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61. 发明授权

US08216558B2 Polymer coating of cells 失效
标题翻译：细胞的聚合物涂层
公开(公告)号：US08216558B2
公开(公告)日：2012-07-10
申请号：US12690011
申请日：2010-01-19
申请人： Sang Van , Yasunobu Tanaka , Lei Yu
发明人： Sang Van , Yasunobu Tanaka , Lei Yu
IPC分类号： A61K8/72
CPC分类号： C08G69/10 , A61K31/765 , A61K35/36 , A61K35/44 , A61K35/545 , A61K47/59 , A61K47/595 , A61K47/6901 , A61L27/18 , A61L27/34 , A61L27/3834 , A61L27/54 , A61L2300/64 , C08G69/02 , C08G69/08 , C08G73/028 , C12N5/0068 , C12N2533/30 , Y10T70/437 , C08L77/00
摘要： Polymers and methods of making them are described. The polymers may be used to coat living cells. The polymer-coated cells are useful in cell therapy applications.
摘要翻译：描述了聚合物及其制备方法。聚合物可用于包衣活细胞。聚合物涂覆的细胞可用于细胞治疗应用。

62. 发明申请

US20120107264A1 NUCLEIC ACID DELIVERY COMPOUNDS 审中-公开
标题翻译：核酸递送化合物
公开(公告)号：US20120107264A1
公开(公告)日：2012-05-03
申请号：US13273106
申请日：2011-10-13
申请人： Padmanabh Chivukula , Jian Liu , Akinobu Soma , Keisaku Okada , Sang Van , Julia Zhu , Nianchun Ma , Chen-Chang Lee , Fu Chen , Lei Yu
发明人： Padmanabh Chivukula , Jian Liu , Akinobu Soma , Keisaku Okada , Sang Van , Julia Zhu , Nianchun Ma , Chen-Chang Lee , Fu Chen , Lei Yu
IPC分类号： A61K47/48 , C08F220/60 , A61P35/00 , A61K47/32 , C12N5/071 , C08F120/60 , C08G65/333
CPC分类号： C12N15/87 , C08F293/005 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell.
摘要翻译：包括两种或更多种不同重复单元的聚合物在本文中公开。本文还公开了使用这种聚合物将核酸递送至细胞的方法。

63. 发明申请

US20120094924A1 NUCLEIC ACID DELIVERY COMPOUNDS 审中-公开
公开(公告)号：US20120094924A1
公开(公告)日：2012-04-19
申请号：US13273091
申请日：2011-10-13
申请人： Padmanabh Chivukula , Jian Liu , Akinobu Soma , Keisaku Okada , Sang Van , Chen-Chang Lee , Lei Yu
发明人： Padmanabh Chivukula , Jian Liu , Akinobu Soma , Keisaku Okada , Sang Van , Chen-Chang Lee , Lei Yu
IPC分类号： A61K38/02 , C07K7/06 , A61P35/00 , C07K7/08 , C07K14/00 , C12N5/10 , C07K9/00
CPC分类号： A61K47/34 , C08G69/48
摘要： Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell.

64. 发明申请

US20120093762A1 NUCLEIC ACID DELIVERY COMPOUNDS 审中-公开
公开(公告)号：US20120093762A1
公开(公告)日：2012-04-19
申请号：US13273100
申请日：2011-10-13
申请人： Padmanabh Chivakula , Jian Liu , Sang Van , Akinobu Soma , Keisaku Okada , Lei Yu , Nianchun Ma
发明人： Padmanabh Chivakula , Jian Liu , Sang Van , Akinobu Soma , Keisaku Okada , Lei Yu , Nianchun Ma
IPC分类号： A61K47/34 , A61P35/00 , C12N5/071 , C08G69/48
CPC分类号： A61K47/34 , C08G69/48
摘要： Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell.

65. 发明申请

US20110224148A1 CARBOHYDRATE-POLYAMINO ACID-DRUG CONJUGATES 审中-公开
标题翻译：碳水化合物 - 聚氨基酸酸 - 药物结合物
公开(公告)号：US20110224148A1
公开(公告)日：2011-09-15
申请号：US13044402
申请日：2011-03-09
申请人： Mohammad Ahmadian , Wendy Taylor , Sang Van , Lei Yu
发明人： Mohammad Ahmadian , Wendy Taylor , Sang Van , Lei Yu
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/645 , A61K47/64
摘要： Compositions that include a polymer conjugate and glucosamine operatively associated with the polymer conjugate, wherein the polymer conjugate includes a first drug, are described herein. Also disclosed herein are methods of using such compositions to treat, ameliorate, or diagnose a disease or condition such as cancer.
摘要翻译：包括与聚合物缀合物操作性相关的聚合物缀合物和葡糖胺的组合物，其中所述聚合物缀合物包括第一种药物，在本文中描述。本文还公开了使用这种组合物来治疗，改善或诊断疾病或病症例如癌症的方法。

66. 发明授权

US08003621B2 Drug carriers 失效
标题翻译：药物载体
公开(公告)号：US08003621B2
公开(公告)日：2011-08-23
申请号：US12210098
申请日：2008-09-12
申请人： Yoshiro Niitsu , Lei Yu , Jian Liu , Gang Zhao , Nianchun Ma , Sang Van
发明人： Yoshiro Niitsu , Lei Yu , Jian Liu , Gang Zhao , Nianchun Ma , Sang Van
IPC分类号： A01N61/00 , A01N43/04 , A61K9/16 , G01N33/53 , C07H21/04
CPC分类号： A61K31/337 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K47/6455
摘要： Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
摘要翻译：本文公开了可以包括阳离子聚合物载体，靶向剂和治疗剂的组合物。治疗剂可以具有治疗活性，例如抑制靶器官或组织内的纤维化或抑制癌细胞的生长。

