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1. 发明申请

US20060165800A1 SHORT DURATION DEPOT FORMULATIONS 审中-公开
标题翻译：短期DEPOT制剂
公开(公告)号：US20060165800A1
公开(公告)日：2006-07-27
申请号：US11278472
申请日：2006-04-03
申请人： Guohua Chen , David Priebe
发明人： Guohua Chen , David Priebe
IPC分类号： A61K9/14
CPC分类号： A61K9/0024 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K31/445 , A61K38/27 , A61K47/10 , A61K47/14 , A61K47/34
摘要： Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.
摘要翻译：描述了通过将有益剂植入受试者进行全身或局部施用的方法和组合物，并且包括例如将凝胶组合物储存在可以注射到所需位置并且可以在短时间内提供受益药物的受控释放的时间。组合物包括低分子量生物相容性聚合物，具有低水混溶性的生物相容性溶剂，其与聚合物形成粘性凝胶并限制植入物吸收水分，以及有益剂。

2. 发明授权

US08278330B2 Short duration depot formulations 有权
标题翻译：短持续时间的药剂配方
公开(公告)号：US08278330B2
公开(公告)日：2012-10-02
申请号：US12924441
申请日：2010-09-27
申请人： Guohua Chen , David Priebe
发明人： Guohua Chen , David Priebe
IPC分类号： A61K31/445
CPC分类号： A61K9/0024 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K31/445 , A61K38/27 , A61K47/10 , A61K47/14 , A61K47/34
摘要： Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.
摘要翻译：描述了通过将有益剂植入受试者进行全身或局部施用的方法和组合物，并且包括例如将凝胶组合物储存在可以注射到所需位置并且可以在短时间内提供受益药物的受控释放的时间。组合物包括低分子量生物相容性聚合物，具有低水混溶性的生物相容性溶剂，其与聚合物形成粘性凝胶并限制植入物吸收水分，以及有益剂。

3. 发明申请

US20110046181A1 Short duration depot formulations 有权
标题翻译：短持续时间的药剂配方
公开(公告)号：US20110046181A1
公开(公告)日：2011-02-24
申请号：US12924441
申请日：2010-09-27
申请人： Guohua Chen , David Priebe
发明人： Guohua Chen , David Priebe
IPC分类号： A61K31/4458 , A61P23/00
CPC分类号： A61K9/0024 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K31/445 , A61K38/27 , A61K47/10 , A61K47/14 , A61K47/34
摘要： Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.
摘要翻译：描述了通过将有益剂植入受试者进行全身或局部施用的方法和组合物，并且包括例如将凝胶组合物储存在可以注射到所需位置并且可以在短时间内提供受益药物的受控释放的时间。组合物包括低分子量生物相容性聚合物，具有低水混溶性的生物相容性溶剂，其与聚合物形成粘性凝胶并限制植入物吸收水分，以及有益剂。

4. 发明授权

US07368126B2 Controlled release depot formulations 失效
标题翻译：控制释放贮库制剂
公开(公告)号：US07368126B2
公开(公告)日：2008-05-06
申请号：US10701939
申请日：2003-11-04
申请人： Guohua Chen , Paul Houston , Roy Bannister , Teresa Kameda , David Priebe , Lothar Kleiner
发明人： Guohua Chen , Paul Houston , Roy Bannister , Teresa Kameda , David Priebe , Lothar Kleiner
IPC分类号： A61F2/00
CPC分类号： A61K9/0024 , A61K9/14 , A61K9/143 , A61K9/145 , A61K9/1611 , A61K9/1688 , A61K9/2013 , A61K9/204 , A61K47/34
摘要： Methods and compositions for systemically or locally administering a beneficialagent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.
摘要翻译：描述了用于系统地或局部施用受试者的有益药物的方法和组合物，并且包括例如将凝胶组合物储存在可以注射到期望的位置并且可以在长时间内提供有益药物的受控释放。组合物包括生物相容性聚合物，具有低水混溶性的生物相容性溶剂，其与聚合物形成粘性凝胶并限制植入物吸收水分，以及有益剂。

5. 发明申请

US20050281879A1 Excipients in drug delivery vehicles 审中-公开
标题翻译：药物递送载体中的赋形剂
公开(公告)号：US20050281879A1
公开(公告)日：2005-12-22
申请号：US10985116
申请日：2004-11-10
申请人： Guohua Chen , David Priebe
发明人： Guohua Chen , David Priebe
IPC分类号： A61K9/00 , A61K47/34 , A61K9/14
CPC分类号： A61K9/0024 , A61K31/445 , A61K38/27 , A61K47/34
摘要： Injectable depot gel compositions and kits that provide an excipient for modulating a release rate and stabilizing beneficial agents are provided. Methods of administering and preparing such systems are also provided. The gel compositions comprise biodegradable, bioerodible polymers and water-immiscible solvents in amounts effective to plasticize the polymers and form gels with the polymers. Suitable excipients include pH modifiers, reducing agents, and antioxidants.
摘要翻译：提供了提供用于调节释放速率和稳定有益剂的赋形剂的可注射贮库凝胶组合物和试剂盒。还提供了施用和制备这种体系的方法。凝胶组合物包含可生物降解的，可生物腐蚀的聚合物和与水不混溶的溶剂，其量有效地使聚合物增塑并与聚合物形成凝胶。合适的赋形剂包括pH调节剂，还原剂和抗氧化剂。

