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61. 发明授权

US07662822B2 Substituted azaquinazolines having an antiviral action 有权
标题翻译：取代的具有抗病毒作用的氮杂喹啉
公开(公告)号：US07662822B2
公开(公告)日：2010-02-16
申请号：US11579919
申请日：2005-04-23
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Süβmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Süβmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
IPC分类号： C07D471/04 , A61K31/497 , C07D213/75 , C07D213/73 , C07F9/06 , C07F9/28 , C07C265/12 , A61P31/12
CPC分类号： C07D471/04
摘要： This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.
摘要翻译：本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

62. 发明申请

US20100022484A1 4-Chromenonyl-1,4-dihydropyridines and their use 失效
标题翻译： 4-色烯酰基-1,4-二氢吡啶及其用途
公开(公告)号：US20100022484A1
公开(公告)日：2010-01-28
申请号：US11989277
申请日：2006-07-12
申请人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Gigueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
发明人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Gigueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
IPC分类号： A61K31/60 , C07D405/02 , A61K31/4433 , A61P9/00 , A61P9/12 , A61P13/12 , A61P1/16
CPC分类号： C07D405/04
摘要： The present application relates to novel 4-chromenonyl-1,4-dihydropyridines, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译：本申请涉及新的4-色烯酮基-1,4-二氢吡啶类，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是心血管疾病。

63. 发明授权

US07354022B2 Device for monitoring tiltable flaps on aircraft wings 有权
标题翻译：用于监控飞机机翼上的倾斜襟翼的装置
公开(公告)号：US07354022B2
公开(公告)日：2008-04-08
申请号：US11316084
申请日：2005-12-21
申请人： Martin Richter , Dieter Lang
发明人： Martin Richter , Dieter Lang
IPC分类号： G05D1/00
CPC分类号： B64D45/0005 , B64D2045/001
摘要： A device for monitoring tiltable flaps on aircraft wings including rotary sensors at the rotary axis of the flap and associated with each actuating element. A rotation sensor is connected to the actuating elements by a spring band. The band is a coupled for angle transmission and the band is connected at a distance from the rotary axis. The spring band is stiff in the direction of rotation, while in the lateral direction, for the purpose of compensating for transverse movements of the actuating elements, the spring band is soft. For each flap, the signals of the rotary sensors, at decentralized monitoring devices to locate errors, are transmitted to an evaluation unit.
摘要翻译：一种用于监控飞机机翼上的可倾斜翼片的装置，包括在翼片的旋转轴线处的旋转传感器并与每个致动元件相关联。旋转传感器通过弹簧带连接到致动元件。该带是用于角度传输的连接，并且该带在与旋转轴线一定距离处连接。弹簧带在旋转方向上是刚性的，而在横向方向上，为了补偿致动元件的横向运动，弹簧带是柔软的。对于每个挡板，旋转传感器的信号在分散监视装置处定位错误，被传送到评估单元。

64. 发明授权

US07317016B2 Methods of treating medical conditions using sulfonate-substituted pyrazolopyridine derivatives 失效
标题翻译：使用磺酸酯取代的吡唑并吡啶衍生物治疗医学病症的方法
公开(公告)号：US07317016B2
公开(公告)日：2008-01-08
申请号：US11175740
申请日：2005-07-05
申请人： Johannes-Peter Stasch , Achim Feurer , Stefan Weigand , Elke Stahl , Dietmar Flubacher , Cristina Alonso-Alija , Frank Wunder , Dieter Lang , Klaus Dembowsky , Alexander Straub , Elisabeth Perzborn
发明人： Johannes-Peter Stasch , Achim Feurer , Stefan Weigand , Elke Stahl , Dietmar Flubacher , Cristina Alonso-Alija , Frank Wunder , Dieter Lang , Klaus Dembowsky , Alexander Straub , Elisabeth Perzborn
IPC分类号： A61K31/4162 , C07D471/04
CPC分类号： C07D471/04
摘要： This invention relates to methods of treatment of cardiovascular disorders, thromboembolic disorders, inflammation, and disorders of the central nervous system using pyrazol pyridine derivatives of formula (I) wherein R1 is a radical of the formula —O—SO2—R3 in which R3 is optionally substituted C1-6-alkyl, optionally substituted C3-8-cycloalkyl, or optionally substituted phenyl; R2 is H, optionally substituted C1-6-alkyl-CO— or optionally substituted C1-6-alkyl-SO2—; as well as salts, stereoisomers, tautomers, and hydrates thereof.
摘要翻译：本发明涉及使用式（I）的吡唑吡啶衍生物治疗心血管疾病，血栓栓塞障碍，炎症和中枢神经系统疾病的方法，其中R 1是式-O的基团其中R 3是任选取代的C 1-6 - 烷基，任选取代的C 1 -C 6 - C 3-8 - 环烷基或任选取代的苯基; R 2是H，任选取代的C 1-6 - 烷基-CO-或任选取代的C 1-6 - 烷基-S SO > 2 - ; 以及其盐，立体异构体，互变异构体及其水合物。

