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61. 发明申请

US20070042392A1 Novel nucleic acids and polypeptides 审中-公开
公开(公告)号：US20070042392A1
公开(公告)日：2007-02-22
申请号：US11218141
申请日：2005-08-31
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Yunqing Ma , Feiyan Ren , Jian-Rui Wang , Thomas Wehrman , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Yi-Cheng Cao , Dunrui Wang , Zhi Wang , Ryle Goodrich
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Yunqing Ma , Feiyan Ren , Jian-Rui Wang , Thomas Wehrman , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Yi-Cheng Cao , Dunrui Wang , Zhi Wang , Ryle Goodrich
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/136
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

62. 发明申请

US20050221342A1 Nucleic acids and polypeptides 审中-公开
公开(公告)号：US20050221342A1
公开(公告)日：2005-10-06
申请号：US10972024
申请日：2004-10-22
申请人： Y. Tang , Vinod Asundi , Ping Zhou , Aidong Xue , Feiyan Ren , Jie Zhang , Jian-Rui Wang , Yonghong Yang , Qing Zhao , Ryle Goodrich , Chenghua Liu , Radoje Drmanac , Yunqing Ma , Zhiwei Wang , Tom Wehrman
发明人： Y. Tang , Vinod Asundi , Ping Zhou , Aidong Xue , Feiyan Ren , Jie Zhang , Jian-Rui Wang , Yonghong Yang , Qing Zhao , Ryle Goodrich , Chenghua Liu , Radoje Drmanac , Yunqing Ma , Zhiwei Wang , Tom Wehrman
IPC分类号： C07H21/04 , C07K14/47 , C12N15/09 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6837
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

63. 发明申请

US20050009819A1 1-Aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands 失效
标题翻译： 1-芳基或1-烷基磺酰基苯并恶唑衍生物作为5-羟基色胺-6配体
公开(公告)号：US20050009819A1
公开(公告)日：2005-01-13
申请号：US10888810
申请日：2004-07-09
申请人： Ping Zhou , Michael Kelly
发明人： Ping Zhou , Michael Kelly
IPC分类号： C07D209/08 , C07D231/56 , C07D405/12 , C07D409/12 , A61K31/541 , A61K31/4162 , A61K31/4184 , A61K31/454 , A61K31/496 , A61K31/5377
CPC分类号： C07D401/12 , C07D209/08 , C07D231/56 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式I化合物及其用于治疗与5-HT 6受体有关或受其影响的病症的用途。

64. 发明授权

US06819819B2 Method and apparatus for optical communication 失效
标题翻译：光通信的方法和装置
公开(公告)号：US06819819B2
公开(公告)日：2004-11-16
申请号：US10338542
申请日：2003-01-07
申请人： Ping Zhou
发明人： Ping Zhou
IPC分类号： G02B626
CPC分类号： H04Q11/0005 , G02B6/29373 , G02B6/29395 , G02B6/351 , G02B6/3524 , G02B6/3528 , G02B6/3538 , G02B6/3544 , G02B6/3546 , G02B6/3556 , G02B6/356 , G02B6/3568 , G02B6/3572 , G02B6/3576 , G02F1/31 , H04Q2011/0035
摘要： A method and apparatus for communications according to various aspects of the present invention comprises a switching system configured to receive optical signals and direct the optical signals along a selected optical path. The switching system suitably includes more than one switch, and at least one of the switches may include a variable refractive material having a first state and a second state, wherein the optical signal is transmitted via a first path when the variable refractive material is in the first state and the individual channel signal is transmitted via a second path when the variable refractive material is in the second state. The switching system may alternatively or additionally include a switch element having a reflective state and a transmissive state, wherein the optical signal is reflected via a first path when the switch element is in the reflective state and the individual channel signal is transmitted via a second path when the switch element is in the transmissive state.
摘要翻译：根据本发明的各个方面的用于通信的方法和装置包括被配置为接收光信号并沿着所选光路引导光信号的切换系统。开关系统适当地包括多于一个开关，并且至少一个开关可以包括具有第一状态和第二状态的可变折射材料，其中当可变折射材料处于当可变折射材料处于第二状态时，第一状态和单个通道信号经由第二路径传输。交换系统可以可选地或另外包括具有反射状态和透射状态的开关元件，其中当开关元件处于反射状态时，光信号经由第一路径被反射，并且单独的通道信号经由第二路径当开关元件处于透射状态时。

65. 发明授权

US06806254B2 Methods and materials relating to alpha-2-macroglobulin-like polypeptides and polynucleotides 失效
标题翻译：与α-2-巨球蛋白样多肽和多核苷酸有关的方法和材料
公开(公告)号：US06806254B2
公开(公告)日：2004-10-19
申请号：US09756247
申请日：2001-01-08
申请人： Shubhada D. Godbole , Bryan J. Boyle , Nancy K. Mize , Cenhua Deng , Ryle W. Goodrich , Matthew C. Arterburn , Ping Zhou , Y. Tom Tang , Chenghua Liu , George Yeung , Radoje T. Drmanac
发明人： Shubhada D. Godbole , Bryan J. Boyle , Nancy K. Mize , Cenhua Deng , Ryle W. Goodrich , Matthew C. Arterburn , Ping Zhou , Y. Tom Tang , Chenghua Liu , George Yeung , Radoje T. Drmanac
IPC分类号： A61K3800
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/8107 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted alpha-2-macroglobulin-like polypeptides. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal brain mRNA (Clontech) (SEQ ID NO: 1) and uterus mRNA (Clontech) (SEQ ID NO: 26). Other aspects of the invention include vectors containing processes for producing novel human secreted alpha-2-macroglobulin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由这样的多核苷酸编码的新的多核苷酸和多肽，其对应于新型人分泌的α-2-巨球蛋白样多肽的突变体或其变体。这些多核苷酸包含从胎儿脑mRNA（Clontech）（SEQ ID NO：1）和子宫mRNA（Clontech）（SEQ ID NO：26）的cDNA文库中分离的核酸序列。本发明的其它方面包括含有产生新的人分泌的α-2-巨球蛋白样多肽的方法的载体和对这些多肽特异的抗体。

