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61. 发明申请

US20050106214A1 Excipients in drug delivery vehicles 审中-公开
公开(公告)号：US20050106214A1
公开(公告)日：2005-05-19
申请号：US10985122
申请日：2004-11-10
申请人： Guohua Chen
发明人： Guohua Chen
IPC分类号： A61K9/14 , A61K38/27 , A61K47/30
CPC分类号： A61K9/0024 , A61K47/34
摘要： Injectable depot gel compositions and kits that provide an excipient for modulating a release rate and stabilizing beneficial agents are provided. Methods of administering and preparing such systems are also provided. The gel compositions comprise biodegradable, bioerodible polymers and water-immiscible solvents in amounts effective to plasticize the polymers and form gels with the polymers. Suitable excipients include pH modifiers, reducing agents, and antioxidants.

62. 发明授权

US09234068B2 Method for preparing aqueous polyacrylate modified polyurethane dispersions 有权
公开(公告)号：US09234068B2
公开(公告)日：2016-01-12
申请号：US12285372
申请日：2008-10-02
申请人： Caideng Yuan , Guohua Chen , Xixiang Zhang , Zongjin Li , Zhimeng Liu
发明人： Caideng Yuan , Guohua Chen , Xixiang Zhang , Zongjin Li , Zhimeng Liu
IPC分类号： C08G18/08 , C08G18/62 , C08G18/12 , C08G18/66 , C08G18/67 , C08G18/75 , C08G18/76 , C09D175/04
CPC分类号： C08G18/6254 , C08G18/0823 , C08G18/12 , C08G18/6692 , C08G18/675 , C08G18/755 , C08G18/7621 , C08G2270/00 , C09D175/04 , C08G18/3228 , C08G18/62
摘要： A novel method for the preparation of an aqueous polyacrylate modified polyurethane dispersion is disclosed. The preparation method includes three main steps: a) preparation of polyacrylate polymer or copolymer emulsion; b) preparation of polyurethane prepolymer with carboxylic groups and neutralization treatment to the carboxylic groups; and c) dispersion and chain-extension of polyurethane prepolymer by adding the polyacrylate emulsion into the polyurethane prepolymer under vigorous agitation, or other mechanical operation. The aqueous polyacrylate modified polyurethane dispersion has self-crosslinkability when an unsaturated acetoacetoxy compound is used for the preparation of the polyacrylate emulsion.

63. 发明申请

US20100011139A1 NETWORK APPARATUS AND METHOD FOR COMMUNICATION BETWEEN DIFFERENT COMPONENTS 有权
标题翻译：网络设备和不同组件之间的通信方法
公开(公告)号：US20100011139A1
公开(公告)日：2010-01-14
申请号：US12442838
申请日：2007-05-09
申请人： Ju Wang , Shunlin Zhou , Rui Wang , Chi Fan , Haidong Wang , Guohua Chen , Shilin Zhang
发明人： Ju Wang , Shunlin Zhou , Rui Wang , Chi Fan , Haidong Wang , Guohua Chen , Shilin Zhang
IPC分类号： G06F13/00 , G06F15/16
CPC分类号： H04L45/14 , G06F13/4221 , H04L12/403 , H04L12/66
摘要： The present invention discloses a method for communication among different components, including integrating a Network Forwarding Component (NFC) for forwarding messages and at least one Independent Application Component (IAC) for performing other service processing into one network device; setting at least one cooperation mode in the NFC and each of the at least one IAC; and communicating with each other, by the NFC and the at least one IAC, according to the at least one cooperation mode. The cooperation mode may be any or any combination of a host mode, a mirror mode, a redirection mode and a pass-through mode. According to the present invention, the NFC and the IAC may communicate according to the cooperation mode so as to ensure that the NFC and the IAC can cooperate to provide various service capabilities including message forwarding and other additional service capabilities.
摘要翻译：本发明公开了一种用于不同组件之间的通信的方法，包括将用于转发消息的网络转发组件（NFC）和至少一个独立应用组件（IAC）集成到一个网络设备中执行其他服务处理; 在NFC中设置至少一个协作模式和所述至少一个IAC中的每一个; 以及根据所述至少一个协作模式，通过所述NFC和所述至少一个IAC彼此进行通信。协作模式可以是主机模式，镜像模式，重定向模式和直通模式的任何或任意组合。根据本发明，NFC和IAC可以根据协作模式进行通信，以便确保NFC和IAC可以协作来提供包括消息转发和其他附加服务能力的各种服务能力。

