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61. 发明申请

US20100210598A1 TOLL-LIKE RECEPTOR MODULATORS AND TREATMENT OF DISEASES 有权
标题翻译： TOLL-LIKE受体调节剂和治疗疾病
公开(公告)号：US20100210598A1
公开(公告)日：2010-08-19
申请号：US12704343
申请日：2010-02-11
申请人： Dennis A. Carson , Howard B. Cottam , Tomoko Hayashi , Michael Chan
发明人： Dennis A. Carson , Howard B. Cottam , Tomoko Hayashi , Michael Chan
IPC分类号： A61K31/522 , C07D473/04 , C07F9/6558 , A61K31/688 , C07F9/6524 , A61K31/685 , A61K31/52 , A61P29/00 , A61P37/06
CPC分类号： C07D473/18 , C07D471/04 , C07D473/16 , C07D473/24 , C07D519/00
摘要： Provided herein are small molecule conjugates that are agonists or antagonists of one or more toll-like receptors.
摘要翻译：本文提供作为一种或多种toll样受体的激动剂或拮抗剂的小分子缀合物。

62. 发明申请

US20070258235A1 Elliptical Reflector and Curved Lens System for a Portable Light 审中-公开
标题翻译：用于便携式灯的椭圆反射器和弯曲透镜系统
公开(公告)号：US20070258235A1
公开(公告)日：2007-11-08
申请号：US10596276
申请日：2004-12-08
申请人： Michael Brockel , Keith Skidmore , James Cormier , Michael Chan
发明人： Michael Brockel , Keith Skidmore , James Cormier , Michael Chan
IPC分类号： F21L4/00 , F21V7/00
CPC分类号： F21V7/04 , F21L4/027 , F21V7/0075 , F21V7/09 , F21V7/22 , F21V14/025 , F21Y2115/10
摘要： An elliptical reflector is provided that produces a small, circular, concentrated light beam and a less bright, larger outer elliptical flood light. The outer rim of the reflector is curved, and a matching curved lens is provided for covering the outer rim of the reflector. The curved outer rim of the reflector and the curved lens permit the light beam to extend in a broader horizontal pattern of light, potentially providing close to 180 degrees of illumination. If desired, a portion of the light can be directed downward to light a dark path, for instance.
摘要翻译：提供了一种椭圆形反射器，其产生小的，圆形的，集中的光束和较不明亮的较大的外部椭圆形泛光灯。反射器的外缘是弯曲的，并且提供匹配的弯曲透镜以覆盖反射器的外缘。反射器和弯曲透镜的弯曲外缘允许光束以更宽的水平光线延伸，潜在地提供接近180度的照明。如果需要，例如，一部分光可以被向下引导以照亮黑暗的路径。

63. 发明授权

US07195021B2 In-situ cleaning of light source collector optics 失效
标题翻译：光源收集器光学原位清洗
公开(公告)号：US07195021B2
公开(公告)日：2007-03-27
申请号：US11217008
申请日：2005-08-30
申请人： Michael Chan , Robert Bristol , Mark Doczy
发明人： Michael Chan , Robert Bristol , Mark Doczy
IPC分类号： B08B6/00
CPC分类号： G21K1/06 , B08B7/0057 , G03F7/70925 , Y10S134/902
摘要： A method for cleaning optics in a chamber. The method can include introducing a first etchant into a chamber that encloses an optical component and a source of electromagnetic radiation that is suitable for lithography, ionizing the first etchant, and removing debris from a surface of the optical component.
摘要翻译：一种清洁室内光学元件的方法。该方法可以包括将第一蚀刻剂引入到包围光学部件的室中，以及适于光刻的电磁辐射源，电离第一蚀刻剂，以及从光学部件的表面去除碎屑。

