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61. 发明申请

US20170027754A1 CORNEAL IMPLANT SYSTEMS AND METHODS 审中-公开
标题翻译： CORNEAL植物系统和方法
公开(公告)号：US20170027754A1
公开(公告)日：2017-02-02
申请号：US15055614
申请日：2016-02-28
申请人： David Muller
发明人： David Muller
IPC分类号： A61F9/008 , B23K26/00 , B23K26/362 , A61F2/14
CPC分类号： A61F9/00804 , A61F2/145 , A61F9/0081 , A61F9/00812 , A61F9/00831 , A61F9/00834 , A61F2009/00842 , A61F2009/00851 , A61F2009/00872 , A61F2009/00878 , A61F2009/00893 , A61F2009/00895 , B23K26/127 , B23K26/361 , B23K26/38 , B23K26/402 , B23K2103/32
摘要： A system for forming a corneal implant includes a cutting apparatus, which includes a laser source that emits a laser and optical elements that direct the laser. The system includes a controller implemented with at least one processor and at least one data storage device. The controller generates a sculpting plan for modifying a first shape of a lenticule formed from corneal tissue and achieving a second shape for the lenticule to produce a corneal implant with a refractive profile to reshape a recipient eye. The sculpting plan is determined from measurements relating to the lenticule having the first shape and information relating to a refractive profile for a corneal implant. The controller controls the cutting apparatus to direct, via the one or more optical elements, the laser from the laser source to sculpt the lenticule according to the sculpting plan to produce the corneal implant with the refractive profile.
摘要翻译：用于形成角膜植入物的系统包括切割装置，其包括发射激光的激光源和引导激光的光学元件。该系统包括用至少一个处理器和至少一个数据存储设备实现的控制器。控制器产生用于修改由角膜组织形成的微透镜的第一形状的雕刻计划，并且获得用于微透镜的第二形状以产生具有折射轮廓的角膜植入物以重塑接受者的眼睛。雕刻方案由与具有第一形状的微透镜相关的测量和与角膜植入物的折射轮廓有关的信息确定。控制器控制切割装置经由一个或多个光学元件引导来自激光源的激光，以根据雕刻方案对微透镜进行雕刻，以产生具有折射轮廓的角膜植入物。

62. 发明申请

US20140264980A1 CORNEAL IMPLANT SYSTEMS AND METHODS 审中-公开
标题翻译： CORNEAL植物系统和方法
公开(公告)号：US20140264980A1
公开(公告)日：2014-09-18
申请号：US14152425
申请日：2014-01-10
申请人： David Muller
发明人： David Muller
IPC分类号： A61F9/00
CPC分类号： A61F2/142 , A61F2/145 , A61F9/0081 , A61F9/00812 , A61F9/00831 , A61F9/00834 , A61F9/00836 , A61F2009/00844 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： According to one aspect of the present disclosure, an implant for correcting vision impairment is disclosed. The implant is made from a donor corneal tissue sized and shaped to provide a predetermined refractive correction and reshaping of a cornea. The donor corneal tissue includes a posterior surface and an anterior surface. The posterior surface has a surface profile that is configured to generally correspond to a shape of an implantation site of the cornea.
摘要翻译：根据本公开的一个方面，公开了一种用于矫正视力障碍的植入物。植入物由供体角膜组织制成，其大小和形状以提供角膜的预定屈光矫正和整形。供体角膜组织包括后表面和前表面。后表面具有被配置为大致对应于角膜植入部位的形状的表面轮廓。

