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1. 发明申请

US20050107772A1 Osmotically driven active agent delivery device providing an ascending release profile 有权
标题翻译：渗透驱动的活性剂递送装置提供上升释放特征
公开(公告)号：US20050107772A1
公开(公告)日：2005-05-19
申请号：US10953895
申请日：2004-09-29
申请人： Guohua Chen , Rupal Ayer , Scott Lautenbach
发明人： Guohua Chen , Rupal Ayer , Scott Lautenbach
IPC分类号： A61K9/00 , A61K9/22 , A61M5/145
CPC分类号： A61K9/0024 , A61K9/0004 , A61M5/145 , A61M2005/14513
摘要： In one aspect, the present invention is directed to an osmotic pump that automatically provides an ascending release rate of active agent as the osmotic pump functions in an environment of operation and may be designed for implantation within a desired animal or human subject. An osmotic pump according to the present invention includes a reservoir, a rate controlling membrane, an expandable osmotic composition, an active agent formulation and an exit orifice. Once administered to an environment of operation, water passes through the rate controlling membrane and into the osmotic composition, which causes the osmotic composition to expand and expel the active agent formulation through the exit orifice at a rate that is directly proportional to the rate at which water passes through the rate controlling membrane. An osmotic pump according to the present invention permits the flow of water through the rate controlling membrane to increase automatically without the need for manipulation of the osmotic pump after administration. As the flow of water through the rate controlling membrane increases, the rate at which active agent is delivered from the osmotic pump will also increase proportionally.
摘要翻译：一方面，本发明涉及一种渗透泵，其随着渗透泵在操作环境中的功能而自动提供活性剂的上升释放速率，并且可被设计用于植入期望的动物或人类受试者内。根据本发明的渗透泵包括储存器，速率控制膜，可膨胀渗透组合物，活性剂制剂和出口孔。一旦施用于操作环境，水通过速率控制膜并进入渗透组合物，其导致渗透组合物通过出口孔膨胀并排出活性剂制剂，速率与其速率成正比水通过速率控制膜。根据本发明的渗透泵允许通过速率控制膜的水流自动增加，而不需要在给药后操纵渗透泵。随着通过速率控制膜的水流量增加，活性剂从渗透泵输送的速率也将成比例地增加。

2. 发明授权

US07241457B2 Osmotically driven active agent delivery device providing an ascending release profile 有权
标题翻译：渗透驱动的活性剂递送装置提供上升释放特征
公开(公告)号：US07241457B2
公开(公告)日：2007-07-10
申请号：US10953895
申请日：2004-09-29
申请人： Guohua Chen , Rupal A. Ayer , Scott Lautenbach
发明人： Guohua Chen , Rupal A. Ayer , Scott Lautenbach
IPC分类号： A61K9/22
CPC分类号： A61K9/0024 , A61K9/0004 , A61M5/145 , A61M2005/14513
摘要： In one aspect, the present invention is directed to an osmotic pump that automatically provides an ascending release rate of active agent as the osmotic pump functions in an environment of operation and may be designed for implantation within a desired animal or human subject. An osmotic pump according to the present invention includes a reservoir, a rate controlling membrane, an expandable osmotic composition, an active agent formulation and an exit orifice. Once administered to an environment of operation, water passes through the rate controlling membrane and into the osmotic composition, which causes the osmotic composition to expand and expel the active agent formulation through the exit orifice at a rate that is directly proportional to the rate at which water passes through the rate controlling membrane. An osmotic pump according to the present invention permits the flow of water through the rate controlling membrane to increase automatically without the need for manipulation of the osmotic pump after administration. As the flow of water through the rate controlling membrane increases, the rate at which active agent is delivered from the osmotic pump will also increase proportionally.
摘要翻译：一方面，本发明涉及一种渗透泵，其随着渗透泵在操作环境中的功能而自动提供活性剂的上升释放速率，并且可被设计用于植入期望的动物或人类受试者内。根据本发明的渗透泵包括储存器，速率控制膜，可膨胀渗透组合物，活性剂制剂和出口孔。一旦施用于操作环境，水通过速率控制膜并进入渗透组合物，其导致渗透组合物通过出口孔膨胀并排出活性剂制剂，速率与其速率成正比水通过速率控制膜。根据本发明的渗透泵允许通过速率控制膜的水流自动增加，而不需要在给药后操纵渗透泵。随着通过速率控制膜的水流量增加，活性剂从渗透泵输送的速率也将成比例地增加。

