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61. 发明申请

US20120109257A1 SYSTEM AND METHOD FOR PROVIDING FLUID REAL-TIME VISUALIZATION OF REGION OF TISSUE ACTIVATION 有权
标题翻译：用于提供组织活化区域的流体实时可视化的系统和方法
公开(公告)号：US20120109257A1
公开(公告)日：2012-05-03
申请号：US13244415
申请日：2011-09-24
申请人： Peter J. Yoo , Michael A. Moffitt , Kerry Bradley
发明人： Peter J. Yoo , Michael A. Moffitt , Kerry Bradley
IPC分类号： A61N1/372
CPC分类号： A61N1/37247 , A61N1/36135 , A61N1/36185
摘要： A system for a tissue stimulator coupled to an array of electrodes. The system comprises a user-controlled input device configured for generating control signals, and at least one processor configured for generating a plurality of stimulation parameter sets in response to the control signals that, when applied to the electrodes, will shift electrical current between electrodes to modify a region of tissue activation. The processor(s) is further configured for computing an estimate of the region of tissue activation, and for generating display signals capable of prompting a monitor to display an animated graphical representation of the computed estimate of the region of tissue activation.
摘要翻译：一种耦合到电极阵列的组织刺激器的系统。该系统包括被配置为产生控制信号的用户控制的输入装置，以及至少一个处理器，被配置为响应于控制信号产生多个刺激参数集合，当被施加到电极时将使电极之间的电流移位到修改组织激活的区域。处理器还被配置用于计算组织激活区域的估计，并且用于产生能够促使监视器显示所计算的组织激活区域的估计的动画图形表示的显示信号。

62. 发明申请

US20120101537A1 SYSTEM AND METHOD FOR INTRODUCING TISSUE STIMULATION LEAD INTO PATIENT USING REAL-TIME COUPLING EFFICIENCY MEASUREMENTS 有权
标题翻译：使用实时耦合效率测量将组织刺激引导引入患者的系统和方法
公开(公告)号：US20120101537A1
公开(公告)日：2012-04-26
申请号：US13244458
申请日：2011-09-24
申请人： David K.L. Peterson , Kerry Bradley
发明人： David K.L. Peterson , Kerry Bradley
IPC分类号： A61N1/372
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36185 , A61N1/372
摘要： A system and method for locating an implantable tissue stimulation lead within a patient. A measurement indicative of a coupling efficiency between the tissue stimulation lead and tissue at a location is taken. The location of the tissue stimulation lead relative to the tissue is tracked. Coupling efficiency information based on the measurement from the monitoring device is generated, tracking information based on the tissue stimulation lead location is generated, and the coupling efficiency information and tracking information is concurrently conveyed to the user.
摘要翻译：一种用于定位患者内的可植入组织刺激引线的系统和方法。采用指示组织刺激引线和组织在一处的耦合效率的测量。跟踪组织刺激引线相对于组织的位置。生成基于来自监视装置的测量的耦合效率信息，生成基于组织刺激引导位置的跟踪信息，并且耦合效率信息和跟踪信息被同时传送给用户。

63. 发明授权

US08155750B2 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
标题翻译：用于避免，逆转和管理神经系统适应电刺激的系统和方法
公开(公告)号：US08155750B2
公开(公告)日：2012-04-10
申请号：US12509340
申请日：2009-07-24
申请人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
发明人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.
摘要翻译：提供了一种用于编程神经刺激装置的方法和编程器。该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

