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61. 发明授权

US4703046A Cephem compounds and processes for preparation thereof 失效
标题翻译：头孢烯化合物及其制备方法
公开(公告)号：US4703046A
公开(公告)日：1987-10-27
申请号：US72990
申请日：1979-09-06
申请人： Ikuo Ueda , Masakazu Kobayashi , Tadashi Kitaguchi
发明人： Ikuo Ueda , Masakazu Kobayashi , Tadashi Kitaguchi
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D277/20 , C07D501/04 , C07D501/20 , C07D501/22 , C07D501/34 , C07D501/36
CPC分类号： C07D277/587
摘要： This invention concerns antibiotic cephalosporins of the formula ##STR1## wherein R.sup.1 is amino or protected amino; R.sup.2 is halogen; R.sup.3 is alkyl; and R.sup.6 is carboxy or protected carboxy.
摘要翻译：本发明涉及式IMA的抗生素头孢菌素，其中R1是氨基或被保护的氨基; R2是卤素; R3是烷基; 并且R 6是羧基或被保护的羧基。

62. 发明授权

US4613608A Mono or dinitroxyalkyl pyridines and vasodilating compositions 失效
标题翻译：单或二硝基烷基吡啶和血管舒张组合物
公开(公告)号：US4613608A
公开(公告)日：1986-09-23
申请号：US731893
申请日：1985-05-08
申请人： Ikuo Ueda , Daizo Morino , Koichi Takimoto
发明人： Ikuo Ueda , Daizo Morino , Koichi Takimoto
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/4418 , A61P9/08 , A61P9/10 , C07D213/30 , C07D213/61 , C07D213/53
CPC分类号： C07D213/30 , C07D213/61
摘要： Compounds of the formula ##STR1## are disclosed whereinR.sup.1 is hydrogen or lower alkyl, one of R.sup.2 and R.sup.3 is mono (or di)-nitroxy(lower)alkyl and the otherR.sup.2 and R.sup.3 is hydrogen and pharmaceutically acceptable salts thereof.Also disclosed are vasodilating compositions containing the above.

63. 发明授权

US4608375A Quinazolinone derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same 失效
标题翻译：喹唑啉酮衍生物，其制备方法和包含其的药物组合物
公开(公告)号：US4608375A
公开(公告)日：1986-08-26
申请号：US622881
申请日：1984-06-21
申请人： Ikuo Ueda , Masayuki Kato
发明人： Ikuo Ueda , Masayuki Kato
IPC分类号： A61K31/505 , A61K31/517 , A61P37/08 , C07D239/95 , C07D239/96 , C07D243/00 , C07D243/08 , C07D403/06 , C07D403/12 , A61K31/445 , C07D239/82
CPC分类号： C07D403/06 , C07D239/95 , C07D239/96 , C07D243/08 , C07D403/12 , Y10S514/826
摘要： The present invention relates to novel quinazolinone derivatives and pharmaceutically acceptable salts thereof. More particularly, it relates to novel quinazolinone derivatives and pharmaceutically acceptable salts thereof which have antiallergic activities, to processes for the preparation thereof, to pharmaceutical composition comprising the same, and to a method of using the same therapeutically in the treatment of allergic symptoms in human being and animals.
摘要翻译：本发明涉及新颖的喹唑啉酮衍生物及其药学上可接受的盐。更具体地说，本发明涉及具有抗过敏活性的新颖的喹唑啉酮衍生物及其药学上可接受的盐，其制备方法，包含其的药物组合物，以及在治疗人类过敏症状中的治疗用途的方法存在和动物。

