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61. 发明授权

US08114289B2 Method and apparatus for microfiltration to perform cell separation 有权
标题翻译：微滤法进行细胞分离的方法和装置
公开(公告)号：US08114289B2
公开(公告)日：2012-02-14
申请号：US12360067
申请日：2009-01-26
申请人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
发明人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
IPC分类号： B01D63/00 , B41J2/175
CPC分类号： B01D69/12 , B01D61/18 , B01D63/082 , B01D67/0034 , B01D71/28 , B01D2325/021
摘要： A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
摘要翻译：一种使用具有顶部多孔膜和底部多孔膜的微量过滤装置从样品中分离诸如循环肿瘤细胞的细胞的微滤装置和方法。多孔膜由聚对二甲苯形成并使用微细加工技术组装。多孔膜被布置成使得顶部膜中的孔与底部膜中的孔偏离。

62. 发明申请

US20110270188A1 FILL-STATUS SENSORS FOR DRUG PUMP DEVICES 有权
标题翻译：用于液体泵装置的FILL状态传感器
公开(公告)号：US20110270188A1
公开(公告)日：2011-11-03
申请号：US13091031
申请日：2011-04-20
申请人： SEAN CAFFEY , Po-Ying Li , Yu-Chong Tai , Jeffrey Brennan
发明人： SEAN CAFFEY , Po-Ying Li , Yu-Chong Tai , Jeffrey Brennan
IPC分类号： A61M5/142
CPC分类号： A61M5/14526 , A61M5/14248 , A61M5/14276 , A61M5/14593 , A61M5/1684 , A61M5/16886 , A61M2005/14204 , A61M2205/3523 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2210/0612
摘要： The filling status of a drug reservoir in a drug pump devices may be determined with mechanical and/or magnetic position sensor associated with a reservoir boundary.
摘要翻译：可以使用与储存器边界相关联的机械和/或磁性位置传感器来确定药物泵装置中药物储存器的填充状态。

63. 发明授权

US07796371B2 Integrated capacitive microfluidic sensors method and apparatus 有权
标题翻译：集成电容微流体传感器的方法和装置
公开(公告)号：US07796371B2
公开(公告)日：2010-09-14
申请号：US11830581
申请日：2007-07-30
申请人： Jun Xie , Jason Shih , Yu-Chong Tai
发明人： Jun Xie , Jason Shih , Yu-Chong Tai
IPC分类号： H01G7/00
CPC分类号： G01N27/226 , B81B7/02 , B81B2201/0292 , B81B2201/058 , G01L9/0042 , G01L9/0072
摘要： A micro fluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.
摘要翻译：一种用于电容式感测的微流体装置和方法。该装置包括流体通道，其包括在第一端处的入口和在第二端处的出口，耦合到流体通道的空腔区域以及耦合在流体通道和腔区域之间的基于聚合物的膜。另外，该器件包括耦合到膜的第一电容器电极，耦合到空腔区域的第二电容器电极，并且至少通过腔区域与第一电容器电极物理分离;以及电源，耦合在第一电容器电极和所述第二电容器电极至少在所述腔区域内引起电场。基于聚合物的膜包括聚合物。

64. 发明申请

US20090306595A1 IMPLANTABLE DRUG-DELIVERY DEVICES, AND APPARATUS AND METHODS FOR FILLING THE DEVICES 有权
标题翻译：可植入药物递送装置，以及用于填充装置的装置和方法
公开(公告)号：US20090306595A1
公开(公告)日：2009-12-10
申请号：US12463247
申请日：2009-05-08
申请人： Jason Shih , Changlin Pang , Fukang Jiang , Sean Caffey , Mark Humayun , Yu-Chong Tai , Raymond Peck
发明人： Jason Shih , Changlin Pang , Fukang Jiang , Sean Caffey , Mark Humayun , Yu-Chong Tai , Raymond Peck
IPC分类号： A61M5/142 , B65B3/12
CPC分类号： A61M5/14212 , A61F9/0017 , A61M5/14276 , A61M5/148 , A61M5/16881 , A61M5/36 , A61M39/0208 , A61M2005/1403 , A61M2039/0072 , A61M2039/0081 , A61M2039/0235 , A61M2209/045
摘要： In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.
摘要翻译：在各种实施方案中，使用工具填充药物递送装置。该工具可以包括例如通过药物递送装置的填充口进入的针。

