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61. 发明申请

US20050208138A1 Local regional chemotherapy and radiotherapy using in situ hydrogel 审中-公开
标题翻译：局部局部化疗和放疗使用原位水凝胶
公开(公告)号：US20050208138A1
公开(公告)日：2005-09-22
申请号：US11036580
申请日：2005-01-14
申请人： David Yang , Dong-Fang Yu , Ali Azhdarinia , Tommy Lee , E. Kim
发明人： David Yang , Dong-Fang Yu , Ali Azhdarinia , Tommy Lee , E. Kim
IPC分类号： A61K47/30 , A61K9/00 , A61K9/16 , A61K31/337 , A61K31/555 , A61K31/7048 , A61K31/717 , A61K31/718 , A61K31/721 , A61K31/722 , A61K31/728 , A61K31/729 , A61K35/76 , A61K36/00 , A61K38/00 , A61K38/22 , A61K47/02 , A61K47/04 , A61K47/18 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/48 , A61K48/00 , A61K51/00 , A61K51/06 , A61K51/12 , A61M37/00 , A61P31/00 , A61P35/00 , A61K9/14 , A61M31/00
CPC分类号： A61K51/1255 , A61K9/0024 , A61K9/1652 , A61K31/717 , A61K31/718 , A61K31/721 , A61K31/722 , A61K31/728 , A61K31/729 , A61K47/183 , A61K47/36 , A61K47/38 , A61K47/6903 , A61K51/06 , A61K51/1213
摘要： Methods regarding local regional treatment in situ for an individual, such as of a tumor, are provided herein. A hydrogel composition is generated in situ in the tumor by administering a polymer, such as a polysaccharide or a polyamino acid, with a therapeutic agent, such as a radionuclide or a drug, and administering a cross-linking agent. The hydrogel/therapeutic agent composition is retained in the tumor for safe and efficient tumor therapy. Alternatively, a hydrogel composition is generated in situ in an artery which nourishes a tumor to occlude the artery.
摘要翻译：本文提供了关于个体如肿瘤的原位局部局部治疗的方法。通过使用诸如多糖或多氨基酸的聚合物与治疗剂如放射性核素或药物一起在肿瘤中原位产生水凝胶组合物，并施用交联剂。水凝胶/治疗剂组合物保留在肿瘤中用于安全和有效的肿瘤治疗。或者，在动脉中产生水凝胶组合物，该动脉会滋养肿瘤以闭塞动脉。

62. 发明申请

US20050129619A1 N2S2 chelate-targeting ligand conjugates 有权
标题翻译： N2S2螯合靶向配体缀合物
公开(公告)号：US20050129619A1
公开(公告)日：2005-06-16
申请号：US10732919
申请日：2003-12-10
申请人： David Yang , Dong-Fang Yu , Chang-Sok Oh , Jerry Bryant
发明人： David Yang , Dong-Fang Yu , Chang-Sok Oh , Jerry Bryant
IPC分类号： A61K51/04 , A61K51/08 , A61K51/10 , A61K49/00 , A61K51/00 , C07F5/00 , C07K16/46
CPC分类号： A61K51/1093 , A61K51/0497 , A61K51/088
摘要： The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor angiogenesis targeting ligand, a tumor apoptosis targeting ligand, a disease receptor targeting ligand, amifostine, angiostatin, monoclonal antibody C225, monoclonal antibody CD31, monoclonal antibody CD40, capecitabine, a COX-2 inhibitor, deoxycytidine, fullerene, herceptin, human serum albumin, lactose, leuteinizing hormone, pyridoxal, quinazoline, thalidomide, transferrin, or trimethyl lysine. The present invention also pertains to kits employing the compounds of interest, and methods of assessing the pharmacology of an agent of interest using the present compounds.
摘要翻译：本发明在一般意义上提供了使用与靶向配体缀合的N 2 S 2 N 2螯合物的化合物的新标记策略，其中靶向配体是疾病细胞周期靶向化合物，肿瘤血管生成靶向配体，肿瘤凋亡靶向配体，疾病受体靶向配体，氨磷汀，血管抑素，单克隆抗体C225，单克隆抗体CD31，单克隆抗体CD40，卡培他滨，COX-2抑制剂，脱氧胞苷，富勒烯，赫赛汀，人血清白蛋白，乳糖，促黄体激素，吡哆醛，喹唑啉，沙利度胺，转铁蛋白或三甲基赖氨酸。本发明还涉及使用目的化合物的试剂盒，以及使用本发明化合物评价感兴趣剂的药理学的方法。

63. 发明申请

US20050100506A1 Mechanism-based targeted pancreatic beta cell imaging and therapy 有权
标题翻译：基于机制的靶向胰腺β细胞成像和治疗
公开(公告)号：US20050100506A1
公开(公告)日：2005-05-12
申请号：US10942615
申请日：2004-09-16
申请人： David Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
发明人： David Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
IPC分类号： A61K31/175 , A61K31/426 , A61K31/4439 , A61K51/00 , A61K51/04
CPC分类号： A61K51/0497
摘要： Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
摘要翻译：用于成像胰腺β细胞的组合物包含螯合剂 - 抗糖尿病药物缀合物和任选的螯合金属。

