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61. 发明申请

US20110117147A1 COOLING SENSATION AGENT COMPOSITION AND SENSORY STIMULATION AGENT COMPOSITION 失效
标题翻译：冷却感觉剂组合物和感觉刺激剂组合物
公开(公告)号：US20110117147A1
公开(公告)日：2011-05-19
申请号：US12936160
申请日：2009-04-01
申请人： Kenya Ishida , Takashi Aida , Tetsuya Yamamoto
发明人： Kenya Ishida , Takashi Aida , Tetsuya Yamamoto
IPC分类号： A61K8/49 , A61K8/55 , A61Q11/00 , C07C69/96 , C07D317/22 , A61Q17/00 , A61K31/357
CPC分类号： C07D317/36 , A23L27/203 , A23L27/2052 , A61K8/0208 , A61K8/37 , A61K8/4973 , A61K2800/244 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C07C69/24 , C07C69/96 , C07C2601/14
摘要： The invention relates to a cooling sensation agent composition with a prolonged cool sensation effect comprising at least one compound selected from Formula (1) wherein each of A and B is a hydrogen atom or a hydrocarbon group which may have one or more substituents, in which A and B are not hydrogen atoms simultaneously, and the total number of carbon atoms in A and B is in the range of 6 to 18; and Formulae (2) to (4) wherein R1, R2, and R3 each represent a residue of an alcohol selected from 1-menthol, 1-isopulegol, 3-(1-menthoxy)propan-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propan-1,2-diol and para-menthan-3,8-diol), and R4 represents a residue of a branched or straight-chain, cyclic or linear, or saturated or unsaturated alcohol having 6 to 18 carbon atoms that may have one or more aromatic rings that may have a condensed ring and substituent groups such as hydroxyl and ether groups; and R6 represents a hydrocarbon group having 11 to 19 carbon atoms that may be branched and contain one or more unsaturated bonds. The invention also relates to a sensory stimulation agent composition comprising the cooling sensation agent composition; a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition or the sensory stimulation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent composition or the sensory stimulation agent composition; and new compounds.
摘要翻译：本发明涉及具有延长的凉爽感觉效果的冷却感觉剂组合物，其包含至少一种选自式（1）的化合物，其中A和B各自为氢原子或可具有一个或多个取代基的烃基，其中 A和B不同时为氢原子，A和B中碳原子总数为6〜18; 和式（2）至（4）其中R 1，R 2和R 3各自表示选自1-薄荷醇，1-异胡耳醇，3-（1-薄荷氧基）丙-1,2-二醇，2- （1-薄荷氧基）乙-1-醇，3-（1-薄荷氧基）丙-1-醇，2-甲基-3-（1-薄荷氧基）丙-1,2-二醇和对 - 薄荷烷-3,8 - 二醇），R4代表具有6-18个碳原子的支链或直链，环状或直链或饱和或不饱和醇的残基，其可具有一个或多个可具有稠环的芳环和取代基如作为羟基和醚基团; R6表示可以具有支链并含有一个以上的不饱和键的碳原子数为11〜19的烃基。本发明还涉及包含冷却感觉剂组合物的感觉刺激剂组合物; 香料或香料组合物，饮料或食品，香水或化妆品，化妆品，日常用品或杂货，纤维，纤维制品，布或包含该冷却感觉组合物或感官的药物刺激剂组成; 其制造方法; 纤维，纤维制品或布的冷却处理方法，其包括将冷却感觉剂组合物或感觉刺激剂组合物混合; 和新化合物。

62. 发明申请

US20110077309A1 HUMECTANT COMPOSITION 审中-公开
标题翻译：成分组成
公开(公告)号：US20110077309A1
公开(公告)日：2011-03-31
申请号：US12959670
申请日：2010-12-03
申请人： Tetsuya Yamamoto , Kenya Ishida
发明人： Tetsuya Yamamoto , Kenya Ishida
IPC分类号： A61K47/42 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/36 , A61K47/46 , A61Q5/12 , A61Q19/00 , A61P17/00 , A61K8/33 , A61Q13/00
CPC分类号： A61K8/345 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q13/00 , A61Q19/00 , A61Q19/10
摘要： The present invention relates to a humectant composition containing, as component (A), at least one member selected from a menthol derivative represented by the following formula (1) and p-menthane-3,8-diol: in which R is an alkylene group having 2 to 5 carbon atoms which may be substituted with at least one member selected from the group consisting of a methyl group and a hydroxyl group, and n is an integer of 1 to 3. The humectant composition of the present invention provides an excellent moisture-retention effect.
摘要翻译：本发明涉及作为组分（A）的至少一种选自由下式（1）表示的薄荷醇衍生物和对 - 薄荷烷-3,8-二醇中的至少一种的组合物：其中R是亚烷基具有2至5个碳原子的基团，其可以被选自甲基和羟基中的至少一种取代，n是1至3的整数。本发明的保湿组合物提供优异的保湿效果。

