专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

US20130123254A1 PHARMACEUTICALLY ACCEPTABLE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND THEIR METHODS OF IDENTIFICATION 审中-公开
标题翻译：药物可接受的MGLUR5阳性免疫调节剂及其鉴定方法
公开(公告)号：US20130123254A1
公开(公告)日：2013-05-16
申请号：US13616619
申请日：2012-09-14
申请人： Barbara Biemans , Georg Jaeschke , Lothar Lindemann , Wolfgang Muster , Heinz Stadler , Eric Vieira
发明人： Barbara Biemans , Georg Jaeschke , Lothar Lindemann , Wolfgang Muster , Heinz Stadler , Eric Vieira
IPC分类号： A61K31/5377 , A61K31/501 , A61K31/444 , A61K31/5355 , A61K31/505 , A61K31/44 , A61K31/4545 , A61K31/4439 , A61K31/506
CPC分类号： A61K31/5377 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5355 , G01N33/5041 , G01N33/5088 , G01N33/74 , G01N33/9406 , G01N2333/70571
摘要： The present invention relates to mGluR5 positive allosteric modulators (PAM) and methods for identifying pharmaceutically acceptable compounds with high tolerability and safety, which method comprises the use of at least one non-competitive mGluR5 allosteric modulator which has a shift factor measured at 10 uM glutamate concentration below 3.0,
摘要翻译：本发明涉及mGluR5阳性变构调节剂（PAM）以及用于鉴定具有高耐受性和安全性的药学上可接受的化合物的方法，该方法包括使用至少一种非竞争性mGluR5变构调节剂，其具有在10μM谷氨酸测量的移位因子浓度低于3.0，

62. 发明申请

US20120277213A1 ETHYNYL COMPOUNDS 有权
标题翻译：乙基化合物
公开(公告)号：US20120277213A1
公开(公告)日：2012-11-01
申请号：US13452973
申请日：2012-04-23
申请人： Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Heinz Stadler , Eric Vieira
发明人： Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Heinz Stadler , Eric Vieira
IPC分类号： A61K31/4439 , C07D401/14 , A61K31/444 , A61P25/00 , A61K31/506 , A61K31/501 , A61K31/55 , C07D401/04 , C07D403/04
CPC分类号： C07D403/04 , A61K31/506 , C07D401/04 , C07D401/14 , Y02T10/7011
摘要： The present invention relates to ethynyl derivatives of formula I X, G, R1, R2, R3, R3′, R4, R4′, R5, R6, R6′, m, and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They can be used for the treatment of schizophrenia or cognitive disorders.
摘要翻译：本发明涉及式IX的乙炔基衍生物，G，R 1，R 2，R 3，R 3'，R 4，R 4'，R 5，R 6，R 6'，m和n如本文所定义或与药学上可接受的酸加成盐，或其相应的对映异构体和/或其旋光异构体和/或立体异构体。式I化合物是代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂（PAM）。它们可用于治疗精神分裂症或认知障碍。

63. 发明申请

US20110251169A1 Arylethynyl derivatives 有权
标题翻译：甲基乙炔基衍生物
公开(公告)号：US20110251169A1
公开(公告)日：2011-10-13
申请号：US13066044
申请日：2011-04-05
申请人： Luke Green , Wolfgang Guba , Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
发明人： Luke Green , Wolfgang Guba , Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
IPC分类号： A61K31/397 , A61K31/501 , C07D417/04 , A61K31/541 , C07D413/04 , A61P25/28 , A61K31/5355 , A61K31/506 , C07D401/04 , A61K31/4439 , C07D401/14 , A61K31/444 , C07D403/04 , A61K31/5377
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/14 , C07D491/107 , C07D498/04
摘要： The present invention relates to ethynyl compounds of formula I wherein R1, R2, R2′, R3, R3′, R4, R4′, U, V, W, Y, m, and n are as defined herein and to a pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof. Compounds of formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
摘要翻译：本发明涉及式I的乙炔基化合物，其中R 1，R 2，R 2'，R 3，R 3'，R 4，R 4'，U，V，W，Y，m和n如本文所定义，加成盐，与外消旋混合物或其相应的对映体和/或光学异构体和/或其立体异构体。式I化合物是代谢型谷氨酸受体亚型5（mGluR5）的变构调节剂。