64. 发明授权

US06538593B2 Method and apparatus for converting a low dynamic range analog signal to a large dynamic range floating-point digital representation 有权
公开(公告)号：US06538593B2
公开(公告)日：2003-03-25
申请号：US10085341
申请日：2002-02-28
申请人： David Yang , Abbas El Gamal , Boyd Fowler
发明人： David Yang , Abbas El Gamal , Boyd Fowler
IPC分类号： H03M1102
CPC分类号： H04N5/2355 , H03M1/38 , H04N5/243
摘要： An analog-to-digital conversion scheme allows the conversion of a small dynamic range analog signal into a floating-point, digital representation with a larger dynamic range. A montonically changing analog signal is reset to a reference value at time t=0. The analog signal is then sub-converted by an analog-to-digital converter with maximum input signal level Ss to corresponding digital representations at several sub-conversion times t=T2>T1, t=T3>T2, . . . t=TM>TM−1, where TM≦T. These digital representations are then suitably combined to produce a cumulative, floating-point digital representation which accurately represents the analog signal even if the analog signal has a value greater than Ss at time t=T.

65. 发明授权

US06515017B1 Water soluble paclitaxel derivatives 有权
公开(公告)号：US06515017B1
公开(公告)日：2003-02-04
申请号：US10153818
申请日：2002-05-24
申请人： Chun Li , Sidney Wallace , Dong-Fang Yu , David Yang
发明人： Chun Li , Sidney Wallace , Dong-Fang Yu , David Yang
IPC分类号： A61K31335
CPC分类号： A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要： Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.

66. 发明授权

US06369737B1 Method and apparatus for converting a low dynamic range analog signal to a large dynamic range floating-point digital representation 失效
标题翻译：用于将低动态范围模拟信号转换为大动态范围浮点数字表示的方法和装置
公开(公告)号：US06369737B1
公开(公告)日：2002-04-09
申请号：US08960823
申请日：1997-10-30
申请人： David Yang , Abbas El Gamal , Boyd Fowler
发明人： David Yang , Abbas El Gamal , Boyd Fowler
IPC分类号： H03M112
CPC分类号： H04N5/2355 , H03M1/38 , H04N5/243
摘要： An analog-to-digital conversion scheme allows the conversion of a small dynamic range analog signal into a floating-point, digital representation with a larger dynamic range. A montonically changing analog signal is reset to a reference value at time t=0. The analog signal is then sub-converted by an analog-to-digital converter with maximum input signal level Ss to corresponding digital representations at several sub-conversion times t=T2>T1t=T3>T2, . . . t=TM>TM−1, where TM≦T. These digital representations are then suitably combined to produce a cumulative, floating-point digital representation which accurately represents the analog signal even if the analog signal has a value greater than Ss at time t=T.
摘要翻译：模数转换方案允许将小动态范围模拟信号转换成具有较大动态范围的浮点数字表示。在时刻t = 0，将一个单态变化的模拟信号复位为一个参考值。然后，模拟信号通过具有最大输入信号电平Ss的模数转换器在几个子转换时间t = T2> T1t = T3> T2处对应的数字表示进行子转换。。。 t = TM> TM-1，其中TM <= T。这些数字表示然后被适当地组合以产生即使在时间t = T时模拟信号具有大于Ss的值也能精确地表示模拟信号的累积浮点数字表示。

67. 发明授权

US5801657A Serial analog-to-digital converter using successive comparisons 失效
标题翻译：使用连续比较的串行模数转换器
公开(公告)号：US5801657A
公开(公告)日：1998-09-01
申请号：US795497
申请日：1997-02-05
申请人： Boyd Fowler , David Yang , Abbas El Gamal
发明人： Boyd Fowler , David Yang , Abbas El Gamal
IPC分类号： H03M1/12 , H03M1/46 , H03M1/38
CPC分类号： H03M1/123 , H03M1/46
摘要： A method for simultaneously performing bit serial analog to digital conversion (ADC) for a potentially very large number of signals is described. The method is ideally suited for performing on chip ADC in area image sensors. In one embodiment, to achieve N-bit precision, the method employs a one-bit comparator per channel (or set of multiplexed channels) and an N-bit DAC. To achieve N bits of precision, 2.sup.N -1 comparisons are sequentially performed. Each comparison is performed by first setting the DAC output to the desired value and then simultaneously comparing each of the pixel values to that value. If a pixel value is greater than the DAC output value, its comparator outputs a one, otherwise it outputs a zero. By appropriately choosing the sequence of comparison values, the pixel values are sequentially generated. In another embodiment, the DAC is omitted and a continuous ramp signal is generated for comparison with the analog input.
摘要翻译：描述了用于同时执行位串行模数转换（ADC）用于潜在非常大量信号的方法。该方法非常适合在区域图像传感器中执行片上ADC。在一个实施例中，为了实现N位精度，该方法采用每通道（或多路复用通道组）和N位DAC的一位比较器。为了实现N位精度，依次执行2N-1比较。通过首先将DAC输出设置为期望值，然后同时将每个像素值与该值进行比较来执行每个比较。如果像素值大于DAC输出值，则其比较器输出1，否则输出零。通过适当地选择比较值的顺序，依次生成像素值。在另一个实施例中，省略了DAC，并且生成连续的斜坡信号以与模拟输入进行比较。

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