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1. 发明授权

US06465482B2 Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression 失效
标题翻译：用于治疗抑郁症的芳基哌嗪基 - 环己基吲哚衍生物
公开(公告)号：US06465482B2
公开(公告)日：2002-10-15
申请号：US09969910
申请日：2001-10-03
申请人： Richard E. Mewshaw , Ping Zhou , Dahui Zhou , Kristin L. Meagher , Magda Asselin , Deborah A. Evrard , Adam M. Gilbert
发明人： Richard E. Mewshaw , Ping Zhou , Dahui Zhou , Kristin L. Meagher , Magda Asselin , Deborah A. Evrard , Adam M. Gilbert
IPC分类号： A61K31454
CPC分类号： C07D401/08 , C07D209/14 , C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04
摘要： Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R1, R2 and R3 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, MeSO2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, alkylaryl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.
摘要翻译：提供了可用于治疗受5-羟色胺影响的神经系统疾病的化合物，其包括：R 1，R 2和R 3各自独立地为氢，卤素，CF 3，烷基，烷氧基，MeSO 2或一起可以形成5-7元碳环或杂环; R 4为氢，卤素或烷基; R 5为氢，烷基，烷基芳基或芳基; R 6为氢，卤素，CF 3，CN，脲或烷氧基; X 1，X 2和X 3为碳或 X1，X2或X3可以是氮; Y是碳或氮; Z为碳或氮; 其药学上可接受的盐。

2. 发明授权

US6110956A N-aryloxyethylamine derivatives for the treatment of depression 失效
标题翻译： N-芳氧基乙胺衍生物用于治疗抑郁症
公开(公告)号：US6110956A
公开(公告)日：2000-08-29
申请号：US287416
申请日：1999-04-07
申请人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
发明人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
IPC分类号： A61P25/24 , C07D209/14 , C07D403/12 , C07D405/12 , A61K31/404 , A61K31/4045 , C07D209/04 , C07D403/08
CPC分类号： C07D403/12 , C07D209/14 , C07D405/12
摘要： Compounds effective in treating disorders of the serotonin-affected neurological systems are provided, such compounds having the following formula: ##STR1## wherein: R.sub.1 and R.sub.2 are each, independently, hydrogen, halogen, CF.sub.3, lower alkyl, lower alkoxy, MeSO.sub.2, or together can form a 5-7 membered carbocyclic or heterocyclic ring;R.sub.3 is alkoxy, halogen, hydrogen or carbamoyl;R.sub.4 is hydrogen, hydroxy, lower alkyl, or lower alkoxy;R.sub.5 is hydrogen, lower alkyl, or halogen;R.sub.6 is hydrogen, lower alkyl, or phenyl;R.sub.7 is hydrogen, lower alkyl, lower alkoxy, halogen, CN, CF.sub.3, or hydroxy; andX is (CH.sub.2).sub.n,wherein n is 0 to 3; or pharmaceutically acceptable salts thereof.
摘要翻译：提供了有效治疗受5-羟色胺影响的神经系统疾病的化合物，具有下式的化合物：其中：R 1和R 2各自独立地为氢，卤素，CF 3，低级烷基，低级烷氧基，MeSO 2或一起可形成 5-7元碳环或杂环; R3是烷氧基，卤素，氢或氨基甲酰基; R4是氢，羟基，低级烷基或低级烷氧基; R5是氢，低级烷基或卤素; R6是氢，低级烷基或苯基; R7是氢，低级烷基，低级烷氧基，卤素，CN，CF3或羟基; X为（CH 2）n，n为0〜3; 或其药学上可接受的盐。

3. 发明授权

US06489342B2 Aryloxy piperidinyl indoles for treating depression 失效
标题翻译：芳氧基哌啶基吲哚用于治疗抑郁症
公开(公告)号：US06489342B2
公开(公告)日：2002-12-03
申请号：US10002340
申请日：2001-11-15
申请人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
发明人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
IPC分类号： A61K31454
CPC分类号： C07D401/14
摘要： This invention provides aryloxy indole derivatives which are useful for the treatment of diseases affected by disorders of the serotonin-affected neurological systems, such as depression and anxiety, the compounds having the formula: wherein R1 is H or alkyl; R2, R3, and R4 are H, alkyl, or halogen; X is H, halogen, CN, or C1-C6 alkoxy; Z is (CH2)n or carbonyl; n is 1 or 2; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了芳氧基吲哚衍生物，其可用于治疗受血清素受影响的神经系统疾病如抑郁和焦虑影响的疾病，具有下式的化合物：其中R1是H或烷基; R2，R3和R4是H，烷基或卤素; X是H，卤素，CN或C 1 -C 6烷氧基; Z是（CH 2）n或羰基; n为1或2; 虚线表示可选的双键; 或其药学上可接受的盐。