65. 发明申请

US20070185121A1 Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents 有权
标题翻译：杂环取代的二氢喹唑啉及其作为抗病毒剂的用途
公开(公告)号：US20070185121A1
公开(公告)日：2007-08-09
申请号：US10556198
申请日：2004-04-28
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang
IPC分类号： A61K31/4985 , C07D403/14
CPC分类号： C07D487/04
摘要： The invention relates to heterocyclyl-substituted dihydroquinazolines of formula (I), to processes for their preparation, to medicaments containing them, and to methods for the treatment and/or prophylaxis of diseases, in particular, for use as anti-viral agents, in particular, against cytomegaloviruses.
摘要翻译：本发明涉及式（I）的杂环基取代的二氢喹唑啉，其制备方法，含有它们的药物，以及用于治疗和/或预防疾病，特别是用作抗病毒剂的方法特别是针对巨细胞病毒。

66. 发明授权

US07105523B2 Carbamate-substituted pyrazolopyridine-derivatives 失效
标题翻译：氨基甲酸酯取代的吡唑并吡啶衍生物
公开(公告)号：US07105523B2
公开(公告)日：2006-09-12
申请号：US10432571
申请日：2001-11-09
申请人： Johannes-Peter Stasch , Achim Feurer , Stefan Weigand , Elke Stahl , Dietmar Flubacher , Cristina Alonso-Alija , Frank Wunder , Dieter Lang , Klaus Dembowsky , Alexander Straub , Elisabeth Perzborn
发明人： Johannes-Peter Stasch , Achim Feurer , Stefan Weigand , Elke Stahl , Dietmar Flubacher , Cristina Alonso-Alija , Frank Wunder , Dieter Lang , Klaus Dembowsky , Alexander Straub , Elisabeth Perzborn
IPC分类号： C07D403/04 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： This invention relates to compounds of the formula wherein R1 is H or a di-C1-6-alkylaminocarbonyl raical, and R2 is a radical of the formula —O—C(X)—NR3R4 wherein X is O or S. A process for preparing such compounds, pharmaceutical compositions containing them, and methods for using them in treatment of hypertension are also disclosed and claimed.
摘要翻译：本发明涉及下式的化合物，其中R 1是H或C 1 -C 6 - 烷基氨基羰基，R 2是式-OC（X）-NR 3 R 4的基团其中X是O或S.制备这种化合物的方法，含有它们的药物组合物和方法用于治疗高血压的用途也被公开并要求保护。

67. 发明申请

US20060128700A1 Morpoline-bridged indazole derivatives 失效
标题翻译：吗啉桥联吲唑衍生物
公开(公告)号：US20060128700A1
公开(公告)日：2006-06-15
申请号：US10528601
申请日：2003-09-16
申请人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard Konig , Johannes-Peter Stasch , Frank Wunder , Dieter Lang , Elke Stahl , Thomas Schenke , Rudy Schreiber
发明人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard Konig , Johannes-Peter Stasch , Frank Wunder , Dieter Lang , Elke Stahl , Thomas Schenke , Rudy Schreiber
IPC分类号： A61K31/538 , A61K31/506 , C07D491/04
CPC分类号： C07D471/04
摘要： The present invention relates to novel morpholine-bridged indazole derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of disorders of the central nervous system.
摘要翻译：本发明涉及刺激可溶性鸟苷酸环化酶的新型吗啉桥连吲唑衍生物，其制备方法及其用于制备药物的用途，特别是用于治疗中枢神经系统疾病的药物。

