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61. 发明授权

US08509893B2 Supraventricular stimulation to control ventricular rate 有权
标题翻译：室上性刺激控制心室率
公开(公告)号：US08509893B2
公开(公告)日：2013-08-13
申请号：US12913354
申请日：2010-10-27
申请人： Yong-Fu Xiao , John L. Sommer , Scott J. Brabec , Lepeng Zeng , Jon F. Urban
发明人： Yong-Fu Xiao , John L. Sommer , Scott J. Brabec , Lepeng Zeng , Jon F. Urban
IPC分类号： A61N1/372
CPC分类号： A61N1/3622 , A61N1/36564 , A61N1/368
摘要： Various techniques for delivering atrial pacing and supraventricular stimulation to achieve a desired ventricular rate and/or cardiac output are described. One example method described includes delivering a pacing signal configured to cause an atrial depolarization to a heart of a patient, wherein the atrial depolarization results in an associated refractory period during the cardiac cycle, and delivering a signal to a supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during a ventricular refractory period of the cardiac cycle.
摘要翻译：描述用于递送心房起搏和室上性刺激以实现期望的心室率和/或心输出量的各种技术。所描述的一个示例性方法包括递送起搏信号，所述起搏信号被配置成对患者的心脏进行心房去极化，其中所述心房去极化在心脏周期期间导致相关联的不应期，并将信号传递到心脏的心脏的室上部分患者在心房不良期后和心动周期心室不应期。

62. 发明申请

US20130006332A1 EVALUATING THERAPEUTIC STIMULATION ELECTRODE CONFIGURATIONS BASED ON PHYSIOLOGICAL RESPONSES 有权
公开(公告)号：US20130006332A1
公开(公告)日：2013-01-03
申请号：US13616300
申请日：2012-09-14
申请人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
发明人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
IPC分类号： A61N1/37 , A61N1/36
CPC分类号： A61N1/36514 , A61N1/056 , A61N1/36114 , A61N1/36185 , A61N1/3684 , A61N1/3686 , A61N2001/0585
摘要： A medical system comprises a plurality of electrodes; at least one sensor configured to output at least one signal based on at least one physiological parameter of a patient; and a processor. The processor is configured to control delivery of stimulation to the patient using a plurality of electrode configurations. Each of the electrode configurations comprises at least one of the plurality of electrodes. For each of the electrode configurations, the processor is configured to determine a first response of target tissue to the stimulation based on the signals, and a second response of non-target tissue to the stimulation based on the signals. The processor is also configured to select at least one of the electrode configurations for delivery of stimulation to the patient based on the first and second responses for the electrode configurations. As examples, the target tissue may be a left ventricle or vagus nerve.

63. 发明授权

US08340783B2 Implantable medical device lead with selectively exposed electrodes and reinforcement member 有权
标题翻译：植入式医疗器械引线带有选择性暴露的电极和加强构件
公开(公告)号：US08340783B2
公开(公告)日：2012-12-25
申请号：US12825647
申请日：2010-06-29
申请人： John L. Sommer , Kenneth C. Gardeski , Xiaonan Shen , Jon D. Schell
发明人： John L. Sommer , Kenneth C. Gardeski , Xiaonan Shen , Jon D. Schell
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/05 , A61N1/0534 , A61N1/0551 , A61N1/0558 , A61N1/086
摘要： An implantable lead including a lead body including an outer surface, a proximal end, a distal end, and at least one electrode; an electrically insulating member that extends axially over a first portion of the outer surface of the lead body between the proximal end and distal end, the electrically insulating member defining at least one aperture that exposes a first portion of the at least one electrode when in a first position over the lead body; and a reinforcement member formed at least partially of a different material than the insulating member and coupled to the insulating member, the reinforcement member extending axially over the outer surface of the lead body between the insulating member and proximal end. The reinforcement member may be configured to transfer at least one of a radial or axial force from a proximal portion of the reinforcement member to the insulating member, wherein the at least one of radial or axial force transferred to the insulating member is sufficient to move the insulating member over the outer surface of the lead body. In some examples, the lead may further include a deployable lobe member configured to anchor the reinforcement member and insulating member adjacent a tissue site within a patient.
摘要翻译：一种可植入引线，包括：引线本体，其包括外表面，近端，远端和至少一个电极; 电绝缘构件，其在所述近端和远端之间轴向延伸到所述引线本体的外表面的第一部分上方，所述电绝缘构件限定在至少一个孔处暴露所述至少一个电极的第一部分，领先身体的第一位; 至少部分地由与所述绝缘构件不同的材料形成并且与所述绝缘构件连接的加强构件，所述加强构件在所述绝缘构件和所述绝缘构件与所述绝缘构件之间的所述引线本体的外表面上轴向延伸。加强构件可以构造成将径向或轴向力中的至少一个从加强构件的近侧部分传递到绝缘构件，其中传递到绝缘构件的径向或轴向力中的至少一个足以使绝缘构件在引线体的外表面上。在一些示例中，引线还可包括可展开的隆起部件，其构造成将加强部件和绝缘部件固定在患者体内的组织部位附近。

64. 发明申请

US20120232606A1 USING FOCAL MYOCARDIAL STIMULATION TO DISTINGUISH SUPRAVENTRICULAR TACHYCARDIA FROM VENTRICULAR TACHYCARDIA 审中-公开
公开(公告)号：US20120232606A1
公开(公告)日：2012-09-13
申请号：US13357659
申请日：2012-01-25
申请人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
发明人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3622 , A61N1/36585
摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.

