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61. 发明申请

US20050149143A1 Baroreflex stimulator with integrated pressure sensor 有权
标题翻译：具有集成压力传感器的Baroreflex刺激器
公开(公告)号：US20050149143A1
公开(公告)日：2005-07-07
申请号：US10745921
申请日：2003-12-24
申请人： Imad Libbus , Rodney Salo
发明人： Imad Libbus , Rodney Salo
IPC分类号： A61N1/36 , A61N1/365 , A61N1/18
CPC分类号： A61N1/36117 , A61N1/36057 , A61N1/36564
摘要： An aspect relates to an implantable medical device. An embodiment of the device comprises a pulse generator, sensor circuitry, a lead, and a controller. The pulse generator generates baroreflex stimulation pulses. The lead is adapted to be electrically connected to the pulse generator and to the sensor circuitry. The lead includes an electrode to distribute the baroreflex stimulation pulses to a baroreflex site and a pressure sensor to provide a signal indicative of blood pressure to the sensor circuitry. The controller is connected to the pulse generator and the sensor circuitry. The controller adapted to adjust the baroreflex stimulation pulses based on the blood pressure. Other aspects are provided herein.
摘要翻译：一个方面涉及可植入医疗装置。该装置的实施例包括脉冲发生器，传感器电路，引线和控制器。脉冲发生器产生压力反射刺激脉冲。引线适于电连接到脉冲发生器和传感器电路。引线包括用于将压力反射刺激脉冲分布到压力反射部位的电极和压力传感器，以向传感器电路提供指示血压的信号。控制器连接到脉冲发生器和传感器电路。控制器适于基于血压调节压力反射刺激脉冲。本文提供了其他方面。

62. 发明申请

US20050149133A1 Sensing with compensation for neural stimulator 审中-公开
标题翻译：感应神经刺激器补偿
公开(公告)号：US20050149133A1
公开(公告)日：2005-07-07
申请号：US10746847
申请日：2003-12-24
申请人： Imad Libbus , Qingsheng Zhu , Steven Girouard
发明人： Imad Libbus , Qingsheng Zhu , Steven Girouard
IPC分类号： A61N1/36 , A61N1/365 , A61N1/362
CPC分类号： A61N1/36117 , A61N1/36135 , A61N1/36564
摘要： An aspect of the present subject matter relates to an implantable medical system. An embodiment of the system comprises a baroreflex stimulator, a cardiac event detector, and communication circuitry. The stimulator includes a pulse generator to apply baroreflex stimulation therapy. The detector includes a sensor to detect electrical signals indicative of cardiac events, and a controller connected to the sensor to determine an occurrence of a cardiac event from the electrical signals using an event detection routine. The communication circuitry communicates between the baroreflex stimulator and the cardiac event detector to account for applied baroreflex stimulation therapy and enable the cardiac event detector to discriminate the electrical signals indicative of the cardiac event from the applied baroreflex stimulation therapy. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器，心脏事件检测器和通信电路。刺激器包括脉冲发生器以应用压力反射刺激疗法。检测器包括用于检测指示心脏事件的电信号的传感器，以及连接到传感器的控制器，以使用事件检测程序从电信号确定心脏事件的发生。通信电路在压力反射刺激器和心脏事件检测器之间进行通信，以解决所施加的压力反射刺激治疗，并且使得心脏事件检测器能够将指示心脏事件的电信号与施加的压力反射刺激疗法区分开。本文提供了其他方面。

63. 发明申请

US20050149131A1 Baroreflex modulation to gradually decrease blood pressure 有权
标题翻译： Baroreflex调制逐渐降低血压
公开(公告)号：US20050149131A1
公开(公告)日：2005-07-07
申请号：US10746845
申请日：2003-12-24
申请人： Imad Libbus , Julio Spinelli
发明人： Imad Libbus , Julio Spinelli
IPC分类号： A61N1/36 , A61N1/362 , A61N1/365
CPC分类号： A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/36146 , A61N1/36564
摘要： An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulation signal to increase the baroreflex stimulation therapy by a predetermined rate of change to lower systemic blood pressure to a target pressure. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及一种压力反射刺激器。刺激器的实施例包括脉冲发生器，以通过电极提供压力反射刺激信号和调制器。该调节剂调节压力反射刺激信号以增加压力反射刺激疗法预定的变化率，从而将全身血压降低到目标压力。本文提供了其他方面。

