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61. 发明申请

US20080161742A1 Safe Device for Iontophoretic Delivery of Drugs 有权
标题翻译：用于离子导入药物的安全装置
公开(公告)号：US20080161742A1
公开(公告)日：2008-07-03
申请号：US10591124
申请日：2005-03-03
申请人： Abraham J. Domb , Joseph Frucht-Pery , Mervyn Shapiro
发明人： Abraham J. Domb , Joseph Frucht-Pery , Mervyn Shapiro
IPC分类号： A61N1/30 , A61M35/00
CPC分类号： A61N1/303 , A61M37/00 , A61M2037/0007 , A61N1/025 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： The present invention provides a device for iontophoretic delivery of a drug to on into a tissue, comprising an arrangement that prevents operation of the device at a current density that is higher than a predetermined value, the arrangement including first means responsive to a first data item, indicative of the surface area through which the current is to pass, as to set the maximal current allowed at the surface area indicated by the data item. The present invention also provides a method for iontophorectivally administering drug to or into a tissue, comprising determination of a maximal allowed level of current density and preventing application of current density above the maximal allowed level.
摘要翻译：本发明提供了一种用于将药物离子电渗疗法输送到组织中的装置，其包括防止在高于预定值的电流密度下操作该装置的装置，该装置包括响应于第一数据项的第一装置，表示电流要通过的表面积，以设定由数据项所指示的表面积处允许的最大电流。本发明还提供了一种向组织中或向组织中进行离子电渗法施用药物的方法，包括确定电流密度的最大允许水平并防止施加电流密度高于最大允许水平。

62. 发明申请

US20080089933A1 Device and method for reducing calorie intake 审中-公开
标题翻译：减少热量摄入的装置和方法
公开(公告)号：US20080089933A1
公开(公告)日：2008-04-17
申请号：US11581175
申请日：2006-10-16
申请人： Amir Alon , Itzhak Katz , Benjamine Alspector , Abraham J. Domb
发明人： Amir Alon , Itzhak Katz , Benjamine Alspector , Abraham J. Domb
IPC分类号： A61K9/48
CPC分类号： A61K9/48 , A61K9/4808
摘要： Devices and methods for substantially reducing the caloric efficiency of the digestive tract by capturing food being digested in the stomach 10 and/or anywhere else in the gastrointestinal (GI) tract, absorbing or encapsulating the captured food into multiple capturing members and moving such multiple capturing members containing the ingestible encapsulated food down the GI tract, practically out of reach of the GI absorption organs, thus excluding the entrapped ingredients from being involved in the digestion and\or absorption process. The device is designed for oral delivery. The system can be comprised of liquid, food bars or a capsule system. The capsule system is comprised of an external capsule that dissolves in accordance with a temporal or ph dependent preset, which allows the food intake to be at least partially fluidic. The capsule system is further comprised of a mechanism designed to capture and isolate a portion of the food being digested.
摘要翻译：通过捕获在胃10和/或胃肠道（GI）道中的任何其他地方消化的食物来显着降低消化道的热量效率的装置和方法，将捕获的食物吸收或包封到多个捕获构件中并移动这种多次捕获在胃肠道下方含有可摄入的包封食物的成员实际上不能接触胃肠吸收器官，因此不包括被捕获的成分参与消化和吸收过程。该设备设计用于口服输送。该系统可以由液体，食品棒或胶囊系统组成。胶囊系统包括外部胶囊，其根据时间或ph依赖性预设溶解，这允许食物摄取至少部分流体化。胶囊系统还包括设计成捕获和分离被消化食物的一部分的机构。

