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61. 发明授权

US08519331B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08519331B2
公开(公告)日：2013-08-27
申请号：US12528173
申请日：2008-02-21
申请人： Robert Harold Bateman , Martin Green , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/0095 , H01J49/423 , H01J49/424
摘要： A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods to allow ions to be ejected radially from the ion trap. The 3D ion trap comprises a central ring electrode which is radially segmented and wherein a slot is provided in each radial segment to allow ions to be ejected radially from the ion trap. Ions having different mass to charge ratios and/or opposite polarities may be simultaneously ejected from the ion trap via different exit pathways.
摘要翻译：公开了包括2D或3D离子阱的质谱仪。 2D离子阱包括四极杆组离子阱，其中在每个棒中设置有槽，以允许离子从离子阱径向喷射。 3D离子阱包括径向分段的中心环电极，并且其中在每个径向段中设置狭槽以允许离子从离子阱径向喷射。具有不同质荷比和/或相反极性的离子可以通过不同的出口通道从离子阱同时喷出。

62. 发明申请

US20110215237A1 Mass Analysis Using Alternating Fragmentation Modes 有权
标题翻译：使用交替分段模式进行质量分析
公开(公告)号：US20110215237A1
公开(公告)日：2011-09-08
申请号：US13109585
申请日：2011-05-17
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： H01J49/40 , H01J49/26
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components in the eluent, repeatedly switching, altering or varying an Electron Capture Dissociation fragmentation device back and forth between a hi-fragmentation mode and a low-fragmentation mode to alternately produce product ions from the precursor ions in the hi-fragmentation mode and to produce substantially fewer product ions in the low-fragmentation mode, and obtaining mass spectra during the period of time from the precursor and product ions received from the Electron Capture Dissociation fragmentation device.
摘要翻译：用于分析组分混合物的方法包括通过使组分在一段时间内顺序洗脱的方式分离或部分分离样品混合物的组分，从洗脱液中的组分形成前体离子，重复切换，在高分裂模式和低碎裂模式之间来回地改变或改变电子俘获解离破碎装置，以在高分裂模式中交替地从前体离子产生产物离子，并在低分散模式中产生基本上更少的产物离子，并且从从电子俘获解离破碎装置接收的前体和产物离子的时间段内获得质谱。

63. 发明申请

US20110062324A1 MASS SPECTROMETER WITH BYPASS OF A FRAGMENTATION DEVICE 有权
标题翻译：具有分段装置旁路的质谱仪
公开(公告)号：US20110062324A1
公开(公告)日：2011-03-17
申请号：US12952619
申请日：2010-11-23
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer.
摘要翻译：用于分析组分混合物的方法包括从组分形成前体离子，交替地使前体离子传递到并绕过碎裂装置，以从通过装置的前体离子形成产物离子并基本上形成来自前体离子的产物离子越过旁路器件，并且从从器件接收的产物离子和从器件旁路的前体离子获得质谱。用于分析样品的装置包括用于从样品的组分形成前体离子的离子源，用于从前体离子形成产物离子的碎裂装置，设置在碎裂装置上游的旁路装置，用于可切换的旁路碎片装置和质量分析器。

64. 发明申请

US20090114808A1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090114808A1
公开(公告)日：2009-05-07
申请号：US11916430
申请日：2006-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Raymond Green , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译：公开了一种质谱法，其中分析了来自离子检测器的电压信号。获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。然后将各种时间和强度数据对被整合以产生平滑的连续质谱。然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。可以确定在连续质谱中观察到的质量峰的开始和结束时间。然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。