64. 发明授权

US4563455A Antiulcer fused imidazole compounds 失效
标题翻译：抗溃疡融合咪唑化合物
公开(公告)号：US4563455A
公开(公告)日：1986-01-07
申请号：US587981
申请日：1984-03-09
申请人： Ikuo Ueda , Masayuki Kato , Masanobu Nagano , Atsushi Akahane
发明人： Ikuo Ueda , Masayuki Kato , Masanobu Nagano , Atsushi Akahane
IPC分类号： A61K31/415 , A61P1/04 , C07D235/10 , C07D235/12 , C07D401/06 , C07D403/06 , C07D417/06 , C07D471/04 , C07D521/00 , A61K31/53
CPC分类号： C07D231/12 , C07D233/56 , C07D235/10 , C07D235/12 , C07D249/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07D471/04
摘要： New fused imidazole compounds of the formula: ##STR1## wherein A is lower alkylene,R.sup.1 is hydrogen, lower alkyl, lower alkoxy or halogen,R.sup.2 is hydrogen, lower alkyl, cyclo(lower)alkyl, pyridyl, ar(lower)alkyl which may be substituted with halogen, or aryl which may be substituted with lower alkyl, lower alkoxy, hydroxy or halogen,R.sup.3 is N-containing unsaturated heterocyclic group which may be substituted with lower alkyl or amino, andY is .dbd.C-- or .dbd.N--,and pharmaceutically acceptable salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiulcer agents.
摘要翻译：其中A为低级亚烷基，R 1为氢，低级烷基，低级烷氧基或卤素，R 2为氢，低级烷基，环（低级）烷基，吡啶基，Ar（低级）烷基，可以被卤素取代，或可以被低级烷基，低级烷氧基，羟基或卤素取代的芳基，R3是可被低级烷基或氨基取代的含N不饱和杂环基，Y是=或= N - 及其药学上可接受的盐，及其制备方法和包含其的药物组合物。这些衍生物和其盐可用作抗溃疡剂。

65. 发明授权

US4438126A Lower alkanoic acid derivatives of 2-oxo-benzoxazolines and aldose reductase inhibiting compositions thereof 失效
标题翻译： 2-氧代 - 苯并恶唑啉的低级链烷酸衍生物及其醛糖还原酶抑制组合物
公开(公告)号：US4438126A
公开(公告)日：1984-03-20
申请号：US409089
申请日：1982-08-18
申请人： Ikuo Ueda , Masaaki Matsuo , Susumu Satoh , Takao Watanabe
发明人： Ikuo Ueda , Masaaki Matsuo , Susumu Satoh , Takao Watanabe
IPC分类号： A61K31/495 , A61P25/04 , A61P29/00 , A61P37/08 , C07C17/26 , C07C205/12 , C07C335/18 , C07C335/26 , C07D209/34 , C07D263/58 , C07D277/68 , C07D277/82 , A61K31/42
CPC分类号： C07D277/82 , C07C205/12 , C07C323/00 , C07C335/18 , C07C335/26 , C07D209/34 , C07D263/58 , C07D277/68 , Y10S514/866
摘要： The invention is directed to compounds of the formula ##STR1## wherein R.sub.a.sup.1 is phenyl,R.sup.2 is halogen,R.sup.3 is carboxy or lower alkoxycarbonyl,Y.sub.a is oxygen,A is C.sub.1 -C.sub.6 alkylene,pharmaceutically acceptable salts thereof, and aldose reductase inhibiting pharmaceutical compositions thereof.
摘要翻译：本发明涉及下式的化合物，其中R 1a是苯基，R 2是卤素，R 3是羧基或低级烷氧基羰基，Ya是氧，A是C 1 -C 6亚烷基，其药学上可接受的盐和醛糖还原酶抑制药物组合物其中。