63. 发明授权

US06958325B2 Cationic polysaccharide compositions 失效
标题翻译：阳离子多糖组合物
公开(公告)号：US06958325B2
公开(公告)日：2005-10-25
申请号：US10044538
申请日：2002-01-10
申请人： Abraham J. Domb
发明人： Abraham J. Domb
IPC分类号： A61K31/715 , A61K47/48 , C08B37/02 , C12N15/85 , C07H21/04 , C07K14/435 , C08B37/00
CPC分类号： C08B37/0021 , A61K31/715 , A61K47/61
摘要： The invention provides a polycation composition comprising a polysaccharide chain having an amount of saccharide units ranging from 2 to 2000, at least one oligoamine directly grafted to said polysaccharide chain per each segment of 5 saccharide units, wherein said oligoamine is selected from the group consisting of a linear, branched and cyclic alkyl amine having at least two amino groups, and at least one further grafted group selected from the group consisting of a hydrophobic and an amphiphilic group directly grafted to said polysaccharide chain per each segment of 50 saccharide units, wherein said hydrophobic or amphiphilic group includes an aliphatic chain of at least 4 carbons atoms.
摘要翻译：本发明提供了一种聚阳离子组合物，其包含多糖链，其多糖单位范围为2至2000，至少一种寡糖直接接枝到每个5个糖单元的所述多糖链上，其中所述寡胺选自具有至少两个氨基的直链，支链和环状烷基胺，以及至少一种选自疏水性和两亲性基团的另外的接枝基团，其每50个糖单元的每个区段直接接枝到所述多糖链上，其中所述疏水或两亲基团包括至少4个碳原子的脂族链。

64. 发明授权

US06637437B1 Cell-culture and polymer constructs 失效
标题翻译：细胞培养和聚合物构建体
公开(公告)号：US06637437B1
公开(公告)日：2003-10-28
申请号：US09712662
申请日：2000-11-14
申请人： David S. Hungerford , Carmelita G. Frondoza , Alan H. Shikani , Abraham J. Domb
发明人： David S. Hungerford , Carmelita G. Frondoza , Alan H. Shikani , Abraham J. Domb
IPC分类号： A61B1900
CPC分类号： A61L27/3817 , A61F2/08 , A61K9/1652 , A61K9/5036 , A61K35/12 , A61K47/36 , C08B15/005 , C08B33/00 , C08B37/00 , C08B37/0021 , C08B37/006 , C08H1/00 , C08J3/12 , C08J2305/08 , C12N5/0075 , C12N5/0654 , C12N5/0655 , C12N2500/02 , C12N2531/00 , C12N2533/70 , C12N2533/72
摘要： The invention is directed to the culture of cells, and particularly chondrocytes for purpose of tissue replacement. The cells are cultured on polymer constructs. Integren expression is used as a measure of chondrocyte viability. Chondrocytes are obtained from the knee, nose and ankle cartilage. Mechanical strain is used to propagate chondrocytes, chitosan and arabinogalactanchitosan are used as scaffolds. Progenitor, pluripotential, stem and mesenchymal cells are operative in this invention.
摘要翻译：本发明涉及细胞的培养，特别是用于组织置换的软骨细胞。细胞在聚合物构建体上培养。 Integren表达被用作软骨细胞活力的量度。软骨细胞从膝盖，鼻子和脚踝软骨获得。机械菌株用于繁殖软骨细胞，壳聚糖和阿拉伯半乳聚糖壳聚糖用作支架。祖细胞，多能性，干细胞和间充质细胞在本发明中是可操作的。

65. 发明授权

US06378527B1 Cell-culture and polymer constructs 失效
公开(公告)号：US06378527B1
公开(公告)日：2002-04-30
申请号：US09275319
申请日：1999-03-24
申请人： David S. Hungerford , Carmelita G. Frondoza , Afshin Sohrabi , Alan H. Shikani , Abraham J. Domb
发明人： David S. Hungerford , Carmelita G. Frondoza , Afshin Sohrabi , Alan H. Shikani , Abraham J. Domb
IPC分类号： A61B1900
CPC分类号： A61L27/3817 , A61F2/08 , A61F2/30756 , A61K9/1652 , A61K9/5036 , A61K35/12 , A61K47/36 , A61L27/3852 , A61L27/3895 , C08B15/005 , C08B33/00 , C08B37/00 , C08B37/0021 , C08B37/006 , C08H1/00 , C08J3/12 , C08J2305/08 , C12N5/0075 , C12N5/0654 , C12N5/0655 , C12N2500/02 , C12N2531/00 , C12N2533/70 , C12N2533/72
摘要： Cells grown on a microcarrier are separated from the microcarrier by enzymatically digesting the microcarrier. More specifically, chondrocytes may be grown on dextran microcarrier beadlets and then the beadlets digested using dextranase to separate the chondrocytes from the carrier. Cells can also be grown on chitosan microcarriers to be used for implantation. In addition, cells can be grown on polysaccharide polymers to be used as implant devices. Various polymers serve as scaffolds for cells to be used for implantation. The polymers can be used for cell culture as well as for preparing scaffolds useful for tissue replacement such as cartilage tissue.

