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61. 发明授权

US5076412A Caster roller unit 失效
标题翻译：烤箱单元
公开(公告)号：US5076412A
公开(公告)日：1991-12-31
申请号：US607335
申请日：1990-10-31
申请人： Thomas Huber
发明人： Thomas Huber
IPC分类号： B65G13/10 , B65G39/09 , B65G39/12
CPC分类号： B65G39/09 , B60B33/08 , B65G13/10 , B65G39/12
摘要： A caster roller unit for a freight conveyor track includes first and second support rollers to support the freight articles from below. The rollers are mounted on a roller carrier rotatably independently of each other about horizontally extending, mutually aligned axes. The roller carrier is supported on a stationary housing base member by a ball bearing assembly rotatably about a vertical axis which is eccentric with respect to the axis of the rollers. The roller carrier, for each of the support rollers, has an upwardly open bearing shell member in the form of a cylinder portion accommodating a plurality of bearing needles on which the respective support roller is rotatably disposed and the longitudinal axes of which are oriented parallel to the horizontally extending axis of rotation of the respective support roller. A housing cover member fixedly connected to the roller carrier embraces the support rollers from above to retain the support rollers and the bearing needles in the bearing shell member, with the support rollers projecting upwardly beyond the upper outward surface of the housing cover member.
摘要翻译：用于货运输送机轨道的脚轮滚子单元包括用于从下方支撑货物的第一和第二支撑辊。辊子围绕水平延伸的相互对准的轴线彼此独立地安装在辊架上。辊架通过滚珠轴承组件支撑在固定的壳体基座构件上，所述滚珠轴承组件围绕相对于辊的轴线偏心的垂直轴线可转动。用于每个支撑辊的辊架具有向上敞开的轴承壳构件，其为容纳多个轴承针的圆筒部分的形式，相应的支撑辊可旋转地布置在其上，并且其纵向轴线平行于相应的支撑辊的水平延伸的旋转轴线。固定连接到辊架的壳体盖构件从上方包围支撑辊，以将支撑辊和轴承针保持在轴承壳构件中，其中支撑辊向上突出超过壳体盖构件的上外表面。

62. 发明授权

US4697694A Roller drive unit 失效
标题翻译：滚筒驱动单元
公开(公告)号：US4697694A
公开(公告)日：1987-10-06
申请号：US717273
申请日：1985-03-20
申请人： Thomas Huber
发明人： Thomas Huber
IPC分类号： B65G13/06 , B65G13/071 , B65G39/06 , B65G13/02
CPC分类号： B65G13/065
摘要： The roller drive unit displays a drive roller (1), which is drivable by a motor (3) and rotatably borne in a guide equipment (5), by which it is pivotable with respect to a base (2) between a lower rest setting and an upper rest setting over a circularly arcuate movement path. A control equipment for the pivotation of the drive roller (1) is provided, which comprises a clutch device constructed for the transmission of a torque between a gear arrangement (50) driving the drive roller (1) and the guide equipment (5). The gear arrangement displays a first gear wheel which is driven by the motor and in opposite sense drives a second gear wheel mounted secure against rotation on the drive shaft of the drive roller (1). In order to attain a simplest possible build-up with small overall height, it is provided that the shaft (20) of the first gear wheel is rotatably borne fixedly located with respect to the base (2) and that the circularly arcuate movement path, constrained by the guide equipment (5), of the drive roller (1) is arranged concentrically with the rotational axis of the shaft (20) of the first gear wheel.
摘要翻译： PCT No.PCT / DE84 / 00149 Sec。 371日期：1985年3月20日 102（e）1985年3月20日PCT PCT。1984年7月16日PCT公布。第WO85 / 00577号公报日期：1985年2月14日。滚子驱动单元显示驱动辊（1），驱动辊（1）可由马达（3）驱动并可转动地支承在引导设备（5）中，通过它可相对于基座 2）位于圆弧运动路径上的较低安置位置和上部安置位置之间。提供了用于驱动辊（1）的枢转的控制设备，其包括用于在驱动驱动辊（1）的齿轮装置（50）和引导设备（5）之间传递扭矩的离合器装置。齿轮装置显示由马达驱动的第一齿轮，并且在相反的意义上驱动安装在驱动辊（1）的驱动轴上的旋转的第二齿轮。为了获得尽可能小的整体高度的最简单的堆积，第一齿轮的轴（20）相对于基座（2）可旋转地固定地定位，并且圆弧形运动路径，由驱动辊（1）的引导装置（5）约束的轴与第一齿轮的轴（20）的旋转轴同心地布置。

