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61. 发明申请

US20140027659A1 VALVE EXTENSION HANDLE 审中-公开
标题翻译：阀门伸缩手柄
公开(公告)号：US20140027659A1
公开(公告)日：2014-01-30
申请号：US13558629
申请日：2012-07-26
申请人： Mukesh Kumar
发明人： Mukesh Kumar
IPC分类号： F16K31/44
CPC分类号： F16K31/465 , A47J37/0713 , F16K31/46 , G05G1/08
摘要： A valve extension handle is disclosed in the present invention. Said valve extension handle is comprised of a extension member with opposed first and second ends, a clamping member connected to the first end of the extension member, and a control member connected to the second end of the extension member. Said clamping member can be attached to the gas tank valve. When the control member connected to the second end of the extension member is turned, the clamping member attached to gas tank valve moves gas tank valve to turn on or shut off the gas flow from said tank.
摘要翻译：在本发明中公开了一种阀延伸手柄。所述阀延伸手柄包括具有相对的第一和第二端的延伸构件，连接到延伸构件的第一端的夹紧构件和连接到延伸构件的第二端的控制构件。所述夹紧构件可以附接到气罐阀。当连接到延伸构件的第二端的控制构件转动时，附接到气罐阀的夹紧构件移动气罐阀，以打开或关闭来自所述罐的气体流。

62. 发明授权

US08608532B2 Climate control duct architecture for a vehicle 有权
公开(公告)号：US08608532B2
公开(公告)日：2013-12-17
申请号：US12148833
申请日：2008-04-23
申请人： Mukesh Kumar , Paul Hoke , Mark Doroudian
发明人： Mukesh Kumar , Paul Hoke , Mark Doroudian
IPC分类号： B60H1/24 , F24F7/04
CPC分类号： B60H1/00564 , B60H1/242 , B60H1/246 , B60H2001/00092
摘要： A climate control duct architecture having partitions to provide effective distribution of air immediately as it exits the HVAC. By strategic positioning and configuring of the partitions the duct architecture may be tuned to provide maximum console airflow and desired system airflow distribution with a minimum amount of interference to the airflow due to turbulence.

63. 发明授权

US08603458B2 Genetic adjuvants for immunotherapy 失效
公开(公告)号：US08603458B2
公开(公告)日：2013-12-10
申请号：US12476896
申请日：2009-06-02
申请人： Shyam S. Mohapatra , Mukesh Kumar
发明人： Shyam S. Mohapatra , Mukesh Kumar
IPC分类号： A61K48/00 , A61K39/385
CPC分类号： A61K38/217 , A61K38/208 , A61K39/35 , A61K39/36 , A61K39/39 , A61K2039/53 , A61K2039/55522 , A61K2039/55538
摘要： The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of nucleic acid molecules encoding interleukin-12 (IL-12), interferon-gamma (IFN-γ), or a combination thereof, to a patient in need of such treatment. The pharmaceutical compositions of the invention contain nucleic acid molecules encoding IL-12 and/or IFN-γ and an operably-linked promoter sequence. In another aspect, the present invention concerns expression vectors containing a nucleotide sequence encoding IL-12 and IFN-γ, and an operably-linked promoter sequence. In another aspect, the present invention concerns cells genetically modified with a nucleotide sequence encoding IL-12 and IFN-γ.

64. 发明申请

US20130207420A1 CLIMATE CONTROL SYSTEM FOR A VEHICLE 审中-公开
标题翻译：一种车辆的气候控制系统
公开(公告)号：US20130207420A1
公开(公告)日：2013-08-15
申请号：US13396941
申请日：2012-02-15
申请人： Mukesh Kumar , Martha Elizabeth Nefcy , Lawrence C. Karas , Paul Bryan Hoke , Harry Christian Martinez , Spencer Dinkins , Frank Fusco , Eric R. Yerke
发明人： Mukesh Kumar , Martha Elizabeth Nefcy , Lawrence C. Karas , Paul Bryan Hoke , Harry Christian Martinez , Spencer Dinkins , Frank Fusco , Eric R. Yerke
IPC分类号： B60J7/043
CPC分类号： B60H1/245 , B60H1/00564 , B60H2001/002 , B60H2001/00242 , B62D25/06
摘要： A climate control system for a vehicle includes an air conditioner positioned in a rear of the vehicle. A roof panel includes a moonroof opening bounded on at least one side by a moonroof rail. The moonroof rail generally defines an air supply duct between a headliner and the roof panel. The air supply duct is in communication with the air conditioner. A plurality of vents are operably connected to the moonroof rail and relay conditioned air from the air supply duct to an interior of the vehicle.
摘要翻译：用于车辆的气候控制系统包括位于车辆后部的空调。屋顶面板包括通过月球轨道限定在至少一侧的天窗。天窗轨道通常在顶篷和屋顶板之间限定一个供气管道。供气管与空气调节器连通。多个通风口可操作地连接到月球轨道，并将调节空气从空气供应管道传递到车辆的内部。