63. 发明申请

US20090198070A1 Condensation Reaction by Metal Catalyst 有权
标题翻译：金属催化剂的缩合反应
公开(公告)号：US20090198070A1
公开(公告)日：2009-08-06
申请号：US12085988
申请日：2006-12-04
申请人： Kazushi Mashima , Takashi Ohshima , Takanori Iwasaki , Hironori Maeda , Kenya Ishida
发明人： Kazushi Mashima , Takashi Ohshima , Takanori Iwasaki , Hironori Maeda , Kenya Ishida
IPC分类号： C07F15/00 , C07D263/08 , C07D263/52
CPC分类号： C07D263/12 , B01J31/2226 , B01J2531/26 , C07C53/18 , C07C231/02 , C07C253/30 , C07D263/10 , C07D263/14 , C07D263/52 , C07D413/06 , C07F3/003 , C07F7/1892 , C07F9/5022 , C07K1/088 , C07K1/10
摘要： The invention relates to a method for producing an azoline compound represented by the general formula (3): wherein R1 represents an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; R3, R4, R5 and R6 may be the same or different and each represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; two arbitrary groups selected from R3, R4, R5 and R6 may bond to each other to form a ring; and Z1 represents an oxygen atom, a sulfur atom or a selenium atom; comprising reacting a carboxylic acid or a carboxylic acid derivative represented by the general formula (1): R1CO2R2 (1) wherein R1 is as defined above; R2 represents a hydrogen atom, an optionally substituted alkyl group or an optionally substituted aryl group; and R1 and R2 may bond to each other to form a ring; with an aminochalcogenide represented by the general formula (2): wherein R3, R4, R5, R6 and Z1 are as defined above; in the presence of a compound containing a group 12 metal element in the periodic table.
摘要翻译：本发明涉及一种制备由通式（3）表示的唑啉化合物的方法：其中R1表示任选取代的烃基，任选取代的烷氧基，任选取代的烷氧基羰基，卤素原子，取代的氨基，取代的氨基甲酰基或任选取代的杂环基; R3，R4，R5和R6可以相同或不同，各自表示氢原子，任选取代的烃基，任选取代的烷氧基，任选取代的烷氧基羰基，卤素原子，取代的氨基，取代的氨基甲酰基基团或任选取代的杂环基团; 选自R3，R4，R5和R6中的两个任意基团可以彼此键合形成环; Z1表示氧原子，硫原子或硒原子; 包括使由通式（1）表示的羧酸或羧酸衍生物反应：<？in-line-formula description =“In-line formula”end =“lead”？> R1CO2R2（1）<？ -formulae description =“In-line Formulas”end =“tail”？>其中R1如上定义; R2表示氢原子，任选取代的烷基或任选取代的芳基; 并且R 1和R 2可以彼此键合形成环; 与通式（2）表示的氨基硫族化物：其中R3，R4，R5，R6和Z1如上定义; 在含有元素周期表中第12族金属元素的化合物存在下进行。

64. 发明申请

US20070225378A1 Menthol Dearivative and Cooling Agent Composition Comprising the Same 有权
标题翻译：薄荷醇衍生物和冷却剂组合物组成
公开(公告)号：US20070225378A1
公开(公告)日：2007-09-27
申请号：US11628086
申请日：2004-05-31
申请人： Kenya Ishida , Takashi Aida , Hiroyuki Matsuda , Fumihiro Yanaka
发明人： Kenya Ishida , Takashi Aida , Hiroyuki Matsuda , Fumihiro Yanaka
IPC分类号： C07C43/196 , C07C43/184
CPC分类号： A61K8/39 , A61K2800/244 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q19/00 , A61Q19/10 , C07C43/196 , C07C2601/14
摘要： The invention relates to innovative menthol derivatives which are represented by the general formula (I) below and are excellent in a cooling effect and cool retaining effect, cooling agent compositions comprising the menthol derivatives, and sensory stimulation agent compositions containing the cooling agent compositions, as well as fragrance compositions, beverage or food products, cosmetic products, toiletry products, bathing agents, and pharmaceutical products containing the cooling agent compositions or sensory stimulation agent compositions. (general formula (I)) wherein R represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 5 carbon atoms; R and R independently represent an alkylene group having 2 to 5 carbon atoms and optionally having a substituent; double dotted line represents a single bond or a double bond; and n is an integer of 1 to 3.
摘要翻译：本发明涉及由以下通式（I）表示并具有优异的冷却效果和冷保持效果的创新薄荷醇衍生物，包含薄荷醇衍生物的冷却剂组合物和含有冷却剂组合物的感觉刺激剂组合物，如以及香料组合物，饮料或食品，化妆品，化妆品，洗浴剂和含有冷却剂组合物或感觉刺激剂组合物的药物制品。（通式（I））其中R 1表示氢原子，具有1至4个碳原子的烷基或具有1至5个碳原子的酰基; R 2和R 3独立地表示具有2至5个碳原子并且任选具有取代基的亚烷基; 双点划线表示单键或双键; n为1〜3的整数。