66. 发明授权

US5486591A Biopolymers derived from hydrolyzable diacid fats 失效
公开(公告)号：US5486591A
公开(公告)日：1996-01-23
申请号：US407183
申请日：1995-03-21
申请人： Abraham J. Domb , Raphael Nudelman
发明人： Abraham J. Domb , Raphael Nudelman
IPC分类号： C07C69/675 , C07C69/70 , C08G63/48 , C08G63/02 , C08G63/44 , C08G69/00
CPC分类号： C08G63/48 , C07C69/675 , C07C69/70
摘要： A monomeric diacid derivative includes at least two fatty acids coupled by hydrolytically or enzymatically degradable bond. In a biological environment, the bond degrades forming naturally occurring fatty acid products thereby allowing elimination.

67. 发明授权

US5188837A Lipsopheres for controlled delivery of substances 失效
标题翻译：用于控制物质输送的脂质体
公开(公告)号：US5188837A
公开(公告)日：1993-02-23
申请号：US770706
申请日：1991-10-03
申请人： Abraham J. Domb
发明人： Abraham J. Domb
IPC分类号： A01N25/26 , A61K9/127 , A61K9/14 , A61K9/16 , A61K9/50
CPC分类号： A61K9/145 , A01N25/26 , A61K9/127 , A61K9/1617 , A61K9/167 , A61K9/5015 , Y10T428/2984
摘要： A microsuspension system and method for its preparation is disclosed. The microsuspension contain lipospheres, which are solid, water-insoluble microparticles that have a layer of a phospholipid embedded on their surface. The core of the liposphere is a solid substance to be delivered, or a substance to be delivered that is dispersed in an inert solid vehicle, such as a wax.
摘要翻译：公开了一种微悬浮体系及其制备方法。微悬浮液含有脂质球，其是固体，水不溶性微粒，其表面上嵌有磷脂层。脂质体的核心是待输送的固体物质或分散在惰性固体载体如蜡中的待输送物质。

68. 发明授权

US4997904A Aromatic polyanhydride compositions 失效
标题翻译：芳香族聚酐组合物
公开(公告)号：US4997904A
公开(公告)日：1991-03-05
申请号：US399222
申请日：1989-08-25
申请人： Abraham J. Domb
发明人： Abraham J. Domb
IPC分类号： A61K9/20 , A61K9/70 , C08G67/00 , C08G67/04 , C08L73/02
CPC分类号： A61K9/7007 , A61K9/2031 , C08G67/04 , C08L73/02
摘要： Aromatic anhydride copolymers containing at least two aromatic diacid units, which are soluble in chloroform or dichloromethane to concentrations between approximately 0.5 to 50% weight/volume, melt at temperatures below 180.degree. C., and have low crystallinity are disclosed. The copolymers may contain between 0 and approximately 30% aliphatic diacid units. All copolymers are insoluble in carbon tetrachloride, i.e., less than 0.1% polymer by weight/volume solvent). The desired properties are the result of adding between 10 and 90% of a second aromatic diacid, to the copolymer composition which introduces irregularity in the polymer chains that dramatically alter the polymer properties, decreasing the crystallinity and melting point and increasing the solubility in the common solvents, dichloromethane or chloroform. An additional decrease in Tg and MP, with an increase in flexibility, is obtained by adding small amount of aliphatic diacid, up to about 30%.