65. 发明授权

US08019420B2 Medical lead connector systems with adapters 有权
标题翻译：具有适配器的医用铅连接器系统
公开(公告)号：US08019420B2
公开(公告)日：2011-09-13
申请号：US10646545
申请日：2003-08-21
申请人： Douglas S. Hine , John L. Sommer , John Gurley
发明人： Douglas S. Hine , John L. Sommer , John Gurley
IPC分类号： A61N1/375
CPC分类号： H01R13/5224 , H01R31/06
摘要： A lead connector including a connector element array is fitted into a selected adaptor from a plurality of adaptors to electrically couple one or more elements of the connector element array, corresponding to one or more selected electrodes from an array of lead electrodes, to one or more contact zones of the selected adaptor in order to facilitate electrical connection with an implantable medical device.
摘要翻译：将包括连接器元件阵列的引线连接器从多个适配器装配到所选择的适配器中，以将来自引线电极阵列的一个或多个所选电极的连接器元件阵列的一个或多个元件电耦合到一个或多个接触区域，以便于与可植入医疗设备的电连接。

66. 发明申请

US20100114282A1 IMPLANTABLE MEDICAL DEVICE CONDUCTOR INSULATION AND PROCESS FOR FORMING 有权
标题翻译：可植入医疗器械导体绝缘及其成型工艺
公开(公告)号：US20100114282A1
公开(公告)日：2010-05-06
申请号：US12683561
申请日：2010-01-07
申请人： Michael J. Ebert , John L. Sommer , Richard D. Ries , Jordan D. Honeck , Pedro A. Meregotte , Kenneth R. Brennen
发明人： Michael J. Ebert , John L. Sommer , Richard D. Ries , Jordan D. Honeck , Pedro A. Meregotte , Kenneth R. Brennen
IPC分类号： A61N1/05
CPC分类号： H01B3/306 , A61L31/10 , A61N1/056 , C08L79/08
摘要： An elongate medical electrical lead conductor includes a layer of hydrolytically stable polyimide formed thereover.
摘要翻译：细长的医用电引线导体包括一层形成在其上的水解稳定的聚酰亚胺。

67. 发明申请

US20100114271A1 SHIELDED CONDUCTOR FILAR - STIMULATION LEADS 审中-公开
标题翻译：屏蔽导体膜 - 刺激引线
公开(公告)号：US20100114271A1
公开(公告)日：2010-05-06
申请号：US12262306
申请日：2008-10-31
申请人： John L. Sommer , Scott Brabec
发明人： John L. Sommer , Scott Brabec
IPC分类号： H01B3/44 , A61N1/04
CPC分类号： A61B5/0031 , A61B5/0006 , A61B2562/222 , A61N1/05 , A61N1/086
摘要： A lead for a medical device includes an elongate filar core member having an axis, which is operable for transmitting a lead signal. Furthermore, the lead includes an insulating layer disposed directly on the elongate filar core member and that extends along the axis. The lead also includes an electrically conductive layer disposed directly on the insulating layer and that extends along the axis.
摘要翻译：用于医疗装置的引线包括具有轴的细长丝状芯构件，其可操作用于传送引导信号。此外，引线包括绝缘层，其直接设置在细长丝状芯部件上并且沿轴线延伸。引线还包括直接设置在绝缘层上并沿轴线延伸的导电层。

