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61. 发明授权

US4691018A Pyridine derivatives and their use as anti-allergic agents 失效
标题翻译：吡啶衍生物及其作为抗过敏剂的用途
公开(公告)号：US4691018A
公开(公告)日：1987-09-01
申请号：US860211
申请日：1986-05-06
申请人： Takashi Mori , Nobuhiro Ohi , Yoshiyuki Ohsugi , Yasuhiro Yamashita
发明人： Takashi Mori , Nobuhiro Ohi , Yoshiyuki Ohsugi , Yasuhiro Yamashita
IPC分类号： C07D213/55 , A61K31/44 , A61K31/4425 , A61K31/455 , A61P37/06 , A61P37/08 , C07D213/56 , C07D213/81 , C07D213/60
CPC分类号： C07D213/81
摘要： A compound of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group which may be substituted with hydroxy, lower alkyl or di-lower alkylamino; R.sub.2 is a hydrogen atom, an amino group or a lower alkylamino group; and R.sub.3 is a lower alkyl group, and a non-toxic salt thereof, and a process for preparing the same are disclosed.The compound and the salts thereof exhibit anti-allergic effects by the two different mechanisms and are expected to be useful as drugs for treating allergic diseases such as asthma, pollen allergy, atopic dermatitis and the like.
摘要翻译：式IMA化合物，其中R 1为氢原子或可被羟基，低级烷基或二低级烷基氨基取代的低级烷基; R2是氢原子，氨基或低级烷基氨基; 和R3为低级烷基，及其无毒盐及其制备方法。化合物及其盐表现出两种不同机理的抗过敏作用，并且预期可用作治疗过敏性疾病如哮喘，花粉过敏，特应性皮炎等的药物。

62. 发明授权

US4543636A Numerically controlled machine tool system capable of setting up tools into tool magazine 失效
标题翻译：数控机床系统能够将工具安装到刀库中
公开(公告)号：US4543636A
公开(公告)日：1985-09-24
申请号：US463808
申请日：1983-02-04
申请人： Shigeo Noda , Yasuhiro Yamashita , Kosei Imamura
发明人： Shigeo Noda , Yasuhiro Yamashita , Kosei Imamura
IPC分类号： B23Q3/157 , B23Q3/155 , B23Q7/04 , G05B19/418 , G06F15/46 , G05B19/18
CPC分类号： B23Q7/04 , B23Q3/15526 , B23Q3/15539 , G05B19/41825 , G05B2219/36232 , G05B2219/36357 , G05B2219/50171 , G05B2219/50243 , G05B2219/50249 , G05B2219/50263 , Y02P90/087 , Y02P90/265 , Y10T483/18
摘要： A numerically controlled machine tool system having a tool transfer device which, with a change in the kind of workpieces to be machined in a numerically controlled machine tool, operates to replace successively unnecessary dedicated tools in a tool magazine of the machine tool with next to be used dedicated tools supplied to the vicinity of the tool magazine. A central processor reads out from an external memory device one of the numerical control (NC) programs corresponding to the kind of a lot of workpieces to be machined and transmits the NC program to a numerical controller. In advance of the machining of a last one of the lot of workpieces, the central processor modifies the NC program by inserting respectively into correct portions of the NC program a number of replacing command data each instructing that one of the dedicated tools in the tool magazine designated by one of the replacing command data be replaced. When the numerical controller executes the modified NC program for machining the last one of the lot of workpieces, tool replacing operations according to the replacing command data are successively carried out. Accordingly, during the machining of the last one of the lot of workpieces, the dedicated tools in the tool magazine designated by the replacing command data are successively indexed to a tool replacing position of the tool magazine and are successively replaced by the transfer device with the next used dedicated tools in the vicinity of the tool magazine.
摘要翻译：一种具有刀具传送装置的数控机床系统，其具有在数控机床中要加工的工件类型的变化，用于在机床的刀架中连续地替换不必要的专用刀具，提供给刀库附近的专用工具。中央处理器从外部存储器件读出与要加工的大量工件类型相对应的数控（NC）程序之一，并将NC程序发送到数字控制器。在加工大量工件的最后一个之前，中央处理器通过分别插入NC程序的正确部分来修改NC程序的多个替换命令数据，每个指令数据指示刀库中的专用工具之一由替换指令数据之一指定。当数字控制器执行用于加工最后一个工件的修改的NC程序时，依次执行根据替换命令数据的刀具更换操作。因此，在加工多个工件中的最后一个工件期间，由替换指令数据指定的刀库中的专用工具被连续地转位到刀库的刀具更换位置，并且被转移装置连续地替换为在刀库附近使用专用工具。

63. 发明授权

US4361572A Tetrahydronicotinamide derivative, pharmaceutical compositions and use 失效
标题翻译：四氢吡啶衍生物，药物组合物及用途
公开(公告)号：US4361572A
公开(公告)日：1982-11-30
申请号：US332856
申请日：1981-12-21
申请人： Sakae Takaku , Fumiaki Matsuura , Takashi Mori , Yasushi Murakami , Shigeyuki Kataoka , Yasuhisa Takeda , Yasuhiro Yamashita , Yumiko Takeda , Takashi Matsuno , Koji Mizuno , Shinichi Kaiho , Tamotsu Yamazaki , Shun-ichi Hata , Shigeru Takanashi
发明人： Sakae Takaku , Fumiaki Matsuura , Takashi Mori , Yasushi Murakami , Shigeyuki Kataoka , Yasuhisa Takeda , Yasuhiro Yamashita , Yumiko Takeda , Takashi Matsuno , Koji Mizuno , Shinichi Kaiho , Tamotsu Yamazaki , Shun-ichi Hata , Shigeru Takanashi
IPC分类号： C07D211/78 , A61K31/455
CPC分类号： C07D211/78 , Y10S514/886
摘要： 1,4,5,6-Tetrahydronicotinamide derivative represented by the formula: ##STR1## (wherein R is defined in the specification), a process of preparing the same and pharmaceutical composition containing the same are disclosed.The compound has action for suppressing aggregation of platelets, and antiinflammatory, antipyretic and analgesic actions.
摘要翻译：公开了由下式表示的1,4,5,6-四氢吡啶酰胺衍生物（其中R在说明书中定义），其制备方法和含有该方法的药物组合物。该化合物具有抑制血小板聚集的作用，以及抗炎，解热和镇痛作用。

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