68. 发明申请

US20060106096A1 Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists 有权
标题翻译：氮杂双环氨基甲酸酯及其作为α-7烟碱乙酰胆碱受体激动剂的用途
公开(公告)号：US20060106096A1
公开(公告)日：2006-05-18
申请号：US10522611
申请日：2003-07-14
申请人： Timo Flessner , Frank-Gerhard Bossw , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Marja Van Kampen , Franz-Josef Van der Staay
发明人： Timo Flessner , Frank-Gerhard Bossw , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Marja Van Kampen , Franz-Josef Van der Staay
IPC分类号： C07D307/87 , A61K31/343
CPC分类号： C07D453/02
摘要： The invention relates to novel benzothiophene-, benzofuran- and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译：本发明涉及新的苯并噻吩 - ，苯并呋喃 - 和吲哚脲，以及其用于制备用于治疗和/或预防疾病以及改善感知，浓度，学习和/或记忆的药物的用途。

69. 发明申请

US20060014951A1 4-amino-substituted pyrimidine derivatives 失效
标题翻译： 4-氨基取代的嘧啶衍生物
公开(公告)号：US20060014951A1
公开(公告)日：2006-01-19
申请号：US10521540
申请日：2003-07-07
申请人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard Konig , Johannes-Peter Stasch , Elke Stahl , Rudy Schreiber , Frank Wunder , Dieter Lang
发明人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard Konig , Johannes-Peter Stasch , Elke Stahl , Rudy Schreiber , Frank Wunder , Dieter Lang
IPC分类号： A61K31/506 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to novel 4-amino-substituted pyrimidine derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of central nervous system diseases.
摘要翻译：本发明涉及刺激可溶性鸟苷酸环化酶的新型4-氨基取代的嘧啶衍生物，其制备方法及其用于制备药物，特别是用于治疗中枢神经系统疾病的药物的用途。

70. 发明申请

US20050245553A1 Methods of treating medical conditions using sulfonate-substituted pyrazolopyridine derivatives 失效
标题翻译：使用磺酸酯取代的吡唑并吡啶衍生物治疗医学病症的方法
公开(公告)号：US20050245553A1
公开(公告)日：2005-11-03
申请号：US11175740
申请日：2005-07-05
申请人： Johannes-Peter Stasch , Achim Feurer , Stefan Weigand , Elke Stahl , Dietmar Flubacher , Cristina Alonso-Alija , Frank Wunder , Dieter Lang , Klaus Dembowsky , Alexander Straub , Elisabeth Perzborn
发明人： Johannes-Peter Stasch , Achim Feurer , Stefan Weigand , Elke Stahl , Dietmar Flubacher , Cristina Alonso-Alija , Frank Wunder , Dieter Lang , Klaus Dembowsky , Alexander Straub , Elisabeth Perzborn
IPC分类号： A61K31/506 , A61K45/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61P15/10 , A61P25/00 , A61P29/00 , C07D471/04 , A61K31/513 , C07D471/02
CPC分类号： C07D471/04
摘要： This invention relates to methods of treatment of cardiovascular disorders, thromboembolic disorders, inflammation, and disorders of the central nervous system using pyrazol pyridine derivatives of formula (I) wherein R1 is a radical of the formula —O—SO2-R3 in which R3 is optionally substituted C1-6-alkyl, optionally substituted C3-8-cycloalkyl, or optionally substituted phenyl; R2 is H, optionally substituted C1-6-alkyl-CO— or optionally substituted C1-6-alkyl-SO2—; as well as salts, stereoisomers, tautomers, and hydrates thereof.
摘要翻译：本发明涉及使用式（I）的吡唑吡啶衍生物治疗心血管疾病，血栓栓塞障碍，炎症和中枢神经系统疾病的方法，其中R 1是式-O的基团其中R 3是任选取代的C 1-6 - 烷基，任选取代的C 1 -C 6 - C 3-8 - 环烷基或任选取代的苯基; R 2是H，任选取代的C 1-6 - 烷基-CO-或任选取代的C 1-6 - 烷基-S SO > 2 - ; 以及其盐，立体异构体，互变异构体及其水合物。

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