
IPC分类号： A61B5/103
CPC分类号： A61B5/103 , A61B5/0053 , A61B5/4381 , A61B5/6885 , A61B8/4254 , A61B2562/0247 , A61B2562/046
摘要： The present invention relates to a transrectal probe and method for real time mechanical imaging of a prostate. The probe is equipped with dual-array pressure sensors—one on the probe head and another on the shaft of the probe spaced away from the head with an angular and linear offset forming an S-shaped transition between the shaft and the head of the probe. The addition of the shaft pressure sensor array together with orientation tracking sensors allows precise calculation of the current head position throughout the examination of the prostate. Display means are used to guide the user in the proper manipulation of the probe in order to reduce the forces on surrounding tissues and organs and to minimize patient's discomfort.
摘要翻译：本发明涉及一种用于前列腺实时机械成像的经直肠探针和方法。探头配有双阵列压力传感器 - 一个在探针头上，另一个位于探头的轴上，与头部间隔开，并具有角度和线性偏移，在轴和探头头部之间形成S形过渡。轴压力传感器阵列与定向跟踪传感器的添加允许在整个前列腺检查期间精确计算当前的头部位置。显示装置用于引导用户适当地操纵探针，以减少对周围组织和器官的力并且最小化患者的不适。

67. 发明申请

US20100152684A1 METHOD AND SYSTEM FOR MEASURING URINARY FLOW RATE 失效
标题翻译：用于测量尿流量的方法和系统
公开(公告)号：US20100152684A1
公开(公告)日：2010-06-17
申请号：US12332896
申请日：2008-12-11
申请人： Kyung Ah Kim , Eun Jong Cha , Seong Su Choi
发明人： Kyung Ah Kim , Eun Jong Cha , Seong Su Choi
IPC分类号： A61M1/00
CPC分类号： A61B5/4381 , A61B5/208 , A61B5/7239
摘要： A method and system for measuring a urinary flow rate minimizes impact noise caused by urine to measure the urinary flow rate using a plurality of load cells when prostatic hypertrophy is diagnosed. The method includes measuring an amount of urine collected into a container using a plurality of load cells, extracting and averaging urinary flow rate signals from the measured results, and removing the impact noise from the urinary flow rate signals, converting the urinary flow rate signals into digital signals through an A/D converting circuit, and outputting the digital signals using a personal computer or a microprocessor analyzer which is interfaced with the A/D converting circuit.
摘要翻译：用于测量尿流率的方法和系统使由尿引起的冲击噪声最小化，以便在诊断前列腺肥大时使用多个称重传感器来测量尿流率。该方法包括使用多个称重传感器测量收集在容器中的尿量，从测量结果中提取和平均尿流率信号，并从尿流率信号中去除冲击噪声，将尿流率信号转换为通过A / D转换电路的数字信号，并且使用与A / D转换电路接口的个人计算机或微处理器分析器输出数字信号。

68. 发明申请

US20100087756A1 METHOD OF CHARACTERIZATION AND DIFFERENTIATION OF TISSUE 有权
标题翻译：表征方法和组织分化
公开(公告)号：US20100087756A1
公开(公告)日：2010-04-08
申请号：US12244235
申请日：2008-10-02
申请人： Vladimir Egorov , Armen P. Sarvazvan
发明人： Vladimir Egorov , Armen P. Sarvazvan
IPC分类号： A61B5/103
CPC分类号： A61B5/4381 , A61B5/0053 , A61B5/4312 , A61B5/442 , A61B5/444 , A61B5/7264 , A61B5/7267 , G06K9/6278
摘要： A novel method for soft tissue characterization includes obtaining a sequence of surface stress patterns as a function of an increasing compression force when a probe is pressed against the tissue over the location of the lesion of interest. A number of elasticity features are then calculated to characterize the tissue and the lesion located therein including strain hardening, loading curve average slope, lesion peak signal under a predetermined load, tissue heterogeneity, lesion shape and lesion mobility. At least three elasticity features are provided as an input to a statistical Bayesian classifier trained on a clinical database to calculate the probability of the lesion being benign or malignant. Additional patient-related parameters may be further provided as inputs to the classifier to increase the accuracy of differentiation between benign and malignant lesions. These parameters include a family history of cancer disease, a patient-inherited genetic factor, a history of said tissue related diseases, patient's age, patient's weight, and patient's lifestyle and dietary factors. The method of the invention along with other non-invasive examinations of lesions may help in reducing the rate of biopsies, specifically breast tissue biopsies.
摘要翻译：用于软组织表征的新颖方法包括当探针在感兴趣的病变位置上被压靠在组织上时，获得作为增加的压缩力的函数的表面应力模式序列。然后计算出许多弹性特征来表征位于其中的组织和病变，其中包括在预定负荷下的应变硬化，负荷曲线平均斜率，病变峰值信号，组织异质性，损伤形状和损伤移动性。提供至少三个弹性特征作为在临床数据库上训练的统计贝叶斯分类器的输入，以计算病变为良性或恶性的概率。可以进一步提供额外的患者相关参数作为分类器的输入，以增加良性和恶性病变之间的分化准确性。这些参数包括癌症病史，患者遗传遗传因素，所述组织相关疾病的病史，患者年龄，患者体重以及患者的生活方式和饮食因素。本发明的方法与病变的其他非侵入性检查可能有助于降低活组织检查的比例，特别是乳腺组织活检。