4. 发明授权

US06313126B1 Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression 失效
标题翻译：用于治疗抑郁症的芳基哌嗪基 - 环己基吲哚衍生物
公开(公告)号：US06313126B1
公开(公告)日：2001-11-06
申请号：US09476254
申请日：1999-12-30
申请人： Richard E. Mewshaw , Ping Zhou , Dahui Zhou , Kristin L. Meagher , Magda Asselin , Deborah A. Evrard , Adam M. Gilbert
发明人： Richard E. Mewshaw , Ping Zhou , Dahui Zhou , Kristin L. Meagher , Magda Asselin , Deborah A. Evrard , Adam M. Gilbert
IPC分类号： A61K31496
CPC分类号： C07D401/08 , C07D209/14 , C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04
摘要： Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R1, R2 and R3 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, MeSO2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, alkylaryl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.
摘要翻译：提供了可用于治疗受5-羟色胺影响的神经系统疾病的化合物，其包括：R 1，R 2和R 3各自独立地为氢，卤素，CF 3，烷基，烷氧基，MeSO 2或一起可以形成5-7元碳环或杂环; R 4为氢，卤素或烷基; R 5为氢，烷基，烷基芳基或芳基; R 6为氢，卤素，CF 3，CN，脲或烷氧基; X 1，X 2和X 3为碳或 X1，X2或X3可以是氮; Y是碳或氮; Z为碳或氮; 其药学上可接受的盐。

5. 发明授权

US06610712B2 Aryloxy piperidinyl derivatives for the treatment of depression 失效
标题翻译：芳氧基哌啶衍生物用于治疗抑郁症
公开(公告)号：US06610712B2
公开(公告)日：2003-08-26
申请号：US10000642
申请日：2001-11-15
申请人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
发明人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
IPC分类号： C07D40104
CPC分类号： C07D401/06 , C07D405/14
摘要： This invention provides compounds useful in treating serotonin-related central nervous system disorders, including anxiety, generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, sleep disorders, sexual dysfunction, alcohol and drug addiction, Alzheimer's disease, Parkinson's disease, obesity and migraine, the compounds having the general formula: wherein: R1 and R2 may each be H or an alkyl or alkoxy group; or R1 and R2 may be concatenated to form a bicyclic ring system with the phenyl ring to which they are bound; X is selected from hydrogen, halogen, cyano, C1-C6 alkoxy; Z is (CH2)n or carbonyl; n is 0, 1 or 2; the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了可用于治疗血清素相关的中枢神经系统疾病的化合物，包括焦虑，广泛性焦虑症，恐慌症，强迫症，睡眠障碍，性功能障碍，酒精和药物成瘾，阿尔茨海默病，帕金森病，肥胖症和偏头痛具有以下通式的化合物：其中：R 1和R 2可以各自为H或烷基或烷氧基; 或者R 1和R 2可以连接形成与它们所结合的苯环的双环系统; X选自氢，卤素，氰基，C 1 -C 6烷氧基; Z是（CH 2）n或羰基; n为0,1或2; 虚线表示可选的双键; 或其药学上可接受的盐。

6. 发明授权

US06313114B1 3,4-Dihydro-2H-benzo[1,4]oxazinyl-methyl)-[3-(1H-indol-3yl)-alkyl]- amines 失效
标题翻译： 3,4-二氢-2H-苯并[1,4]恶嗪基 - 甲基） - [3-（1H-吲哚基） - 烷基] - 胺
公开(公告)号：US06313114B1
公开(公告)日：2001-11-06
申请号：US09475940
申请日：1999-12-30
申请人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
发明人： Richard E. Mewshaw , Dahui Zhou , Ping Zhou
IPC分类号： C07D41312
CPC分类号： C07D413/12
摘要： Compounds are provided which have the following formula: wherein: R is hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, or substituted phenyl; X and Y are each, independently, hydrogen, halogen, cyano, or alkoxy of 1 to 6 carbon atoms; and m is 1 to 5; or a pharmaceutically acceptable salt thereof.
摘要翻译：提供具有下式的化合物：其中：R是氢，1至6个碳原子的烷基，苯基或取代的苯基; X和Y各自独立地是氢，卤素，氰基或1-6个碳的烷氧基原子 andm是1到5; 或其药学上可接受的盐。

