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61. 发明授权

US09446195B2 Injection device with cammed ram assembly 有权
公开(公告)号：US09446195B2
公开(公告)日：2016-09-20
申请号：US13930166
申请日：2013-06-28
申请人： Antares Pharma, Inc.
发明人： Thomas E. Kramer , Matthew H. Rust , Paul M. Goudreau , Peter A. Hoeft , Julius C. Sund , Peter L. Sadowski
IPC分类号： A61M5/24 , A61M5/20 , A61M5/30 , A61M5/32 , A61M5/50
CPC分类号： A61M5/5086 , A61M5/2033 , A61M5/30 , A61M5/3007 , A61M5/3204 , A61M5/326 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2005/3247 , A61M2205/584
摘要： An exemplary embodiment of the present disclosure can provide an injector including a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger member can include a trigger member having a retainer portion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom and a trigger engagement member configured to engage the retainer portion of the trigger member in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation between the trigger engagement member and the retainer portion from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retainer portion to allow the energy source to fire the ram.

62. 发明授权

US09333309B2 Intradermal injector 有权
公开(公告)号：US09333309B2
公开(公告)日：2016-05-10
申请号：US14311332
申请日：2014-06-22
申请人： Antares Pharma, Inc.
发明人： Peter L. Sadowski , Paul R. Lesch, Jr. , David L. Bremseth
IPC分类号： A61M5/00 , A61M5/42 , A61M5/20 , A61M5/24 , A61M5/32 , A61M5/31
CPC分类号： A61M5/3204 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/2459 , A61M5/3134 , A61M5/3202 , A61M5/326 , A61M5/425 , A61M2005/206 , A61M2005/2073 , A61M2005/3118
摘要： An injection device that comprises a chamber configured for containing a substance to be injected and a needle operatively associated with the chamber and having a length sufficient to deliver the substance to an intradermal injection site. A collar surrounds the needle, defining a collar cavity. The collar also has a peripheral forward skin-contacting surface that surrounds and is radially spaced from the needle and injection site by an area that is sufficiently large to allow a patient's skin to move into the collar cavity to properly position the needle for intradermal delivery of the substance to the injection site to allow spread of the injected substance under the skin while inhibiting or preventing backpressure within the skin from forcing the substance out through the injection site.

63. 发明申请

US20160015897A1 Push Button Safety Injector 审中-公开
标题翻译：按钮安全注射器
公开(公告)号：US20160015897A1
公开(公告)日：2016-01-21
申请号：US14774064
申请日：2014-03-12
申请人： ANTARES PHARMA, INC.
发明人： Kevin David Swanson , Julius Sund , Peter A. Hoeft , Patrick E. Madsen
IPC分类号： A61M5/20
CPC分类号： A61M5/2033 , A61M5/30 , A61M5/3202 , A61M5/3204 , A61M5/326 , A61M2005/2026 , A61M2005/206 , A61M2005/2073 , A61M2005/208 , A61M2005/3247 , A61M2005/3267
摘要： A push button safety injector includes a housing having a proximal end, a distal end spaced from the proximal end, and a longitudinal axis. An injection ram is positioned along the longitudinal axis and configured to actuate a fluid chamber. The injection ram is biased toward the distal end in an initial position. A sliding member is configured to retain the injection ram in the initial position. A safety member confines radial movement of the sliding member in the initial position and allows radial movement of the sliding member in an armed position. A button is moveable between an initial extended position and a depressed position. The button is engagable with the sliding member and configured to move the sliding member radially in the armed position. The sliding member releases the injection ram when the button is in the depressed position.
摘要翻译：按钮安全注射器包括具有近端，与近端隔开的远端和纵向轴线的壳体。注射柱塞沿着纵向轴线定位并且构造成致动流体室。注射压头在初始位置偏向远端。滑动构件被构造成将注射压头保持在初始位置。安全构件将滑动构件的径向移动限制在初始位置，并允许滑动构件在布置位置的径向移动。按钮可在初始延伸位置和按压位置之间移动。按钮可与滑动构件接合并且构造成使滑动构件在布置位置径向移动。当按钮处于按压位置时，滑动构件释放注射压头。

64. 发明授权

US09220660B2 Liquid-transfer adapter beveled spike 有权
标题翻译：液体转移适配器倾斜钉
公开(公告)号：US09220660B2
公开(公告)日：2015-12-29
申请号：US13184211
申请日：2011-07-15
申请人： Julius Craig Sund , Kevin David Swanson
发明人： Julius Craig Sund , Kevin David Swanson
IPC分类号： A61J1/20 , A61J1/14 , A61M5/30
CPC分类号： A61J1/201 , A61J1/1406 , A61J1/2051 , A61J1/2055 , A61J1/2065 , A61J1/2096 , A61J2200/10 , A61M5/20 , A61M5/30
摘要： A liquid-transfer adapter operatively interposable between an injector and a vial is provided. The adapter has an injector engaging portion configured for fluidly coupling to an injector and a vial coupling. The vial coupling includes a spike that has a spike axis and a tip portion configured for piercing a septum of a vial. The tip portion includes a plurality of facets that meet each other at one or more edges and at least one of the one or more edges is sloped with respect to the spike axis. The spike defines a channel extending therethrough in fluid communication with the injector engaging portion. A channel opening is defined in at least one of the facets and disposed without interrupting the edges.
摘要翻译：提供了可操作地插入注射器和小瓶之间的液体传送适配器。适配器具有配置成流体地联接到注射器和小瓶联接器的注射器接合部分。小瓶联接器包括具有尖峰轴线的尖峰和构造成用于刺穿小瓶的隔膜的尖端部分。尖端部分包括在一个或多个边缘处彼此相遇的多个小面，并且所述一个或多个边缘中的至少一个相对于尖峰轴线倾斜。尖钉限定了与注射器接合部分流体连通的通道。通道开口被限定在至少一个小平面上并且被设置而不中断边缘。

