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61. 发明授权

US08986944B2 Methods and compositions for separating rare cells from fluid samples 有权
标题翻译：用于从流体样品中分离稀有细胞的方法和组合物
公开(公告)号：US08986944B2
公开(公告)日：2015-03-24
申请号：US11497919
申请日：2006-08-02
申请人： Douglas T. Yamanishi , Paul G. Hujsak , Sara F. Snyder , George Walker , Junquan Xu , Mingxian Huang , Guoliang Tao , Lei Wu , Xiaobo Wang , Joe Ouyang , Charina Schmitigal , Jing Cheng , Jia Xu
发明人： Douglas T. Yamanishi , Paul G. Hujsak , Sara F. Snyder , George Walker , Junquan Xu , Mingxian Huang , Guoliang Tao , Lei Wu , Xiaobo Wang , Joe Ouyang , Charina Schmitigal , Jing Cheng , Jia Xu
IPC分类号： C12Q1/24 , C12Q1/68 , G01N1/40 , G01N33/569 , G01N33/574 , B01L3/00
CPC分类号： C12Q1/6881 , B01L3/5027 , C12N5/0602 , G01N1/40 , G01N1/4077 , G01N33/56966 , G01N33/57407 , G01N2333/4724 , Y10T436/25375
摘要： The present invention includes methods of enriching rare cells, such as cancer cells, from biological samples, such as blood samples. The methods include performing at least one debulking step on a blood sample and selectively removing at least one type undesirable component from the blood sample to obtain a blood sample that is enriched in a rare cell of interest. In some embodiments magnetic beads coupled to specific binding members are used to selectively removed components.
摘要翻译：本发明包括从诸如血液样品的生物样品中富集稀有细胞如癌细胞的方法。所述方法包括对血液样品进行至少一个减压步骤，并从血液样品中选择性地除去至少一种不需要的组分以获得富含稀有细胞的血液样品。在一些实施例中，耦合到特定结合构件的磁珠用于选择性地去除组分。

62. 发明授权

US08680016B2 Testing method of nucleic acid binding protein based on biochip 有权
标题翻译：基于生物芯片的核酸结合蛋白检测方法
公开(公告)号：US08680016B2
公开(公告)日：2014-03-25
申请号：US11791157
申请日：2004-11-23
申请人： Wei Shao , Yongchao Zhao , Yimin Sun , Jiying Qiao , Huajiang Wei , Weiping Yang , Yuxiang Zhou , Jing Cheng
发明人： Wei Shao , Yongchao Zhao , Yimin Sun , Jiying Qiao , Huajiang Wei , Weiping Yang , Yuxiang Zhou , Jing Cheng
IPC分类号： C40B20/02
CPC分类号： G01N33/54366 , C12Q1/6806 , C12Q1/6837 , C12Q2565/531 , C12Q2565/501 , C12Q2563/131
摘要： A testing method of nucleic acid binding protein based on biochip, comprises the following steps: 1. puts a plurality of groups solution including nucleic acid captured probes into biological sample including a plurality of nucleic acid binding protein to be test, and thus forming nucleic acid captured probe-nucleic acid binding protein complexes; such nucleic acid captured probe includes at least a segment of binding sequence which can bind with aimed nucleic acid binding protein; 2. separates such nucleic acid captured probe-nucleic acid binding protein complexes, then recoveries nucleic acid captured probes; 3. hybridizes the nucleic acid captured probes according to step 2 with a plurality of single strand blotting probes on biochip substrate; the sequence of such blotting probe compensates with such nucleic acid captured probe or one of its strand; 4. detects the result of hybridization.
摘要翻译：一种基于生物芯片的核酸结合蛋白的检测方法，包括以下步骤：1.将包含核酸捕获探针的多组溶液放入包括待测试的多种核酸结合蛋白的生物样品中，从而形成核酸捕获的探针 - 核酸结合蛋白复合物; 此类核酸捕获的探针包括可与靶核酸结合蛋白结合的至少一段结合序列; 2.分离这些核酸捕获的探针 - 核酸结合蛋白复合物，然后回收核酸捕获的探针; 3.将根据步骤2的核酸捕获探针与生物芯片底物上的多个单链印迹探针杂交; 这种印迹探针的序列用这种核酸捕获的探针或其一条链补偿; 4.检测杂交结果。

