专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

US20100120116A1 NANOPATTERNED BIOPOLYMER OPTICAL DEVICE AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：纳米生物聚合物光学器件及其制造方法
公开(公告)号：US20100120116A1
公开(公告)日：2010-05-13
申请号：US12513394
申请日：2007-11-05
申请人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi
发明人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi
IPC分类号： B29D11/00 , G02B1/12 , G02B1/04 , C12N11/08
CPC分类号： B29D11/00 , G02B1/04 , Y10T428/24479 , C08L1/00 , C08L3/00 , C08L5/00 , C08L89/00
摘要： A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a nanopatterned surface, casting the biopolymer matrix solution on the nanopatterned surface of the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film on the substrate, where the solidified biopolymer film is formed with a surface having a nanopattern thereon. In another embodiment, the method also includes annealing the solidified biopolymer film. A nanopatterned biopolymer optical device includes a solidified biopolymer film with a surface having a nanopattern is also provided.
摘要翻译：制备纳米图案生物聚合物光学器件的方法包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，向基质提供纳米图案化的表面，将生物聚合物基质溶液浇铸在基底的纳米图案化表面上，并干燥生物聚合物基质溶液以在基底上形成固化的生物聚合物膜，其中固化的生物聚合物膜形成有其上具有纳米图案的表面。在另一个实施方案中，该方法还包括退火固化的生物聚合物膜。还提供了纳米图案生物聚合物光学装置，其包括具有具有纳米图案的表面的固化的生物聚合物膜。

62. 发明授权

US07674882B2 Silk biomaterials and methods of use thereof 有权
标题翻译：丝素生物材料及其使用方法
公开(公告)号：US07674882B2
公开(公告)日：2010-03-09
申请号：US11020650
申请日：2004-12-23
申请人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
发明人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
IPC分类号： A61K38/17 , A61L15/00
CPC分类号： D01D5/0038 , A61L27/227 , A61L27/3604 , D01F1/02 , D01F4/02 , D01F6/94 , D06M13/17 , D06M15/03 , D06M15/11 , A61L27/48 , C08L71/02 , A61L27/44
摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
摘要翻译：本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

63. 发明申请

US20100046902A1 BIOPOLYMER PHOTONIC CRYSTALS AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：生物聚合物光子晶体及其制造方法
公开(公告)号：US20100046902A1
公开(公告)日：2010-02-25
申请号：US12513384
申请日：2007-11-05
申请人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi
发明人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi
IPC分类号： G02B6/122 , B29D11/00
CPC分类号： G02B1/005 , B29D11/00 , B82Y20/00 , G02B6/1225 , Y10T428/24273 , Y10T428/24355 , Y10T428/31678
摘要： A method of manufacturing a biopolymer photonic crystal includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film. A surface of the film is formed with a nanopattern, or a nanopattern is machined on a surface of the film. In another embodiment, a plurality of biopolymer films is stacked together. A photonic crystal is also provided that is made of a biopolymer and has a nanopatterned surface. In another embodiment, the photonic crystal includes a plurality of nanopatterned films that are stacked together.
摘要翻译：制备生物聚合物光子晶体的方法包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，提供基材，将基质溶液浇铸在基材上，以及干燥生物聚合物基质溶液以形成固化的生物聚合物膜。膜的表面形成有纳米图案，或者在膜的表面上加工纳米图案。在另一个实施方案中，多个生物聚合物膜堆叠在一起。还提供了由生物聚合物制成并具有纳米图案表面的光子晶体。在另一个实施例中，光子晶体包括堆叠在一起的多个纳米图案化膜。

64. 发明申请

US20100028451A1 SILK MICROSPHERES FOR ENCAPSULATION AND CONTROLLED RELEASE 审中-公开
标题翻译：用于封装和控制释放的SILK微孔
公开(公告)号：US20100028451A1
公开(公告)日：2010-02-04
申请号：US12442595
申请日：2007-09-26
申请人： David L. Kaplan , Xiaoqin Wang
发明人： David L. Kaplan , Xiaoqin Wang
IPC分类号： A61K9/14 , A61K38/02 , A61K31/7088 , A61K39/395 , A61K38/43 , A61K38/16 , A61K38/21 , A61K38/20 , A61K38/28
CPC分类号： A61K38/44 , A61K9/127 , A61K9/16 , A61K9/1658 , A61K9/19 , A61K9/5052 , A61K31/7076 , A61K47/34 , A61K47/42
摘要： A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in β-sheet structure dominant silk microsphere structures having about 2 μm in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.
摘要翻译：开发了一种使用脂质囊泡作为模板来制备丝素蛋白微球的方法，以有效地加载活性形式的治疗剂用于控制释放。随后通过使用脱水剂如甲醇或氯化钠除去脂质，得到具有约2μm直径的β-片状结构优势的丝微球结构。治疗剂可以包埋在丝微球中并用于药物制剂中用于控制释放处理。