65. 发明授权

US09180259B2 Prefilled syringe jet injector 有权
标题翻译：预充注射器喷射器
公开(公告)号：US09180259B2
公开(公告)日：2015-11-10
申请号：US14173659
申请日：2014-02-05
申请人： Antares Pharma, Inc.
发明人： Paul R. Lesch, Jr.
IPC分类号： A61M5/48 , A61M5/20 , A61M5/30 , A61M5/178 , A61M5/28
CPC分类号： A61M5/2033 , A61M5/178 , A61M5/28 , A61M5/30 , A61M5/3202 , A61M5/46 , A61M5/484 , A61M2005/2013 , A61M2005/206
摘要： A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.
摘要翻译：包括预充式注射器的喷射器。注射器包括含有药物的流体室。注射器还具有注射辅助针，并且柱塞可在流体室内移动。壳体构造成允许针头插入穿透深度。能量源被构造成偏置柱塞以在流体室中的药物中产生介于约80和1000p.s.i之间的注射压力。以将药物从流体室喷射通过针头注射到注射部位。

66. 发明申请

US20150231333A1 PREFILLED SYRINGE WITH BREAKAWAY FORCE FEATURE 审中-公开
标题翻译：具有破碎力特征的预充式注射器
公开(公告)号：US20150231333A1
公开(公告)日：2015-08-20
申请号：US14702275
申请日：2015-05-01
申请人： Antares Pharma, Inc.
发明人： James W. LANNAN , Julius C. SUND
IPC分类号： A61M5/20
CPC分类号： A61M5/2033 , A61M5/50 , A61M2005/2013 , A61M2005/2073 , A61M2005/3267
摘要： A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. The housing includes a retractable guard and an interference component, e.g., a lock ring, adjacent to the retractable guard that interferes with the movement of the retractable guard. An energy source is configured for biasing the plunger to produce an injecting pressure to jet inject the medicament from the fluid chamber through the needle to an injection site.
摘要翻译：包括预充式注射器的喷射器。注射器包括含有药物的流体室。注射器还具有注射辅助针，并且柱塞可在流体室内移动。壳体构造成允许针头插入穿透深度。壳体包括可伸缩防护件和与可伸缩护罩相邻的干涉部件，例如锁环，其干扰可伸缩护罩的运动。能量源构造成用于偏置柱塞以产生喷射压力，以将药物从流体室通过针喷射到注射部位。

67. 发明申请

US20130030367A1 HAZARDOUS AGENT INJECTION SYSTEM 有权
标题翻译：危险代理注射系统
公开(公告)号：US20130030367A1
公开(公告)日：2013-01-31
申请号：US13607659
申请日：2012-09-07
申请人： Paul Wotton , Peter L. Sadowski , John William Hayes
发明人： Paul Wotton , Peter L. Sadowski , John William Hayes
IPC分类号： A61M5/20
CPC分类号： A61M5/30 , A61K9/0019 , A61K9/0087 , A61K31/519 , A61K31/568 , A61M5/178 , A61M5/2033 , A61M5/3202 , A61M5/326 , A61M2005/2013 , A61M2005/2073 , A61M2005/3247
摘要： A hazardous agent injection system including from about 0.02 ml to about 4.0 ml of methotrexate at a concentration of from about 7.5 mg/ml to about 150 mg/ml; a needle-assisted jet injector including a container configured to contain the methotrexate; a injection outlet member associated with the container; an injection-assisting needle coupled to the injection outlet member; a firing mechanism associated with the container; an energy source associated with the firing mechanism; and a trigger mechanism associated with the firing mechanism, wherein the needle-assisted jet injector is configured to eject the methotrexate from the injection outlet member such that the Cmax, Tmax and bioavailability of the needle-assisted jet injected methotrexate falls between about 80% and about 125% of the Cmax, Tmax and bioavailability of methotrexate delivered by a hand-powered syringe.
摘要翻译：一种危险剂注射系统，包括约0.02ml至约4.0ml浓度为约7.5mg / ml至约150mg / ml的甲氨蝶呤; 一种针辅助喷射喷射器，其包括容纳甲氨蝶呤的容器; 与所述容器相关联的注射出口构件; 注射辅助针，其联接到所述注射出口构件; 与容器相关联的击发机构; 与发射机构相关联的能量源; 以及与所述击发机构相关联的触发机构，其中所述针辅助喷射器被配置为从所述注射出口构件喷射所述甲氨蝶呤，使得针刺喷射的甲氨蝶呤的C max，T max和生物利用度落在约80％和用手动注射器输送的甲氨蝶呤的Cmax，Tmax和生物利用度的约125％。