65. 发明授权

US07196052B2 Fragrance composition 有权
标题翻译：香料组成
公开(公告)号：US07196052B2
公开(公告)日：2007-03-27
申请号：US10369520
申请日：2003-02-21
申请人： Kenya Ishida , Kenji Arata , Kenji Maruyama
发明人： Kenya Ishida , Kenji Arata , Kenji Maruyama
IPC分类号： A61K8/18
CPC分类号： A61Q13/00 , A61K8/345 , C11B9/0015
摘要： A fragrance composition having high fragrance properties such as fragrance diffusivity and long-lasting property obtained without changing the fragrance note of the fragrance composition which is useful in various fragrance providing products such as cosmetics, toiletry products, bath compositions and pharmaceuticals having satisfactory fragrance properties such as fragrance diffusivity and long-lasting property. The fragrance composition contains 0.1 to 90% by weight of a glyceryl ether derivative represented by the following general formula (I), such as 2-ethylhexyloxypropanediol as a fixative or fragrance note-improving agent. The fragrance-providing product contains 0.01 to 50% by weight of the fragrance composition in the final product composition. General formula (I) is: wherein R1 represents an aliphatic hydrocarbon group having 4 to 12 carbon atoms which may have a branched chain or an aromatic hydrocarbon group, which may have a substituent.
摘要翻译：具有高芳香性的香料组合物，其香味扩散性和持久性优异，而不改变香料组合物的香味，可用于各种香料提供产品如化妆品，化妆品，浴组合物和具有令人满意的香料性能的药物如作为香味的扩散性和持久性。芳香剂组合物含有0.1〜90重量％的由以下通式（I）表示的甘油醚衍生物，例如作为固定剂或香味促进剂的2-乙基己基氧基丙二醇。提供香料的产品在最终产品组合物中含有0.01至50重量％的香料组合物。通式（I）是：

66. 发明授权

US5831125A Method of making primary amide derivative 失效
标题翻译：制备伯酰胺衍生物的方法
公开(公告)号：US5831125A
公开(公告)日：1998-11-03
申请号：US843838
申请日：1997-04-17
申请人： Kazutoshi Sakurai , Kenya Ishida , Miharu Ogura
发明人： Kazutoshi Sakurai , Kenya Ishida , Miharu Ogura
IPC分类号： C07C231/16 , C07C231/02 , C07C233/18 , C07C233/20 , C07C235/08 , C07C231/08 , C07C231/10
CPC分类号： C07C231/02
摘要： A method of selective N-acylation of an aminodiol having a primary alcoholic hydroxyl group and a secondary alcoholic hydroxyl group, in which the objective product can be prepared in high yield and without troublesome extraction and purification operations. More particularly, a method of making a primary amide derivative represented by the following general formula (3) is disclosed: ##STR1## wherein R.sup.1 represents a linear saturated aliphatic hydrocarbon group having 11 to 19 carbon atoms, R.sup.2 represents a linear saturated or unsaturated aliphatic hydrocarbon group having 9 to 19 carbon atoms which may have a hydroxyl group at the 1-position, which includes the steps of reacting an aminodiol represented by the following general formula (1): ##STR2## wherein R.sup.1 is the same as R.sup.1 in general formula (3) with a fatty acid alkyl ester represented by the following general formula (2): R.sup.2 --COO--R.sup.3 (2) wherein R.sup.2 is the same as R.sup.2 in general formula (3) and R.sup.3 represents a lower alkyl group, in a reaction system comprising an alcoholic solvent and in the presence of a basic catalyst, said reacting step forming a lower alcohol as a by-product; and removing the lower alcohol formed during the reaction from the reaction system.
摘要翻译：具有初级醇羟基和仲醇羟基的氨基二醇的选择性N-酰化的方法，其中可以高产率制备目标产物并且不需要麻烦的提取和纯化操作。更具体地说，公开了制备由以下通式（3）表示的伯酰胺衍生物的方法：其中R1表示具有11至19个碳原子的直链饱和脂族烃基，R2表示直链饱和或可以在1位具有羟基的碳原子数9〜19的不饱和脂肪族烃基，其包括使下述通式（1）表示的氨基二醇反应的步骤：其中R1为与通式（3）中的R 1与由以下通式（2）表示的脂肪酸烷基酯相同：R2-COO-R3（2）其中R2与通式（3）中的R2相同，R3表示在含有醇溶剂的反应体系中，在碱性催化剂的存在下，所述反应步骤形成作为副产物的低级醇; 并从反应体系中除去反应期间形成的低级醇。

