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61. 发明申请

US20090318702A1 PROCESS FOR PRODUCTION OF 4-OXOQUINOLINE COMPOUND 有权
标题翻译： 4-氧杂环戊烯化合物的生产方法
公开(公告)号：US20090318702A1
公开(公告)日：2009-12-24
申请号：US12281921
申请日：2007-03-06
申请人： Koji Matsuda , Koji Ando , Shigeji Ohki , Takahiro Yamasaki , Jun-ichi Hoshi
发明人： Koji Matsuda , Koji Ando , Shigeji Ohki , Takahiro Yamasaki , Jun-ichi Hoshi
IPC分类号： C07D215/233 , C07C229/34 , C07C69/612 , C07C49/303
CPC分类号： C07C229/30 , C07C65/21 , C07C69/716 , C07C229/34 , C07D215/233 , C07D215/56 , C07F7/1804 , Y02P20/55
摘要： The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, the present invention provides, for example, compounds represented by the formulas (6), (7-1), (7-2) and (8): wherein R is a fluorine atom or a methoxy group, R1 is a C1-C4 alkyl group, R2 is a hydroxyl-protecting group, and X2 is a halogen atom, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
摘要翻译：本发明提供了可用作具有整合酶抑制活性的抗HIV剂的合成中间体的化合物，其制备方法和使用该合成中间体的抗HIV药物的制备方法。具体地说，本发明提供例如由式（6），（7-1），（7-2）和（8）表示的化合物：其中R是氟原子或甲氧基，R1是C1 -C4烷基，R2为羟基保护基，X2为卤素原子，其制造方法以及使用该合成中间体的抗HIV剂的制造方法。

62. 发明申请

US20090036684A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND 有权
标题翻译：生产4-氧杂环戊烯化合物的方法
公开(公告)号：US20090036684A1
公开(公告)日：2009-02-05
申请号：US12281889
申请日：2007-03-06
申请人： Koji Matsuda , Koji Ando , Shigeki Ohki , Jun-ichi Hoshi , Takahiro Yamasaki
发明人： Koji Matsuda , Koji Ando , Shigeki Ohki , Jun-ichi Hoshi , Takahiro Yamasaki
IPC分类号： C07D215/00 , C07C69/76 , C07C65/00 , C07C49/105
CPC分类号： C07C229/30 , C07C43/215 , C07C57/72 , C07C57/76 , C07C61/40 , C07C67/333 , C07C67/343 , C07C69/708 , C07C69/716 , C07C69/738 , C07C69/92 , C07C69/94 , C07C229/34 , C07D215/56
摘要： The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2′): wherein R is a fluorine atom or a methoxy group, and R400 is a hydrogen atom or a C1-C4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
摘要翻译：本发明提供了可用作具有整合酶抑制活性的抗HIV剂的合成中间体的化合物及其制备方法，以及使用该合成中间体的抗HIV剂的制备方法。具体而言，例如，式（2'）表示的化合物或其盐，其中R为氟原子或甲氧基，R400为氢原子或C1-C4烷基，以及使用该合成中间体的抗HIV剂的制造方法。

63. 发明授权

US07425717B2 Particle beam irradiation apparatus, treatment planning unit, and particle beam irradiation method 有权
标题翻译：粒子束照射装置，处理计划单元和粒子束照射方法
公开(公告)号：US07425717B2
公开(公告)日：2008-09-16
申请号：US11646298
申请日：2006-12-28
申请人： Koji Matsuda , Takahide Nakayama
发明人： Koji Matsuda , Takahide Nakayama
IPC分类号： H05H13/04
CPC分类号： H05H7/10 , A61N5/1043 , A61N5/1044 , A61N2005/1087 , G21K1/08 , G21K5/04 , H05H7/04
摘要： A particle beam irradiation apparatus includes a synchrotron, two scanning electromagnets, an beam delivery apparatus for outputting an ion beam extracted from the synchrotron, and an accelerator and transport system controller, and a scanning controller. These controllers stop the output of the ion beam from the beam delivery apparatus; in a state where the output of the ion beam is stopped, change the irradiation position of the ion beam by controlling the scanning electromagnets; and after this change, control the scanning electromagnets to start the output of the ion beam from the beam delivery apparatus and to perform irradiations of the ion beam to at least one irradiation position a plurality of times based on treatment planning information.
摘要翻译：粒子束照射装置包括同步加速器，两个扫描电磁体，用于输出从同步加速器提取的离子束的射束输送装置，以及加速器和输送系统控制器以及扫描控制器。这些控制器停止来自束输送装置的离子束的输出; 在离子束的输出停止的状态下，通过控制扫描电磁体来改变离子束的照射位置; 并且在该变化之后，控制扫描电磁铁开始来自光束输送装置的离子束的输出，并且基于处理计划信息，多次对离子束进行至少一个照射位置的照射。

