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61. 发明授权

US5980862A Magnetic resonance imaging agents for the detection of physiological agents 失效
公开(公告)号：US5980862A
公开(公告)日：1999-11-09
申请号：US134072
申请日：1998-08-13
申请人： Thomas Meade , Scott Fraser , Russell Jacobs , Wenhong Li
发明人： Thomas Meade , Scott Fraser , Russell Jacobs , Wenhong Li
IPC分类号： A61K49/06 , A61K49/08 , A61K49/00 , G01N31/00 , G01N33/48
CPC分类号： A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106 , A61K49/122 , A61K49/128 , A61K49/146
摘要： The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.

62. 发明授权

US08084418B2 Methods of inhibiting insects by treatment with a complex comprising a Photorhabdus insecticidal protein and one or two Xenorhabdus enhancer proteins 有权
标题翻译：通过用包含Photorhabdus杀虫蛋白和一种或两种Xenorhabdus增强子蛋白的复合物处理来抑制昆虫的方法
公开(公告)号：US08084418B2
公开(公告)日：2011-12-27
申请号：US12371825
申请日：2009-02-16
申请人： Timothy D. Hey , Amanda D. Schleper , Scott A. Bevan , Scott B. Bintrim , Jon C. Michell , Ze Sheng Li , Weiting Ni , Baolong Zhu , Donald J. Merlo , Patricia C. Apel-Birkhold , Thomas Meade
发明人： Timothy D. Hey , Amanda D. Schleper , Scott A. Bevan , Scott B. Bintrim , Jon C. Michell , Ze Sheng Li , Weiting Ni , Baolong Zhu , Donald J. Merlo , Patricia C. Apel-Birkhold , Thomas Meade
IPC分类号： A01N33/04 , A01N25/00 , A61K38/16 , C07K14/195
CPC分类号： C07K14/195 , A01N37/46 , A01N63/02 , C07K14/24 , C12N15/8286 , Y02A40/162
摘要： The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdus, and Paenibacillus, can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a “stand-alone” TC protein (from Photorhabdus, Xenorhabdus, or Paenibacillus, for example) is enhanced by one or more TC protein “potentiators” derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will now be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone Xenorhabdus protein toxin as well as a stand-alone Photorhabdus protein toxin. (As one skilled in the art knows, Xenorhabdus toxin proteins tend to be more desirable for controlling lepidopterans while Photorhabdus toxin proteins tend to be more desirable for controlling coleopterans.) This reduces the number of genes, and transformation events, needed to be expressed by a transgenic plant to achieve effective control of a wider spectrum of target pests. Certain preferred combinations of heterologous TC proteins are also disclosed herein. Other objects, advantages, and features of the subject invention will be apparent to one skilled in the art having the benefit of the subject disclosure.
摘要翻译：本发明涉及令人惊奇的发现，可以从Xenorhabdus，Photorhabdus和Paenibacillus获得的毒素复合物（TC）蛋白质彼此互换使用。在本发明的特别优选的实施方案中，“独立”TC蛋白（例如，来自Photorhabdus，Xenorhabdus或Paenibacillus的例如）的毒性由一种或多种衍生自以下物质的来源生物体的TC蛋白“增强剂”增强来源于毒素的不同属。本领域技术人员将会认识到本公开的益处，这具有广泛的含义并扩大了现在将认识到各种类型的TC蛋白质具有的效用范围。最重要的优点之一是，本领域技术人员现在将能够使用单一增强剂来增强独立的Xenorhabdus蛋白毒素的活性以及独立的Photorhabdus蛋白毒素。（如本领域技术人员所知，Xenorhabdus毒素蛋白质倾向于更好地控制鳞翅目，而Photorhabdus毒素蛋白质倾向于更有利于控制鞘翅目）。这减少了需要表达的基因数量和转化事件一个转基因植物，以实现更广泛的目标害虫的有效控制。异源TC蛋白的某些优选组合也在本文中公开。受益于本发明的本发明的其它目的，优点和特征对本领域技术人员而言是显而易见的。