63. 发明申请

US20190119375A1 Antibody Drug Conjugates 审中-公开
公开(公告)号：US20190119375A1
公开(公告)日：2019-04-25
申请号：US15988659
申请日：2018-05-24
申请人： Tinya Abrams , Steven Bruce Cohen , Jason Damiano , Clemens Dürr , Thomas Huber , Daniel Menezes , Kathy Miller , Katherine Rendahl , Jean-Michel Rene Rondeau
发明人： Tinya Abrams , Steven Bruce Cohen , Jason Damiano , Clemens Dürr , Thomas Huber , Daniel Menezes , Kathy Miller , Katherine Rendahl , Jean-Michel Rene Rondeau
IPC分类号： C07K16/28 , A61K47/68 , C07K16/30 , A61K31/5365 , G01N33/574
摘要： This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

65. 发明申请

US20180118834A1 PHOSPHOGLYCERATE KINASE 1 (PGK) PROMOTERS AND METHODS OF USE FOR EXPRESSING CHIMERIC ANTIGEN RECEPTOR 审中-公开
公开(公告)号：US20180118834A1
公开(公告)日：2018-05-03
申请号：US15543688
申请日：2016-01-15
申请人： Jennifer Brogdon , Hilmar Erhard Ebersbach , David Glass , Thomas Huber , Julia Jascur , Carl H. June , Jihyun Lee , Joan Mannick , Michael C. Milone , Leon Murphy , Avery D. Posey , Huijuan Song , Yongqiang Wang , Lai Wei , Qilong Wu , Qiumei Yang , Jiquan Zhang , Novartis Pharma AG , NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. , China Novartis Institutes for Biomedical Research , The Trustees of the University of Pennsylvania
发明人： Jennifer Brogdon , Hilmar Erhard Ebersbach , David Glass , Thomas Huber , Julia Jascur , Carl H. June , Jihyun Lee , Joan Mannick , Michael C. Milone , Leon Murphy , Avery D. Posey , Huijuan Song , Yongqiang Wang , Lai Wei , Qilong Wu , Qiumei Yang , Jiquan Zhang
IPC分类号： C07K16/28 , C07K14/705 , C07K14/725 , A61K35/17 , C07K16/30 , A61P35/00 , A61P35/02 , A61K48/00 , C12N15/86
CPC分类号： C07K16/2863 , A61K35/17 , A61K48/0058 , A61K2035/124 , A61P35/00 , A61P35/02 , C07K14/705 , C07K14/7051 , C07K14/70521 , C07K16/28 , C07K16/30 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C12N15/86 , C12N2740/10043 , C12N2740/15043 , C12N2800/60
摘要： The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.

66. 发明授权

US09850063B2 Freight floor, freight container, use of a multilayer panel to produce a freight floor, and method for producing a freight floor 有权
公开(公告)号：US09850063B2
公开(公告)日：2017-12-26
申请号：US14123571
申请日：2012-06-06
申请人： Thomas Huber
发明人： Thomas Huber
IPC分类号： B65D88/00 , B65D88/14 , B65D90/02
CPC分类号： B65D88/14 , B65D90/022 , Y10T428/249951
摘要： A freight floor having a multilayer construction and that is formed as a composite material, comprising a core layer of carbon-fiber-reinforced and/or glass-fiber-reinforced plastic and a seating layer of a metal alloy, in particular an aluminum alloy.

67. 发明申请

US20160096892A1 TREATMENT OF CANCER USING A CD33 CHIMERIC ANTIGEN RECEPTOR 有权
标题翻译：使用CD33基因抗原受体治疗癌症
公开(公告)号：US20160096892A1
公开(公告)日：2016-04-07
申请号：US14805236
申请日：2015-07-21
申请人： Jennifer Brogdon , Hilmar Erhard Ebersbach , Saar Gill , David Glass , Thomas Huber , Julia Jascur , Saad Kenderian , Joan Mannick , Michael C. Milone , Leon Murphy , Celeste Richardson , Reshma Singh , Huijuan Song , Qilong Wu , Jiquan Zhang
发明人： Jennifer Brogdon , Hilmar Erhard Ebersbach , Saar Gill , David Glass , Thomas Huber , Julia Jascur , Saad Kenderian , Joan Mannick , Michael C. Milone , Leon Murphy , Celeste Richardson , Reshma Singh , Huijuan Song , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , C07K14/725 , A61K45/06 , C07K14/705 , A61K38/17 , A61K39/395 , C07K16/30 , C07K14/715
CPC分类号： C07K16/2851 , A61K31/436 , A61K31/711 , A61K35/28 , A61K38/00 , A61K38/1774 , A61K38/1793 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/5156 , C07K14/7051 , C07K14/70517 , C07K14/7056 , C07K14/70578 , C07K14/7151 , C07K16/2803 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C07K2319/70 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
摘要翻译：本发明提供用于治疗与CD33表达相关的疾病的组合物和方法。本发明还涉及对CD33特异性的嵌合抗原受体（CAR），编码它的载体和包含CD33 CAR的重组T细胞。本发明还包括施用表达包含CD33结合结构域的CAR的遗传修饰的T细胞的方法。

