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1. 发明授权

US06479483B2 4-phenyl-pyridine derivatives 有权
标题翻译： 4-苯基 - 吡啶衍生物
公开(公告)号：US06479483B2
公开(公告)日：2002-11-12
申请号：US09901982
申请日：2001-07-10
申请人： Michael Bös , Quirico Branca , Guido Galley , Thierry Godel , Torsten Hoffmann , Walter Hunkeler , Patrick Schnider , Heinz Stadler
发明人： Michael Bös , Quirico Branca , Guido Galley , Thierry Godel , Torsten Hoffmann , Walter Hunkeler , Patrick Schnider , Heinz Stadler
IPC分类号： C07D21382
CPC分类号： C07D213/30 , C07D213/38 , C07D213/40 , C07D213/74 , C07D213/75 , C07D213/82 , C07D401/04 , C07D401/12 , C07D413/12 , C07D413/14
摘要： Compounds of the present invention are 4-phenyl-pyridine derivatives with activity as NK-1 receptor antagonists.
摘要翻译：本发明化合物是具有作为NK-1受体拮抗剂活性的4-苯基 - 吡啶衍生物。

2. 发明授权

US06747047B2 Insecticidal anthranilamides 有权
标题翻译：杀虫剂邻氨基苯甲酰胺
公开(公告)号：US06747047B2
公开(公告)日：2004-06-08
申请号：US10220450
申请日：2002-08-28
申请人： George P. Lahm , Brian J. Myers , Thomas P. Selby , Thomas M. Stevenson
发明人： George P. Lahm , Brian J. Myers , Thomas P. Selby , Thomas M. Stevenson
IPC分类号： C07D21382
CPC分类号： C07D213/82 , A01N37/22 , A01N37/46 , A01N43/08 , A01N43/10 , A01N43/36 , A01N43/40 , A01N43/42 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/647 , A01N43/653 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/84 , A01N43/90 , A01N47/02 , C07C237/42 , C07C237/44 , C07C255/29 , C07C255/57 , C07C317/28 , C07C317/44 , C07C323/42 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07D213/81 , C07D231/06 , C07D231/12 , C07D231/14 , C07D233/90 , C07D235/08 , C07D239/28 , C07D249/08 , C07D275/03 , C07D277/56 , C07D295/192 , C07D333/38 , C07D401/04 , C07D403/04
摘要： This invention provides compounds of Formula (1), their N-oxides and agriculturally suitable salts wherein A, B, J, R1, R2, R3 and R4 and n are as defined in the disclosure. Also disclosed are methods for controlling arthropods comprising contacting the arthropods or their environment with an arthropodicidally effective amount of a compound of Formula (1) and compositions containing the compounds of Formula (1).
摘要翻译：本发明提供式（1）化合物，其N-氧化物和农业上合适的盐，其中A，B，J，R 1，R 2，R 3和R 4和n如披露。还公开了控制节肢动物的方法，包括使节肢动物或其环境与节肢动物学有效量的式（1）化合物和含有式（1）化合物的组合物接触。