66. 发明授权

US4429126A Sodium salt of 4-oxo-10-(2,3-dimethylpentanamido)-4H-pyrimido[1,2-c]quinozoline-3-carbo xylic acid 失效
标题翻译： 4-氧代-10-（2,3-二甲基戊酰氨基）-4H-嘧啶并[1,2-c]喹唑啉-3-羧酸钠盐
公开(公告)号：US4429126A
公开(公告)日：1984-01-31
申请号：US384998
申请日：1982-06-04
申请人： Ikuo Ueda , Masayuki Kato , Masanobu Nagano
发明人： Ikuo Ueda , Masayuki Kato , Masanobu Nagano
IPC分类号： C07D239/94 , C07D239/95 , C07D239/96 , C07D265/26 , C07D487/04 , A61K31/505 , C07D239/80 , C07D471/14
CPC分类号： C07D487/04 , C07D239/94 , C07D239/95 , C07D239/96 , C07D265/26
摘要： Quinazoline derivatives of the formulae: ##STR1## wherein A.sup.1 is ##STR2## A.sup.2 is ##STR3## R.sup.1 is hydrogen, carboxy or esterified carboxy, R.sub.a.sup.1 and R.sub.b.sup.1 are esterified carboxy,R.sup.2 and R.sup.3 are hydrogen, alkyl, halogen, nitro, amino, alkoxy, aryloxy, alkylthio, alkylpiperazinyl, acylamino or dialkylamino which may be substituted with hydroxy,R.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy, dialkylamino or 2,2-dialkoxycarbonylvinylaminoR.sub.a.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy or dialkylamino,R.sup.5 is alkyl or alkenyl, andR.sup.6 is carboxy or esterified carboxy.
摘要翻译：喹啉衍生物，其结构式如下：其中A1是甲基，R1是氢，羧基或酯化的羧基，Ra1和Rb1是酯化的羧基，R2和R3是氢，烷基，卤素，硝基，可以被羟基取代的氨基，烷氧基，芳氧基，烷硫基，烷基哌嗪基，酰基氨基或二烷基氨基，R 4是氢，烷基，羟基，烷氧基，烯氧基，二烷基氨基或2,2-二烷氧基羰基乙烯基氨基R 4a是氢，烷基，羟基，烷氧基，烯氧基或二烷基氨基，R 5是烷基或烯基，R 6是羧基或酯化的羧基。

67. 发明授权

US4367238A Phenyl-alkanoic acid derivative and preparation thereof 失效
标题翻译：苯基 - 链烷酸衍生物及其制备
公开(公告)号：US4367238A
公开(公告)日：1983-01-04
申请号：US226908
申请日：1981-01-21
申请人： Ikuo Ueda , Yoshihiko Kitaura , Masaaki Matsuo , Nobukiyo Konishi
发明人： Ikuo Ueda , Yoshihiko Kitaura , Masaaki Matsuo , Nobukiyo Konishi
IPC分类号： A61K31/095 , C07C45/40 , C07C45/71 , C07C47/575 , C07C51/09 , C07C59/52 , C07C59/56 , C07C59/64 , C07C59/68 , C07C317/00 , C07D307/83 , C07D307/86 , C07D311/18 , A61K31/365
CPC分类号： C07D311/18 , C07C255/00 , C07C317/00 , C07C323/00 , C07C45/40 , C07C45/71 , C07C47/575 , C07C59/68 , C07D307/83 , C07D307/86
摘要： This invention relates to new phenyl-alkanoic acids, their derivatives at the carboxy group, and pharmaceutically acceptable salts thereof, which have anti-inflammatory, analgesic and antipyretic activities.
摘要翻译：本发明涉及具有抗炎，止痛和解热活性的新的苯基 - 链烷酸，它们在羧基上的衍生物及其药学上可接受的盐。

68. 发明授权

US4298529A Alkoxyimino dioxy butyric acid derivatives 失效
标题翻译：烷氧基亚氨基二氧代丁酸衍生物
公开(公告)号：US4298529A
公开(公告)日：1981-11-03
申请号：US101527
申请日：1979-12-10
申请人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
发明人： Ikuo Ueda , Takao Takaya , Masakazu Kobayashi , Takashi Masugi , Hisashi Takasugi , Hiromu Kochi , Tadashi Kitaguchi
IPC分类号： C07D317/30 , C07D319/06 , C07D501/04 , C07D501/14 , C07D501/20 , C07D317/28
CPC分类号： C07D317/30 , C07D319/06
摘要： The invention relates to new antimicrobially active 3-cephem compounds, processes for preparing such compounds, new intermediate compounds comprising alkoxyimino dioxy butyric acid derivatives useful in said processes, and processes for preparation of said intermediates.
摘要翻译：本发明涉及新的抗微生物活性3-头孢烯化合物，制备这种化合物的方法，包括可用于所述方法的烷氧基亚氨基二氧基丁酸衍生物的新中间体化合物，以及所述中间体的制备方法。