68. 发明授权

US09085364B2 Locking element 有权
标题翻译：锁定元件
公开(公告)号：US09085364B2
公开(公告)日：2015-07-21
申请号：US13379989
申请日：2009-06-22
申请人： Thomas Huber , Richard Holzner
发明人： Thomas Huber , Richard Holzner
IPC分类号： B60P7/08 , B64D9/00 , B60P7/13
CPC分类号： B64D9/003 , B60P7/13
摘要： A locking element is described for securing containers, pallets or similar freight items in the cargo bay of an aircraft, wherein a first and a second locking claw are mounted on a frame swivellable from a lowered loading position into a raised working position for securing containers. A remotely controllable adjustment device is provided to change and adjust the state of the locking claws between the loading state in which the locking claws are in the loading position, a holding state in which the locking claws are in the working position and fixed, and a trigger state in which the locking claws are in the working position but can be swivelled from the working position into the loading position if a force acting on the locking claws exceeds a predetermined amount.
摘要翻译：描述了锁定元件，用于将集装箱，托盘或类似货物物品固定在飞机的货舱中，其中第一和第二锁定爪安装在可从降低的装载位置转动到用于固定容器的升高工作位置的框架上。提供一种可远程控制的调节装置，用于在锁定爪处于装载位置的装载状态，锁定爪处于工作位置并固定的保持状态下改变和调节锁定爪的状态，以及触发状态，其中锁定爪处于工作位置，但是如果作用在锁定爪上的力超过预定量，则可以从工作位置旋转到装载位置。

69. 发明授权

US09046464B2 Device and method for detecting a substance using a thin film resonator (FBAR) having an insulating layer 有权
标题翻译：使用具有绝缘层的薄膜谐振器（FBAR）检测物质的装置和方法
公开(公告)号：US09046464B2
公开(公告)日：2015-06-02
申请号：US13124913
申请日：2009-09-29
申请人： Thomas Huber , Martin Nirschl , Dana Pitzer , Matthias Schreiter
发明人： Thomas Huber , Martin Nirschl , Dana Pitzer , Matthias Schreiter
IPC分类号： G01R29/22 , G01N29/036 , G01N29/02
CPC分类号： G01N29/036 , G01N29/022 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426
摘要： A device for detecting at least one substance of a fluid, has a piezoacoustic thin film resonator with a piezoelectric layer on which electrode layers are arranged, and an adsorption surface for adsorbing the fluid substance, wherein the piezoelectric and electrode layers and the adsorption surface are designed and arranged on each other such that by electrically activating the electrode layers, an excitation alternating field can be coupled into the piezoelectric layer. The thin film resonator can be excited to a resonance oscillation frequency fR which depends on an amount of the substance adsorbed on the adsorption surface because of an excitation alternating field coupled into the piezoelectric layer. An electrical insulating layer is arranged directly on a side of one of the electrode layers facing away from the piezoelectric layer. Particularly advantageous is the combination of an aluminum electrode layer and a silicon dioxide insulating layer.
摘要翻译：一种用于检测至少一种流体物质的装置，具有压电层薄膜谐振器，其上设置有电极层的压电层和用于吸附流体物质的吸附表面，其中压电层和电极层和吸附面是设计和布置在彼此之间，使得通过电激活电极层，激励交变场可耦合到压电层中。可以将薄膜谐振器激发到谐振振荡频率fR，其取决于吸附在吸附表面上的物质的量，因为耦合到压电层中的激发交变场。电绝缘层直接布置在背离压电层的一个电极层的一侧上。铝电极层和二氧化硅绝缘层的组合特别有利。

70. 发明授权

US08999320B2 Nanoscale bound bilayers, methods of use and production 有权
标题翻译：纳米尺度双层膜，使用和生产方法
公开(公告)号：US08999320B2
公开(公告)日：2015-04-07
申请号：US12865615
申请日：2009-01-30
申请人： Thomas P. Sakmar , Thomas Huber , Sourabh Banerjee
发明人： Thomas P. Sakmar , Thomas Huber , Sourabh Banerjee
IPC分类号： A61K9/127 , A61K38/00 , A61K47/00
CPC分类号： A61K9/1277 , A61K9/127 , A61K9/1275 , A61K45/06
摘要： Methods for rapidly obtaining a nanoscale apolipoprotein bound phospholipid bilayer (NABB) associated with at least one membrane protein are provided. Also disclosed are methods for rapidly obtaining a NABB not associated with membrane proteins. Immunogenic compositions comprising NABBs with native conformational epitopes are also provided along with their methods of use.
摘要翻译：提供了与至少一种膜蛋白相关的快速获得纳米级载脂蛋白结合磷脂双层（NABB）的方法。还公开了用于快速获得与膜蛋白不相关的NABB的方法。还提供包含具有天然构象表位的NABB的免疫原性组合及其使用方法。

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