3. 发明申请

US20050281877A1 Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems 审中-公开
标题翻译：渗透输送系统，渗透输送系统半透性体装配和用于控制来自渗透递送系统的有益药物递送速率的方法
公开(公告)号：US20050281877A1
公开(公告)日：2005-12-22
申请号：US11196758
申请日：2005-08-02
申请人： Guohua Chen , Scott Lautenbach , Keith Dionne , Scott Jordan , Steve Berry , Craig Rodenberger , Rupal Ayer
发明人： Guohua Chen , Scott Lautenbach , Keith Dionne , Scott Jordan , Steve Berry , Craig Rodenberger , Rupal Ayer
IPC分类号： A61K9/00 , A61K9/22 , A61K9/24 , A61K9/52
CPC分类号： A61K9/0004
摘要： Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies are provided. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate, the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, and the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.
摘要翻译：提供了渗透输送系统半透性体组件，其从包含半透性体组件的渗透输送系统控制有益剂的输送速率。半透性体组件或塞子包括半渗透体，其可定位在渗透递送系统的开口中。半透明体具有中空的内部部分，其具有选择的尺寸以获得通过半透性体的预定液体渗透速率。由于渗透输送系统中的有益剂以基本上相同的速率递送，所以渗透剂吸收从周围环境透过塞子的液体，并且通过塞子的液体渗透速率控制有益剂的输送速率渗透输送系统。可以改变通过半透性体的液体渗透速率，以通过改变半透性体的厚度或通过改变暴露于液体的半透明体的表面积的量来控制有益剂从渗透递送系统的输送速率，渗透输送系统位于使用的液体环境中。

4. 发明申请

US20050124941A1 Package for pharmaceutical formulation 审中-公开
标题翻译：药物配方包装
公开(公告)号：US20050124941A1
公开(公告)日：2005-06-09
申请号：US10988020
申请日：2004-11-12
申请人： Martin Panchula , Stan Lam , Pete McArthur , Scott Lautenbach
发明人： Martin Panchula , Stan Lam , Pete McArthur , Scott Lautenbach
IPC分类号： A61K20060101 , A61M5/315
CPC分类号： A61M5/3129 , A61K9/0019 , A61M5/3134 , A61M5/346 , A61M2005/312
摘要： Cartridges are provided for storing and facilitating the delivery of pharmaceutical formulations. In one preferred embodiment, the cartridge comprises a body including a bore extending through the body, and a plunger movably disposed in the bore. The bore has a transverse dimension at a distal end that is equivalent to that at a midpoint. The plunger has a planar contact surface that is transversely coextensive with the bore for applying a force to a pharmaceutical formulation contained in the bore. This configuration helps to eliminate dead volume, and therefore enables filing by volume rather than weight to ensure accurate dosing.
摘要翻译：墨盒用于储存和促进药物制剂的递送。在一个优选实施例中，盒包括主体，其包括延伸穿过主体的孔，以及可移动地设置在孔中的柱塞。孔在远端具有等于在中点处的横向尺寸。柱塞具有与孔相横向共同延伸的平面接触表面，用于向包含在孔中的药物制剂施加力。该配置有助于消除死体积，因此可以通过体积而不是重量进行归档，以确保准确的定量。