3. 发明授权

US06624174B2 2-amino-nicotinamide derivatives and their use as VEGF-receptor tyrosine kinase inhibitors 有权
标题翻译： 2-氨基 - 烟酰胺衍生物及其作为VEGF-受体酪氨酸激酶抑制剂的用途
公开(公告)号：US06624174B2
公开(公告)日：2003-09-23
申请号：US10181005
申请日：2002-07-11
申请人： Paul William Manley , Guido Bold
发明人： Paul William Manley , Guido Bold
IPC分类号： C07D21382
CPC分类号： C07D213/82 , A61K31/445 , C07D213/89 , C07D401/14 , C07D417/14
摘要： The invention relates to the use of 2 amino-nicotinamide derivatives of formula I wherein n is from 1 up to and including 6; W is O or S; R1 and R3 represent independently of each other hydrogen, lower alkyl or lower acyl; R2 represents a cycloalkyl group, an aryl group, or a mono- or bicyclic heteroaryl group comprising one or more ring nitrogen atoms and 0, 1 or 2 heteroatoms independently from each other selected from the group consisting of oxygen and sulfur, which groups in each case are unsubstituted or mono- or polysubstituted; R and R′ are independently of each other hydrogen or lower alkyl; X represents an aryl group, or a mono- or bicyclic heteroaryl group comprising one or more ring nitrogen atoms and 0, 1 or 2 heteroatoms independently from each other selected from the group consisting of oxygen and sulfur, which groups in each case are unsubstituted or mono- or polysubstituted; or a N-oxide, a possible tautomer thereof or a pharmaceutically acceptable salt of such a compound, alone or in combination with one or more other pharmaceutically active compounds for the preparation of a pharmaceutical composition for use for therapy of a disease which responds to an inhibition of the VEGF-receptor tyrosine kinase activity; and to new 2-amino-nicotinamide derivatives of formula I and processes for the preparation thereof.
摘要翻译：本发明涉及式I的2种氨基 - 烟酰胺衍生物的用途，其中n为1至6，W为O或S; R 1和R 3彼此独立地为氢，低级烷基或低级酰基; R 2表示环烷基，芳基或包含一个或多个环氮原子和0,1或2个彼此独立地选自氧和硫的杂原子的单环或双环杂芳基，这些基团在每种情况下是未取代的或单取代或多取代; R和R'彼此独立地为氢或低级烷基; X表示芳基，或单环或双环杂芳基，其包含一个或多个环氮原子和0,1或2个独立地为彼此选自氧和硫，这些基团在每种情况下都是未取代的或单取代或多取代的;或N-氧化物，其可能的互变异构体或这种化合物的药学上可接受的盐，alo ne或与一种或多种其它药学活性化合物组合用于制备用于治疗对VEGF-受体酪氨酸激酶活性的抑制作出反应的疾病的药物组合物;以及新的2-氨基 - 烟酰胺衍生物式I及其制备方法。

4. 发明授权

US06794397B2 Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效
标题翻译：取代的烟酰胺和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途
公开(公告)号：US06794397B2
公开(公告)日：2004-09-21
申请号：US09769420
申请日：2001-01-26
申请人： Sui Xiong Cai , John A. Drewe
发明人： Sui Xiong Cai , John A. Drewe
IPC分类号： C07D21382
CPC分类号： C07D213/75 , A61K31/341 , A61K31/44 , A61K31/4965 , C07D207/34 , C07D213/82 , C07D239/28 , C07D241/24 , C07D307/68 , C07D401/12 , C07D405/12
摘要： The present invention is directed to substituted nicotinamides and analogs thereof, represented by Formula V: or a pharmaceutically acceptable salt or prodrug thereof, wherein: Ar′ and Ar are independently optionally substituted aryl or optionally substituted heteroaryl, provided that the ring structure of said optionally substituted heteroaryl comprises not more than two nitrogen atoms; and R11 is hydrogen; or alkyl, cycloalkyl, aryl or heteroaryl, each of which is optionally substituted. The present invention also relates to the discovery that compounds having Formula V are activators of caspases and inducers of apoptosis. Therefore, the compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：本发明涉及由式V代表的取代烟酰胺及其类似物：或其药学上可接受的盐或前药，其中：Ar'和Ar独立地为任选取代的芳基或任选取代的杂芳基，条件是所述任选的取代的杂芳基包含不多于两个氮原子; 和R 11是氢; 或烷基，环烷基，芳基或杂芳基，其各自任选被取代。本发明还涉及发现具有式V的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。因此，本发明的化合物可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。

5. 发明授权

US06297375B1 4-phenyl-pyridine derivatives 有权
标题翻译： 4-苯基 - 吡啶衍生物
公开(公告)号：US06297375B1
公开(公告)日：2001-10-02
申请号：US09507456
申请日：2000-02-22
申请人： Michael Bös , Quirico Branca , Guido Galley , Thierry Godel , Torsten Hoffmann , Walter Hunkeler , Patrick Schnider , Heinz Stadler
发明人： Michael Bös , Quirico Branca , Guido Galley , Thierry Godel , Torsten Hoffmann , Walter Hunkeler , Patrick Schnider , Heinz Stadler
IPC分类号： C07D21382
CPC分类号： C07D213/30 , C07D213/38 , C07D213/40 , C07D213/74 , C07D213/75 , C07D213/82 , C07D401/04 , C07D401/12 , C07D413/12 , C07D413/14
摘要： The compounds of the related invention are related to 4-phenyl-pyridine derivatives connected by a bridge containing oxygen or nitrogen to a phenyl derivative.
摘要翻译：相关发明的化合物涉及通过含有氧或氮的桥与苯基衍生物连接的4-苯基 - 吡啶衍生物。

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