65. 发明授权

US08500819B2 Drug delivery and diagnostic system for orthopedic implants 有权
标题翻译：骨科植入物的药物输送和诊断系统
公开(公告)号：US08500819B2
公开(公告)日：2013-08-06
申请号：US13039362
申请日：2011-03-03
申请人： Jason Meridew , Mukesh Kumar , Tayler E. Kreider
发明人： Jason Meridew , Mukesh Kumar , Tayler E. Kreider
IPC分类号： A61N1/30
CPC分类号： A61M5/14 , A61F2/34 , A61F2/3662 , A61F2/389 , A61F2002/3068 , A61F2002/368 , A61F2002/3694 , A61M5/14276 , A61M39/0208 , A61M2205/3523 , A61M2210/086
摘要： A drug delivery and diagnostic system can include an orthopedic implant having an outer attachment surface. A conduit can be coupled to the outer attachment surface. The conduit can have an inlet and a plurality of perforations formed along a length thereof. The conduit can be adapted to pass fluid between the inlet and the perforations. A subcutaneous port can be fluidly coupled to the inlet and be adapted to communicate fluid through the inlet, along the conduit and out of the perforations around and along the outer attachment surface of the orthopedic implant.
摘要翻译：药物递送和诊断系统可以包括具有外部附接表面的矫形植入物。管道可以联接到外部附接表面。导管可以具有沿其长度形成的入口和多个穿孔。导管可适于在入口和穿孔之间传递流体。皮下端口可以流体地联接到入口，并且适于沿着导管和通过整形外科植入物的外部附接表面的穿孔穿过入口传送流体。

66. 发明授权

US08407158B2 System and method for providing interactive troubleshooting 有权
标题翻译：提供交互式故障排除的系统和方法
公开(公告)号：US08407158B2
公开(公告)日：2013-03-26
申请号：US12233637
申请日：2008-09-19
申请人： Syam S. Suri , Mukesh Kumar , Ravi S. Guduru
发明人： Syam S. Suri , Mukesh Kumar , Ravi S. Guduru
IPC分类号： G06F17/00 , G06N5/00
CPC分类号： H04L41/5061 , G06Q10/10 , H04L41/5074
摘要： An approach provides interactive troubleshooting. A robotic chat application receives a service inquiry over a chat session from a chat-enabled device, wherein the service inquiry is associated with a service provider network. A troubleshooting engine collects information from a user of the chat-enabled device regarding the service inquiry. The robotic chat application retrieves a flow definition and an associated query corresponding to the service inquiry based upon the collected information. The troubleshooting engine generates a command, based on the query, for resolving the service inquiry.
摘要翻译：一种方法提供交互式故障排除。机器人聊天应用程序通过来自启用聊天的设备的聊天会话接收服务查询，其中服务询问与服务提供商网络相关联。故障排除引擎从具有聊天功能的设备的用户收集有关服务查询的信息。机器人聊天应用程序基于所收集的信息检索对应于服务询问的流定义和相关联的查询。故障排除引擎根据查询生成一个用于解析服务查询的命令。