64. 发明授权

US08035468B2 Magnet system extrusion coating for a relay 有权
标题翻译：用于继电器的磁体系统挤压涂层
公开(公告)号：US08035468B2
公开(公告)日：2011-10-11
申请号：US10535052
申请日：2003-11-06
申请人： Ralf Hoffmann , Heinz Stadler
发明人： Ralf Hoffmann , Heinz Stadler
IPC分类号： H01H67/02
CPC分类号： H01H50/042 , H01H49/00 , H01H50/26 , H01H50/36
摘要： A relay has a magnet system with a core partially enclosed by a coil. A yoke has a first yoke leg attached to a first end of the core and a second yoke leg extending parallel to the core. The second yoke leg has an armature mounting portion formed on an upper side of the second yoke leg remote from the coil. A pole has a first pole leg connected to a second end of the core and a second pole leg extending parallel to the core. The second pole leg has an upper surface substantially aligned with the armature mounting portion. A fixed contact is arranged on a fixed contact carrier substantially aligned with the second pole leg. The arrangement of the magnet system ensures precise positional alignment during extrusion coating with a plastic material.
摘要翻译：继电器具有磁体系统，其中芯部被线圈部分地包围。轭具有附接到芯的第一端的第一轭腿和平行于芯延伸的第二轭腿。第二轭腿具有形成在远离线圈的第二轭腿的上侧上的电枢安装部分。杆具有连接到芯的第二端的第一极腿和平行于芯延伸的第二极腿。第二极腿具有与电枢安装部分大致对准的上表面。固定触点布置在基本上与第二极腿对齐的固定触点支架上。磁体系统的布置确保了在用塑料材料的挤出涂覆期间精确的位置对准。

65. 发明申请

US20050090533A1 Dual NK1/NK3 receptor antagonists 审中-公开
标题翻译：双NK1 / NK3受体拮抗剂
公开(公告)号：US20050090533A1
公开(公告)日：2005-04-28
申请号：US10884707
申请日：2004-07-02
申请人： Torsten Hoffmann , Andreas Koblet , Jens-Uwe Peters , Patrick Schnider , Andrew Sleight , Heinz Stadler
发明人： Torsten Hoffmann , Andreas Koblet , Jens-Uwe Peters , Patrick Schnider , Andrew Sleight , Heinz Stadler
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/46 , A61K31/496 , A61K31/4995 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/547 , A61K31/551 , A61K31/554 , C07D213/75 , C07D401/04 , C07D413/04 , C07D417/04 , C07D419/04 , C07D451/04 , C07D487/08 , C07D491/10 , C07D495/10 , C07D497/10 , C07D498/08 , C07D513/08
CPC分类号： C07D213/75 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/46 , A61K31/496 , A61K31/4995 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/547 , A61K31/551 , A61K31/554 , C07D401/04 , C07D413/04 , C07D417/04 , C07D419/04 , C07D451/04 , C07D487/08 , C07D491/10 , C07D495/10 , C07D497/10 , C07D513/08
摘要： The present invention provides a method for the treatment of schizophrenia which comprises administering a compound of formula wherein the substituents are as described herein or a pharmaceutically active acid-addition salt thereof. In particular, the invention provides methods for treating both positive and negative symptoms of schizophrenia through dual inhibition of NK1 and NK3 receptors. The invention also provides novel compounds with formula I and methods for preparing compounds of the invention.
摘要翻译：本发明提供了一种治疗精神分裂症的方法，其包括给予下列化合物，其中取代基如本文所述或其药学活性的酸加成盐。特别地，本发明提供了通过NK1和NK3受体的双重抑制来治疗精神分裂症的正和负症状的方法。本发明还提供具有式I的新化合物和制备本发明化合物的方法。

66. 发明授权

US06770637B2 Substituted 4-phenyl-pyridine compounds with activity as antagonists of neurokinin 1 receptors 有权
标题翻译：取代的4-苯基 - 吡啶化合物，具有作为神经激肽1受体拮抗剂的作用
公开(公告)号：US06770637B2
公开(公告)日：2004-08-03
申请号：US09922066
申请日：2001-08-03
申请人： Thierry Godel , Torsten Hoffmann , Patrick Schnider , Heinz Stadler
发明人： Thierry Godel , Torsten Hoffmann , Patrick Schnider , Heinz Stadler
IPC分类号： A61K3133
CPC分类号： C07D213/75 , C07D213/74 , C07D213/79 , C07D213/82 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Substituted 4-phenyl-pyridine compounds with activity as antagonists of Neurokinin 1 receptors, methods of making these compounds and preparing.
摘要翻译：具有作为神经激肽1受体拮抗剂的活性的取代的4-苯基 - 吡啶化合物，制备这些化合物的方法和制备。

67. 发明授权

US06479483B2 4-phenyl-pyridine derivatives 有权
标题翻译： 4-苯基 - 吡啶衍生物
公开(公告)号：US06479483B2
公开(公告)日：2002-11-12
申请号：US09901982
申请日：2001-07-10
申请人： Michael Bös , Quirico Branca , Guido Galley , Thierry Godel , Torsten Hoffmann , Walter Hunkeler , Patrick Schnider , Heinz Stadler
发明人： Michael Bös , Quirico Branca , Guido Galley , Thierry Godel , Torsten Hoffmann , Walter Hunkeler , Patrick Schnider , Heinz Stadler
IPC分类号： C07D21382
CPC分类号： C07D213/30 , C07D213/38 , C07D213/40 , C07D213/74 , C07D213/75 , C07D213/82 , C07D401/04 , C07D401/12 , C07D413/12 , C07D413/14
摘要： Compounds of the present invention are 4-phenyl-pyridine derivatives with activity as NK-1 receptor antagonists.
摘要翻译：本发明化合物是具有作为NK-1受体拮抗剂活性的4-苯基 - 吡啶衍生物。