64. 发明申请

US20060183888A1 Pyrrolysine synthesis and modification 审中-公开
标题翻译：吡咯啉的合成和改性
公开(公告)号：US20060183888A1
公开(公告)日：2006-08-17
申请号：US11203820
申请日：2005-08-15
申请人： Michael Chan , Joseph Krzycki
发明人： Michael Chan , Joseph Krzycki
IPC分类号： C07K14/47 , C07D207/12
CPC分类号： C12N9/93 , C07D207/20 , C07D207/22
摘要： Synthetic L-pyrrolysine of formula I, and derivatives thereof, chemical methods of preparing these amino acids and derivatives, and methods of derivatizing these amino acids after incorporation into a peptide or protein. Also provided are derivatives and methods of preparing derivatives, including addition of substituents at any substitutable position; modifications to the lysine alkyl chain; modifications of the pyrroline ring. Also provided are methods of adding labels to the pyrrolysine or derivative thereof.
摘要翻译：式I的合成L-吡咯赖氨酸及其衍生物，制备这些氨基酸和衍生物的化学方法，以及在掺入肽或蛋白质后将这些氨基酸衍生化的方法。还提供了衍生物和制备衍生物的方法，包括在任何可取代的位置加成取代基; 对赖氨酸烷基链的修饰; 吡咯啉环的改性。还提供了向吡咯赖氨酸或其衍生物添加标签的方法。

65. 发明申请

US20060175605A1 Organometallic light-emitting material 审中-公开
公开(公告)号：US20060175605A1
公开(公告)日：2006-08-10
申请号：US11401537
申请日：2006-04-10
申请人： Chi-Ming Che , Wei Lu , Michael Chan
发明人： Chi-Ming Che , Wei Lu , Michael Chan
IPC分类号： C07F15/00 , H01L29/08 , H01J1/62
CPC分类号： C07F15/0086 , C07F15/0033 , C09K11/06 , C09K2211/10 , C09K2211/1007 , C09K2211/1029 , C09K2211/1092 , C09K2211/185 , H01L51/006 , H01L51/0071 , H01L51/0081 , H01L51/0087 , H01L51/5016 , H05B33/14 , Y10S428/917
摘要： Disclosed herein are novel light-emitting materials of Formula I and II below. These new complexes are synthesized and found to be sufficiently stable to allow sublimation and vacuum deposition. These new emitters are electrophosphorescent and can be used in organic light-emitting devices (OLEDs) for device elements capable of emitting light of color ranging from orange to red with high-efficiency and high-brightness. wherein E=Group 16 elements (including sulphur); M=Group 10 metal (including platinum); R1-R14 are each independently selected from the group consisting of hydrogen; halogen; alkyl; substituted alkyl; aryl; substituted aryl, with substituents selected from the group consisting of halogen, lower alkyl and recognized donor and acceptor groups. R1 can also be selected from (C≡C)nR15, where (C≡C) represents a carbon-carbon triple bond (acetylide group), n is selected from 1 to 10, and R15 is selected from alkyl, aryl, substituted aryl, and tri(alkyl)silyl.

66. 发明申请

US20060166319A1 Charging tRNA with pyrrolysine 审中-公开
标题翻译：用吡咯赖氨酸充电tRNA
公开(公告)号：US20060166319A1
公开(公告)日：2006-07-27
申请号：US11204295
申请日：2005-08-15
申请人： Michael Chan , Joseph Krzycki
发明人： Michael Chan , Joseph Krzycki
IPC分类号： C12P21/06 , C12N15/74 , C12N1/21
CPC分类号： C12N9/93 , C12N15/11
摘要： Provided herein is a method for preparing a cell that, when exposed to the non-canonical amino acid, pyrrolysine or a derivative thereof and transformed or transfected with a polynucleotide comprising an in-frame UAG or TAG codon incorporates the pyrrolysine residue or derivative thereof into the protein or polynucleotide into the protein or polypeptide encoded by the polynucleotide. The method comprises introducing a first polynucleotide comprising a sequence that encodes a protein having pyrrolysyl-tRNA synthetase activity and a second polynucleotide comprising a sequence that encodes a pyrrolysine specific tRNA into the cell and maintining the cell under conditions that permit expression of the first and second polynucleotide. Also provided herein are modified cells produced in accordance with the present method and methods of making peptides, polypeptides, and proteins which utilize such modified cells. Also provide are kits comprising pyrrolysine or a pyrrolysine or both. The kits also provide the first polynucleotide and the second polynucelotide or cells produced in accordance with the present methods or both.
摘要翻译：本文提供了一种制备细胞的方法，当暴露于非标准氨基酸时，吡咯赖氨酸或其衍生物，并用包含框内UAG或TAG密码子的多核苷酸转化或转染，将吡咯赖氨酸残基或其衍生物掺入该蛋白质或多核苷酸进入由多核苷酸编码的蛋白质或多肽。该方法包括引入包含编码具有吡咯赖氨酰-tRNA合成酶活性的蛋白质的序列的第一多核苷酸和含有编码吡咯赖氨酸特异性tRNA的序列的第二多核苷酸进入细胞并在允许表达第一和第二多核苷酸。本文还提供根据本方法产生的修饰细胞和制备利用这种修饰细胞的肽，多肽和蛋白质的方法。还提供包含吡咯赖斯或吡咯赖斯或两者的试剂盒。试剂盒还提供根据本发明方法或两者生产的第一多核苷酸和第二聚选肽或细胞。