67. 发明授权

US5786386A Antibacterial and fungicidal agent 失效
标题翻译：抗菌杀菌剂
公开(公告)号：US5786386A
公开(公告)日：1998-07-28
申请号：US678598
申请日：1996-07-15
申请人： Kenya Ishida , Kazutoshi Sakurai
发明人： Kenya Ishida , Kazutoshi Sakurai
IPC分类号： A01N33/04 , A01N33/06 , A01N33/10 , A01N43/30 , A01N43/50 , C07C217/58 , C07D233/54 , C07D317/58
CPC分类号： C07D233/64 , A01N33/04 , A01N33/06 , A01N33/10 , A01N43/30 , A01N43/50 , C07C217/58 , C07D317/58
摘要： The present invention provides an antibacterial and fungicidal agent containing an amino compound of formula (1) or a salt thereof. The invention also provides a method for imparting antibacterial and fungicidal properties to a variety of objects using the compound. ##STR1## wherein .phi. represents a phenyl group, a substituted phenyl group (wherein the substituents are 1-5 members arbitrarily selected from the group consisting of a hydroxyl group, halogen atoms, lower alkoxyl groups, trifluoromethyl group, an amino group, and a methylenedioxy group), or an imidazolyl group; R.sup.1 represents a hydrogen atom or a lower alkyl group; and R.sup.2 represents a C6-C12 alkyl group. The amino compound of formula (1) or a salt thereof exhibits excellent antibacterial effects and fungicidal effects, and when it is applied to a variety of articles used in industry, commodities, etc., enhanced antibacterial effects and fungicidal effects are obtained.
摘要翻译：本发明提供含有式（1）的氨基化合物或其盐的抗细菌剂和杀真菌剂。本发明还提供了使用该化合物赋予各种物体抗菌和杀真菌性能的方法。（1）其中phi表示苯基，取代的苯基（其中取代基任选地选自羟基，卤素原子，低级烷氧基，三氟甲基，氨基，和亚甲二氧基）或咪唑基; R1表示氢原子或低级烷基; R2代表C6-C12烷基。式（1）的氨基化合物或其盐具有优异的抗菌效果和杀真菌效果，并且当其应用于工业，商品等中使用的各种制品时，获得了增强的抗菌效果和杀真菌效果。

68. 发明授权

US5380763A Topical composition for treating acne vulgaris 失效
标题翻译：用于治疗寻常痤疮的局部组合物
公开(公告)号：US5380763A
公开(公告)日：1995-01-10
申请号：US154458
申请日：1993-11-19
申请人： Toshiya Sato, deceased , Kenya Ishida
发明人： Toshiya Sato, deceased , Kenya Ishida
IPC分类号： A61K8/30 , A61K8/00 , A61K8/34 , A61K31/00 , A61K31/045 , A61P17/00 , A61P17/10 , A61P31/04 , A61Q19/00
CPC分类号： A61K8/342 , A61K31/045 , A61Q19/00 , Y10S514/844 , Y10S514/859
摘要： A topical composition for treating acne vulgaris comprising 1-pentadecanol as an active ingredient and a carrier or diluent acceptable for topical composition is disclosed. The composition is highly effective on Propionibacterium acnes and of high safety.
摘要翻译：公开了一种用于治疗寻常痤疮的局部组合物，其包含1-十五烷醇作为活性成分和局部组合物可接受的载体或稀释剂。该组合物对痤疮丙酸杆菌高度安全有效。

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