65. 发明授权

US07629797B2 Resonance-induced sensitivity enhancement method for conductivity sensors 失效
标题翻译：电导率传感器的共振诱导灵敏度增强方法
公开(公告)号：US07629797B2
公开(公告)日：2009-12-08
申请号：US11697060
申请日：2007-04-05
申请人： Yu-Chong Tai , Chi-yuan Shih , Wei Li , Siyang Zheng
发明人： Yu-Chong Tai , Chi-yuan Shih , Wei Li , Siyang Zheng
IPC分类号： G01R27/26
CPC分类号： G01N27/023 , G01N15/1056 , G01N15/12 , G01N27/4473 , G01N2030/645 , G01R27/22
摘要： Methods and systems for improving the sensitivity of a variety of conductivity sensing devices, in particular capacitively-coupled contactless conductivity detectors. A parallel inductor is added to the conductivity sensor. The sensor with the parallel inductor is operated at a resonant frequency of the equivalent circuit model. At the resonant frequency, parasitic capacitances that are either in series or in parallel with the conductance (and possibly a series resistance) is substantially removed from the equivalent circuit, leaving a purely resistive impedance. An appreciably higher sensor sensitivity results. Experimental verification shows that sensitivity improvements of the order of 10,000-fold are possible. Examples of detecting particulates with high precision by application of the apparatus and methods of operation are described.
摘要翻译：用于提高各种电导率传感装置的灵敏度的方法和系统，特别是电容耦合的非接触电导检测器。并联电感器被添加到电导率传感器。具有并联电感器的传感器以等效电路模型的谐振频率工作。在谐振频率下，与电导串联或并联的寄生电容（和可能的串联电阻）基本上从等效电路中去除，留下纯电阻阻抗。传感器敏感度会更高。实验验证表明灵敏度提高可达10,000倍。描述了通过应用该装置和操作方法检测高精度的微粒的实例。

66. 发明申请

US20090188864A1 METHOD AND APPARATUS FOR MICROFILTRATION TO PERFORM CELL SEPARATION 有权
标题翻译：用于微细分离以进行细胞分离的方法和装置
公开(公告)号：US20090188864A1
公开(公告)日：2009-07-30
申请号：US12360067
申请日：2009-01-26
申请人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
发明人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
IPC分类号： B01D69/12 , B01D61/14 , B01D65/02 , B44C1/22
CPC分类号： B01D69/12 , B01D61/18 , B01D63/082 , B01D67/0034 , B01D71/28 , B01D2325/021
摘要： A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
摘要翻译：一种使用具有顶部多孔膜和底部多孔膜的微量过滤装置从样品中分离诸如循环肿瘤细胞的细胞的微滤装置和方法。多孔膜由聚对二甲苯形成并使用微细加工技术组装。多孔膜被布置成使得顶部膜中的孔与底部膜中的孔偏离。

67. 发明申请

US20080210306A1 Integrated surface-machined micro flow controller method and apparatus 审中-公开
标题翻译：综合表面加工微流量控制器的方法和装置
公开(公告)号：US20080210306A1
公开(公告)日：2008-09-04
申请号：US11515794
申请日：2006-09-06
申请人： Jun Xie , Jason Shih , Yu-Chong Tai
发明人： Jun Xie , Jason Shih , Yu-Chong Tai
IPC分类号： B81B3/00 , F16K31/02 , F17D1/00 , H01L41/22 , H01L41/083 , F15C5/00
CPC分类号： F16K99/0001 , F16K99/0015 , F16K99/0044 , F16K99/0051 , F16K99/0061 , F16K2099/0074 , F16K2099/008 , G01F1/6845 , G01F15/005 , G05D7/0694 , Y10T29/49412 , Y10T137/0391
摘要： A surface-micromachined mass flow controller (MFC) comprises an electrostatically actuated microvalve integrated with a thermal flow sensor. The microvalve comprises a normally-open diaphragm defining an aperture allowing fluid communication between first and second flow channels. The diaphragm includes a second electrode actuable toward a valve seat including a first electrode. Fabricated utilizing a multilayer Parylene process, the active microvalve and the flow sensor are integrated onto a single chip to perform closed-loop flow control. For flow control, both Pulse Width Modulation (PWM) and actuation voltage adjustment are demonstrated.
摘要翻译：表面微加工质量流量控制器（MFC）包括与热流传感器集成的静电致动微型阀。微型阀包括限定允许第一和第二流动通道之间流体连通的孔的常开的隔膜。隔膜包括能够朝向包括第一电极的阀座致动的第二电极。采用多层Parylene工艺制造，将活性微型阀和流量传感器集成到单个芯片上，以执行闭环流量控制。对于流量控制，展示了脉宽调制（PWM）和启动电压调节。