67. 发明授权

US07047333B2 Method for the serial transfer of data between two electronic bus stations and communication system 有权
标题翻译：在两个电子总线站和通信系统之间串行传输数据的方法
公开(公告)号：US07047333B2
公开(公告)日：2006-05-16
申请号：US10487488
申请日：2002-08-10
申请人： Franken Leung , Matthew Au , Michael Chan , Lawrence Tse
发明人： Franken Leung , Matthew Au , Michael Chan , Lawrence Tse
IPC分类号： G06F13/00
CPC分类号： G06F13/4286
摘要： The invention relates to a serial data transfer method for exchanging data between two electronic bus stations. The bus connection consists of two lines, the first line being dedicated to data/control signals and the second line being dedicated to a power supply voltage. Data transfer is started by pulling the first line to an activated potential for a first period of time, and then leaving the first line inactive for a second period of time. Data transmission commences via the first and second lines after the second period of time has elapsed. Preferably, data is transferred in a number of blocks in the data frame.
摘要翻译：本发明涉及一种用于在两个电子总线站之间交换数据的串行数据传输方法。总线连接由两条线组成，第一条线专用于数据/控制信号，第二条线专用于电源电压。通过在第一时间段内将第一行拉到激活电位，然后使第一行在第二时间段内不活动而开始数据传送。在第二时间段之后经由第一和第二行开始数据传输。优选地，数据在数据帧中的多个块中传送。

68. 发明授权

US06965249B2 Programmable logic device with redundant circuitry 失效
标题翻译：具有冗余电路的可编程逻辑器件
公开(公告)号：US06965249B2
公开(公告)日：2005-11-15
申请号：US10159581
申请日：2002-05-30
申请人： Christopher Lane , Ketan Zaveri , Hyun Yi , Giles Powell , Paul Leventis , David Jefferson , David Lewis , Triet Nguyen , Vikram Santurkar , Michael Chan , Andy Lee , Brian Johnson , David Cashman
发明人： Christopher Lane , Ketan Zaveri , Hyun Yi , Giles Powell , Paul Leventis , David Jefferson , David Lewis , Triet Nguyen , Vikram Santurkar , Michael Chan , Andy Lee , Brian Johnson , David Cashman
IPC分类号： H01L21/82 , H03K19/177
CPC分类号： H03K19/17764 , H03K19/17736 , H03K19/17744
摘要： A programmable logic device and associated method is provided with repairable regions. In one aspect, general routing interconnect lines are segmented within repairable regions. In another aspect, IO bus lines and associated circuitry are provided that accommodate redundancy in a staggered segmented architecture. In another aspect, a dedicated routing architecture between particular logic regions accommodates shifting to define and utilize repairable regions. Principles of other aspects are illustrated and described in the context of several exemplary embodiments of aspects of the invention.
摘要翻译：可编程逻辑器件和相关方法提供有可修复区域。在一个方面，一般布线互连线在可修复区域内被分段。在另一方面，提供IO总线线路和相关电路，其适应交错分段结构中的冗余。在另一方面，特定逻辑区域之间的专用路由架构适应移位以限定和利用可修复区域。在本发明的方面的几个示例性实施例的上下文中示出和描述了其它方面的原理。