63. 发明申请

US20110200684A1 SYNERGISTIC PESTICIDAL MIXTURES 有权
标题翻译：协同杀虫剂混合物
公开(公告)号：US20110200684A1
公开(公告)日：2011-08-18
申请号：US13096218
申请日：2011-04-28
申请人： Jim X. Huang , Jonathan M. Babcock , Thomas Meade , Marc Farrow
发明人： Jim X. Huang , Jonathan M. Babcock , Thomas Meade , Marc Farrow
IPC分类号： A01N59/22 , A01N59/10 , A01N43/24 , A01N43/04 , A01N43/16 , A01N57/00 , A01N57/14 , A01N57/26 , A01N33/26 , A01N43/88 , A01N43/42 , A01N43/40 , A01P15/00
CPC分类号： A01N43/40 , A01N47/24 , A01N47/40 , A01N51/00 , A01N37/40 , A01N43/22 , A01N53/00 , A01N57/16 , A01N61/00 , A01N2300/00
摘要： Synergistic pesticidal mixtures are provided.
摘要翻译：提供协同的杀虫混合物。

64. 发明申请

US20110196001A1 METHOD TO CONTROL INSECTS RESISTANT TO COMMON INSECTICIDES 失效
标题翻译：防止普通杀虫剂耐药的方法
公开(公告)号：US20110196001A1
公开(公告)日：2011-08-11
申请号：US13081886
申请日：2011-04-07
申请人： Jim X. Huang , Richard B. Rogers , Nailah Orr , Thomas C. Sparks , James M. Gifford , Michael R. Loso , Yuanming Zhu , Thomas Meade
发明人： Jim X. Huang , Richard B. Rogers , Nailah Orr , Thomas C. Sparks , James M. Gifford , Michael R. Loso , Yuanming Zhu , Thomas Meade
IPC分类号： A01N43/40 , A01P7/04
CPC分类号： A01N43/40 , A01N43/10 , A01N43/18 , A01N43/80
摘要： N-Substituted sulfoximines are effective at controlling insects resistant to common insecticides.
摘要翻译： N-取代的亚磺酰亚胺对控制对常见杀虫剂有抗性的昆虫是有效的。

65. 发明授权

US07812131B2 Sources for, and types of, insecticidally active proteins, and polynucleotides that encode the proteins 有权
标题翻译：杀虫活性蛋白质的来源和类型，以及编码蛋白质的多核苷酸
公开(公告)号：US07812131B2
公开(公告)日：2010-10-12
申请号：US11366918
申请日：2006-03-02
申请人： Ignacio Mario Larrinua , Aaron Todd Woosley , Thomas Meade , Donald Joseph Merlo , Timothy Denver Hey , Stephanie Love Burton
发明人： Ignacio Mario Larrinua , Aaron Todd Woosley , Thomas Meade , Donald Joseph Merlo , Timothy Denver Hey , Stephanie Love Burton
IPC分类号： C07K14/415 , A61K38/56 , A61K38/00
CPC分类号： C07K14/195 , A01N63/00 , A01N63/04 , C07K14/20 , C07K14/21 , C07K14/37 , C07K16/14 , C07K2319/00 , Y10S530/858
摘要： The subject invention provides exciting new sources for surprising, new types of toxin complex (“TC”) proteins. The subject invention includes these new classes and types of TC proteins. The subject invention also includes polynucleotides that encode the subject proteins. The subject invention further provides vectors and cells comprising these polynucleotides. The subject invention also provides novel methods of controlling insects. The subject invention relates in part to the surprising discovery that new types of TC proteins can be obtained from a widely diverse phylogenetic spectrum of organisms including, most notably and surprisingly, eukaryotic fungus.
摘要翻译：本发明为令人惊奇的新型毒素复合物（“TC”）蛋白质提供令人兴奋的新来源。本发明包括这些新类型和TC蛋白。本发明还包括编码受试蛋白的多核苷酸。本发明进一步提供了包含这些多核苷酸的载体和细胞。本发明还提供了控制昆虫的新方法。本发明部分地涉及令人惊奇的发现，即可以从广泛多样的生物系统发育谱获得新型TC蛋白质，包括最显着和令人惊讶的真核真菌。