67. 发明授权

US08292967B2 Method and apparatus for use of porous implants 有权
标题翻译：使用多孔植入物的方法和装置
公开(公告)号：US08292967B2
公开(公告)日：2012-10-23
申请号：US11294692
申请日：2005-12-05
申请人： David R Brown , Brian May , Jennifer Woodell-May , Jacy C Hoeppner , Elizabeth Schlueter , Mukesh Kumar , John R White , Russell Parrott
发明人： David R Brown , Brian May , Jennifer Woodell-May , Jacy C Hoeppner , Elizabeth Schlueter , Mukesh Kumar , John R White , Russell Parrott
IPC分类号： A61F2/32
CPC分类号： A61B17/7225 , A61B17/0401 , A61B17/866 , A61B2017/00831 , A61B2017/0459 , A61F2/0811 , A61F2/30767 , A61F2/30907 , A61F2/36 , A61F2/367 , A61F2/3859 , A61F2/40 , A61F2002/2817 , A61F2002/30013 , A61F2002/30153 , A61F2002/30187 , A61F2002/30217 , A61F2002/30276 , A61F2002/30329 , A61F2002/30387 , A61F2002/30433 , A61F2002/30449 , A61F2002/30451 , A61F2002/30596 , A61F2002/30616 , A61F2002/30677 , A61F2002/30733 , A61F2002/30736 , A61F2002/30738 , A61F2002/30785 , A61F2002/30787 , A61F2002/30823 , A61F2002/30878 , A61F2002/30909 , A61F2002/30915 , A61F2002/30919 , A61F2002/30952 , A61F2002/30967 , A61F2002/30968 , A61F2002/3097 , A61F2002/3401 , A61F2002/3611 , A61F2002/3625 , A61F2002/3696 , A61F2002/407 , A61F2220/0025 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2230/0019 , A61F2230/0034 , A61F2230/0067 , A61F2230/0086 , A61F2250/0024 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00796 , B33Y80/00
摘要： A prosthesis includes an implant defining an attachment surface thereon. A porous insert is selectively coupled to the implant. The porous insert is adapted to be received at the attachment surface of the implant in a retained position. The porous insert is adapted to facilitate tissue ingrowth. In one embodiment the implant comprises a femoral component. The femoral component comprises an inner condylar portion having a first and second lateral sidewalls, an anterior wall and a posterior wall defining a box. The box defines the attachment surface. In other embodiments, the implant comprises a hip stem and an acetabular shell.
摘要翻译：假体包括限定其上的附接表面的植入物。选择性地将多孔插入件联接到植入物。多孔插入件适于在植入物的附着表面处于保持位置。多孔插入物适于促进组织向内生长。在一个实施例中，植入物包括股骨部件。股骨部件包括具有第一和第二侧壁的内髁部分，前壁和限定盒的后壁。盒子定义了附件表面。在其他实施例中，植入物包括髋部柄和髋臼壳。

68. 发明授权

US08043382B2 Reinforced medical implants 有权
标题翻译：强化医疗植入物
公开(公告)号：US08043382B2
公开(公告)日：2011-10-25
申请号：US11712360
申请日：2007-02-28
申请人： Mukesh Kumar , James B. Fleming
发明人： Mukesh Kumar , James B. Fleming
IPC分类号： A61F2/28
CPC分类号： A61L27/427 , A61B17/68 , A61B17/70 , A61B17/80 , A61F2/30767 , A61F2/3094 , A61F2/30942 , A61F2/30965 , A61F2/34 , A61F2/3601 , A61F2/3859 , A61F2/4003 , A61F2/44 , A61F2002/2817 , A61F2002/30113 , A61F2002/30154 , A61F2002/30156 , A61F2002/30166 , A61F2002/30289 , A61F2002/30291 , A61F2002/30303 , A61F2002/30841 , A61F2002/30878 , A61F2002/30892 , A61F2002/30909 , A61F2002/30957 , A61F2002/30968 , A61F2002/30986 , A61F2002/4007 , A61F2230/0006 , A61F2230/0021 , A61F2230/0023 , A61F2230/0028 , A61F2230/0063 , A61F2230/0091 , A61F2310/00179 , A61F2310/00185 , A61F2310/00203 , A61F2310/00227 , A61F2310/00239 , A61F2310/00263 , A61F2310/00269 , A61F2310/00281 , A61F2310/00293 , A61F2310/00299 , A61F2310/00395 , A61L27/30 , A61L27/42
摘要： Medical implants having a ceramic body reinforced with a plurality of metal wires. Methods of making the implant and methods of implanting the medical implant are also provided.
摘要翻译：具有用多个金属丝加强的陶瓷体的医疗植入物。还提供了制造植入物的方法和植入医用植入物的方法。