64. 发明授权

US07394082B2 Ion beam delivery equipment and an ion beam delivery method 有权
标题翻译：离子束输送设备和离子束输送方法
公开(公告)号：US07394082B2
公开(公告)日：2008-07-01
申请号：US11414204
申请日：2006-05-01
申请人： Hisataka Fujimaki , Koji Matsuda , Hiroshi Akiyama , Masaki Yanagisawa , Alfred R. Smith , Kazuo Hiramoto
发明人： Hisataka Fujimaki , Koji Matsuda , Hiroshi Akiyama , Masaki Yanagisawa , Alfred R. Smith , Kazuo Hiramoto
IPC分类号： A61N5/00
CPC分类号： A61N5/1048 , A61N2005/1087 , A61N2005/1095 , G21K1/10 , G21K5/04
摘要： The invention is intended to confirm whether the SOBP (spread-out Bragg peak) width is a desired value in real time during beam irradiation, and to improve safety in treatment. Ion beam delivery equipment comprises a beam generator including a synchrotron, an RMW (range modulation wheel) device for forming an SOBP width of an ion beam extracted from the beam generator, a beam delivery nozzle including a reference dose monitor and a main dose monitor which are installed respectively upstream and downstream of the RMW device in the direction of travel of the ion beam, and an SOBP width computing unit for computing the SOBP width of the ion beam, which is formed by the RMW device, based on values detected by both the reference dose monitor and the main dose monitor.
摘要翻译：本发明旨在确认在光束照射期间SOBP（展开布拉格峰）宽度是否是实时的期望值，并且提高了处理中的安全性。离子束输送设备包括一个光束发生器，它包括同步加速器，用于形成从光束发生器提取的离子束的SOBP宽度的RMW（范围调制轮）装置，包括参考剂量监测器和主剂量监测器分别安装在RMW装置的上游和下游沿着离子束行进的方向;以及SOBP宽度计算单元，用于根据由两个检测到的值计算由RMW装置形成的离子束的SOBP宽度参考剂量监测仪和主剂量监测仪。

65. 发明申请

US20080067405A1 CHARGED PARTICLE BEAM IRRADIATION SYSTEM AND CHARGED PARTICLE BEAM EXTRACTION METHOD 有权
标题翻译：充电颗粒光束辐射系统和充电颗粒光束提取方法
公开(公告)号：US20080067405A1
公开(公告)日：2008-03-20
申请号：US11678300
申请日：2007-02-23
申请人： Hideaki Nihongi , Koji Matsuda , Kazuo Hiramoto , Hiroshi Akiyama
发明人： Hideaki Nihongi , Koji Matsuda , Kazuo Hiramoto , Hiroshi Akiyama
IPC分类号： G01K1/08
CPC分类号： G21K1/10 , A61N5/1048 , A61N5/1065 , A61N2005/1087 , A61N2005/1095 , A61N2005/1096 , H05H7/10
摘要： A charged particle beam irradiation system and a charged particle beam extraction method which can prevent erroneous irradiation of a charged particle beam in the direction of advance of the charged particle beam. The system and method are featured in stopping supply of an ion beam to one or more of a plurality of angle zones in each of which a target dose is attained, the angle zones being formed by dividing an RMW in a rotating direction thereof, and in allowing the supply of the ion beam to one or more other angle zones in each of which a target dose is not yet attained. The invention can easily adjust beam doses at various positions in an affected part of the patient body in the direction of advance of the ion beam, and can greatly reduce the probability of erroneous irradiation that the beam dose becomes excessive or deficient at the various positions within the affected part of the patient body in the direction of advance of the ion beam.
摘要翻译：带电粒子束照射系统和带电粒子束提取方法，其可以防止带电粒子束沿着带电粒子束的前进方向的错误照射。该系统和方法的特征在于停止向多个角区域中的一个或多个角度区域供应目标剂量，其中角度区域通过沿其旋转方向分割RMW而形成，并且在允许将离子束供应到一个或多个其他角度区域，其中每个角度区域中尚未获得目标剂量。本发明可以容易地在离子束前进方向上调整患者身体的受影响部位的各个位置处的光束剂量，并且可以大大降低光束剂量在各种位置内过度或不足的错误照射的可能性患者身体的受影响部分在离子束前进方向。