63. 发明申请

US20130131664A1 Eye Therapy System 失效
标题翻译：眼科治疗系统
公开(公告)号：US20130131664A1
公开(公告)日：2013-05-23
申请号：US13470975
申请日：2012-05-14
申请人： David Muller , Ronald Scharf , Thomas Ryan , Neal Marshall , Radha Pertaub , Artie Wu
发明人： David Muller , Ronald Scharf , Thomas Ryan , Neal Marshall , Radha Pertaub , Artie Wu
IPC分类号： A61F9/007
CPC分类号： A61F9/007 , A61B18/1477 , A61B18/18 , A61B18/22 , A61B2018/00702 , A61B2018/00791 , A61B2018/1425 , A61B2018/1807 , A61F9/0079 , A61F9/009 , A61F2009/00853 , A61F2009/00872 , A61H35/02 , A61H2201/0207 , A61H2201/0214 , A61H2201/0242 , A61H2201/0292 , A61H2201/10 , A61H2201/5007 , A61H2230/50
摘要： A system for applying therapy to an eye selectively applies coolant to the corneal surface to minimize heat-related damage to the corneal surface during thermokeratoplasty. Embodiments may include an energy source, a conducting element, a coolant supply, and a coolant delivery system. The conducting element is operably connected to the energy source and extends from a proximal end to a distal end. The conducting element directs energy from the energy source to the distal end, which is positionable at the eye. The coolant delivery system is in communication with the coolant supply and is operable to deliver a micro-controlled pulse of coolant to the distal end.
摘要翻译：用于向眼睛施加治疗的系统选择性地将冷却剂施加到角膜表面，以在热机器人成形期间最小化对角膜表面的热损伤。实施例可以包括能量源，导电元件，冷却剂供应和冷却剂输送系统。导电元件可操作地连接到能量源并且从近端延伸到远端。导电元件将能量从能量源引导到可在眼睛处定位的远端。冷却剂输送系统与冷却剂供应源连通并且可操作以将冷却剂的微控制脉冲输送到远端。

64. 发明申请

US20130072852A1 SYSTEMS AND METHODS FOR TREATING PATHOGENIC INFECTION 有权
标题翻译：用于治疗致病性感染的系统和方法
公开(公告)号：US20130072852A1
公开(公告)日：2013-03-21
申请号：US13592883
申请日：2012-08-23
申请人： Anthony Natale , David Muller
发明人： Anthony Natale , David Muller
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61N5/0603 , A61N5/0624 , A61N2005/063 , A61N2005/0661
摘要： An internal anatomic target that is infected by pathogenic microorganisms is treated using an applicator configured for delivering a therapeutic solution thereto and an UV light-emitting device transmits UV light thereon.
摘要翻译：用致病微生物感染的内部解剖靶标，使用配置用于将治疗溶液输送到其上的施用器进行处理，并且UV发光装置在其上透射UV光。

65. 发明授权

US08398628B2 Eye therapy system 失效
标题翻译：眼科治疗系统
公开(公告)号：US08398628B2
公开(公告)日：2013-03-19
申请号：US12562625
申请日：2009-09-18
申请人： David Muller
发明人： David Muller
IPC分类号： A61B18/12
CPC分类号： A61F9/013 , A61B18/1815 , A61B2018/00011 , A61F9/0079 , A61F9/009
摘要： The cornea is reshaped in multiple steps according to varying amounts of energy in varying patterns and/or at varying locations to achieve a customized reshaping of the cornea to address the specific needs of an individual patient. The varying amounts of energy may be applied via one or more conducting elements, which include an outer conductor and an inner conductor disposed within the outer conductor, a distal end of the outer conductor and the inner conductor defining the varying patterns. For example, one step may form a substantially circular lesion to flatten a first portion of the cornea to treat presbyopia, while another step may form a substantially circular and concentric lesion having a greater diameter to steepen a second portion of the cornea to treat hyperopia. Advantageously, continuous transitional regions are formed relative to the reshaped portions to provide vision for intermediate distances.
摘要翻译：根据不同模式和/或在不同位置处的不同量的能量，角膜重新成形，以实现角膜的定制重塑以满足个体患者的特定需要。可以经由一个或多个导电元件施加不同量的能量，所述导电元件包括设置在外导体内的外导体和内导体，外导体的远端和限定变化图案的内导体。例如，一个步骤可以形成基本圆形的损伤，以使角膜的第一部分平坦化以治疗老花眼，而另一步骤可以形成具有较大直径的基本圆形且同心的病变，以使角膜的第二部分陡峭以治疗远视。有利地，相对于重新成形的部分形成连续的过渡区域以提供中间距离的视觉。