68. 发明授权

US6002312A Electromagnetic relay 失效
标题翻译：电磁继电器
公开(公告)号：US6002312A
公开(公告)日：1999-12-14
申请号：US142155
申请日：1998-09-02
申请人： Michael Dittmann , Jens Heinrich , Heinz Stadler
发明人： Michael Dittmann , Jens Heinrich , Heinz Stadler
IPC分类号： H01H50/02 , H01H50/04 , H01H50/14 , H01H51/22
CPC分类号： H01H50/02 , H01H51/2281 , H01H50/023 , H01H50/026 , H01H50/14
摘要： An electromagnetic relay has a base with a contact arrangement and a rocker armature mounted on the base. Above the base, a magnet system with a coil, a core and two yokes is provided, this system working together with the rocker armature. At least the coil with the core is embedded in the insulating material of a basic body which surrounds the base in box-type fashion with side walls that are integrally formed downwardly, and forms a sealed contact chamber. By means of the basic body surrounding the coil, a high insulation strength of the relay between the coil and the contact system is ensured, as is a high stability of the construction.
摘要翻译： PCT No.PCT / DE97 / 00686 Sec。 371日期：1998年9月2日 102（e）1998年9月2日PCT 1997年4月3日PCT PCT。 WO97 / 39467 PCT公开号日期1997年10月23日电磁继电器具有基座，触点布置和安装在基座上的摇臂电枢。在基座之上，提供了具有线圈，铁芯和两个轭的磁体系统，该系统与摇臂电枢一起工作。至少具有芯的线圈被嵌入在基本体的绝缘材料中，该基体以箱形方式围绕底部，侧壁一体形成，并形成密封的接触室。通过围绕线圈的基体，确保线圈和接触系统之间的继电器的高绝缘强度，以及该结构的高稳定性。

69. 发明授权

US5572176A Relay having a movable slide and method for the manufacture thereof 失效
标题翻译：具有可动滑块的继电器及其制造方法
公开(公告)号：US5572176A
公开(公告)日：1996-11-05
申请号：US385694
申请日：1995-02-08
申请人： Alfred Heinzl , Heinz Stadler
发明人： Alfred Heinzl , Heinz Stadler
IPC分类号： H01H49/00 , H01H50/54 , H01H50/64 , H01H51/22
CPC分类号： H01H50/642 , H01H49/00 , H01H50/54
摘要： An improved relay of conventional design is disclosed wherein the relay has an armature and at least one moveable contact element. A slide is attached to the armature and moveable contact element. The slide is of a length matched to the actual distance between the armature and the moveable contact element after the armature and moveable contact element are secured to a base and moved to a contact position.
摘要翻译：公开了传统设计的改进的继电器，其中继电器具有电枢和至少一个可移动接触元件。滑块连接到电枢和可移动的接触元件。在电枢和可移动接触元件固定到基座并移动到接触位置之后，滑块的长度与电枢和可移动接触元件之间的实际距离相匹配。

70. 发明授权

US5389616A Amino acid derivatives 失效
标题翻译：氨基酸衍生物
公开(公告)号：US5389616A
公开(公告)日：1995-02-14
申请号：US99028
申请日：1993-07-29
申请人： Quirico Branca , Werner Neidhart , Jenri Ramuz , Henri Ramuz , Heinz Stadler , Wolfgang Wostl
发明人： Quirico Branca , Werner Neidhart , Jenri Ramuz , Henri Ramuz , Heinz Stadler , Wolfgang Wostl
IPC分类号： C07C215/26 , C07C237/00 , C07C317/44 , C07D233/54 , C07D263/04 , C07D263/24 , C07D277/30 , C07D307/52 , C07D333/24 , C07D401/12 , C07D405/06 , C07D405/12 , C07D417/06 , C07D417/12 , A61K37/00
CPC分类号： C07D233/64 , C07C215/26 , C07C237/00 , C07C317/44 , C07D263/04 , C07D263/24 , C07D277/30 , C07D307/52 , C07D333/24 , C07D401/12 , C07D405/06 , C07D405/12 , C07D417/06 , C07D417/12
摘要： The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as set forth above, are described.The compounds of formula I have an inhibitory activity on the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations for the control or prevention of high blood pressure and cardiac insufficiency.
摘要翻译：其中A，R 1，R 2，R 3，R 4，R 5和R 6如上所述的式Ⅺ化合物被描述。式I的化合物对天然酶肾素具有抑制活性，因此可以以用于控制或预防高血压和心脏功能不全的药物制剂的形式使用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式