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61. 发明授权

US10317308B2 Test disc system 有权
公开(公告)号：US10317308B2
公开(公告)日：2019-06-11
申请号：US15515239
申请日：2015-08-27
申请人： Michael Keil
发明人： Michael Keil , Christopher Keil
IPC分类号： G01M3/32
摘要： The invention relates to a test disc system having at least one test disc for testing the seal of a glove which is installed in a port of an insulator. The test disc (1) can be connected in a hermetically sealed fashion to the port, wherein the glove encloses with the test disc (1) a glove volume which can be placed under overpressure by the test disc (1). The test disc (1) has a base body in which electronic components for recording and storing a pressure profile in the glove volume, and at least one data interface are arranged. The test disc (1) also has a reading device for reading both a first identification element which is arranged on the glove and a second identification element which is assigned to the port.

62. 发明授权

US09920002B2 Methods for producing sulfonic acid diamides 有权
公开(公告)号：US09920002B2
公开(公告)日：2018-03-20
申请号：US12681843
申请日：2008-10-10
申请人： Axel Pleschke , Thomas Schmidt , Joachim Gebhardt , Sandra Loehr , Michael Keil , Jan Hendrik Wevers
发明人： Axel Pleschke , Thomas Schmidt , Joachim Gebhardt , Sandra Loehr , Michael Keil , Jan Hendrik Wevers
IPC分类号： C07C303/34 , C07C307/06 , C07D239/54 , A01N43/54 , C07C381/00
CPC分类号： C07C303/34 , A01N43/54 , C07C307/06 , C07C381/00 , C07D239/54
摘要： The present invention relates to a process for preparing sulfuric diamides of the general formula I R1R2N—S(O)2—NH2 (I) in which R1 and R2 are each independently a primary alkyl radical having from 1 to 8 carbon atoms, a secondary alkyl radical having from 3 to 8 carbon atoms or a cycloalkyl radical having from 5 to 8 carbon atoms, or, together with the nitrogen atom, form a 5- to 8-membered, saturated nitrogen heterocycle which, as well as the nitrogen atom, may have a further heteroatom selected from O and S as a ring member, where the nitrogen heterocycle is unsubstituted or may have 1, 2, 3 or 4 alkyl groups having in each case from 1 to 4 carbon atoms as substituents. The process comprises the following steps: i) the reaction of a secondary amine of the formula II R1R2NH (II) in which R1 and R2 are each as defined above with sulfuryl chloride in an inert solvent, especially an aromatic solvent, in the presence of a tertiary amine to give a sulfamoyl chloride of the formula III R1R2N—S(O)2—Cl (III) in which R1 and R2 are each as defined above, and ii) reaction of the sulfamoyl chloride of the formula III obtained in step i) with ammonia, the sulfamoyl chloride of the formula III being used in step ii) in the form of the solution obtained in step i) in the inert solvent, especially the aromatic solvent.

63. 发明申请

US20170042458A1 PUNCTURING SYSTEM AND LANCET CARRIER TAPE 审中-公开
标题翻译：打孔系统和LANCET卡带
公开(公告)号：US20170042458A1
公开(公告)日：2017-02-16
申请号：US15339056
申请日：2016-10-31
申请人： Ahmet Konya , Hans-Juergen Kuhr , Frank Deck , Hans List , Michael Keil , Christian Hoerauf , Thomas Weiss , Marcus Schlothauer
发明人： Ahmet Konya , Hans-Juergen Kuhr , Frank Deck , Hans List , Michael Keil , Christian Hoerauf , Thomas Weiss , Marcus Schlothauer
IPC分类号： A61B5/151 , A61B5/15 , A61B17/3209
CPC分类号： A61B5/15169 , A61B5/1411 , A61B5/150022 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15107 , A61B5/15146 , A61B5/15153 , A61B5/15171 , A61B5/15178 , A61B5/1518 , A61B17/32093
摘要： A puncturing system has a carrier tape carrying multiple lancets, a device housing comprising a conveying facility for moving the lancets into a usage position consecutively by moving the carrier tape in a conveying direction, a puncturing drive for accelerating one of the lancets that is positioned in the usage position in a puncturing motion, an opening in the device housing for touching against a body part in which a puncture is to be made by the puncturing motion of one of the lancets, an actuation facility for driving the conveying facility, and an unlockable interlock comprising a stop that blocks further transport of the carrier tape as soon as one of the lancets has reached the usage position.
摘要翻译：穿刺系统具有携带多个柳叶刀的载带，一个装置壳体，包括用于通过沿输送方向移动载带将柳叶刀连续移动到使用位置的输送装置，用于加速位于刺穿运动中的使用位置，用于与身体部分接触的装置壳体中的一个开口，其中通过其中一个刺血针的穿刺运动将产生穿刺，用于驱动输送设备的致动设备和可解锁的互锁包括一旦其中一个刺血针已经到达使用位置就阻止载带的进一步运输的停止件。