69. 发明申请

US20100016844A1 TRANSILLUMINATING FOLEY CATHETER TO FACILITATE PROSTATE AND BLADDER SURGERY 审中-公开
标题翻译：可透过前列腺和刀片手术的透射式食管
公开(公告)号：US20100016844A1
公开(公告)日：2010-01-21
申请号：US12176639
申请日：2008-07-21
申请人： Manoj B. Patel, JR.
发明人： Manoj B. Patel, JR.
IPC分类号： A61B18/18 , A61M25/10
CPC分类号： A61B5/6874 , A61B5/0084 , A61B5/0086 , A61B5/202 , A61B5/4381 , A61B90/30 , A61B2090/306 , A61M25/04 , A61M2210/1085
摘要： A catheter assembly includes an elongated flexible (transparent or translucent) tube with a drainage lumen, an inflatable balloon fluidly coupled to an inflation adapter by an inflation lumen, and an illumination adapter configured to optically couple a light source to the catheter assembly. At least one illumination lumen contains at least one flexible elongated light emitting element such as an optical fiber, OLED fiber, LED strand or waveguide adapted to emit light at one or more points along the length of the flexible elongated light emitting element. The flexible elongated light emitting element emits sensible light through the bladder and through the urethra between the urethral meatus and prostate to illuminate the bladder, the bladder neck, the urethra adjacent to the prostate and surrounding tissue, thereby reducing the risk of damage to adjacent tissue. To provide various colors of light, colored light sources and/or colored filters may be utilized. To enable emission of light at determined points of an optical fiber, cladding (and jacket, if any) is removed from the optical fiber.
摘要翻译：导管组件包括具有排液腔的细长柔性（透明或半透明）管，通过膨胀腔流体耦合到充气适配器的可膨胀气囊，以及配置成将光源光学耦合到导管组件的照明适配器。至少一个照明腔包含至少一个柔性细长的发光元件，例如光纤，OLED光纤，LED线或波导，其适于在沿着柔性细长发光元件的长度的一个或多个点处发光。柔性细长的发光元件通过膀胱和通过尿道口和前列腺之间的尿道发出明显的光，以照亮膀胱，膀胱颈，与前列腺和周围组织相邻的尿道，从而降低对相邻组织的损伤的风险。为了提供各种颜色的光，可以使用有色光源和/或彩色滤光片。为了在光纤的确定点处发射光，可以从光纤去除包层（和护套，如果有的话）。

70. 发明申请

US20090005707A1 Method and device for real time mechanical imaging of prostate 有权
标题翻译：前列腺实时机械成像的方法和装置
公开(公告)号：US20090005707A1
公开(公告)日：2009-01-01
申请号：US11123999
申请日：2005-05-06
申请人： Armen P. Sarvazyan , Vladimir Egorov , Sergiv Kanilo , Suren Ayrapetyan
发明人： Armen P. Sarvazyan , Vladimir Egorov , Sergiv Kanilo , Suren Ayrapetyan
IPC分类号： A61B5/117
CPC分类号： A61B5/1077 , A61B5/11 , A61B5/4381 , A61B5/6847 , A61B5/72 , A61B5/7425 , A61B2562/0247 , A61B2562/046
摘要： The present invention relates to a method for real time mechanical imaging of a prostate with a transrectal probe. In the method, generating a composite two- and three-dimensional prostate mechanical image from a plurality of partial mechanical images extracted from pressure response data and a probe orientation data starts with examining the prostate by pressing a probe head pressure sensor array against it at various overlapping locations. Merging of partial mechanical images together is accomplished by analyzing an overlap between each subsequent and previous partial mechanical image. Finding the prostate is assisted with a supplemental pressure response data indicating the location of a sphincter known to be about 4-5 cm away from the prostate. Data processing is improved by including probe orientation data to further increase the accuracy and sensitivity of the method. The probe is equipped with a two-dimensional head pressure sensor array, a supplemental shaft sensor array and orientation tracking sensors including a three-axis magnetic sensor and a two-axis accelerometer sensor for calculating elevation, rotation and azimuth angles of the probe.
摘要翻译：本发明涉及一种具有经直肠探针的前列腺实时机械成像的方法。在该方法中，从从压力响应数据和探针取向数据提取的多个部分机械图像中生成复合二维和三维前列腺机械图像开始于通过以各种方式按压探针头压力传感器阵列来抵抗前列腺重叠位置。通过分析每个后续和之前的部分机械图像之间的重叠来实现将部分机械图像合并在一起。通过补充压力响应数据来辅助前列腺，指示已知距离前列腺约4-5cm的括约肌的位置。通过包括探针取向数据来进一步提高该方法的准确度和灵敏度来改进数据处理。探头配备有二维头部压力传感器阵列，补充轴传感器阵列和定向跟踪传感器，其包括用于计算探头的仰角，旋转和方位角的三轴磁传感器和双轴加速度传感器。

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