64. 发明申请

US20120004707A1 USE OF STIMULATION PULSE SHAPE TO CONTROL NEURAL RECRUITMENT ORDER AND CLINICAL EFFECT 审中-公开
标题翻译：刺激脉冲形状的使用来控制神经激励和临床效果
公开(公告)号：US20120004707A1
公开(公告)日：2012-01-05
申请号：US13231493
申请日：2011-09-13
申请人： Dongchul Lee , Michael Moffitt , Christopher Ewan Gillespie , Kerry Bradley
发明人： Dongchul Lee , Michael Moffitt , Christopher Ewan Gillespie , Kerry Bradley
IPC分类号： A61N1/372
CPC分类号： A61N1/36146 , A61N1/36003 , A61N1/36007 , A61N1/36017 , A61N1/36036 , A61N1/36046 , A61N1/3605 , A61N1/3606 , A61N1/36135 , A61N1/37247 , A61N1/378 , A61N1/3787 , A61N1/3906
摘要： A method, electrical tissue stimulation system, and programmer for providing therapy to a patient are provided. Electrodes are placed adjacent tissue (e.g., spinal cord tissue) of the patient, electrical stimulation energy is delivered from the electrodes to the tissue in accordance with a defined waveform, and a pulse shape of the defined waveform is modified, thereby changing the characteristics of the electrical stimulation energy delivered from the electrode(s) to the tissue. The pulse shape may be modified by selecting one of a plurality of different pulse shape types or by adjusting a time constant of the pulse shape.
摘要翻译：提供了一种用于向患者提供治疗的方法，电组织刺激系统和程序员。电极被放置在患者的组织（例如，脊髓组织）的附近，电刺激能量根据定义的波形从电极传送到组织，并且限定波形的脉冲形状被修改，从而改变从电极传递到组织的电刺激能量。可以通过选择多种不同的脉冲形状类型之一或通过调整脉冲形状的时间常数来修改脉冲形状。

65. 发明授权

US07991482B2 Method for optimizing search for spinal cord stimulation parameter setting 有权
标题翻译：优化脊髓刺激参数设置搜索的方法
公开(公告)号：US07991482B2
公开(公告)日：2011-08-02
申请号：US11937316
申请日：2007-11-08
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/04
CPC分类号： A61N1/36071
摘要： A method of stimulating tissue of a patient is provided. The method comprises placing an array of electrodes in proximity to the tissue, conveying electrical current between the electrodes of the array to stimulate a tissue site, incrementally shifting the electrical current from at least one cathode to at least another cathode over a first range of fractionalized current values, and incrementally shifting the electrical current from at least one anode to at least another anode over a second range of fractionalized current values. The step sizes for the first and second ranges of fractionalized current values differ.
摘要翻译：提供了刺激患者组织的方法。该方法包括将电极阵列放置在组织附近，在阵列的电极之间传送电流以刺激组织部位，在第一范围内将电流从至少一个阴极递增移位至至少另一个阴极电流值，并且在分数电流值的第二范围上将电流从至少一个阳极递增移位到至少另一个阳极。分数电流值的第一和第二范围的步长不同。

66. 发明申请

US20110152988A1 CAVERNOUS NERVE STIMULATION VIA UNIDIRECTIONAL PROPAGATION OF ACTION POTENTIALS 有权
标题翻译：通过行动潜力的联合传播促进神经刺激
公开(公告)号：US20110152988A1
公开(公告)日：2011-06-23
申请号：US13036278
申请日：2011-02-28
申请人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes.
摘要翻译：提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。

67. 发明申请

US20110106214A1 CHARGE RECOVERY BI-PHASIC CONTROL FOR TISSUE STIMULATION 有权
标题翻译：用于组织刺激的电荷恢复双相控制
公开(公告)号：US20110106214A1
公开(公告)日：2011-05-05
申请号：US12938202
申请日：2010-11-02
申请人： Rafael Carbunaru , Kerry Bradley
发明人： Rafael Carbunaru , Kerry Bradley
IPC分类号： A61N1/36 , A61N1/08
CPC分类号： A61N1/36178 , A61N1/0551 , A61N1/36125 , A61N1/36128 , A61N1/36185
摘要： A method and external control device for providing therapy to a patient using first and second electrodes implanted within the patient is provided. A train of electrical multi-phasic pulses is generated. A first electrical current is sourced from the second electrode and at least a portion of the first electrical current is sunk to the first electrode during a stimulation phase of each multi-phasic pulse, thereby therapeutically stimulating a first tissue region adjacent the first electrode. A second electrical current is sourced from the first electrode and at least a portion of the second electrical current is sunk to the second electrode during a charge recovery phase of each multi-phasic pulse, thereby recovering at least a portion of the charge that had been injected into the patient during the stimulation phase of each multi-phasic pulse, and therapeutically stimulating a second tissue region adjacent the second electrode.
摘要翻译：提供了一种方法和外部控制装置，其用于使用植入患者体内的第一和第二电极向患者提供治疗。产生一系列电多相脉冲。第一电流来自第二电极，并且在每个多相脉冲的刺激阶段期间，第一电流的至少一部分被吸入第一电极，从而治疗性地刺激与第一电极相邻的第一组织区域。在每个多相脉冲的充电恢复阶段期间，第二电流来自第一电极，并且第二电流的至少一部分被吸入第二电极，由此回收至少一部分电荷在每个多阶段脉冲的刺激阶段期间注射到患者体内，以及治疗性刺激与第二电极相邻的第二组织区域。