66. 发明申请

US20070114472A1 Particle beam irradiation apparatus, treatment planning unit, and particle beam irradiation method 有权
标题翻译：粒子束照射装置，处理计划单元和粒子束照射方法
公开(公告)号：US20070114472A1
公开(公告)日：2007-05-24
申请号：US11646298
申请日：2006-12-28
申请人： Koji Matsuda , Takahide Nakayama
发明人： Koji Matsuda , Takahide Nakayama
IPC分类号： H01J5/18
CPC分类号： H05H7/10 , A61N5/1043 , A61N5/1044 , A61N2005/1087 , G21K1/08 , G21K5/04 , H05H7/04
摘要： A particle beam irradiation apparatus includes a synchrotron, two scanning electromagnets, an beam delivery apparatus for outputting an ion beam extracted from the synchrotron, and an accelerator and transport system controller, and a scanning controller. These controllers stop the output of the ion beam from the beam delivery apparatus; in a state where the output of the ion beam is stopped, change the irradiation position of the ion beam by controlling the scanning electromagnets; and after this change, control the scanning electromagnets to start the output of the ion beam from the beam delivery apparatus and to perform irradiations of the ion beam to at least one irradiation position a plurality of times based on treatment planning information.
摘要翻译：粒子束照射装置包括同步加速器，两个扫描电磁体，用于输出从同步加速器提取的离子束的射束输送装置，以及加速器和输送系统控制器以及扫描控制器。这些控制器停止来自束输送装置的离子束的输出; 在离子束的输出停止的状态下，通过控制扫描电磁体来改变离子束的照射位置; 并且在该变化之后，控制扫描电磁铁开始来自光束输送装置的离子束的输出，并且基于处理计划信息，多次对离子束进行至少一个照射位置的照射。

67. 发明授权

US07122811B2 Particle beam irradiation apparatus, treatment planning unit, and particle beam irradiation method 有权
标题翻译：粒子束照射装置，处理计划单元和粒子束照射方法
公开(公告)号：US07122811B2
公开(公告)日：2006-10-17
申请号：US11236621
申请日：2005-09-28
申请人： Koji Matsuda , Takahide Nakayama
发明人： Koji Matsuda , Takahide Nakayama
IPC分类号： A61N5/00 , G21G5/00
CPC分类号： H05H7/10 , A61N5/1043 , A61N5/1044 , A61N2005/1087 , G21K1/08 , G21K5/04 , H05H7/04
摘要： A particle beam irradiation apparatus includes a synchrotron, two scanning electromagnets, an beam delivery apparatus for outputting an ion beam extracted from the synchrotron, and an accelerator and transport system controller, and a scanning controller. These controllers stop the output of the ion beam from the beam delivery apparatus; in a state where the output of the ion beam is stopped, change the irradiation position of the ion beam by controlling the scanning electromagnets; and after this change, control the scanning electromagnets to start the output of the ion beam from the beam delivery apparatus and to perform irradiations of the ion beam to at least one irradiation position a plurality of times based on treatment planning information.
摘要翻译：粒子束照射装置包括同步加速器，两个扫描电磁体，用于输出从同步加速器提取的离子束的射束输送装置，以及加速器和输送系统控制器以及扫描控制器。这些控制器停止来自束输送装置的离子束的输出; 在离子束的输出停止的状态下，通过控制扫描电磁体来改变离子束的照射位置; 并且在该变化之后，控制扫描电磁铁开始来自光束输送装置的离子束的输出，并且基于处理计划信息，多次对离子束进行至少一个照射位置的照射。

68. 发明授权

US07047993B2 Pilot switching valve apparatus and a method of switching pilot switching valve 失效
标题翻译：先导换向阀装置及切换先导换向阀的方法
公开(公告)号：US07047993B2
公开(公告)日：2006-05-23
申请号：US10809081
申请日：2004-03-25
申请人： Nobuyuki Manaka , Koji Matsuda
发明人： Nobuyuki Manaka , Koji Matsuda
IPC分类号： F15B13/042
CPC分类号： F16K31/1225 , F15B13/042 , F15B20/008 , F16K11/044 , Y10S137/907 , Y10T137/0396 , Y10T137/8663
摘要： In a valve chest of the pilot switching valve, a positive pressure chamber and a negative pressure chamber are formed on opposite sides of a valve spindle making a reciprocating motion in the valve chest due to repulsion by a return spring, and by connecting a positive pressure source for feeding a positive pilot pressure to the positive pressure chamber, and a negative pressure source for feeding a negative pilot pressure to the negative pressure chamber, the pilot switching valve has the configuration such that displacement of the valve spindle takes place against the urging of the return spring and connection among respective ports in the pilot switching valve can be switched only when pilot pressures from the positive pressure source and the negative pressure source are fed into the positive pressure chamber, and the negative pressure chamber, respectively where a malfunction of a switching valve is prevented.
摘要翻译：在先导换向阀的阀室中，在阀芯的相对侧形成有正压室和负压室，其通过复位弹簧的排斥而在阀体内进行往复运动，并且通过连接正压用于向正压室供给正的先导压力的源和用于向负压室供给负先导压的负压源，所述先导换向阀具有这样的构造，使得阀心的位移反对只有当来自正压源和负压源的先导压力被供给到正压室和负压室中时，才能切换导向开关阀的各个端口之间的复位弹簧和连接，切换阀被防止。