63. 发明授权

US08636954B2 Calibration slide for fluorescence detection instruments and process of preparation 有权
标题翻译：用于荧光检测仪器的校准载玻片和制备过程
公开(公告)号：US08636954B2
公开(公告)日：2014-01-28
申请号：US11660469
申请日：2004-11-22
申请人： Yu Ge , Wenjun Yang , Shuying Zhao , Lianghong Guo , Jing Cheng
发明人： Yu Ge , Wenjun Yang , Shuying Zhao , Lianghong Guo , Jing Cheng
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/278 , Y10T436/255
摘要： The present invention relates to calibration slides for fluorescence detection instruments and processing method of making them. The aim of this invention is to disclose calibration slides with high photostability and long lifetime for fluorescence detection instruments. The calibration slides are fabricated by patterning calibration spot arrays of modified inorganic phosphors on the glass slide. The process for producing a calibration slide comprises the following procedure: 1) Dispersing the inorganic phosphors of rare-earth doped complex in water; 2) Patterning the array of the above suspension on the glass slide. The calibration slides in the present invention employ a very stable fluorescing material that is insensitive to photobleaching, has long lifetime and stability under mild storage condition. The calibration slides in the present invention can be used to calibrate and test for some fluorescence instruments, i.e. microarray scanner, fluorescent microscopy, fluorescence spectrometer, fluorescent multiwell-plate reader.
摘要翻译：本发明涉及用于荧光检测仪器的校准载片及其制作方法。本发明的目的是公开具有高荧光检测仪器的高光稳定性和长寿命的校准载玻片。通过在玻璃载片上图案化修饰的无机磷光体的校准点阵列来制造校准载玻片。制备校准载玻片的方法包括以下步骤：1）将稀土掺杂络合物的无机磷光体分散在水中; 2）将上述悬浮液的阵列图案化在载玻片上。本发明中的校准载玻片使用对光漂白不敏感的非常稳定的荧光材料，在温和储存条件下具有长寿命和稳定性。本发明中的校准载玻片可用于校准和测试一些荧光仪器，即微阵列扫描仪，荧光显微镜，荧光光谱仪，荧光多孔板读数器。

64. 发明授权

US08353685B2 Method for fluid transfer and the micro peristaltic pump 有权
标题翻译：流体转移方法和微蠕动泵
公开(公告)号：US08353685B2
公开(公告)日：2013-01-15
申请号：US10543619
申请日：2003-07-14
申请人： Chengxun Liu , Min Guo , Jing Cheng
发明人： Chengxun Liu , Min Guo , Jing Cheng
IPC分类号： F04B17/00
CPC分类号： F04B43/02 , F04B43/028 , F04B43/14
摘要： This invention relates generally to the field of peristaltic pump. In particular, the invention provides a peristaltic pump, which peristaltic pump comprises, inter alia, an actuating part, a cartridge part comprising at least three chambers and mechanisms for controlling movement of the actuating part to and from the cartridge part to control opening or closing of the inlet and outlet to the chamber(s).
摘要翻译：本发明一般涉及蠕动泵领域。特别地，本发明提供了一种蠕动泵，蠕动泵尤其包括致动部件，包括至少三个腔室的药筒部分和用于控制致动部件到药筒部分和从药筒部分移动以控制打开或关闭的机构的入口和出口到腔室。