69. 发明授权

US4283492A Production of antibiotics WS-3442 A, B, C, D and E, and their acyl derivatives 失效
标题翻译：生产抗生素WS-3442A，B，C，D和E及其酰基衍生物
公开(公告)号：US4283492A
公开(公告)日：1981-08-11
申请号：US915215
申请日：1978-06-13
申请人： Hiroshi Imanaka , Junzi Hosoda , Kazuyoshi Jomon , Heiichi Sakai , Ikuo Ueda , Daizou Morino
发明人： Hiroshi Imanaka , Junzi Hosoda , Kazuyoshi Jomon , Heiichi Sakai , Ikuo Ueda , Daizou Morino
IPC分类号： C12P35/06 , C12P35/08 , C12D9/14
CPC分类号： C12P35/06 , C12P35/08 , Y10S435/886
摘要： Production of antibiotic WS-3442 A, B, C, D and E, and their acyl derivatives thereof, the production of antibiotic WS-3442 A, B, C, D and E being a new method by culturing a new species of Streptomyces and their acyl derivatives of said antibiotics being prepared by acylating said antibiotics with an acylating agent. The acyl derivative of antibiotic WS-3442 A, B, C, D and E has antimicrobiological activity and is also useful for intermediate for preparing Cephalosporin derivatives having antimicrobiological activity.
摘要翻译：生产抗生素WS-3442A，B，C，D和E及其酰基衍生物，生产抗生素WS-3442A，B，C，D和E是一种新方法，通过培养新品种的链霉菌和所述抗生素的酰基衍生物通过用酰化剂酰化所述抗生素来制备。抗生素WS-3442A，B，C，D和E的酰基衍生物具有抗微生物活性，也可用于制备具有抗微生物活性的头孢菌素衍生物的中间体。

70. 发明授权

US4094870A 2-Substituted thio-1,4-benzodiazepine derivatives 失效
标题翻译： 2-取代的硫代-1,4-苯并二氮杂衍生物
公开(公告)号：US4094870A
公开(公告)日：1978-06-13
申请号：US732929
申请日：1976-10-15
申请人： Ikuo Ueda , Masaaki Matsuo
发明人： Ikuo Ueda , Masaaki Matsuo
IPC分类号： C07D243/22 , A61K31/395
CPC分类号： C07D243/22
摘要： 2-substituted thio-1,4-benzodiazepine derivatives having medicinal use of the general formula ##STR1## wherein R.sub.1 and R.sub.2 individually signify hydrogen atom or a halogen atom, or a nitro, amino, hydroxy, cyano, alkyl, haloalkyl, alkoxy, alkylthio, alkanesulfinyl, alkanesulfonyl, alkanoylamino or dialkylamino group, R.sub.3 signifies an alkylene group, and R.sub.4 and R.sub.5 individually signify hydrogen atom or an alkyl group and, when R.sub.4 and R.sub.5 are both alkyl groups, said alkyl groups together may form a ring with or without oxygen atom or an imino group, said ring optionally having a substituent or substituents, and its non-toxic pharmaceutically acceptable salts.
摘要翻译：其中R1和R2各自表示氢原子或卤素原子，或硝基，氨基，羟基，氰基，烷基，卤代烷基，烷氧基，苯基，烷硫基，链烷亚磺酰基，烷磺酰基，烷酰基氨基或二烷基氨基，R3表示亚烷基，R4和R5分别表示氢原子或烷基，当R4和R5均为烷基时，所述烷基一起可以与无氧原子或亚氨基，所述环任选具有取代基，及其无毒的药学上可接受的盐。

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