69. 发明授权

US08703119B2 Injectable biodegradable polymer compositions for soft tissue repair and augmentation 失效
标题翻译：用于软组织修复和增强的可注射生物可降解聚合物组合物
公开(公告)号：US08703119B2
公开(公告)日：2014-04-22
申请号：US12678492
申请日：2008-10-05
申请人： Lior Yankelson , Abraham J. Domb
发明人： Lior Yankelson , Abraham J. Domb
IPC分类号： A61K31/765 , A61P13/00 , A61P17/00 , A61F2/02
CPC分类号： A61L27/58 , A61L27/18 , A61L27/50 , A61L2400/06 , C08L67/04
摘要： Methods for soft tissue repair and/or augmentation using injectable, biodegradable polymers are described herein. In one embodiment, the polymer compositions are liquid or pastes at room temperature. In a preferred embodiment, the polymer composition contains liquid or pasty hydroxy fatty acid-based copolyesters, polyester-anhydrides, or combinations thereof. The viscosity of the polymers increases upon contact with bodily fluid to form a solid or semisolid implant suitable for soft tissue repair and/or augmentation. In another embodiment, the polymer composition contains particles of a polymer stereocomplex. One or more active agents may be incorporated into the polymer compositions. Suitable classes of active agents include local anesthetics, anti-inflammatory agents, antibiotics, analgesics, growth factors and agents that induce and/or enhance growth of tissue within the filled cavity or control the growth of a certain type of tissue, and combinations thereof. The polymer compositions may also contain one or more additives or excipients that modify the physical and/or mechanical properties of the polymer. The polymer compositions are typically administered by injection. The injectable polymers can be used for a variety of soft tissue repair and augmentation procedures.
摘要翻译：本文描述了使用可注射的可生物降解的聚合物进行软组织修复和/或增加的方法。在一个实施方案中，聚合物组合物在室温下为液体或糊状物。在优选的实施方案中，聚合物组合物含有液体或糊状羟基脂肪酸基共聚酯，聚酯酸酐或其组合。当与体液接触时，聚合物的粘度增加，以形成适于软组织修复和/或增加的固体或半固体植入物。在另一个实施方案中，聚合物组合物含有聚合物立体络合物的颗粒。一种或多种活性剂可以并入聚合物组合物中。合适类别的活性剂包括局部麻醉剂，抗炎剂，抗生素，止痛剂，生长因子和诱导和/或增强填充腔内组织生长或控制某种类型组织生长的试剂及其组合。聚合物组合物还可以含有改变聚合物的物理和/或机械性能的一种或多种添加剂或赋形剂。聚合物组合物通常通过注射施用。可注射聚合物可用于各种软组织修复和增强程序。

70. 发明授权

US08623206B2 Gravitational filter and liquid purification device 有权
标题翻译：重力过滤器和液体净化装置
公开(公告)号：US08623206B2
公开(公告)日：2014-01-07
申请号：US12310626
申请日：2007-08-28
申请人： Haim Wilder , Abraham J. Domb
发明人： Haim Wilder , Abraham J. Domb
IPC分类号： B01D24/00
CPC分类号： C02F1/003 , C02F1/688 , C02F1/766 , C02F2101/103 , C02F2201/006 , C02F2303/04 , C02F2307/02 , C02F2307/04
摘要： A system, that may be portable, for purifying liquid flowing gravitationally from a source/reservoir into a purified liquid receptacle is described. The system includes a housing with a generally horizontal filtering space. More than one liquid inlet disposed at a top portion of the filter is provided as well as one or more liquid outlets disposed at a bottom portion. The liquid flows in a generally lateral direction through the liquid treatment medium. Two or more first walls extending upwardly into the filtering space from a bottom wall thereof and ending with an apex are provided inside the device. One or more second walls downwardly extending into the filtering space from a top wall thereof are also provided. Each of the walls defines a closed path. The first and second walls jointly cause the liquid to flow in a curvilinear flow path from the inlet to the outlet. Apexes of the first walls may be defined such that each apex more distal along the liquid flow path is at a lower level than an apex of a first wall more proximal along the flow path. One or more venting ports may be formed at a top wall portion of the housing for releasing gas from the filter.
摘要翻译：描述了可以便携式的用于将从源/储存器重力流动的液体净化成纯化的液体容器的系统。该系统包括具有大致水平的过滤空间的壳体。提供设置在过滤器顶部的多于一个的液体入口以及设置在底部的一个或多个液体出口。液体在大致横向上流过液体处理介质。设置在设备内部的两个或多个从其底壁向上延伸到过滤空间并以顶点结尾的第一壁。还提供从其顶壁向下延伸到过滤空间中的一个或多个第二壁。每个墙壁都定义一个封闭的路径。第一和第二壁共同地使液体在从入口到出口的曲线流动路径中流动。可以限定第一壁的顶点，使得沿着液体流动路径更远的每个顶点处于比沿着流动路径更靠近的第一壁的顶点的较低水平处。可以在壳体的顶壁部分处形成一个或多个排气口，以从过滤器释放气体。

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