7. 发明授权

US6162803A Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression 失效
标题翻译：吲哚-3-基 - 环己基胺衍生物用于治疗抑郁症
公开(公告)号：US6162803A
公开(公告)日：2000-12-19
申请号：US287676
申请日：1999-04-07
申请人： Richard E. Mewshaw , Ping Zhou
发明人： Richard E. Mewshaw , Ping Zhou
IPC分类号： C07D413/12 , A61K31/536 , A61K31/4985 , C07D215/12 , C07D241/38 , C07D413/08
CPC分类号： C07D413/12
摘要： Compounds effective in treating disorders of the serotonin-affected neurological symptoms are provided, such compounds having the following formula: ##STR1## wherein: R.sub.1 and R.sub.5 are each, independently, hydrogen, halogen, lower alkoxy, lower alkyl, cyano, or trifluoromethyl;R.sub.2 and R.sub.4 are each, independently, hydrogen, lower alkyl, phenyl, or substituted phenyl;R.sub.3 is hydrogen or lower alkyl; andX and Y are each, independently, O, NR.sub.6, or CH.sub.2, whereinR.sub.6 is hydrogen, lower alkyl, phenyl, or substituted phenyl; or pharmaceutically acceptable salts thereof.
摘要翻译：提供了有效治疗血清素受影响的神经症状的疾病的化合物，具有下式的化合物：其中：R 1和R 5各自独立地为氢，卤素，低级烷氧基，低级烷基，氰基或三氟甲基; R2和R4各自独立地为氢，低级烷基，苯基或取代的苯基; R3是氢或低级烷基; 并且X和Y各自独立地是O，NR 6或CH 2，其中R 6是氢，低级烷基，苯基或取代的苯基; 或其药学上可接受的盐。

8. 发明授权

US08990157B2 Replication support for structured data 有权
标题翻译：对结构化数据的复制支持
公开(公告)号：US08990157B2
公开(公告)日：2015-03-24
申请号：US13299931
申请日：2011-11-18
申请人： Ping Zhou , Stephen Shepherd
发明人： Ping Zhou , Stephen Shepherd
IPC分类号： G06F17/30
CPC分类号： G06F17/30575
摘要： A method, system and computer readable storage medium for replicating structured data stored in a database. The method includes identifying the stored structured data, mapping the data to an unstructured data type, and sending the mapped data to one or more replicate databases as unstructured data.
摘要翻译：一种用于复制存储在数据库中的结构化数据的方法，系统和计算机可读存储介质。该方法包括识别存储的结构化数据，将数据映射到非结构化数据类型，以及将映射的数据作为非结构化数据发送到一个或多个复制数据库。

9. 发明申请

US20120317078A1 Replication Support for Structured Data 有权
标题翻译：复制支持结构化数据
公开(公告)号：US20120317078A1
公开(公告)日：2012-12-13
申请号：US13299931
申请日：2011-11-18
申请人： Ping Zhou , Stephen Shepherd
发明人： Ping Zhou , Stephen Shepherd
IPC分类号： G06F7/00
CPC分类号： G06F17/30575
摘要： A method, system and computer readable storage medium for replicating structured data stored in a database. The method includes identifying the stored structured data, mapping the data to an unstructured data type, and sending the mapped data to one or more replicate databases as unstructured data.
摘要翻译：一种用于复制存储在数据库中的结构化数据的方法，系统和计算机可读存储介质。该方法包括识别存储的结构化数据，将数据映射到非结构化数据类型，以及将映射的数据作为非结构化数据发送到一个或多个复制数据库。

10. 发明申请

US20120284383A1 CLOUD WORKLOAD MANAGEMENT WITH AUTOMATED WORKLOAD BIDDING 审中-公开
标题翻译：具有自动工作负载的云工作负载管理
公开(公告)号：US20120284383A1
公开(公告)日：2012-11-08
申请号：US13102538
申请日：2011-05-06
申请人： Clark A. Dudek , Phillip D. Jones , David B. Roberts , Adrian X. Rodriguez , Ian C. Tewksbury , Ping Zhou
发明人： Clark A. Dudek , Phillip D. Jones , David B. Roberts , Adrian X. Rodriguez , Ian C. Tewksbury , Ping Zhou
IPC分类号： G06F15/173
CPC分类号： G06F9/5072 , G06F9/5027
摘要： A computer program product is provided for managing workload in a computer system. Computer usable program code cause a first compute node to broadcast a workload bid request to a plurality of compute nodes, wherein the workload bid request includes workload parameters. The compute nodes each receive the request from the first compute node, and each compute node uses the workload parameters to calculate a cost of running the workload. One or more individual compute nodes within the plurality of compute nodes send a workload bid to the first compute node, wherein each workload bid includes the cost of running the workload on the individual compute node sending the workload bid. The first compute node receives and uses each workload bid to select a target compute node to run the workload, wherein the target compute node is selected from the individual compute nodes and the first compute node.
摘要翻译：提供了一种用于管理计算机系统中的工作负载的计算机程序产品。计算机可用程序代码导致第一计算节点向多个计算节点广播工作负荷出价请求，其中所述工作负荷出价请求包括工作负载参数。计算节点各自接收来自第一计算节点的请求，并且每个计算节点使用工作负载参数来计算运行工作负载的成本。多个计算节点内的一个或多个单独计算节点向第一计算节点发送工作负荷出价，其中每个工作负荷出价包括在发送工作量出价的个别计算节点上运行工作负荷的成本。第一计算节点接收并使用每个工作负荷出价来选择目标计算节点来运行工作负载，其中从各个计算节点和第一计算节点中选择目标计算节点。

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