5. 发明申请

US20050101943A1 Modular imbibition rate reducer for use with implantable osmotic pump 审中-公开
标题翻译：用于植入式渗透泵的模块化吸入减速器
公开(公告)号：US20050101943A1
公开(公告)日：2005-05-12
申请号：US10978597
申请日：2004-11-01
申请人： Rupal Ayer , Scott Lautenbach , Michael Desjardin , Adrienne Higa
发明人： Rupal Ayer , Scott Lautenbach , Michael Desjardin , Adrienne Higa
IPC分类号： A61K9/00 , A61K9/22 , A61K9/48
CPC分类号： A61K9/0004
摘要： An osmotic pump system includes a capsule having at least one delivery port, a membrane plug retained at an open end of the capsule remote from the delivery port, the membrane plug providing a fluid-permeable barrier between an interior and an exterior of the capsule, and a removable imbibition rate reducer attachable to the capsule. The imbibition rate reducer comprises one or more flow controllers selected from the group consisting of an orifice having a selected size smaller than a surface area of the membrane plug and a membrane having a selected thickness, surface area, radial compression, and permeability. The imbibition rate reducer allows customizable delivery of medicaments.
摘要翻译：渗透泵系统包括具有至少一个输送端口的胶囊，保持在远离输送端口的胶囊的开口端处的膜塞，膜塞在胶囊的内部和外部之间提供流体可渗透屏障，以及可附接到胶囊的可移除的吸入减速器。吸入减速器包括一个或多个流量控制器，其选自具有选定尺寸小于膜塞的表面积的孔口和选择的厚度，表面积，径向压缩和渗透性的膜。吸入减速器允许定制的药物递送。

6. 发明申请

US20060111693A1 Minimally compliant, volume-efficient piston for osmotic drug delivery systems 有权
公开(公告)号：US20060111693A1
公开(公告)日：2006-05-25
申请号：US11219960
申请日：2005-09-06
申请人： Scott Lautenbach
发明人： Scott Lautenbach
IPC分类号： A61K9/22
CPC分类号： A61K9/48 , A61K9/0004 , A61M31/002 , A61M2005/14513
摘要： An osmotic pump having a minimally compliant, volume-efficient piston positioned within a capsule is provided. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length-to-total-diameter ratio of about 1.1:1 and a core-diameter-to-total-diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and, in turn, cause delivery of the beneficial agent from the capsule.

7. 发明申请

US20070088337A1 Minimally compliant, volume efficient piston for osmotic drug delivery systems 审中-公开
标题翻译：体积有效的活塞用于渗透药物输送系统
公开(公告)号：US20070088337A1
公开(公告)日：2007-04-19
申请号：US11526983
申请日：2006-09-26
申请人： Scott Lautenbach
发明人： Scott Lautenbach
IPC分类号： A61K9/22
CPC分类号： A61K9/48 , A61K9/0004 , A61M31/002 , A61M2005/14513
摘要： An osmotic pump having a minimally compliant, volume-efficient piston positioned within a capsule is provided. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length-to-total-diameter ratio of about 1.1:1 and a core-diameter-to-total-diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and, in turn, cause delivery of the beneficial agent from the capsule.
摘要翻译：提供了一种具有位于胶囊内的最小顺应性体积效率的活塞的渗透泵。胶囊具有内表面，有益剂和渗透剂。活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。可移动密封件将渗透剂与有益剂分离。活塞具有约1.1:1的长度与总直径之比和约0.9:1的芯直径与总直径之比。该活塞能够增加更大的有益剂和/或渗透剂有效载荷，而不增加胶囊的尺寸。渗透剂通过半渗透体吸收来自周围环境的液体，引起活塞移动，从而使有益剂从胶囊输送。