64. 发明申请

US20090111934A1 Method for preparing aqueous polyacrylate modified polyurethane dispersions 有权
标题翻译：制备水性聚丙烯酸酯改性聚氨酯分散体的方法
公开(公告)号：US20090111934A1
公开(公告)日：2009-04-30
申请号：US12285372
申请日：2008-10-02
申请人： Caideng Yuan , Guohua Chen , Xixiang Zhang , Zongjin Li , Zhimeng Liu
发明人： Caideng Yuan , Guohua Chen , Xixiang Zhang , Zongjin Li , Zhimeng Liu
IPC分类号： C08G18/32
CPC分类号： C08G18/6254 , C08G18/0823 , C08G18/12 , C08G18/6692 , C08G18/675 , C08G18/755 , C08G18/7621 , C08G2270/00 , C09D175/04 , C08G18/3228 , C08G18/62
摘要： A novel method for the preparation of an aqueous polyacrylate modified polyurethane dispersion is disclosed. The preparation method includes three main steps: a) preparation of polyacrylate polymer or copolymer emulsion; b) preparation of polyurethane prepolymer with carboxylic groups and neutralization treatment to the carboxylic groups; and c) dispersion and chain-extension of polyurethane prepolymer by adding the polyacrylate emulsion into the polyurethane prepolymer under vigorous agitation, or other mechanical operation. The aqueous polyacrylate modified polyurethane dispersion has self-crosslinkability when an unsaturated acetoacetoxy compound is used for the preparation of the polyacrylate emulsion.
摘要翻译：公开了一种制备聚丙烯酸酯改性聚氨酯水分散体的新方法。制备方法包括三个主要步骤：a）制备聚丙烯酸酯聚合物或共聚物乳液; b）制备具有羧基的聚氨酯预聚物，并对羧基进行中和处理; 和c）通过在剧烈搅拌或其它机械操作下将聚丙烯酸酯乳液加入聚氨酯预聚物中，聚氨酯预聚物的分散和链延长。当不饱和乙酰乙酰氧基化合物用于制备聚丙烯酸酯乳液时，聚丙烯酸酯改性聚氨酯分散体具有自交联性。

65. 发明申请

US20070196415A1 DEPOT COMPOSITIONS WITH MULTIPLE DRUG RELEASE RATE CONTROLS AND USES THEREOF 审中-公开
标题翻译：具有多种药物释放速率控制的DEPOT组合物及其用途
公开(公告)号：US20070196415A1
公开(公告)日：2007-08-23
申请号：US11553925
申请日：2006-10-27
申请人： Guohua Chen , Lothar Kleiner , Paul Houston , Jeremy Wright
发明人： Guohua Chen , Lothar Kleiner , Paul Houston , Jeremy Wright
IPC分类号： A61F2/02
CPC分类号： A61K47/34 , A61K9/0024 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/19 , A61K47/10 , A61K47/14
摘要： Injectable depot compositions with dual mechanisms of release rate control are provided for sustained beneficial agent delivery in a patient. The composition includes bioerodible particles and an injectable depot vehicle containing a bioerodible polymer in an organic solvent, for forming a bioerodible depot implant after administration to the patient. The bioerodible particles are dispersed in the depot vehicle and contain a beneficial agent and a release rate controlling agent retarding the release of the beneficial agent from the bioerodible particles and from the depot implant.
摘要翻译：提供具有释放速率控制的双重机制的可注射储库组合物，用于在患者中持续的有益药物递送。该组合物包括生物可腐蚀颗粒和在有机溶剂中含有生物可腐蚀聚合物的可注射贮存载体，用于在给予患者之后形成生物可浸润的储库植入物。生物可腐蚀颗粒分散在贮存载体中并含有有益剂和释放速率控制剂，其阻止有益剂从生物可侵蚀颗粒和贮存植入物的释放。

66. 发明申请

US20070077304A1 Sustained Release Small Molecule Drug Formulation 有权
标题翻译：持续释放小分子药物制剂
公开(公告)号：US20070077304A1
公开(公告)日：2007-04-05
申请号：US11535398
申请日：2006-09-26
申请人： Andrew Luk , Gunjan Junnarkar , Guohua Chen
发明人： Andrew Luk , Gunjan Junnarkar , Guohua Chen
IPC分类号： A61K9/14
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/1617 , A61K9/1647 , A61K31/341 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/34 , A61K51/1213
摘要： An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having Cmax to Cmin ratio less than 200 and lag time less than 0.2.
摘要翻译：可注射的贮库制剂包括生物相容性聚合物，与生物相容性聚合物结合以形成粘性凝胶的有机溶剂和掺入粘性凝胶中的小分子药物，使得制剂表现出体内释放曲线，其具有C max / SUB>至C 比小于200，滞后时间小于0.2。