65. 发明申请

US20090014639A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090014639A1
公开(公告)日：2009-01-15
申请号：US12094661
申请日：2006-11-23
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： B01D59/44
CPC分类号： H01J49/0045 , B82Y30/00
摘要： A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source (1) are transmitted to a fragmentation device (4) comprising an Electron Capture Dissociation, an Electron Transfer Dissociation or a Surface Induced Dissociation fragmentation device. The fragmentation device (4) is alternately and repeatedly switched between a first mode wherein the ions are substantially fragmented to produce daughter ions and a second mode wherein the ions are not substantially fragmented. Mass spectra are taken in both modes. At the end of an experimental run parent and daughter ions are recognised by comparing the mass spectra obtained in the two different modes. Daughter ions are matched to particular parent ions on the basis of the closeness of fit of their elution times, and this enables parent ions then to be identified.
摘要翻译：公开了一种通过匹配发现在母体离子从混合物中洗脱出的基本上同时产生的子离子来鉴定亲本离子的方法。从离子源（1）发射的离子被传输到包括电子俘获解离，电子转移解离或表面诱导解离破碎装置的断裂装置（4）。碎片装置（4）在其中离子基本上分裂以产生子离子的第一模式和第二模式之间交替地和重复地切换，其中离子基本上不分散。质谱采用两种模式。在实验运行结束时，通过比较两种不同模式中获得的质谱来识别母体和子离子。基于其洗脱时间的拟合程度，子离子与特定的母体离子相匹配，这使得母体离子可以被鉴别。

66. 发明申请

US20080265152A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20080265152A1
公开(公告)日：2008-10-30
申请号：US11909996
申请日：2006-04-03
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： H01J49/26
CPC分类号： B01D59/44 , G01N30/724 , G01N2030/8447 , G01N2030/8868 , H01J49/004 , H01J49/04
摘要： A mass spectrometer is disclosed comprising a High Pressure Liquid Chromatography system (10) which is interfaced to a combustion chamber (16) and isotope ratio mass analyser (19) by means of an Electrospray Ionisation ion source (11) and a Field Asymmetric Ion Mobility Spectrometry device (13). Analyte and solvent molecules are ionised by the ion source (11). Desired analyte ions are substantially onwardly transmitted by the Field Asymmetric Ion Mobility Spectrometry device (13) to the combustion chamber (16) whereas undesired solvent ions are substantially attenuated by the Field Asymmetric Ion Mobility Spectrometry device (13).
摘要翻译：公开了一种质谱仪，其包括通过电喷雾离子源（11）和场非对称离子迁移率（11）与燃烧室（16）和同位素比质量分析器（19）相连的高压液相色谱系统（10）光谱测定装置（13）。分析物和溶剂分子被离子源（11）电离。期望的分析物离子通过场非对称离子迁移率分析装置（13）基本向上传输到燃烧室（16），而不期望的溶剂离子被场非对称离子迁移率装置（13）基本上衰减。

67. 发明授权

US07038197B2 Mass spectrometer and method of mass spectrometry 有权
标题翻译：质谱仪和质谱法
公开(公告)号：US07038197B2
公开(公告)日：2006-05-02
申请号：US10274989
申请日：2002-10-22
申请人： Robert Harold Bateman , Martin Green , Michael Jackson
发明人： Robert Harold Bateman , Martin Green , Michael Jackson
IPC分类号： H01J49/40 , H01J49/26 , G01K1/08 , G01N27/62
CPC分类号： H01J49/067 , H01J49/0027
摘要： A mass spectrometer is disclosed wherein a z-lens upstream of an orthogonal acceleration Time of Flight mass analyser is repeatedly switched between a first mode wherein ions are transmitted to the mass analyser for subsequent mass analysis with a relatively high transmission and a second mode wherein ions are transmitted with a relatively low transmission. If it is determined that mass spectral data obtained when the mass analyser is in the first mode is suffering from saturation, then suitably scaled mass spectral data obtained when the mass analyser is in the second mode is used instead. If the saturation is severe then the mass spectral data obtained in the first mode may be replaced in its entirety with mass spectral data obtained in the second mode.
摘要翻译：公开了一种质谱仪，其中在正交加速时间飞行质量分析仪上游的z轴透镜在第一模式之间重复切换，其中离子被传输到质量分析器以进行相对较高透射率的后续质量分析，其中离子以较低的传输速率传输。如果确定当质量分析器处于第一模式时获得的质谱数据饱和，则使用质量分析器处于第二模式时获得的适当缩放的质谱数据。如果饱和度严重，则在第一模式中获得的质谱数据可以用第二模式获得的质谱数据全部替代。