66. 发明申请

US20120310083A1 SYSTEMS AND METHODS FOR MONITORING TIME BASED PHOTO ACTIVE AGENT DELIVERY OR PHOTO ACTIVE MARKER PRESENCE 有权
标题翻译：用于监控基于时间的照片活动代理商交付或照片活动标记的系统和方法
公开(公告)号：US20120310083A1
公开(公告)日：2012-12-06
申请号：US13488097
申请日：2012-06-04
申请人： Marc D. Friedman , Pavel Kamaev , David Muller , Radha Pertaub , Ronald Scharf , Evan Sherr , David Usher
发明人： Marc D. Friedman , Pavel Kamaev , David Muller , Radha Pertaub , Ronald Scharf , Evan Sherr , David Usher
IPC分类号： A61B6/08 , A61F9/01
CPC分类号： A61M5/007 , A61B3/10 , A61B3/107 , A61B3/135 , A61B3/145 , A61B5/0066 , A61B5/0071 , A61F9/0079 , A61F9/008 , A61F2009/00851 , A61F2009/00872 , A61F2009/00893 , A61K49/006 , A61M37/0092 , A61N5/062 , A61N2005/0626 , A61N2005/0661 , A61N2005/067
摘要： Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.
摘要翻译：用于监测基于时间的光活性剂递送或光活性标记物在眼睛中的存在的装置和方法。提供一种监测系统，用于通过照亮眼睛来测量光活性标记物的存在，以激发光活性标记，然后观察来自光活性标记的特征发射。示例系统包括Scheimpflug光学系统或裂隙灯光学系统，以观察眼睛的横截面图像以监测施加到眼睛上的光活性剂的瞬时分布，扩散模式和摄取速率。系统和方法还允许利用受监控的眼睛中的光活性剂的分布作为交联系统的反馈。

67. 发明申请

US20120303008A1 SYSTEMS AND METHODS FOR RESHAPING AN EYE FEATURE 有权
标题翻译：用于修复眼睛特征的系统和方法
公开(公告)号：US20120303008A1
公开(公告)日：2012-11-29
申请号：US13480127
申请日：2012-05-24
申请人： David Muller , Vance Thompson
发明人： David Muller , Vance Thompson
IPC分类号： A61F9/01 , A61F9/007
CPC分类号： A61F9/013 , A61F9/00804 , A61F9/00836 , A61F2009/00853 , A61F2009/00872
摘要： Systems and methods include a cutting instrument that creates incisions in selected areas of the cornea; an eye therapy system that applies reshaping forces to the cornea; and a controller that determines the selected areas of the cornea for the incisions and the reshaping forces from the eye therapy system, such that the reshaping forces and the incisions combine to achieve corrective reshaping of the cornea. Other systems and methods include measuring an eye to determine a required amount of reshaping of a cornea; determining one or more doses of cross-linking agent and one or more corresponding doses of photoactivating light according to the required amount of reshaping; applying the cross-linking agent to the cornea; and delivering, from a light source, the photoactivating light to the area of the eye, the photoactivating light combining with the cross-linking agent to induce the corrective reshaping of the cornea.
摘要翻译：系统和方法包括在角膜的选定区域中产生切口的切割工具; 一种将矫正力应用于角膜的眼科治疗系统; 以及控制器，其确定角膜的选择区域用于切口和来自眼部治疗系统的重塑力，使得重塑力和切口结合以实现角膜的矫正重塑。其他系统和方法包括测量眼睛以确定角膜重塑的所需量; 根据所需的重塑量确定一种或多种剂量的交联剂和一种或多种相应剂量的光活化光; 将交联剂施用于角膜; 以及从光源将光活化光输送到眼睛的区域，所述光活化光与交联剂结合以引起角膜的矫正重塑。

68. 发明申请

US20120283621A1 STERILIZING APPLICATION OF CROSS-LINKING AGENT 审中-公开
标题翻译：消毒交联剂的应用灭菌
公开(公告)号：US20120283621A1
公开(公告)日：2012-11-08
申请号：US13468760
申请日：2012-05-10
申请人： David Muller
发明人： David Muller
IPC分类号： A61M37/00
CPC分类号： A61F9/008 , A61B3/107 , A61F9/0079 , A61F2009/00844 , A61F2009/00857 , A61F2009/00872 , A61N5/062
摘要： A method for treating an eye includes applying, to an outer protective layer of an area of an eye, one or more initial doses of a cross-linking agent that acts as a photosensitizer. The method also includes delivering, from a light source, one or more initial doses of ultraviolet light to the area of the eye. The cross-linking agent increases absorption of the ultraviolet light by the area of the eye, and the absorption of the ultraviolet light sterilizes the area of the eye before the outer protective layer is penetrated. Additionally, the method includes penetrating the outer protective layer of the eye to provide access to an area below the outer protective layer. Moreover, the method includes applying a treatment to the eye via the access provided by cutting the outer protective layer. In some embodiments, the cross-linking agent is Riboflavin, and the treatment is LASIK surgery.
摘要翻译：用于治疗眼睛的方法包括将一种或多种初始剂量的用作光敏剂的交联剂施加到眼睛区域的外部保护层。该方法还包括从光源将一个或多个初始剂量的紫外光输送到眼睛的区域。交联剂通过眼睛的面积增加紫外线的吸收，并且紫外线的吸收在外部保护层被穿透之前对眼睛的区域进行消毒。此外，该方法包括穿透眼睛的外保护层以提供对外保护层下方的区域的通路。此外，该方法包括通过切割外部保护层提供的接近对眼睛进行治疗。在一些实施方案中，交联剂是核黄素，治疗是LASIK手术。