68. 发明申请

US20060271129A1 Magnetic material-containing microfabricated devices for wireless data and power transfer 有权
标题翻译：含磁性材料的微加工设备，用于无线数据和电力传输
公开(公告)号：US20060271129A1
公开(公告)日：2006-11-30
申请号：US11272383
申请日：2005-11-10
申请人： Yu-Chong Tai , Damien Rodger , Wen Li
发明人： Yu-Chong Tai , Damien Rodger , Wen Li
IPC分类号： A61N2/02
CPC分类号： A61N2/02
摘要： This invention relates to the design and fabrication of micro electromechanical systems (MEMS) for applications in such varied fields as the biomedical, micro-fluidics and chemical analysis fields.
摘要翻译：本发明涉及在诸如生物医学，微流体学和化学分析领域的各种领域中的应用的微机电系统（MEMS）的设计和制造。

69. 发明申请

US20060254972A1 Membrane filter for capturing circulating tumor cells 有权
标题翻译：用于捕获循环肿瘤细胞的膜过滤器
公开(公告)号：US20060254972A1
公开(公告)日：2006-11-16
申请号：US11408501
申请日：2006-04-20
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： B01D63/00
CPC分类号： B01D69/02 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D71/022 , B01D71/72 , B01D2325/021 , Y10T436/25375
摘要： The present invention provides a parylene-based membrane filter device for capturing of circulating tumor cells (CTC). The membrane filter has an array of holes having a predetermined geometric design with precisely controlled size, shape and density. In one aspect, the device has a stack of substantially parallel membrane filters with uniformly-spaced and/or monodispersed holes.
摘要翻译：本发明提供了一种用于捕获循环肿瘤细胞（CTC）的聚对二甲苯基膜过滤装置。膜过滤器具有具有预定几何设计并具有精确控制的尺寸，形状和密度的孔阵列。在一个方面，该装置具有基本上平行的具有均匀间隔和/或单分散孔的膜过滤器的堆叠。

70. 发明申请

US20060240294A1 Actuatable and reversible pressure generation based on fuel cell operation 审中-公开
公开(公告)号：US20060240294A1
公开(公告)日：2006-10-26
申请号：US11455886
申请日：2006-06-20
申请人： Michael Freund , Yu-Chong Tai , Colin Cameron , Xing Yang
发明人： Michael Freund , Yu-Chong Tai , Colin Cameron , Xing Yang
IPC分类号： H01M8/04 , H01M4/96 , H01M8/02 , H01M8/18 , H01M8/08
CPC分类号： H01M8/1004 , H01M8/00 , H01M8/0289 , H01M8/04089 , H01M8/0656 , H01M8/1007 , H01M8/186 , Y02E60/528
摘要： A fuel cell is used to create pressure by reverse biasing the fuel cell. A voltage is applied across the fuel cell to change the liquid near the fuel cell into gas, and expand its volume. The volume expansion is used for work function, either to expand a housing or move a piston or the like. By removing the voltage, the fuel cell can regenerate by absorbing the gas to again create energy, thereby retracting the volume expansion. In an embodiment, water may be the electrolyte which is electrolyzed to form hydrogen and oxygen gas, and then recombined into water.

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