65. 发明申请

US20120328597A1 Topical Compositions Comprising Fermented Extracts of Traditional Chinese Medicinal (TCM) Ingredients, and Methods of Making and Using Same 有权
标题翻译：中成药发酵提取物的专题组成及其制作与使用方法
公开(公告)号：US20120328597A1
公开(公告)日：2012-12-27
申请号：US13270529
申请日：2011-10-11
申请人： Jing Cheng , Chia-Wen Chen , Steven Francis Schnittger , Ming Lu
发明人： Jing Cheng , Chia-Wen Chen , Steven Francis Schnittger , Ming Lu
IPC分类号： A61K8/97 , A61K36/28 , A61K36/539 , A61Q19/00 , A61K36/899 , A61K36/804 , A61P17/10 , A61Q19/08 , A61K36/752 , A61K36/535
CPC分类号： A61K36/725 , A61K8/97 , A61K8/99 , A61K36/06 , A61K36/068 , A61K36/074 , A61K36/076 , A61K36/10 , A61K36/16 , A61K36/185 , A61K36/23 , A61K36/235 , A61K36/236 , A61K36/258 , A61K36/28 , A61K36/41 , A61K36/535 , A61K36/539 , A61K36/65 , A61K36/69 , A61K36/704 , A61K36/752 , A61K36/756 , A61K36/804 , A61K36/8998 , A61K2800/85 , A61Q19/00
摘要： The present invention relates to topical compositions containing fermented extracts of Traditional Chinese Medicinal (TCM) ingredients for improving the appearance and skin condition of the user. The topical compositions of the present invention are tailored for different users of different skin compositions according to TCM principles. The fermented TCM extracts are characterized by reduced odor and/or color in comparison with unfermented TCM extracts and are therefore more suitable for use in cosmetic products.
摘要翻译：本发明涉及含有用于改善使用者的外观和皮肤状况的中药（TCM）成分的发酵提取物的局部组合物。根据TCM原理，本发明的局部组合物针对不同皮肤组合物的不同使用者而定制。与未发酵的TCM提取物相比，发酵的TCM提取物的特征在于减少气味和/或颜色，因此更适合用于化妆品。

66. 发明授权

US08137622B2 Device for washing and hybridization of biochips 有权
标题翻译：用于生物芯片的洗涤和杂交的装置
公开(公告)号：US08137622B2
公开(公告)日：2012-03-20
申请号：US12527184
申请日：2007-10-09
申请人： Hang Li , Jianxin Ye , Xingling Al , Xianhua Wang , Liang Zhang , Jing Cheng
发明人： Hang Li , Jianxin Ye , Xingling Al , Xianhua Wang , Liang Zhang , Jing Cheng
IPC分类号： B01F11/00 , B01F11/04
CPC分类号： B08B3/044 , B01F11/0028 , B01J2219/00326 , B01J2219/00328 , B01J2219/00527 , B01J2219/00659 , B01L7/00 , B01L2300/0819 , B08B11/02 , Y10S435/809
摘要： A device for biochip hybridization or washing is provided, which comprises a carousel (12), a translational movement controller, a revolving movement controller, and optionally a heating chamber (13). The revolving movement controller controls the revolving movement of the carousel and allows it to move in a wobbling fashion, allowing liquid movement of the hybridization or washing boxes (11) during hybridization and/or washing of biochips on the carousel. The translational movement controller brings the carousel back to horizontal position once the revolving movement controller stops, thereby ensures that the liquid do not spill out. The heating chamber circulates hot air within the device, thereby ensures that the hybridization and washing in a thermostatic condition.
摘要翻译：提供了用于生物芯片杂交或洗涤的装置，其包括圆盘传送带（12），平移运动控制器，旋转运动控制器和可选的加热室（13）。旋转运动控制器控制圆盘传送带的旋转运动，并允许其以摆动的方式移动，允许杂交或洗涤盒（11）在传送带上的生物芯片的杂交和/或洗涤期间的液体移动。一旦旋转运动控制器停止，平移运动控制器将转盘回到水平位置，从而确保液体不会溢出。加热室在装置内循环热空气，从而确保在恒温条件下进行杂交和洗涤。

67. 发明授权

US08124382B2 Methods, microarray, and kits for detection of drug resistance genes in gram-negative bacteria 有权
标题翻译：用于检测革兰氏阴性菌耐药基因的方法，微阵列和试剂盒
公开(公告)号：US08124382B2
公开(公告)日：2012-02-28
申请号：US12097237
申请日：2007-01-18
申请人： Lingxiang Zhu , Zhiwei Zhang , Di Jiang , Ning Du , Can Wang , Huawei Yang , Qiong Zhang , Huafang Gao , Yuxiang Zhou , Jing Cheng
发明人： Lingxiang Zhu , Zhiwei Zhang , Di Jiang , Ning Du , Can Wang , Huawei Yang , Qiong Zhang , Huafang Gao , Yuxiang Zhou , Jing Cheng
IPC分类号： C12P19/34
CPC分类号： C12Q1/689 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166
摘要： The present invention provides kits and microarrays containing primer pairs for amplifying drug resistance genes and/or probes for detection of drug resistance genes. Also provided are methods of detecting drug resistance genes using kits and microarrays described herein.
摘要翻译：本发明提供了包含用于扩增用于检测药物抗性基因的药物抗性基因和/或探针的引物对的试剂盒和微阵列。还提供了使用本文所述的试剂盒和微阵列检测药物抗性基因的方法。