68. 发明申请

US20110077721A1 IMPLANTABLE MICROSTIMULATORS AND METHODS FOR UNIDIRECTIONAL PROPAGATION OF ACTION POTENTIALS 失效
标题翻译：可移植的微生物和方法促进动作电位的传播
公开(公告)号：US20110077721A1
公开(公告)日：2011-03-31
申请号：US12960722
申请日：2010-12-06
申请人： Todd K. Whitehurst , Rafael Carbunaru , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley , Janusz A. Kuzma
发明人： Todd K. Whitehurst , Rafael Carbunaru , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley , Janusz A. Kuzma
IPC分类号： A61N1/372 , A61N1/08
CPC分类号： A61N1/37252 , A61N1/05 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37217 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) are capable of producing unidirectionally propagating action potentials (UPAPs). The methods and configurations described may, for instance, arrest action potentials traveling in one direction, arrest action potentials of small diameters nerve fibers, arrest action potentials of large diameter nerve fibers. These methods and systems may limit side effects of bidirectional and/or less targeted stimulation.
摘要翻译：微型植入式刺激器（即微型刺激器）能够产生单向传播动作电位（UPAP）。所描述的方法和结构可以例如阻止在一个方向上行进的动作电位，阻止小直径神经纤维的动作电位，阻止大直径神经纤维的动作电位。这些方法和系统可以限制双向和/或较少靶向刺激的副作用。

69. 发明授权

US07899539B2 Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：通过动作电位的单向传播进行海绵体神经刺激
公开(公告)号：US07899539B2
公开(公告)日：2011-03-01
申请号：US11536565
申请日：2006-09-28
申请人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05 , A61N1/372
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes. A method of stimulating a cavernous nerve includes providing at least one implantable stimulator with at least two cathodic electrodes; programming stimulation parameters for the cathodic electrodes to radially steer an electric field generated by the cathodic electrodes to apply stimulation that unidirectionally propagates action potentials along a cavernous nerve; and applying the stimulation to the cavernous nerve in accordance with the stimulation parameters to generate orthodromic action potentials traveling in one direction along the nerve, thereby limiting side effects of bidirectional stimulation.
摘要翻译：提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。刺激海绵体神经的方法包括：提供至少一个可植入的刺激器，其具有至少两个阴极电极; 用于阴极电极的编程刺激参数以径向转向由阴极电极产生的电场，以施加沿着海绵状神经单向传播动作电位的刺激; 并根据刺激参数对海绵体神经施加刺激，以产生沿着神经沿一个方向行进的正常动作电位，从而限制双向刺激的副作用。

70. 发明授权

US07856271B2 Detecting atrial evoked response 有权
标题翻译：检测心房诱发反应
公开(公告)号：US07856271B2
公开(公告)日：2010-12-21
申请号：US11948671
申请日：2007-11-30
申请人： Kerry Bradley , Laurence S. Sloman
发明人： Kerry Bradley , Laurence S. Sloman
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61N1/3716
摘要： A method for sensing cardiac activity in an atrium of a patient's heart includes delivering a pulse to the atrium using an electrode configuration that includes at least a cathode electrode; sensing cardiac activity in the atrium using a unipolar electrode configuration to provide a sensed signal wherein the unipolar electrode configuration does not include the cathode electrode; determining the duration during which the voltage of the sensed signal falls below a threshold voltage; and comparing the determined duration to a parameter to determine whether the pulse caused an atrial evoked response.
摘要翻译：用于感测患者心脏的心脏活动的方法包括：使用至少包括阴极电极的电极配置将脉冲输送到心房; 使用单极电极配置感测心房中的心脏活动以提供感测信号，其中单极电极配置不包括阴极电极; 确定感测信号的电压下降到阈值电压以下的持续时间; 以及将所确定的持续时间与参数进行比较以确定所述脉冲是否引起心房诱发反应。

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