64. 发明授权

US08629287B2 Process for the sulfinylation of a pyrazole derivative 失效
标题翻译：吡唑衍生物亚硫酰化的方法
公开(公告)号：US08629287B2
公开(公告)日：2014-01-14
申请号：US12514103
申请日：2007-11-05
申请人： Martin Sukopp , Oliver Kuhn , Carsten Gröning , Michael Keil , Jon J. Longlet
发明人： Martin Sukopp , Oliver Kuhn , Carsten Gröning , Michael Keil , Jon J. Longlet
IPC分类号： C07D231/18
CPC分类号： C07D231/44 , A01N43/56
摘要： The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from cyclic secondary amines and the acid(s) are selected from sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF3S(O)]2O; or CF3S(O)X wherein X means fluoro, chloro, bromo, iodo, a hydroxy group, or an alkaline or alkaline earth metal salt of the hydroxy group; or mixtures thereof.
摘要翻译：本发明涉及吡唑衍生物亚硫酰化的方法，其特征在于5-氨基-1- [2,6-二氯-4-（三氟甲基）苯基] -1H-吡唑-3-甲腈（II）是在至少一种胺酸络合物存在下与亚硫酰化剂S反应，其中胺选自环状仲胺，酸选自磺酸衍生物，并且通过加入卤化剂，其中S是[CF 3 S（O）] 2 O; 或CF 3 S（O）X，其中X表示氟，氯，溴，碘，羟基或羟基的碱金属或碱土金属盐; 或其混合物。

65. 发明授权

US08629279B2 Process for manufacturing 5-formyl-pyridine-2,3-dicarboxylic acid esters 有权
标题翻译： 5-甲酰基 - 吡啶-2,3-二羧酸酯的制备方法
公开(公告)号：US08629279B2
公开(公告)日：2014-01-14
申请号：US13133013
申请日：2009-12-07
申请人： Michael Rack , Joachim Gebhardt , Frederik Menges , Michael Keil , Rodney F. Klima , David Cortes , Robert Leicht , Helmut Zech , Jochen Schröder
发明人： Michael Rack , Joachim Gebhardt , Frederik Menges , Michael Keil , Rodney F. Klima , David Cortes , Robert Leicht , Helmut Zech , Jochen Schröder
IPC分类号： C07D213/48 , C07D213/55
CPC分类号： C07D213/80
摘要： A process for manufacturing a 5-formyl-pyridine-2,3-dicarboxylic acid ester (I) wherein Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro and R1, R2 are independently C1-C10-alkyl, comprising the steps of (i) reacting a compound of formula (II), wherein the symbols are as in formula (I), with a nitrosation agent (III) R3—O—N═O (III) wherein R3 is C1-C8-alkyl, in the presence of an alkali metal or alkaline earth metal alcoholates or carbonates in a polar aprotic solvent at a temperature of from −45 to 40° C., to obtain an oxime compound (IV) where Z, Z1, R1 and R2 are as in formula (I), and (ii) reacting oxime compound (IV) with an aliphatic C1-C10-aldehyde in the presence of a Lewis acid at a temperature in the range of from 0 to 100° C. The compounds of formula (I) are useful intermediates in the synthesis of herbicidal imidazolinones, like imazamox.
摘要翻译：制备其中Z为氢或卤素的5-甲酰基 - 吡啶-2,3-二羧酸酯（I）的方法; Z1是氢，卤素，氰基或硝基，R1，R2独立地是C1-C10-烷基，包括以下步骤：（ⅰ）使符号如式（I）所示的式（ⅱ）化合物与式在碱金属或碱土金属醇盐或碳酸盐存在下，在极性非质子溶剂中，温度为-45〜40℃的亚硝化剂（Ⅲ）R3-ON = O（Ⅲ）其中R3为C1-C8-烷基 ℃，得到其中Z，Z 1，R 1和R 2如式（I）中的肟化合物（Ⅳ），和（ⅱ）使肟化合物（Ⅳ）与脂族C 1 -C 10 - 醛在在0至100℃的温度范围内的路易斯酸。式（I）化合物是合成除草咪唑啉酮如咪唑氧化物的有用中间体。