67. 发明申请

US20050281879A1 Excipients in drug delivery vehicles 审中-公开
标题翻译：药物递送载体中的赋形剂
公开(公告)号：US20050281879A1
公开(公告)日：2005-12-22
申请号：US10985116
申请日：2004-11-10
申请人： Guohua Chen , David Priebe
发明人： Guohua Chen , David Priebe
IPC分类号： A61K9/00 , A61K47/34 , A61K9/14
CPC分类号： A61K9/0024 , A61K31/445 , A61K38/27 , A61K47/34
摘要： Injectable depot gel compositions and kits that provide an excipient for modulating a release rate and stabilizing beneficial agents are provided. Methods of administering and preparing such systems are also provided. The gel compositions comprise biodegradable, bioerodible polymers and water-immiscible solvents in amounts effective to plasticize the polymers and form gels with the polymers. Suitable excipients include pH modifiers, reducing agents, and antioxidants.
摘要翻译：提供了提供用于调节释放速率和稳定有益剂的赋形剂的可注射贮库凝胶组合物和试剂盒。还提供了施用和制备这种体系的方法。凝胶组合物包含可生物降解的，可生物腐蚀的聚合物和与水不混溶的溶剂，其量有效地使聚合物增塑并与聚合物形成凝胶。合适的赋形剂包括pH调节剂，还原剂和抗氧化剂。

68. 发明申请

US20050281877A1 Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems 审中-公开
标题翻译：渗透输送系统，渗透输送系统半透性体装配和用于控制来自渗透递送系统的有益药物递送速率的方法
公开(公告)号：US20050281877A1
公开(公告)日：2005-12-22
申请号：US11196758
申请日：2005-08-02
申请人： Guohua Chen , Scott Lautenbach , Keith Dionne , Scott Jordan , Steve Berry , Craig Rodenberger , Rupal Ayer
发明人： Guohua Chen , Scott Lautenbach , Keith Dionne , Scott Jordan , Steve Berry , Craig Rodenberger , Rupal Ayer
IPC分类号： A61K9/00 , A61K9/22 , A61K9/24 , A61K9/52
CPC分类号： A61K9/0004
摘要： Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies are provided. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate, the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, and the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.
摘要翻译：提供了渗透输送系统半透性体组件，其从包含半透性体组件的渗透输送系统控制有益剂的输送速率。半透性体组件或塞子包括半渗透体，其可定位在渗透递送系统的开口中。半透明体具有中空的内部部分，其具有选择的尺寸以获得通过半透性体的预定液体渗透速率。由于渗透输送系统中的有益剂以基本上相同的速率递送，所以渗透剂吸收从周围环境透过塞子的液体，并且通过塞子的液体渗透速率控制有益剂的输送速率渗透输送系统。可以改变通过半透性体的液体渗透速率，以通过改变半透性体的厚度或通过改变暴露于液体的半透明体的表面积的量来控制有益剂从渗透递送系统的输送速率，渗透输送系统位于使用的液体环境中。

69. 发明授权

US06923800B2 Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems 有权
公开(公告)号：US06923800B2
公开(公告)日：2005-08-02
申请号：US09859428
申请日：2001-05-18
申请人： Guohua Chen , Scott D. Lautenbach , Keith E. Dionne , Scott D. Jordan , Steve A. Berry , Craig I. Rodenberger , Rupal Ayer
发明人： Guohua Chen , Scott D. Lautenbach , Keith E. Dionne , Scott D. Jordan , Steve A. Berry , Craig I. Rodenberger , Rupal Ayer
IPC分类号： A61K9/00 , A61K9/22 , A61K9/24 , A61K9/52
CPC分类号： A61K9/0004
摘要： Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies are provided. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate, the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, and the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.

70. 发明申请

US20050079202A1 Implantable elastomeric depot compositions and uses thereof 审中-公开
标题翻译：可植入弹性体贮库组合物及其用途
公开(公告)号：US20050079202A1
公开(公告)日：2005-04-14
申请号：US10857609
申请日：2004-05-28
申请人： Guohua Chen , Paul Houston , Lothar Kleiner , Aruna Nathan , Joel Rosenblatt
发明人： Guohua Chen , Paul Houston , Lothar Kleiner , Aruna Nathan , Joel Rosenblatt
IPC分类号： A61F2/00 , A61K9/00
CPC分类号： A61K9/0024
摘要： Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric polymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.
摘要翻译：描述了用于向受试者全身或局部施用有益剂的方法和组合物，并且包括例如可植入的弹性体贮库组合物，其可以注射到期望的位置并且可以在延长的持续时间内提供有益剂的受控释放时间。组合物包括生物相容的弹性体聚合物，具有低水混溶性的生物相容性溶剂，其与聚合物形成弹性体粘性凝胶并限制植入物吸收水分，以及有益剂。

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