69. 发明申请

US20110143127A1 METHODS FOR COATING IMPLANTS 审中-公开
标题翻译：涂层的方法
公开(公告)号：US20110143127A1
公开(公告)日：2011-06-16
申请号：US12636379
申请日：2009-12-11
申请人： Gautam Gupta , Mukesh Kumar , Robert M. Ronk
发明人： Gautam Gupta , Mukesh Kumar , Robert M. Ronk
IPC分类号： B32B15/04 , C23C28/00 , B05D1/08 , C23C4/08 , C23C16/00
CPC分类号： A61L27/32 , A61L27/30 , A61L27/306 , A61L27/3604 , A61L27/365 , A61L27/54 , A61L2420/02 , A61L2420/08 , Y10T428/265
摘要： An implant and method for applying an osteoconductive coating on a non-conductive surface of an implant. The method includes depositing an electroconductive interlayer on at least a portion of a non-conductive implant surface. A secondary process is applied to the interlayer and an osteoconductive coating is thereby formed on the implant. In various embodiments, the electroconductive interlayer is deposited as a non-structural film and comprises a dense, non-porous metal such as titanium, titanium alloys, cobalt, cobalt alloys, chromium, chromium alloys, tantalum, tantalum alloys, iron alloys, stainless steel, and mixtures thereof. The osteoconductive coating may include a metal, a porous metal, or calcium phosphate. The osteoconductive coating may include additional agents, such as bone product, growth factor, bioactive agent, antibiotic, or combinations thereof.
摘要翻译：用于在植入物的非导电表面上施加骨传导性涂层的植入物和方法。该方法包括在非导电植入物表面的至少一部分上沉积导电中间层。将二次方法应用于中间层，由此在植入物上形成骨传导性涂层。在各种实施方案中，导电中间层作为非结构膜沉积并且包含致密的非多孔金属如钛，钛合金，钴，钴合金，铬，铬合金，钽，钽合金，铁合金，不锈钢钢及其混合物。骨传导性涂层可以包括金属，多孔金属或磷酸钙。骨传导性涂层可以包括另外的试剂，例如骨产品，生长因子，生物活性剂，抗生素或其组合。

70. 发明授权

US07922120B2 Wing ice protection heater element network 失效
标题翻译：翼冰保护加热器元件网络
公开(公告)号：US07922120B2
公开(公告)日：2011-04-12
申请号：US11939313
申请日：2007-11-13
申请人： Mukesh Kumar , Edwin Wing-Kwong Yue , David Lazarovich
发明人： Mukesh Kumar , Edwin Wing-Kwong Yue , David Lazarovich
IPC分类号： B64D15/14
CPC分类号： B64D15/14
摘要： An ice prevention network comprising a plurality of non-overlapping heater elements arranged in a grid along an airfoil is provided, powered by a multiphase power source, each phase powering selected heater elements that can selectively be powered on and powered off. The grid has a number of zones extending along the airfoil perpendicular to the airflow over the airfoil and a number of sections extending along the surface of the airfoil parallel to the airflow over the airfoil. Each of the heater elements is assigned to a single power phase and arranged such that an arbitrary section may be deactivated without causing a phase imbalance of more than one heating unit and such that a single zone may be activated without causing a phase imbalance of more than one heating unit.
摘要翻译：提供了一种防冰网络，其包括沿着翼型布置在格栅中的多个非重叠的加热器元件，由多相电源供电，每相为所选择的加热器元件供电，所述加热器元件可选择性地通电并断电。格栅具有沿机翼垂直于机翼上方的气流延伸的多个区域，以及沿翼型表面平行于翼型上的气流延伸的多个部分。每个加热器元件被分配到单个电力相位并且被布置成使得任意部分可以被去激活而不引起多于一个加热单元的相位不平衡，并且使得单个区域可以被激活而不引起相位不平衡一个加热单元。

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