66. 发明申请

US20090325892A1 Synergistic pesticidal mixtures 有权
标题翻译：协同农药混合物
公开(公告)号：US20090325892A1
公开(公告)日：2009-12-31
申请号：US12150801
申请日：2008-05-01
申请人： Jim X. Huang , Jonathan M. Babcock , Thomas Meade , Marc Farrow
发明人： Jim X. Huang , Jonathan M. Babcock , Thomas Meade , Marc Farrow
IPC分类号： A01N43/40 , A01N43/16 , A01N57/16 , A01P7/04
CPC分类号： A01N43/40 , A01N47/24 , A01N47/40 , A01N51/00 , A01N37/40 , A01N43/22 , A01N53/00 , A01N57/16 , A01N61/00 , A01N2300/00
摘要： Synergistic pesticidal mixtures are provided.
摘要翻译：提供协同的杀虫混合物。

67. 发明申请

US20070006340A1 Combinations of Cry1Ab and Cry1Fa as an insect resistance management tool 审中-公开
标题翻译： Cry1Ab和Cry1Fa作为昆虫抗性管理工具的组合
公开(公告)号：US20070006340A1
公开(公告)日：2007-01-04
申请号：US11072812
申请日：2005-03-04
申请人： Bruce Lang , James Bing , Jonathan Babcock , Thomas Meade , Nicholas Storer , Blair Siegfried , Elisen Guedes Pereire
发明人： Bruce Lang , James Bing , Jonathan Babcock , Thomas Meade , Nicholas Storer , Blair Siegfried , Elisen Guedes Pereire
IPC分类号： A01H5/00 , A01H1/00
CPC分类号： A01N63/02 , C07K14/32 , C07K14/325 , C12N15/8286 , Y02A40/162
摘要： Compositions for controlling lepidopteran insects use Cry1Fa and Cry1Ab core toxin containing proteins in combination to delay or prevent development of resistance.
摘要翻译：用于控制鳞翅目昆虫的组合物使用含有Cry1Fa和Cry1Ab核心毒素的蛋白质组合以延迟或预防抗性发展。

68. 发明申请

US20060099631A1 Electrodes linked via oligomers to nucleic acids 有权
标题翻译：通过低聚物连接到核酸的电极
公开(公告)号：US20060099631A1
公开(公告)日：2006-05-11
申请号：US11295993
申请日：2005-12-06
申请人： Jon Kayyem , Stephen O'Conner , Michael Gozin , Changjun Yu , Thomas Meade
发明人： Jon Kayyem , Stephen O'Conner , Michael Gozin , Changjun Yu , Thomas Meade
IPC分类号： C12Q1/68 , C07H21/04 , C12M1/34
CPC分类号： C07H21/00 , C12Q1/6825
摘要： The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
摘要翻译：本发明涉及通过导电低聚物共价偶联到电极上的核酸。更具体地，本发明涉及具有电子转移部分和电极的核酸的位点选择性修饰以产生新类别的生物材料，以及制备和使用它们的方法。

69. 发明申请

US20050244954A1 Binding acceleration techniques for the detection of analytes 审中-公开
公开(公告)号：US20050244954A1
公开(公告)日：2005-11-03
申请号：US11083780
申请日：2005-03-16
申请人： Gary Blackburn , Stephen Creager , Scott Fraser , Bruce Irvine , Thomas Meade , Stephen O'Connor , Robert Terbrueggen , Jost Vielmetter , Thomas Welch
发明人： Gary Blackburn , Stephen Creager , Scott Fraser , Bruce Irvine , Thomas Meade , Stephen O'Connor , Robert Terbrueggen , Jost Vielmetter , Thomas Welch
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/68
CPC分类号： B82Y30/00 , B01L3/502753 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L2400/0421 , B82Y15/00 , C12Q1/682 , C12Q1/6825 , C12Q2565/607 , C12Q2537/125 , C12Q2565/501
摘要： The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.

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