66. 发明申请

US20130096312A1 Process for Preparing 4-hydroxypyridines 有权
标题翻译： 4-羟基吡啶的制备方法
公开(公告)号：US20130096312A1
公开(公告)日：2013-04-18
申请号：US13805567
申请日：2011-06-20
申请人： Volker Maywald , Frederik Menges , Uwe Josef Vogelbacher , Michael Rack , Michael Keil , Wassilios Grammenos , Marianna Vrettou-Schultes , Jan Klaas Lohmann , Bernd Mueller , Thorsten Jabs
发明人： Volker Maywald , Frederik Menges , Uwe Josef Vogelbacher , Michael Rack , Michael Keil , Wassilios Grammenos , Marianna Vrettou-Schultes , Jan Klaas Lohmann , Bernd Mueller , Thorsten Jabs
IPC分类号： C07D213/68 , C07D213/61
CPC分类号： C07D213/68 , C07D213/08 , C07D213/61
摘要： The present invention relates to a process for preparing 4-hydroxypyridines of formula I wherein R1, R2, R3 and R4 have the meanings defined in the description.
摘要翻译：本发明涉及制备式I的4-羟基吡啶的方法，其中R1，R2，R3和R4具有说明书中定义的含义。

67. 发明申请

US20130066356A1 PUNCTURING SYSTEM 审中-公开
标题翻译：打孔系统
公开(公告)号：US20130066356A1
公开(公告)日：2013-03-14
申请号：US13619459
申请日：2012-09-14
申请人： Hans List , Christian Hoerauf , Frank Deck , Thomas Weiss , Michael Keil , Guenther Schmelzeisen-Redeker , Heinrich Fruhstorfer , Hans-Peter Haar , Uwe Kraemer , Joachim Hoenes , Karl Miltner
发明人： Hans List , Christian Hoerauf , Frank Deck , Thomas Weiss , Michael Keil , Guenther Schmelzeisen-Redeker , Heinrich Fruhstorfer , Hans-Peter Haar , Uwe Kraemer , Joachim Hoenes , Karl Miltner
IPC分类号： A61B17/34
CPC分类号： A61B5/1519 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150412 , A61B5/150503 , A61B5/150824 , A61B5/150954 , A61B5/15113
摘要： The invention relates to a puncturing system for generating a puncture wound for obtaining a sample of a body fluid, comprising a press-on part to be pressed onto a body part in which a puncture wound is to be generated, a triggering means with which a user can trigger a puncturing motion of a puncturing element after the press-on part is pressed on, and a testing facility for determining a test parameter on which a sample-obtaining probability depends. A securing facility is also provided that, in a locked state, locks the triggering means and, in a triggering state, releases the triggering means such that a puncturing motion can be triggered by actuation thereof. The securing facility is transitioned from the locked state to the triggering state by the testing facility when the test parameter determined by the testing facility meets defined minimum requirements.
摘要翻译：本发明涉及一种用于产生用于获得体液样品的穿刺伤口的穿刺系统，包括：压制部件，其被压在其上将产生穿刺伤口的身体部位;触发装置，其中，用户可以在按下按压部分之后触发穿刺元件的穿刺运动，以及用于确定取样概率所依赖的测试参数的测试设备。还提供了一种固定装置，其处于锁定状态，锁定触发装置，并且在触发状态下释放触发装置，使得可以通过致动来触发穿刺运动。当由测试设备确定的测试参数达到规定的最低要求时，固定设施由测试设备从锁定状态转换到触发状态。

68. 发明授权

US08263783B2 Process for the sulfinylation of a pyrazole derivative 有权
标题翻译：吡唑衍生物亚硫酰化的方法
公开(公告)号：US08263783B2
公开(公告)日：2012-09-11
申请号：US12514098
申请日：2007-11-05
申请人： Martin Sukopp , Oliver Kuhn , Carsten Gröning , Michael Keil , Jon J. Longlet
发明人： Martin Sukopp , Oliver Kuhn , Carsten Gröning , Michael Keil , Jon J. Longlet
IPC分类号： C07D231/18
CPC分类号： C07D231/44
摘要： The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent selected from trifluoromethylsulfinic acid, trifluoromethylsulfinic acid anhydride, and a trifluoromethylsulfinate alkaline or alkaline earth metal salt and mixtures of the acid and/or the salt(s), in the presence of at least one amine acid complex wherein the amine(s) are selected from tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent.
摘要翻译：本发明涉及吡唑衍生物亚硫酰化的方法，其特征在于5-氨基-1- [2,6-二氯-4-（三氟甲基）苯基] -1H-吡唑-3-甲腈（II）是与选自三氟甲基亚磺酸，三氟甲基亚磺酸酐和三氟甲基亚硫酸盐碱金属或碱土金属盐的亚磺酰化剂以及酸和/或盐的混合物在至少一种胺酸络合物的存在下反应，其中胺选自叔胺，酸选自氢氟酸，盐酸，氢溴酸和氢碘酸以及磺酸衍生物，并加入卤化剂。