64. 发明申请

US20050149130A1 Baroreflex stimulation synchronized to circadian rhythm 有权
标题翻译： Baroreflex刺激与昼夜节律同步
公开(公告)号：US20050149130A1
公开(公告)日：2005-07-07
申请号：US10746844
申请日：2003-12-24
申请人： Imad Libbus
发明人： Imad Libbus
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61N1/36114 , A61N1/3601 , A61N1/36117 , A61N1/36135 , A61N1/36564
摘要： An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator comprises a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator to modulate the baroreflex stimulation signal based on a circadian rhythm template. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及一种压力反射刺激器。刺激器的实施例包括脉冲发生器，以通过电极提供压力反射刺激信号，以及调制器，用于基于昼夜节律模板来调节压力反射刺激信号。本文提供了其他方面。

65. 发明申请

US20050143785A1 Baroreflex therapy for disordered breathing 有权
标题翻译： Baroreflex治疗无序呼吸
公开(公告)号：US20050143785A1
公开(公告)日：2005-06-30
申请号：US10864070
申请日：2004-06-08
申请人： Imad Libbus
发明人： Imad Libbus
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61N1/36114 , A61N1/3601 , A61N1/36117 , A61N1/36135 , A61N1/36564
摘要： An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator comprises a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator to modulate the baroreflex stimulation signal based on a circadian rhythm template. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及一种压力反射刺激器。刺激器的实施例包括脉冲发生器，以通过电极提供压力反射刺激信号，以及调制器，用于基于昼夜节律模板来调节压力反射刺激信号。本文提供了其他方面。

66. 发明申请

US20050143779A1 Baroreflex modulation based on monitored cardiovascular parameter 有权
标题翻译：基于监测心血管参数的Baroreflex调制
公开(公告)号：US20050143779A1
公开(公告)日：2005-06-30
申请号：US10939544
申请日：2004-09-13
申请人： Imad Libbus
发明人： Imad Libbus
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/36117 , A61N1/3627 , A61N1/36514 , A61N1/37235
摘要： An aspect of the present subject matter relates to a system for providing baroreflex stimulation. An embodiment of the system comprises a heart rate monitor to sense a heart rate and provide a signal indicative of the heart rate, and a baroreflex stimulator. The stimulator includes a pulse generator to intermittently generate a stimulation signal to provide baroreflex stimulation for a baroreflex therapy, and further includes a modulator to adjust the stimulation signal based on the signal indicative of the heart rate such that the stimulation signal provides a desired baroreflex stimulation corresponding to a desired heart rate. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及一种用于提供压力反射刺激的系统。系统的实施例包括用于感测心率并提供指示心率的信号的心率监测器和压力反射刺激器。刺激器包括脉冲发生器，间歇地产生刺激信号以提供压力反射治疗的压力反射刺激，并且还包括调节器，用于基于指示心率的信号来调节刺激信号，使得刺激信号提供期望的压力反射刺激对应于期望的心率。本文提供了其他方面。

67. 发明授权

US09555252B2 Systems for providing neural markers for sensed autonomic nervous system activity 有权
标题翻译：用于提供感觉到的自主神经系统活动的神经标记物的系统
公开(公告)号：US09555252B2
公开(公告)日：2017-01-31
申请号：US12612494
申请日：2009-11-04
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/37 , A61B5/04 , A61N1/36 , A61N1/362 , A61N1/372 , A61B5/00
CPC分类号： A61N1/37 , A61B5/04001 , A61B5/4035 , A61B5/4047 , A61B5/4052 , A61B5/726 , A61N1/36135 , A61N1/3627 , A61N1/3702 , A61N1/37217 , A61N1/37235
摘要： In various method embodiments, a neural activity signal is sensed, a feature from the sensed neural activity signal is extracted, and a neural marker for the extracted feature is created. The neural marker includes information regarding the extracted feature. Various device embodiments comprise a port to receive a neural activity signal, and a feature extractor adapted to receive and process the neural activity signal to produce a neural marker that includes information for the neural activity signal. Various device embodiments comprise a display, a memory adapted to store a neural marker associated with a sensed neural activity signal, and a controller adapted to communicate with the memory and the display to provide a representation of the neural marker on the display.
摘要翻译：在各种方法实施例中，感测神经活动信号，提取来自所感测的神经活动信号的特征，并且创建用于提取的特征的神经标记。神经标记包括关于提取的特征的信息。各种装置实施例包括用于接收神经活动信号的端口，以及适于接收和处理所述神经活动信号以产生神经标记的特征提取器，所述神经标记包括所述神经活动信号的信息。各种设备实施例包括显示器，适于存储与感测的神经活动信号相关联的神经标记的存储器，以及适于与存储器和显示器通信以提供显示器上的神经标记的表示的控制器。