65. 发明授权

US07635755B2 Concentrated aqueous silk fibroin solution and use thereof 有权
标题翻译：浓缩水性丝素蛋白溶液及其用途
公开(公告)号：US07635755B2
公开(公告)日：2009-12-22
申请号：US11247358
申请日：2005-10-11
申请人： David L. Kaplan , Ung-Jin Kim , Jaehyung Park , Hyoung-Joon Jin
发明人： David L. Kaplan , Ung-Jin Kim , Jaehyung Park , Hyoung-Joon Jin
IPC分类号： A61K38/17 , C07K14/00
CPC分类号： A61L27/227 , A61L27/3604 , A61L27/38 , A61L27/52 , A61L27/56 , A61L2430/02 , B29C39/003 , B29C39/203 , B29C55/005 , B29D7/01 , B29K2089/00 , B29L2007/00 , B29L2009/00 , C07K14/43536 , C07K14/43586 , C08J3/07 , C08J3/075 , C08J5/18 , C08J9/0061 , C08J9/26 , C08J9/28 , C08J2201/0444 , C08J2201/0504 , C08J2205/022 , C08J2389/00 , C08L89/00 , D01D5/0007 , D01F4/02 , Y10T428/249921 , Y10T442/10 , Y10T442/60
摘要： The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
摘要翻译：本发明提供浓缩的水性丝素蛋白溶液和用于制备浓缩的丝心蛋白溶液的全水模式，避免使用有机溶剂，直接添加剂或刺激性化学品。本发明进一步提供了这些溶液在生产例如纤维，薄膜，泡沫，网眼，支架和水凝胶的材料中的用途。

66. 发明申请

US20090234026A1 CONCENTRATED AQUEOUS SILK FIBROIN SOLUTION AND USE THEREOF 有权
标题翻译：浓缩水性丝素纤维素溶液及其用途
公开(公告)号：US20090234026A1
公开(公告)日：2009-09-17
申请号：US12425541
申请日：2009-04-17
申请人： David L. Kaplan , Ung-Jin Kim , Jaehyung Park , Hyoung-Joon Jin
发明人： David L. Kaplan , Ung-Jin Kim , Jaehyung Park , Hyoung-Joon Jin
IPC分类号： A61K47/42
CPC分类号： A61L27/227 , A61L27/3604 , A61L27/38 , A61L27/52 , A61L27/56 , A61L2430/02 , B29C39/003 , B29C39/203 , B29C55/005 , B29D7/01 , B29K2089/00 , B29L2007/00 , B29L2009/00 , C07K14/43536 , C07K14/43586 , C08J3/07 , C08J3/075 , C08J5/18 , C08J9/0061 , C08J9/26 , C08J9/28 , C08J2201/0444 , C08J2201/0504 , C08J2205/022 , C08J2389/00 , C08L89/00 , D01D5/0007 , D01F4/02 , Y10T428/249921 , Y10T442/10 , Y10T442/60
摘要： The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
摘要翻译：本发明提供浓缩的水性丝素蛋白溶液和用于制备浓缩的丝心蛋白溶液的全水模式，避免使用有机溶剂，直接添加剂或刺激性化学品。本发明进一步提供了这些溶液在生产例如纤维，薄膜，泡沫，网眼，支架和水凝胶的材料中的用途。

67. 发明申请

US20090202614A1 METHODS FOR STEPWISE DEPOSITION OF SILK FIBROIN COATINGS 有权
标题翻译：用于步骤沉积硅胶涂层的方法
公开(公告)号：US20090202614A1
公开(公告)日：2009-08-13
申请号：US11997193
申请日：2006-07-28
申请人： David L. Kaplan , Xianyan Wang
发明人： David L. Kaplan , Xianyan Wang
IPC分类号： A61K9/70 , B05D3/04 , B32B9/00 , A61P43/00
CPC分类号： A61L31/10 , A61J3/00 , A61L15/32 , A61L15/44 , A61L27/3604 , A61L27/50 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2400/12 , A61L2400/18 , C09D189/00 , Y10T428/31768
摘要： The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.
摘要翻译：本发明提供了一种使用水性丝素蛋白材料控制组合层状丝素蛋白涂层的方法。本文所述的方法可用于涂覆任何材料，形状或尺寸的基材。重要的是，所描述的方法使得能够使用分层薄膜涂层或散装涂层来控制生物材料表面化学，厚度，形态和结构。此外，所述方法可以在所有的水中进行，并且不需要强化的化学处理，从而能够控制不稳定的分子例如药物，细胞因子甚至细胞或病毒的捕获，以产生可用于各种应用的功能性涂层。