68. 发明授权

US06982414B2 Method of mass spectrometry and a mass spectrometer 有权
标题翻译：质谱法和质谱仪
公开(公告)号：US06982414B2
公开(公告)日：2006-01-03
申请号：US10464513
申请日：2003-06-19
申请人： Robert Harold Bateman , James Ian Langridge , Therese McKenna , Keith Richardson
发明人： Robert Harold Bateman , James Ian Langridge , Therese McKenna , Keith Richardson
IPC分类号： B01D59/44
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method of mass spectrometry is disclosed wherein a gas collision cell is repeatedly switched between a fragmentation and a non-fragmentation mode. Parent ions from a first sample are passed through the collision cell and parent ion mass spectra and fragmentation ion mass spectra are obtained. Parent ions from a second sample are then passed through the collision cell and a second set of parent ion mass spectra and fragmentation ion mass spectra are obtained. The mass spectra are then compared and if either certain parent ions or certain fragmentation ions in the two samples are expressed differently then further analysis is performed to seek to identify the ions which are expressed differently in the two different samples.
摘要翻译：公开了一种质谱法，其中气体碰撞池在分段和非碎裂模式之间重复切换。来自第一个样品的亲本离子通过碰撞池，并获得亲本离子质谱和碎裂离子质谱。然后将来自第二个样品的亲本离子通过碰撞池，并获得第二组母体离子质谱和碎片离子质谱。然后比较质谱，并且如果两个样品中的某些亲本离子或某些断裂离子不同地表达，则进行进一步分析以寻找在两个不同样品中不同表达的离子。

69. 发明授权

US06906317B2 Ion detector 有权
标题翻译：离子检测器
公开(公告)号：US06906317B2
公开(公告)日：2005-06-14
申请号：US10733925
申请日：2003-12-11
申请人： Robert Harold Bateman , Jeff Brown , Daniel James Kenny
发明人： Robert Harold Bateman , Jeff Brown , Daniel James Kenny
IPC分类号： B01D59/44 , G01K1/08 , H01J49/00
CPC分类号： H01J43/246
摘要： An ion detector for a mass spectrometer is disclosed comprising one or more microchannel plates and an anode arranged to receive electrons emitted from the one or more microchannel plates. The anode is permanently magnetized and electrons emitted from the microchannel plates preferably spiral around lines of magnetic field towards the anode.
摘要翻译：公开了一种用于质谱仪的离子检测器，其包括一个或多个微通道板和布置成接收从一个或多个微通道板发射的电子的阳极。阳极被永久磁化，并且从微通道板发射的电子优选地绕着磁场线向着阳极旋转。

70. 发明授权

US06891157B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06891157B2
公开(公告)日：2005-05-10
申请号：US10449030
申请日：2003-06-02
申请人： Robert Harold Bateman , Andrew Entwistle
发明人： Robert Harold Bateman , Andrew Entwistle
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/065
摘要： A mass spectrometer is disclosed comprising an AC or RF ion guide having a plurality of plate electrodes and an upper plate electrode and a lower plate electrode. One or more channels are formed within the plate electrodes so that an ion guiding region is formed within the ion guide. The channels and hence the ion guiding region may be curved.
摘要翻译：公开了一种质谱仪，其包括具有多个板电极和上板电极和下板电极的AC或RF离子导向器。一个或多个通道形成在板电极内，使得离子引导区形成在离子导向器内。通道，因此离子导向区域可以是弯曲的。

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