8. 发明申请

US20080091176A1 Osmotic delivery systems and piston assemblies for use therein 有权
标题翻译：渗透输送系统和用于其中的活塞组件
公开(公告)号：US20080091176A1
公开(公告)日：2008-04-17
申请号：US11890836
申请日：2007-08-08
申请人： Thomas Alessi , Michael DesJardin , Stan Lam , Scott Lautenbach , Pauline Zamora
发明人： Thomas Alessi , Michael DesJardin , Stan Lam , Scott Lautenbach , Pauline Zamora
IPC分类号： A61K9/22
CPC分类号： F16J9/26 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513 , A61M2205/0216 , F16J9/28 , Y10T29/49826
摘要： An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.
摘要翻译：公开了用于将活性剂制剂递送到流体环境的渗透递送系统。渗透递送系统通常包括储存器，其具有包含活性剂制剂的内腔和渗透剂制剂以及位于内腔中的活塞组件，以将活性剂制剂与渗透剂制剂隔离。活塞组件通常包括构造和布置成用于定位在内腔中的主体。主体通常由例如耐有机溶剂浸出的聚合材料制成。在一个实施例中，主体是一个柱状体，其具有在其远端处的边缘，用于接合和密封储存器的壁，并且活塞组件还包括保持在柱状体的远端处的弹簧，用于偏置柱状体抵靠水库的墙壁。

9. 发明申请

US20050010196A1 Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems 审中-公开
标题翻译：渗透输送系统和减少渗透输送系统启动时间的方法
公开(公告)号：US20050010196A1
公开(公告)日：2005-01-13
申请号：US10815169
申请日：2004-03-31
申请人： Pamela Fereira , Scott Lautenbach , Stephen Berry
发明人： Pamela Fereira , Scott Lautenbach , Stephen Berry
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K31/00 , A61K47/10
CPC分类号： A61K9/2013 , A61K9/0004 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K31/00 , A61K47/10
摘要： The present invention includes devices and methods for reducing the start-up time of osmotically driven drug delivery systems capable of delivering a desired drug at a controlled rate over time. In particular, the present invention includes osmotic pumps that have a preloaded membrane, which includes a semipermeable material that has been preloaded with a nonaqueous, incompressible liquid filler that is miscible with water. The present invention further includes methods for making such osmotic pumps. The preloaded membranes included in the osmotic pumps according to the present invention have proven to provide significant decreases in average start-up times relative to osmotic pumps that include semipermeable membranes that are not preloaded.
摘要翻译：本发明包括用于减少能够以受控速率随时间输送所需药物的渗透驱动的药物递送系统的启动时间的装置和方法。特别地，本发明包括具有预加载膜的渗透泵，其包括预先装有与水混溶的非水不可压缩液体填料的半透性材料。本发明还包括制造这种渗透泵的方法。包括在根据本发明的渗透泵中的预加载膜已被证明相对于包括未预加载的半透膜的渗透泵的平均启动时间显着减少。

10. 发明授权

US6113938A Beneficial agent delivery system with membrane plug and method for controlling delivery of beneficial agents 失效
标题翻译：具有膜塞的有益代理输送系统和用于控制有益药物输送的方法
公开(公告)号：US6113938A
公开(公告)日：2000-09-05
申请号：US121835
申请日：1998-07-24
申请人： Guohua Chen , Scott Lautenbach , Keith Dionne , Lawton Hom
发明人： Guohua Chen , Scott Lautenbach , Keith Dionne , Lawton Hom
IPC分类号： A61K9/00 , A61K9/52 , A61F2/02
CPC分类号： A61K9/0004
摘要： An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule containing a beneficial agent and an osmotic agent which swells on contact with water causing the release of the beneficial agent over time. The osmotic delivery system has a membrane plug which allows water to pass through the plug from an exterior of the capsule while preventing the compositions within the capsule from passing out of the capsule. A delivery rate for delivery of the beneficial agent from the implant capsule is controlled by varying a core diameter of the membrane plug within a constant diameter capsule. The membrane plug has a variable water permeation rate depending on an extent to which the membrane plug is constrained by the capsule walls.
摘要翻译：用于有益药物的受控递送的渗透递送系统包括含有有益剂的植入物胶囊和在与水接触时溶胀的渗透剂，随着时间推移释放有益剂。渗透递送系统具有膜塞，其允许水从胶囊的外部通过塞子，同时防止胶囊内的组合物从胶囊中流出。通过在恒定直径的胶囊内改变膜塞的芯直径来控制从植入物胶囊输送有益剂的递送速率。膜塞具有可变的水渗透速率，这取决于膜塞被胶囊壁约束的程度。

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