69. 发明授权

US06777700B2 Particle beam irradiation system and method of adjusting irradiation apparatus 有权
标题翻译：粒子束照射系统及照射装置调整方法
公开(公告)号：US06777700B2
公开(公告)日：2004-08-17
申请号：US10455497
申请日：2003-06-06
申请人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
发明人： Masaki Yanagisawa , Hiroshi Akiyama , Koji Matsuda , Hisataka Fujimaki
IPC分类号： H05H900
CPC分类号： A61N5/1042 , A61N2005/1087 , A61N2005/1095 , G21K1/10 , G21K5/04
摘要： The present invention provides an increased degree of uniformity of radiation dose distribution for the interior of a diseased part. A particle beam therapy system includes a charged particle beam generation apparatus and an irradiation apparatus. An ion beam is generated by the charged particle beam generation apparatus. The irradiation apparatus exposes a diseased part to the generated ion beam. A scattering device, a range adjustment device, and a Bragg peak spreading device are installed upstream of a first scanning magnet and a second scanning magnet. The scattering device and the range adjustment device are combined together and moved along a beam axis, whereas the Bragg peak spreading device is moved independently along the beam axis. The scattering device moves to adjust the degree of ion beam scattering. The range adjustment device moves to adjust ion beam scatter changes caused by an absorber thickness adjustment. The Bragg peak spreading device moves to adjust ion beam scatter changes arising out of an SOBP device. These adjustments provide uniformity of radiation dose distribution for the diseased part.
摘要翻译：本发明提供了患病部位的内部的辐射剂量分布的增加的均匀度。粒子束治疗系统包括带电粒子束产生装置和照射装置。由带电粒子束产生装置产生离子束。照射装置将患病部分暴露于产生的离子束。散射装置，量程调节装置和布拉格峰扩展装置安装在第一扫描磁体和第二扫描磁体的上游。散射装置和范围调节装置组合在一起并沿着光束轴线移动，而布拉格峰扩展装置沿着光束轴线独立地移动。散射装置移动以调节离子束散射的程度。范围调整装置移动以调节由吸收体厚度调整引起的离子束散射变化。布拉格峰扩展装置移动以调整由SOBP装置引起的离子束散射变化。这些调整提供了患病部位的辐射剂量分布的均匀性。

70. 发明授权

US06617598B1 Charged particle beam irradiation apparatus 有权
标题翻译：带电粒子束照射装置
公开(公告)号：US06617598B1
公开(公告)日：2003-09-09
申请号：US10253488
申请日：2002-09-25
申请人： Koji Matsuda
发明人： Koji Matsuda
IPC分类号： G21G500
CPC分类号： H05H13/04 , A61N2005/1087 , A61N2005/1095 , G21K5/04
摘要： An charged particle beam irradiation apparatus is provided which increases the width in a depth direction of a Bragg peak to be formed, by means of a simple construction. The charged particle beam irradiation apparatus includes a charged particle beam generation device and an irradiation field forming device. The charged particle beam generation device has a front accelerator and a synchrotron. An ion beam is guided to the irradiation field forming device from the synchrotron. The irradiation field forming device has a beam enlarging device, a Bragg peak enlarging device and a ridge filter. A pair of filter elements which constitute the Bragg peak enlarging device have a plurality of stick-shaped portions spaced apart from one another. The filter elements are disposed with their respective stick-shaped portions partly superposed to extend in mutually different directions. An ion beam that has passed through the Bragg peak enlarging device contains three ion beam components having different energies produced according to the difference between passed positions of each of the filter elements, whereby the width of a Bragg peak formed in the body of a patient is increased.
摘要翻译：提供一种带电粒子束照射装置，其通过简单的结构增加要形成的布拉格峰的深度方向的宽度。带电粒子束照射装置包括带电粒子束产生装置和照射场形成装置。带电粒子束产生装置具有前加速器和同步加速器。离子束从同步加速器引导到照射场形成装置。照射场形成装置具有光束放大装置，布拉格峰扩大装置和脊形滤波器。构成布拉格峰扩大装置的一对滤波器元件具有彼此间隔开的多个棒状部分。过滤元件设置成其各自的棒状部分被部分地重叠以在相互不同的方向上延伸。已经通过布拉格峰值放大装置的离子束包含根据每个滤光元件的通过位置之间的差产生的具有不同能量的三个离子束分量，由此形成在患者体内的布拉格峰的宽度为增加。

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