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61. 发明授权

US08295927B2 Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods 有权
标题翻译：基于闭环阻抗的心脏再同步治疗系统，装置和方法
公开(公告)号：US08295927B2
公开(公告)日：2012-10-23
申请号：US12254631
申请日：2008-10-20
申请人： Jiang Ding , Yinghong Yu , Julio C. Spinelli , Jeffrey E. Stahmann
发明人： Jiang Ding , Yinghong Yu , Julio C. Spinelli , Jeffrey E. Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量峰 - 峰体积或最大心室容积变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

62. 发明授权

US08214026B2 Method and apparatus for determining the coronary sinus vein branch accessed by a coronary sinus lead 有权
标题翻译：用于确定冠状静脉窦导管接近的冠状静脉窦静脉分支的方法和装置
公开(公告)号：US08214026B2
公开(公告)日：2012-07-03
申请号：US12976397
申请日：2010-12-22
申请人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio C. Spinelli
发明人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio C. Spinelli
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0456 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/3682
摘要： Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
摘要翻译：公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。电极位置的确定可用于自动调整VRT器件的工作参数。此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

63. 发明授权

US07966066B2 Apparatus and method for optimizing atrioventricular delay 有权
标题翻译：用于优化房室延迟的装置和方法
公开(公告)号：US07966066B2
公开(公告)日：2011-06-21
申请号：US11126490
申请日：2005-05-11
申请人： Yinghong Yu , Jiang Ding , Jeffrey E. Stahmann
发明人： Yinghong Yu , Jiang Ding , Jeffrey E. Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/3706
摘要： Systems and methods to optimize atrioventricular delay during sensing or pacing of the atrium and for a plurality of sensed rates or pacing rates. In one example, a paced atrioventricular delay is calculated using a sensed atrioventricular interval and a paced atrioventricular interval. In another example, a plurality of paced atrioventricular delays for different pacing rates can be calculated. In another example embodiment, a plurality of sensed atrioventricular delays for different sensing rates can be calculated. Combinations of the various systems and methods are also possible.
摘要翻译：在心房的感测或起搏期间以及多个感测速率或起搏速率下优化房室延迟的系统和方法。在一个示例中，使用感测的房室间隔和起搏房室间隔来计算起搏房室延迟。在另一个示例中，可以计算用于不同起搏速率的多个起搏房室延迟。在另一示例性实施例中，可以计算用于不同感测速率的多个感测的房室延迟。各种系统和方法的组合也是可能的。

64. 发明授权

US07869873B2 Method and system for setting cardiac resynchronization therapy parameters 有权
标题翻译：设置心脏再同步治疗参数的方法和系统
公开(公告)号：US07869873B2
公开(公告)日：2011-01-11
申请号：US11681244
申请日：2007-03-02
申请人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
发明人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.
摘要翻译：提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。

65. 发明申请

US20100137932A1 METHOD AND APPARATUS FOR OPTIMIZING ELECTRICAL STIMULATION PARAMETERS USING HEART RATE VARIABILITY 有权
标题翻译：使用心率变化优化电刺激参数的方法和装置
公开(公告)号：US20100137932A1
公开(公告)日：2010-06-03
申请号：US12699457
申请日：2010-02-03
申请人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
发明人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/08 , A61N1/365
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。

66. 发明授权

US07672725B2 Method and apparatus for using heart rate variability as a safety check in electrical therapies 失效
标题翻译：使用心率变异性作为电疗法安全检查的方法和装置
公开(公告)号：US07672725B2
公开(公告)日：2010-03-02
申请号：US11037309
申请日：2005-01-18
申请人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
发明人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61N1/36592
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。

67. 发明授权

US07672724B2 Method and apparatus for optimizing electrical stimulation parameters using heart rate variability 有权
标题翻译：使用心率变异优化电刺激参数的方法和装置
公开(公告)号：US07672724B2
公开(公告)日：2010-03-02
申请号：US11037308
申请日：2005-01-18
申请人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
发明人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/362
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。

68. 发明申请

US20100023078A1 Cardiac resynchronization therapy parameter optimization 有权
标题翻译：心脏再同步治疗参数优化
公开(公告)号：US20100023078A1
公开(公告)日：2010-01-28
申请号：US11338935
申请日：2006-01-25
申请人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
发明人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36585 , A61N1/3684
摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.
摘要翻译：系统和方法涉及使用多个CRT优化过程来确定CRT参数。每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。可以基于返回的推荐参数的组合来确定CRT参数。可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

69. 发明申请

US20100010557A1 SELECTIVE RESYNCHRONIZATION THERAPY OPTIMIZATION BASED ON USER PREFERENCE 有权
标题翻译：基于用户偏好的选择性修复治疗优化
公开(公告)号：US20100010557A1
公开(公告)日：2010-01-14
申请号：US12565344
申请日：2009-09-23
申请人： Richard Fogoros , Jiang Ding , Yinghong Yu
发明人： Richard Fogoros , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method and system for calculating an atrio-ventricular delay interval based upon an inter-atrial delay exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may optimize the stroke volume exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may be blended with another atrio-ventricular delay interval that may optimize another performance characteristic, such as left ventricular contractility. Such blending may include finding an arithmetic mean, geometric mean, or weighted mean of two or more proposed atrio-ventricular delay intervals.
摘要翻译：一种用于根据患者心脏表现的心房间延迟来计算心房延迟间隔的方法和系统。上述的心室延迟间隔可以优化患者心脏展示的搏动量。上述房室延迟间隔可以与可以优化另一性能特征（例如左心室收缩力）的另一心房延迟间隔混合。这种混合可以包括找到两个或更多个提出的心房延迟间隔的算术平均值，几何平均值或加权平均值。

70. 发明授权

US07555340B2 Electrogram morphology-based CRT optimization 有权
标题翻译：基于电图形态的CRT优化
公开(公告)号：US07555340B2
公开(公告)日：2009-06-30
申请号：US11097460
申请日：2005-04-01
申请人： Yanting Dong , Jiang Ding , Douglas R. Daum , Scott A. Meyer , Yinghong Yu
发明人： Yanting Dong , Jiang Ding , Douglas R. Daum , Scott A. Meyer , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/371
摘要： A method and system for determining an optimum atrioventricular delay (AVD) interval and/or ventriculo-ventricular delay (VVD) intervals for delivering ventricular resynchronization pacing in an atrial tracking or atrial sequential pacing mode. Evoked response electrograms recorded at different AVD and VVD intervals are used to determine the extent of paced and intrinsic activation.
摘要翻译：一种用于确定用于在心房跟踪或心房顺序起搏模式中递送心室再同步起搏的最佳房室延迟（AVD）间隔和/或心室 - 心室延迟（VVD）间隔的方法和系统。以不同的AVD和VVD间隔记录的诱发反应电图用于确定起搏和内在激活的程度。

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