66. 发明授权

US06710069B2 1-aryl- or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands 失效
标题翻译： 1-芳基或1-烷基磺酰基吲唑衍生物作为5-羟基色胺-6配体
公开(公告)号：US06710069B2
公开(公告)日：2004-03-23
申请号：US10314726
申请日：2002-12-09
申请人： Ping Zhou , Michael Gerard Kelly
发明人： Ping Zhou , Michael Gerard Kelly
IPC分类号： A61F31405
CPC分类号： C07D405/12 , C07D209/08 , C07D231/56 , C07D409/12
摘要： The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式I化合物及其用于治疗与5-HT 6受体有关或受其影响的病症的用途。

67. 发明授权

US06521989B2 Methods and apparatus for hermetically sealing electronic packages 失效
标题翻译：密封电子封装的方法和装置
公开(公告)号：US06521989B2
公开(公告)日：2003-02-18
申请号：US09169511
申请日：1998-10-08
申请人： Ping Zhou
发明人： Ping Zhou
IPC分类号： H01L2322
CPC分类号： H01L31/0203 , G02B6/4248 , H01L23/10 , H01L2924/0002 , H01L2924/01079 , H01L2924/00
摘要： An electronic package and/or package lid includes at least one connection slot for receiving a line, such as an optical fiber. The package and/or package lid also includes at least one sealant slot proximate the connection slot. Optical fibers are connected to a component, such as an opto-electronic component, through the connection slot. A sealant provided via the sealant slot hermetically seals the optical fibers within the connection slot.
摘要翻译：电子封装和/或封装盖包括用于接收诸如光纤的线的至少一个连接槽。包装和/或包装盖还包括靠近连接槽的至少一个密封剂槽。光纤通过连接槽连接到诸如光电子部件的部件。通过密封剂狭缝提供的密封剂使连接槽内的光纤密封。

68. 发明授权

US06489342B2 Aryloxy piperidinyl indoles for treating depression 失效
标题翻译：芳氧基哌啶基吲哚用于治疗抑郁症
公开(公告)号：US06489342B2
公开(公告)日：2002-12-03
申请号：US10002340
申请日：2001-11-15
申请人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
发明人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
IPC分类号： A61K31454
CPC分类号： C07D401/14
摘要： This invention provides aryloxy indole derivatives which are useful for the treatment of diseases affected by disorders of the serotonin-affected neurological systems, such as depression and anxiety, the compounds having the formula: wherein R1 is H or alkyl; R2, R3, and R4 are H, alkyl, or halogen; X is H, halogen, CN, or C1-C6 alkoxy; Z is (CH2)n or carbonyl; n is 1 or 2; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了芳氧基吲哚衍生物，其可用于治疗受血清素受影响的神经系统疾病如抑郁和焦虑影响的疾病，具有下式的化合物：其中R1是H或烷基; R2，R3和R4是H，烷基或卤素; X是H，卤素，CN或C 1 -C 6烷氧基; Z是（CH 2）n或羰基; n为1或2; 虚线表示可选的双键; 或其药学上可接受的盐。

69. 发明授权

US06436703B1 Nucleic acids and polypeptides 失效
标题翻译：核酸和多肽
公开(公告)号：US06436703B1
公开(公告)日：2002-08-20
申请号：US09668680
申请日：2000-09-22
申请人： Y. Tom Tang , Chenghua Liu , Ping Zhou , Vinod Asundi , Jie Zhang , Jian-Rui Wang , Aidong J. Xue , Chongjun Xu , Radoje T. Drmanac
发明人： Y. Tom Tang , Chenghua Liu , Ping Zhou , Vinod Asundi , Jie Zhang , Jian-Rui Wang , Aidong J. Xue , Chongjun Xu , Radoje T. Drmanac
IPC分类号： C12N1512
CPC分类号： C07K14/47 , A61K38/00 , C07K14/8107
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译：本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。

70. 发明授权

US06313126B1 Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression 失效
标题翻译：用于治疗抑郁症的芳基哌嗪基 - 环己基吲哚衍生物
公开(公告)号：US06313126B1
公开(公告)日：2001-11-06
申请号：US09476254
申请日：1999-12-30
申请人： Richard E. Mewshaw , Ping Zhou , Dahui Zhou , Kristin L. Meagher , Magda Asselin , Deborah A. Evrard , Adam M. Gilbert
发明人： Richard E. Mewshaw , Ping Zhou , Dahui Zhou , Kristin L. Meagher , Magda Asselin , Deborah A. Evrard , Adam M. Gilbert
IPC分类号： A61K31496
CPC分类号： C07D401/08 , C07D209/14 , C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04
摘要： Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R1, R2 and R3 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, MeSO2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, alkylaryl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.
摘要翻译：提供了可用于治疗受5-羟色胺影响的神经系统疾病的化合物，其包括：R 1，R 2和R 3各自独立地为氢，卤素，CF 3，烷基，烷氧基，MeSO 2或一起可以形成5-7元碳环或杂环; R 4为氢，卤素或烷基; R 5为氢，烷基，烷基芳基或芳基; R 6为氢，卤素，CF 3，CN，脲或烷氧基; X 1，X 2和X 3为碳或 X1，X2或X3可以是氮; Y是碳或氮; Z为碳或氮; 其药学上可接受的盐。

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