68. 发明授权

US07776015B2 Needle assisted jet injector 有权
标题翻译：针辅助喷射器
公开(公告)号：US07776015B2
公开(公告)日：2010-08-17
申请号：US11002687
申请日：2004-12-03
申请人： Peter L. Sadowski , David M. Deboer , Claude L. Berman , Paul R. Lesch, Jr. , Margaret L. Holland
发明人： Peter L. Sadowski , David M. Deboer , Claude L. Berman , Paul R. Lesch, Jr. , Margaret L. Holland
IPC分类号： A61M37/00
CPC分类号： A61M5/326 , A61M5/002 , A61M5/20 , A61M5/24 , A61M5/2425 , A61M5/2466 , A61M5/282 , A61M5/288 , A61M5/30 , A61M5/3202 , A61M5/3232 , A61M5/3243 , A61M5/3286 , A61M5/349 , A61M2005/3247 , A61M2205/583
摘要： A jet injection device with a fluid chamber in a housing member for holding about 0.02 ml to about 3 ml of a medicament. An injection-assisting needle has an injection end that extends from the housing for inserting into a patient to a depth of up to about 5 mm. A force-generating source is configured to apply a pressure reaching about 100-1000 psi to the medicament in the chamber to expel the medicament through the injecting end of the needle.
摘要翻译：一种喷射装置，其具有用于容纳约0.02ml至约3ml药物的壳体构件中的流体室。注射辅助针具有从壳体延伸以插入患者到达约5mm的深度的注射端。力产生源被配置为向腔室中的药物施加达到约100-1000psi的压力，以通过针的注射端排出药物。

69. 发明申请

US20090292240A1 TWO-STAGE RECONSTITUTING INJECTOR 有权
标题翻译：两级重建注射器
公开(公告)号：US20090292240A1
公开(公告)日：2009-11-26
申请号：US12299274
申请日：2007-05-02
申请人： Thomas E. KraMer , Peter L. Sadowski
发明人： Thomas E. KraMer , Peter L. Sadowski
IPC分类号： A61M5/31
CPC分类号： A61M5/31596 , A61M5/19 , A61M5/2033 , A61M5/2066 , A61M5/2466 , A61M5/30 , A61M5/3202 , A61M5/3204 , A61M5/326 , A61M2005/2013 , A61M2005/2073 , A61M2005/2474 , A61M2005/3125
摘要： An injector for injecting a medicament into a patient. The injector includes a container defining a first chamber, which contains a fluid therein, and a second chamber. The injector also includes an injection conduit configured for directing the fluid fired from the container into the patient. A transfer mechanism is operable by a user to transfer the fluid from the first chamber to the second chamber in a first stage of operation, and a firing mechanism is operable by the user for firing the fluid from the second chamber through the injection conduit in a second stage of operation. An energy source is in powering association with the firing mechanism to drive firing mechanism in the first and second stages.
摘要翻译：一种用于将药物注射到患者体内的注射器。喷射器包括限定在其中包含流体的第一室的容器和第二室。注射器还包括注射管道，其被配置用于将从容器中喷出的流体引导到患者体内。传送机构可由用户操作以在第一操作阶段将流体从第一腔室传送到第二腔室，并且击发机构可由使用者操作，用于通过喷射导管从第二腔室喷射流体第二阶段运作。一个能量源与击发机构相关联，以驱动第一和第二阶段的击发机构。

70. 发明申请

US20040134563A1 Medical injector and medicament loading system for use therewith 有权
标题翻译：医用注射器和药物装载系统
公开(公告)号：US20040134563A1
公开(公告)日：2004-07-15
申请号：US10743436
申请日：2003-12-23
申请人： Antares Pharma, Inc.
发明人： Mark W. Rice , Paul R. Lesch JR. , Sheldon J. Nelson , Timothy D. Byland
IPC分类号： B65B001/04
CPC分类号： A61M5/30 , A61M5/1782 , A61M5/24 , A61M5/2448 , A61M5/31551
摘要： The present invention discloses a medical injector and medicament loading system for use therewith. The medicament loading system includes cap for a medicament cartridge. The cap has a post for causing movement of the cartridge stopper toward the seal when the cap engages the medicament cartridge to thereby eliminate adhesion between the medicament chamber and the stopper. The medical injector according to the present invention includes the medicament loading system, i.e., a cartridge assembly, a needle free syringe assembly, and a power pack assembly.
摘要翻译：本发明公开了一种与其一起使用的医用注射器和药物装载系统。药物装载系统包括用于药剂盒的盖。当帽与药剂盒接合时，帽具有用于使药筒止动器朝向密封件运动的柱，从而消除药剂室与止动器之间的粘附。根据本发明的医用注射器包括药物加载系统，即药筒组件，无针注射器组件和电源组件。

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