68. 发明申请

US20090054947A1 ELECTRODE CONFIGURATIONS FOR DIRECTIONAL LEADS 审中-公开
标题翻译：用于方向导线的电极配置
公开(公告)号：US20090054947A1
公开(公告)日：2009-02-26
申请号：US12195277
申请日：2008-08-20
申请人： David Wayne Bourn , John L. Sommer , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
发明人： David Wayne Bourn , John L. Sommer , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
IPC分类号： A61N1/362 , A61N1/05
CPC分类号： A61N1/368 , A61N1/0534 , A61N1/0551 , A61N1/056 , A61N1/36114 , A61N1/3684 , A61N2001/0585
摘要： A system includes an implantable electrical stimulation lead configured for intravenous introduction into a vessel proximate to a heart and an electrical stimulator. The lead comprises a lead body and at least three electrode segments. The electrical stimulator is coupled to the electrode segments and configures a first of the electrode segments as a first anode, a second of the electrode segments as a cathode, and a third of the electrode segments as a second anode, and delivers electrical stimulation to the heart via the cathode and first and second anodes. Additional techniques for delivering electrical stimulation include using multiple electrode segments as cathodes and electrically isolating other electrode segments. Other examples are directed to techniques for directing electrical therapy to a vagus nerve of a patient.
摘要翻译：系统包括可植入的电刺激引线，其被配置为静脉内引入靠近心脏的血管和电刺激器。引线包括引线体和至少三个电极段。电刺激器耦合到电极段并且将第一电极段配置为第一阳极，将第二电极段作为阴极，将第三电极段作为第二阳极，并将电刺激传递到心脏通过阴极和第一和第二阳极。用于递送电刺激的附加技术包括使用多个电极段作为阴极并电隔离其它电极段。其他实例涉及将电疗法引导到患者的迷走神经的技术。

69. 发明申请

US20090054946A1 EVALUATING THERAPEUTIC STIMULATION ELECTRODE CONFIGURATIONS BASED ON PHYSIOLOGICAL RESPONSES 有权
标题翻译：基于生理反应评估治疗性刺激电极配置
公开(公告)号：US20090054946A1
公开(公告)日：2009-02-26
申请号：US12195317
申请日：2008-08-20
申请人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
发明人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
IPC分类号： A61N1/08
CPC分类号： A61N1/36514 , A61N1/056 , A61N1/36114 , A61N1/36185 , A61N1/3684 , A61N1/3686 , A61N2001/0585
摘要： A medical system comprises a plurality of electrodes; at least one sensor configured to output at least one signal based on at least one physiological parameter of a patient; and a processor. The processor is configured to control delivery of stimulation to the patient using a plurality of electrode configurations. Each of the electrode configurations comprises at least one of the plurality of electrodes. For each of the electrode configurations, the processor is configured to determine a first response of target tissue to the stimulation based on the signals, and a second response of non-target tissue to the stimulation based on the signals. The processor is also configured to select at least one of the electrode configurations for delivery of stimulation to the patient based on the first and second responses for the electrode configurations. As examples, the target tissue may be a left ventricle or vagus nerve.
摘要翻译：医疗系统包括多个电极; 至少一个传感器被配置为基于患者的至少一个生理参数输出至少一个信号; 和处理器。处理器被配置为使用多个电极配置来控制对患者的刺激递送。每个电极配置包括多个电极中的至少一个。对于每个电极配置，处理器被配置为基于信号来确定目标组织对刺激的第一响应，以及基于该信号来确定非目标组织对刺激的第二响应。处理器还被配置为基于电极配置的第一和第二响应来选择用于将刺激递送到患者的电极配置中的至少一个。作为示例，靶组织可以是左心室或迷走神经。

70. 发明申请

US20080300664A1 METHOD AND APPARATUS FOR PLACING A CORONARY SINUS/CARDIAC VEIN PACING AND DEFIBRILLATION LEAD WITH ADJUSTABLE ELECTRODE SPACING 审中-公开
标题翻译：用于放置可调节电极间隔的冠状动脉/心脏瓣膜和断裂引线的方法和装置
公开(公告)号：US20080300664A1
公开(公告)日：2008-12-04
申请号：US12115961
申请日：2008-05-06
申请人： DOUGLAS S. HINE , John L. Sommer , James H. Vaughan , Rick D. McVenes , Paulus C. Van Venrooij , Pierre-Andre Grandjean
发明人： DOUGLAS S. HINE , John L. Sommer , James H. Vaughan , Rick D. McVenes , Paulus C. Van Venrooij , Pierre-Andre Grandjean
IPC分类号： A61N1/05 , A61B5/042
CPC分类号： A61N1/056 , A61F2/88 , A61F2/958 , A61N2001/0585
摘要： A medical electrical lead, which may be useful in coupling an implantable medical device, is comprised of a first and second lead. The first lead has a first electrode coupled adjacent a distal end portion thereof. The distal end portion of the first lead is anchorable in the coronary sinus of a patient. The second lead is coupled with and moveable along the first lead. The second lead has a second electrode located thereon wherein the position of the first and second electrodes may be varied relative to one another by movement of the second lead along the first lead. A rubber tip holds the relative position of each electrode.
摘要翻译：可用于联接可植入医疗装置的医用电引线由第一和第二引线组成。第一引线具有邻近其远端部分耦合的第一电极。第一引线的远端部分可锚定在患者的冠状窦中。第二个领先者与第一个领先者相结合并可以移动。第二引线具有位于其上的第二电极，其中第一和第二电极的位置可以通过第二引线沿着第一引线的移动而相对于彼此变化。橡胶尖端保持每个电极的相对位置。

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