69. 发明申请

US20120143235A1 LANCET DEVICE WITH OPTIONALLY REUSABLE LANCETS STORED IN A MAGAZINE 有权
标题翻译：具有存储在杂志中的可选择的可重复使用的LANCET设备
公开(公告)号：US20120143235A1
公开(公告)日：2012-06-07
申请号：US13308141
申请日：2011-11-30
申请人： Hans-Juergen Kuhr , Michael Keil , Hans List
发明人： Hans-Juergen Kuhr , Michael Keil , Hans List
IPC分类号： A61B17/32
CPC分类号： A61B5/15146 , A61B5/150022 , A61B5/150175 , A61B5/150412 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/15163
摘要： An inventive lancet device for producing a puncture wound, in particular for collecting a sample of a body fluid which has a magazine holder for a lancet magazine containing a plurality of lancets. The lancet device can be alternatively operated such that either a new lancet is used for each puncture process by automatically advancing the lancet magazine stepwise or the automatic stepwise advance of the lancet magazine can be suppressed or deactivated so that, if desired, several punctures can be carried out with the last used lancet before an unused lancet is used at a desired time.
摘要翻译：一种本发明的刺血针装置，用于产生穿刺伤口，特别是用于收集体液样品，该体液具有用于包含多个刺血针的柳叶刀匣的药筒保持器。柳叶刀装置可选择地操作，使得通过逐步自动推进柳叶刀刀库来使每个穿刺过程使用新的刺血针，或者可以抑制或去激活柳叶刀刀库的自动逐步前进，使得如果需要，可以进行若干穿刺在所需时间使用未使用的柳叶刀之前，用最后使用的柳叶刀进行。

70. 发明授权

US08114028B2 Analysis system for determining an analyte in a body fluid and disposable integrated sample acquisition and analysis element 有权
标题翻译：用于确定体液中的分析物和一次性综合样品采集和分析元件的分析系统
公开(公告)号：US08114028B2
公开(公告)日：2012-02-14
申请号：US12548479
申请日：2009-08-27
申请人： Hans List , Volker Zimmer , Michael Keil
发明人： Hans List , Volker Zimmer , Michael Keil
IPC分类号： A61B5/00
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/150511 , A61B5/150572 , A61B5/15186 , A61B2562/0295
摘要： An analyte determination analysis system with a disposable integrated sample acquisition and analysis element is disclosed. A piercing element has a tip for generating a bodily puncture wound and a test strip having a body fluid sample receiving zone to perform an analysis on a body fluid sample. A reusable analysis instrument comprises a coupling unit that couples the integrated sample acquisition and analysis element to a drive that drives a piercing element in a piercing movement comprising two phases: a propulsion phase wherein the piercing element moves on a puncture path in a puncture direction and a retraction phase wherein the piercing element moves opposite to the puncture direction after reaching a reversal point. A measuring and analysis unit measures a variable characteristic for the determination of the analyte and determines a desired analysis result on the basis of the measurement. The sample receiving zone of the test strip forms a sample contact. The piercing element, located parallel to the test strip, moves on a movement path relative to the test strip a puncture path. The piercing element, located adjacent to the sample contact, has a capillary channel with a sample inlet for body fluid entry after the piercing and a sample outlet for body fluid exit. The piercing element movement has a sample transfer position wherein the sample outlet is adjacent to the sample receiving zone such that the body fluid may be transferred from the capillary channel through the sample outlet to the sample receiving zone.
摘要翻译：公开了一种具有一次性集成样品采集和分析元件的分析物测定分析系统。穿刺元件具有用于产生身体穿刺伤口的尖端和具有体液样品接收区以对体液样品进行分析的测试条。一种可重复使用的分析仪器包括耦合单元，该耦合单元将集成采样和分析元件耦合到驱动器，该驱动器以穿刺运动的方式驱动穿刺元件，所述穿孔运动包括两相：推进阶段，其中穿刺元件在穿刺方向上在穿刺路径上移动，其中穿刺元件在达到反转点之后与穿刺方向相反移动。测量和分析单元测量用于测定分析物的可变特性，并且基于测量确定期望的分析结果。测试条的样品接收区形成样品接触。刺穿元件平行于测试条移动，相对于测试条在穿刺路径上移动。位于邻近样品接触处的刺穿元件具有毛细通道，其具有用于在穿刺之后进入体液的样品入口和用于体液排出的样品出口。穿刺元件移动具有样品转移位置，其中样品出口与样品接收区相邻，使得体液可以从毛细通道通过样品出口转移到样品接收区。

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