68. 发明申请

US20110177339A1 FLUORESCENT MAGNETIC NANOPARTICLES AND PROCESS OF PREPARATION 有权
标题翻译：荧光磁性纳米粒子及其制备方法
公开(公告)号：US20110177339A1
公开(公告)日：2011-07-21
申请号：US12970688
申请日：2010-12-16
申请人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
发明人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
IPC分类号： B32B5/16 , B05D7/00 , B06B1/20
CPC分类号： B82Y15/00 , G01N33/54326 , G01N33/588 , Y10T428/2991
摘要： This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.
摘要翻译：本发明提供纳米级荧光磁性颗粒及其制备方法。纳米颗粒具有包含磁性材料和荧光材料的核心颗粒，并且其粒径小于约1微米。纳米颗粒可以用无机或有机层涂覆并且可以进行表面改性。纳米颗粒可用于许多生物测定。

69. 发明授权

US07857957B2 Integrated portable biological detection system 失效
标题翻译：综合便携式生物检测系统
公开(公告)号：US07857957B2
公开(公告)日：2010-12-28
申请号：US11702417
申请日：2007-02-05
申请人： Jing Cheng , Lei Wu , Michael J. Heller , Edward L. Sheldon , Jonathan M. Diver , James P. O'Connell , Dan Smolko , Shila Jalali , David Willoughby
发明人： Jing Cheng , Lei Wu , Michael J. Heller , Edward L. Sheldon , Jonathan M. Diver , James P. O'Connell , Dan Smolko , Shila Jalali , David Willoughby
IPC分类号： G01N27/447 , C12N1/06
CPC分类号： C12Q1/24 , B01L3/502 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L2400/0424 , B01L2400/0487 , G01N21/6428
摘要： We have performed separation of bacterial and cancer cells from peripheral human blood in microfabricated electronic chips by dielectrophoresis. The isolated cells were examined by staining the nuclei with fluorescent dye followed by laser induced fluorescence imaging. We have also released DNA and RNA from the isolated cells electronically and detected specific marker sequences by DNA amplification followed by electronic hybridization to immobilized capture probes. Efforts towards the construction of a “laboratory-on-a-chip” system are presented which involves the selection of DNA probes, dyes, reagents and prototyping of the fully integrated portable instrument.
摘要翻译：我们通过介电电泳在微细电子芯片中进行细胞和癌细胞与外周血液分离。通过用荧光染料染色细胞核，然后激光诱导荧光成像来检查分离的细胞。我们还通过电子方式从分离的细胞中释放DNA和RNA，并通过DNA扩增检测特异性标记序列，然后与固定的捕获探针进行电子杂交。提出了建立“芯片实验室”系统的努力，其中包括选择DNA探针，染料，试剂和完全集成的便携式仪器的原型。

70. 发明授权

US07776580B2 Magnetism based rapid cell separation 有权
标题翻译：基于磁性的快速细胞分离
公开(公告)号：US07776580B2
公开(公告)日：2010-08-17
申请号：US10538498
申请日：2002-12-31
申请人： Xu Zhang , Xin Xie , Depu Chen , Weiyang Fei , Jing Cheng
发明人： Xu Zhang , Xin Xie , Depu Chen , Weiyang Fei , Jing Cheng
IPC分类号： C12N7/02 , C12N5/00 , C12N1/02 , C12P19/34 , G01N33/50
CPC分类号： G01N33/54333 , C12N1/02 , C12N7/00 , C12N2760/16051 , C12N2795/14151 , C12Q1/24 , G01N33/54326
摘要： This invention relates generally to the field of cell seperation. In particular, the invention provides processes for isolating a target cell, cellular organelle or virus from a sample, using inter alia, nonspecific binding between a target cell, cellular organelle or virus with a magnetic microbead modified to comprise hydroxyl, carboxyl or epoxy groups.
摘要翻译：本发明一般涉及细胞分离领域。特别地，本发明提供了从样品中分离靶细胞，细胞器官细胞或病毒的方法，尤其是靶细胞，细胞器或病毒与修饰成包含羟基，羧基或环氧基团的磁性微珠之间非特异性结合。

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