68. 发明申请

US20090043520A1 User Interface and User Control in a Power Aggregation System for Distributed Electric Resources 审中-公开
标题翻译：用于分布式电力资源的电力聚合系统中的用户界面和用户控制
公开(公告)号：US20090043520A1
公开(公告)日：2009-02-12
申请号：US12252950
申请日：2008-10-16
申请人： Seth B. Pollack , Seth W. Bridges , David L. Kaplan
发明人： Seth B. Pollack , Seth W. Bridges , David L. Kaplan
IPC分类号： G01R21/06
CPC分类号： G06Q30/0283 , B60L3/12 , B60L53/14 , B60L53/20 , B60L53/305 , B60L53/57 , B60L53/64 , B60L53/65 , B60L53/665 , B60L55/00 , B60L2240/72 , B60L2240/80 , B60L2250/10 , B60L2250/16 , B60L2260/52 , B60L2260/54 , B60L2260/58 , B60L2270/32 , H02J13/0079 , H02J13/0086 , Y02E60/721 , Y02T10/7005 , Y02T10/7088 , Y02T10/7291 , Y02T90/121 , Y02T90/127 , Y02T90/128 , Y02T90/14 , Y02T90/163 , Y02T90/169 , Y04S10/126 , Y04S30/14 , Y04S50/14 , Y04S50/16
摘要： Systems and methods are described for a power aggregation system. In one implementation, an electric charging station connected to a power grid includes a power connection operable to connect an electric resource to the electric charging station. Additionally, the electric charging station includes a user interface operable to provide a user access to information associated with the electric resource and the power grid.
摘要翻译：为功率聚合系统描述了系统和方法。在一个实施方式中，连接到电网的充电站包括可操作以将电力资源连接到充电站的电力连接。此外，充电站包括用户界面，其可操作以向用户提供对与电力资源和电网相关联的信息的访问。

69. 发明授权

US06287844B1 Compositions and methods for controlling genetically engineered organisms 失效
标题翻译：用于控制转基因生物的组合物和方法
公开(公告)号：US06287844B1
公开(公告)日：2001-09-11
申请号：US09019966
申请日：1998-02-06
申请人： Przemyslaw Szafranski , Charlene Mello , Takeshi Sano , Cassandra L. Smith , David L. Kaplan , Charles R. Cantor
发明人： Przemyslaw Szafranski , Charlene Mello , Takeshi Sano , Cassandra L. Smith , David L. Kaplan , Charles R. Cantor
IPC分类号： C12N120
CPC分类号： C07K14/36 , C12N15/72 , C12N15/74
摘要： Compositions and methods for the control of genetically engineered organisms are described. A more effective cell suicide approach is contemplated based on the conditional expression of the lethal Streptomyces avidinii streptavidin gene. Toxicity of streptavidin is derived from its exceptionally high binding affinity for an essential prosthetic group, D-biotin. The general requirement for biotin through the living world makes streptavidin-based conditional lethal designs applicable to a broad range of containment strategies.
摘要翻译：描述了用于控制转基因生物的组合物和方法。基于致死性链霉菌链霉亲和素链霉亲和素基因的条件表达考虑了更有效的细胞自杀方法。链霉抗生物素蛋白的毒性源自其对必需的假基团D-生物素的极高的结合亲和力。生物素通过生活世界的一般要求使基于链霉亲和素的条件致命设计适用于广泛的遏制策略。

70. 发明授权

US5737591A Database view generation system 失效
标题翻译：数据库视图生成系统
公开(公告)号：US5737591A
公开(公告)日：1998-04-07
申请号：US653716
申请日：1996-05-23
申请人： David L. Kaplan , Andrew R. Miller , Andrew McRae Warden
发明人： David L. Kaplan , Andrew R. Miller , Andrew McRae Warden
IPC分类号： G06F17/30
CPC分类号： G06F17/30554 , Y10S707/99931 , Y10S707/99932 , Y10S707/99933
摘要： A database view generation system for viewing a result set of data extracted from a database by a query. The database view generation system includes selecting a viewpoint from among at least one field set record source of a database sub-schema and generating a view of the result set in at least one level from a perspective of the viewpoint. Generating a view from a viewpoint includes analyzing the sub-schema for connectedness, identifying the sub-schema type, assigning a level indicator value that is indicative of the hierarchical position of record sources in the sub-schema relative to the viewpoint, and displaying a view of the result set based on the level indicator value assigned to each record source containing data in the result set.
摘要翻译：数据库视图生成系统，用于通过查询查看从数据库提取的数据的结果集。数据库视图生成系统包括从数据库子模式的至少一个字段集记录源中选择视点，并从视点的角度生成至少一个级别中的结果集合的视图。从视点生成视图包括分析用于连接的子模式，识别子模式类型，分配指示相对于视点的子模式中的记录源的分层位置的级别指示符值，以及显示根据分配给包含结果集中数据的每个记录源的级别指示符值，查看结果集。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式