67. 发明申请

US20110013623A1 METHOD AND SYSTEM OF CIRCUIT SWITCHED DOMAIN PAGE REALIZATION, METHOD OF SERVICE REALIZATION 有权
标题翻译：电路切换域实现的方法和系统，服务实现方法
公开(公告)号：US20110013623A1
公开(公告)日：2011-01-20
申请号：US12865952
申请日：2009-01-24
申请人： Ying Hu , Zhiming Yu , Jinguo Zhu , Lei Yu , Liping Geng
发明人： Ying Hu , Zhiming Yu , Jinguo Zhu , Lei Yu , Liping Geng
IPC分类号： H04L12/66
CPC分类号： H04W68/12 , H04W8/06 , H04W60/005
摘要： A method and a system for implementing CS domain paging are disclosed, applied in scenarios of performing CS domain paging for a called UE after ISR function is introduced in PS domain, and comprising: MSC/VLR only storing one Gs association; during CS domain paging, MSC/VLR sending a CS domain paging request message to the PS domain network element recorded in the Gs association in the MSC/VLR; after receiving the message, the PS domain network element initiating one or two CS domain paging procedures in the PS domain to transmit the CS domain paging to the called UE; or sending a paging response to the MSC/VLR directly without initiating CS domain paging. A method for transferring service information is also disclosed, applied in the scenarios that ISR function is activated in PS domain, and comprising: transmitting service message(s) between the ISR-associated PS domain network elements serving the UE to implement transfer of service information.
摘要翻译：公开了一种用于实现CS域寻呼的方法和系统，其应用于在PS域中引入ISR功能之后为被叫UE执行CS域寻呼的场景，并且包括：MSC / VLR仅存储一个Gs关联; 在CS域寻呼期间，MSC / VLR向MSC / VLR中的Gs关联中记录的PS域网元发送CS域寻呼请求消息; 接收到该消息后，PS域网单元在PS域中发起一个或两个CS域寻呼过程，将CS域寻呼发送给被叫UE; 或直接向MSC / VLR发送寻呼响应而不发起CS域寻呼。还公开了一种用于传送服务信息的方法，其应用于在PS域中激活ISR功能的场景，包括：在服务于UE的ISR相关联的PS域网元之间传送业务消息，实现业务信息的传输。

68. 发明申请

US20100210715A1 BIODEGRADABLE CATIONIC POLYMERS 失效
标题翻译：生物可降解阳离子聚合物
公开(公告)号：US20100210715A1
公开(公告)日：2010-08-19
申请号：US12707959
申请日：2010-02-18
申请人： Gang Zhao , Xiaoli Fu , Lei Yu
发明人： Gang Zhao , Xiaoli Fu , Lei Yu
IPC分类号： A61K31/7088 , C08G73/04 , A61K47/34 , C12N5/00
CPC分类号： C08G73/02 , A61K31/12 , A61K41/0038 , A61K47/59 , A61K47/593 , A61K48/0041 , A61K49/0002 , C08G63/6856 , C08G73/0206 , C08L67/02 , C08L79/02 , C12N15/88 , Y10S977/702 , Y10S977/704 , Y10S977/705 , C08L2666/26
摘要： Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
摘要翻译：包含聚乙烯亚胺，可生物降解基团和相对疏水的基团的聚合物可用于将生物活性剂递送至细胞。

69. 发明授权

US07700565B2 Peptide nucleic acid based guanidinium compounds 有权
标题翻译：基于肽核酸的胍盐化合物
公开(公告)号：US07700565B2
公开(公告)日：2010-04-20
申请号：US11525482
申请日：2006-09-21
申请人： Gang Zhao , Chieko Kitaura , Jian Liu , Lei Yu
发明人： Gang Zhao , Chieko Kitaura , Jian Liu , Lei Yu
IPC分类号： A61K38/00
CPC分类号： C07K14/003 , A61K47/62 , A61K47/645
摘要： Disclosed herein are transmembrane transporter compounds containing guanidinium groups to enhance transport of a polymer backbone across biomembranes. Therapeutic and other biologically active moieties may be attached to the compounds. The polymer backbone may include peptide nucleic acid monomer units.
摘要翻译：本文公开了含有胍基的跨膜转运蛋白化合物，以增强聚合物骨架在生物膜上的转运。治疗性和其他生物活性部分可以连接到化合物上。聚合物主链可以包括肽核酸单体单元。

70. 发明授权

US07674452B2 Polymer coating of cells 失效
标题翻译：细胞的聚合物涂层
公开(公告)号：US07674452B2
公开(公告)日：2010-03-09
申请号：US11359811
申请日：2006-02-22
申请人： Sang Van , Yasunobu Tanaka , Lei Yu
发明人： Sang Van , Yasunobu Tanaka , Lei Yu
IPC分类号： A61Q7/00
CPC分类号： C08G69/10 , A61K31/765 , A61K35/36 , A61K35/44 , A61K35/545 , A61K47/59 , A61K47/595 , A61K47/6901 , A61L27/18 , A61L27/34 , A61L27/3834 , A61L27/54 , A61L2300/64 , C08G69/02 , C08G69/08 , C08G73/028 , C12N5/0068 , C12N2533/30 , Y10T70/437 , C08L77/00
摘要： Polymers and methods of making them are described. The polymers may be used to coat living cells. The polymer-coated cells are useful in cell therapy applications.
摘要翻译：描述了聚合物及其制备方法。聚合物可用于包衣活细胞。聚合物涂覆的细胞可用于细胞治疗应用。

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