69. 发明授权

US08121356B2 Long distance multimodal biometric system and method 有权
标题翻译：长距离多模态生物识别系统及方法
公开(公告)号：US08121356B2
公开(公告)日：2012-02-21
申请号：US12208328
申请日：2008-09-10
申请人： Marc D. Friedman , Nicholas A. Accomando , Faisal Bashir , Pablo Casaverde , Stephen F. Daly , David J. Hitchcock , Romina Marie Johnson Jose , Tim McNerney , David Muller , Vladimir Ruzhitsky , Yasunari Tosa , David Usher
发明人： Marc D. Friedman , Nicholas A. Accomando , Faisal Bashir , Pablo Casaverde , Stephen F. Daly , David J. Hitchcock , Romina Marie Johnson Jose , Tim McNerney , David Muller , Vladimir Ruzhitsky , Yasunari Tosa , David Usher
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： G06K9/00604 , G06K9/00255
摘要： A system for multimodal biometric identification has a first imaging system that detects one or more subjects in a first field of view, including a targeted subject having a first biometric characteristic and a second biometric characteristic; a second imaging system that captures a first image of the first biometric characteristic according to first photons, where the first biometric characteristic is positioned in a second field of view smaller than the first field of view, and the first image includes first data for biometric identification; a third imaging system that captures a second image of the second biometric characteristic according to second photons, where the second biometric characteristic is positioned in a third field of view which is smaller than the first and second fields of view, and the second image includes second data for biometric identification. At least one active illumination source emits the second photons.
摘要翻译：一种用于多模式生物识别的系统具有第一成像系统，其检测第一视场中的一个或多个被摄体，包括具有第一生物特征和第二生物特征的目标对象; 第二成像系统，其根据第一光子捕获第一生物特征的第一图像，其中第一生物特征位于小于第一视场的第二视野中，并且第一图像包括用于生物识别的第一数据 ; 第三成像系统，其根据第二光子捕获第二生物特征的第二图像，其中所述第二生物特征位于小于所述第一和第二视场的第三视场中，并且所述第二图像包括第二图像生物识别数据。至少一个有源照明源发射第二光子。

70. 发明授权

US08010194B2 Determining site-to-site pacing delay for multi-site anti-tachycardia pacing 有权
标题翻译：确定多站点抗心动过速起搏的站点到站点起搏延迟
公开(公告)号：US08010194B2
公开(公告)日：2011-08-30
申请号：US12416778
申请日：2009-04-01
申请人： David Muller
发明人： David Muller
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61B5/0452 , A61N1/3682 , A61N1/3684
摘要： An exemplary method includes delivering a pace using an electrode positioned on the lateral wall of the left ventricle of a heart, sensing the pace using an electrode positioned in the right ventricle of the heart, determining a left to right directional conduction time (TLR), delivering a pace using an electrode positioned in the right ventricle of the heart, sensing the pace using an electrode positioned on the lateral wall of the left ventricle of the heart, determining a right to left directional conduction time (TRL), calculating a site-to-site offset (VVATP) for multi-site anti-tachycardia pacing based on the left to right directional conduction time and the right to left directional conduction time and instructing an implantable device to deliver multi-site anti-tachycardia pacing using the site-to-site offset (VVATP). Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括使用位于心脏左心室侧壁上的电极来传送步速，使用位于心脏右心室的电极来感测步速，确定从左到右的方向传导时间（TLR），使用位于心脏右心室中的电极进行步调，使用位于心脏左心室侧壁上的电极感测步速，确定右向左方向传导时间（TRL），计算位置 - 基于从左到右定向导通时间和从右到左定向传导时间的多位点抗心动过速起搏的现场偏移（VVATP），并且指示植入装置使用位置偏移起搏来提供多部位抗心动过速起搏，站点偏移（VVATP）。还公开了其它示例性方法，装置，系统等。

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