68. 发明授权

US09031650B2 Closed loop neural stimulation synchronized to cardiac cycles 有权
标题翻译：闭环神经刺激与心脏周期同步
公开(公告)号：US09031650B2
公开(公告)日：2015-05-12
申请号：US12986762
申请日：2011-01-07
申请人： Aaron R. McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
发明人： Aaron R. McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36139 , A61N1/36114 , A61N1/36135 , A61N1/365 , A61N1/36592 , A61N1/3962 , A61N1/3987
摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面涉及一种方法。根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。基于对神经刺激的检测反应来滴定神经刺激。本文提供了其它方面和实施例。

69. 发明授权

US08965503B2 Systems and methods for treating supraventricular arrhythmias 有权
标题翻译：用于治疗室上性心律失常的系统和方法
公开(公告)号：US08965503B2
公开(公告)日：2015-02-24
申请号：US13555784
申请日：2012-07-23
申请人： Imad Libbus
发明人： Imad Libbus
IPC分类号： A61N1/00 , A61N1/36 , A61N1/362 , A61N1/39
CPC分类号： A61N1/36114 , A61N1/3621 , A61N1/3962
摘要： In various method embodiments, a supraventricular arrhythmia event is detected, and a supraventricular arrhythmia treatment, including neural stimulation to elicit a sympathetic response, is delivered in response to a detected supraventricular arrhythmia event. Some embodiments detect a precursor for a supraventricular arrhythmia episode, and deliver prophylactic neural stimulation to avoid the supraventricular arrhythmia event. Some embodiments detect a supraventricular arrhythmia episode, and deliver therapeutic neural stimulation for the supraventricular arrhythmia event.
摘要翻译：在各种方法实施例中，检测到室上性心律失常事件，并且响应于检测到的室上性心律失常事件递送室上性心律失常治疗，包括引起交感神经反应的神经刺激。一些实施方案检测室上性心律失常发作的前体，并提供预防性神经刺激以避免室上性心律失常事件。一些实施例检测室上性心律失常发作，并为室上性心律失常事件递送治疗性神经刺激。

70. 发明授权

US08929990B2 Transvascular neural stimulation device and method for treating hypertension 有权
标题翻译：血管神经刺激装置及治疗高血压的方法
公开(公告)号：US08929990B2
公开(公告)日：2015-01-06
申请号：US12968831
申请日：2010-12-15
申请人： Julia Moffitt , Imad Libbus
发明人： Julia Moffitt , Imad Libbus
IPC分类号： A61N1/36 , A61N1/05 , A61N1/362
CPC分类号： A61N1/37288 , A61M31/00 , A61N1/0558 , A61N1/056 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/362 , A61N1/3627 , A61N1/37217
摘要： This document discusses, among other things, apparatus, systems, and methods for transvascularly stimulation of a nerve or nerve trunk. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. The apparatus includes an expandable electrode that is chronically implantable in a blood vessel proximate a nerve trunk. The expandable electrode is configured to abut a predetermined surface area of the vessel wall along a predetermined length of the vessel. An electrical lead is coupled to the expandable electrode. An implantable pulse generator is coupled to the lead and configured to deliver an electrical stimulation signal to the electrode through the lead. In an example method, an electrical signal is delivered from an implanted medical device to an electrode chronically implanted in a blood vessel proximate a nerve trunk to transvascularly deliver neural stimulation from the electrode to the nerve trunk.
摘要翻译：本文件还讨论了用于神经或神经干的经血管刺激的装置，系统和方法。在一个实例中，一种装置构造成通过血管经血管刺激神经干。该装置包括可长期植入在靠近神经干的血管中的可扩张电极。可膨胀电极构造成沿容器的预定长度邻接容器壁的预定表面积。电引线耦合到可扩张电极。可植入脉冲发生器耦合到引线并且被配置为通过引线将电刺激信号传递到电极。在一个示例性方法中，将电信号从植入的医疗装置输送到长期植入在靠近神经干的血管中的电极，从而将神经刺激从电极转移到神经干。

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