69. 发明授权

US06895570B2 System and method for optimizing routing lines in a programmable logic device 有权
标题翻译：用于优化可编程逻辑器件中路由线路的系统和方法
公开(公告)号：US06895570B2
公开(公告)日：2005-05-17
申请号：US10057232
申请日：2002-01-25
申请人： David M. Lewis , Vaughn Betz , Paul Leventis , Michael Chan , Cameron R. McClintock , Andy L. Lee , Christopher F. Lane , Srinivas T. Reddy , Richard Cliff
发明人： David M. Lewis , Vaughn Betz , Paul Leventis , Michael Chan , Cameron R. McClintock , Andy L. Lee , Christopher F. Lane , Srinivas T. Reddy , Richard Cliff
IPC分类号： G06F17/50 , H01L21/82 , H03K19/177
CPC分类号： H03K19/17736 , G06F17/5054 , G06F17/5077
摘要： An embodiment of this invention pertains to a wire that interconnects multiple function blocks within a programmable logic device (“PLD”). An electrically optimum physical length is determined for the wire. A wire having the electrically optimum physical length transmits a signal down the wire as fast as possible. Some of the wires used in the PLD have a physical length substantially the same as the electrically optimum physical length or an adjustment of the electrically optimum physical length to account for non-electrical considerations. The physical length, as used herein, is the measured length of the wire. A logical length of the wire, as used herein, is the number of function blocks that the wire spans. Given that the function blocks have a different height and width, the logical length of the wire varies depending on the orientation of the wire.A routing architecture is an array that includes rows and columns of function blocks. The columns of the array are connected with horizontal lines (“H-line”) and the rows of the array are connected with vertical lines (“V-line). The types of H-lines include a H4 line that spans four function blocks, a H8 line that spans eight function blocks, and a H24 line that spans twenty-four function blocks. The types of V-lines include a V4 line that spans four function blocks, a V8 line that spans eight function blocks, and a V16 line that spans sixteen function blocks.
摘要翻译：本发明的实施例涉及将可编程逻辑器件（“PLD”）内的多个功能块互连的导线。确定电线最佳物理长度。具有最佳物理长度的导线尽可能快地将信号沿导线传送。在PLD中使用的一些电线具有与电最佳物理长度基本相同的物理长度或电学最佳物理长度的调整以考虑非电学考虑。如本文所使用的物理长度是测量的线的长度。如本文所使用的，线的逻辑长度是导线跨越的功能块的数量。假设功能块具有不同的高度和宽度，则线的逻辑长度根据线的方向而变化。路由架构是包括功能块的行和列的数组。数组的列与水平线（“H-line”）连接，阵列与垂直线（“V线”）连接，H线的类型包括四条功能块的H4线，一个跨越八个功能块的H8线，以及跨越二十四个功能块的H24线，V线的类型包括跨越四个功能块的V4线，跨越八个功能块的V8线，以及V16线线跨越十六个功能块。

70. 发明申请

US20050011802A1 Gift display box 审中-公开
标题翻译：礼品展示盒
公开(公告)号：US20050011802A1
公开(公告)日：2005-01-20
申请号：US10608054
申请日：2003-06-27
申请人： Michael Chan
发明人： Michael Chan
IPC分类号： B42D15/04 , B65D5/42 , B65D77/04 , B65D85/00
CPC分类号： B65D77/0413 , B42D15/045 , B65D5/4204
摘要： A device for display and mailing of a gift. The device includes an inner gift holding box having a transparent top surface through which a display item could be viewed. This inner gift box is inserted into an outer mailing box. When the gift holding box is nested into the outer mailing box, the gift may still be viewed through a cutout on the top of outer mailing box. An opaque panel is inserted inside the outer mailing box over the transparent top surface of inner gift holding box. This panel allows the mailing box to be shipped without showing the contents of the box.
摘要翻译：用于展示和邮寄礼物的设备。该装置包括具有透明顶表面的内部礼物保持盒，通过该顶部表面可以看到显示项目。这个内部礼品盒插入外部邮箱。当礼品盒被嵌套到外部邮箱中时，礼物仍然可以通过外部邮箱顶部的切口查看。外部邮寄箱内装有一个不透明的面板，位于内部礼品盒的透明顶面上。此面板允许发送邮箱而不显示框的内容。

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