6. 发明授权

US09268799B1 System and method for restoring data from a remote repository 有权
标题翻译：从远程存储库恢复数据的系统和方法
公开(公告)号：US09268799B1
公开(公告)日：2016-02-23
申请号：US13928843
申请日：2013-06-27
申请人： Feng Qi , Pei Mao , Guohua Chen
发明人： Feng Qi , Pei Mao , Guohua Chen
IPC分类号： G06F17/30
CPC分类号： G06F11/1469 , G06F11/1451 , G06F2201/835
摘要： A method includes receiving a request to restore a memory of a client and determining a selected full session from a plurality of full sessions, each full session comprising a respective copy of data received from the memory of the client and a respective backup time stamp. The selected full session includes a most recent full backup having a respective backup time stamp prior to a selected restore time. The method further includes copying the selected full session to a restore session and determining a selected incremental session from a plurality of incremental sessions. Each incremental session includes a respective incremental backup time stamp, and respective changes to the data received from the memory of the client. The method further includes modifying the restore session in a cloud computing environment based on the selected incremental session, and transmitting the modified restore session across a network to the client.
摘要翻译：一种方法包括接收请求以恢复客户端的存储器并且从多个完整会话确定所选择的完整会话，每个完整会话包括从客户端的存储器接收的相应的数据副本和相应的备份时间戳。所选的完整会话包括在选择的恢复时间之前具有各自的备份时间戳的最新的完整备份。该方法还包括将所选择的完整会话复制到恢复会话并且从多个增量会话确定所选择的增量会话。每个增量会话包括相应的增量备份时间戳，以及对从客户机的存储器接收到的数据的相应改变。该方法还包括基于所选择的增量会话在云计算环境中修改恢复会话，以及通过网络将修改的恢复会话发送到客户端。

7. 发明授权

US09114238B2 Solvent-cast microprotrusion arrays containing active ingredient 有权
标题翻译：含有活性成分的溶剂滴注微阵列
公开(公告)号：US09114238B2
公开(公告)日：2015-08-25
申请号：US12148180
申请日：2008-04-16
申请人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
IPC分类号： A61M5/00 , A61M37/00 , A61K9/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61K38/29 , A61K38/385 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61M2202/0007 , A61M2202/07 , A61M2202/30 , A61M2207/00
摘要： In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
摘要翻译：在本发明的一个方面，通过向模具提供对应于微突起的负极的空腔形成微突起阵列，在模具上方铸造包含生物相容性材料和溶剂的第一溶液，除去溶剂，铸造第二溶液在第一浇铸溶液顶部，从第二溶液中除去溶剂，并将得到的阵列从模具中脱模。第一溶液优选含有活性成分。

8. 发明申请

US20120100740A1 ELECTRIC TERMINAL FOR LEADING A LINE THROUGH A WALL 有权
标题翻译：用于通过墙壁引导线的电气端子
公开(公告)号：US20120100740A1
公开(公告)日：2012-04-26
申请号：US13265038
申请日：2010-04-13
申请人： Heinz Reibke , Rudolf Merz , Guohua Chen , Dennis Sprenger
发明人： Heinz Reibke , Rudolf Merz , Guohua Chen , Dennis Sprenger
IPC分类号： H01R13/621
CPC分类号： H01R13/74 , H01R4/30 , H01R11/12
摘要： The invention relates to an electric terminal for leading a conductor through a wall, comprising a first terminal piece (1) to be mounted on one side of the wall, and a second terminal piece (2) to be mounted on the other side of the wall. The first terminal piece (1) has a first connecting element (5) and a holding element (7) for positioning the first connecting element (5), while the second terminal piece (2) has a busbar (4) to be electrically connected to the first connecting element (5). According to the invention, the first connecting element (5) in such an electric terminal for leading a conductor through a wall can be connected to the conductor and/or the busbar (4) in a particularly simple fashion because the first connecting element (5) is positioned in the first terminal piece (1) by the holding element (7).
摘要翻译：本发明涉及一种用于将导体引导通过壁的电端子，其包括将安装在壁的一侧的第一端子件（1）和安装在壁的另一侧上的第二端子件（2）壁。第一端子件（1）具有用于定位第一连接元件（5）的第一连接元件（5）和保持元件（7），而第二端子件（2）具有电连接的汇流条（4）到第一连接元件（5）。根据本发明，用于引导导体穿过壁的这种电端子中的第一连接元件（5）可以以特别简单的方式连接到导体和/或母线（4），因为第一连接元件（5））通过保持元件（7）定位在第一端子件（1）中。

9. 发明申请

US20110276028A1 METHOD AND DEVICE FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE USING A MICROPROJECTION ARRAY 有权
标题翻译：使用微阵列阵列进行直接递送帕拉霉素激素的方法和装置
公开(公告)号：US20110276028A1
公开(公告)日：2011-11-10
申请号：US13101071
申请日：2011-05-04
申请人： Parminder Singh , Danir Bairamov , Guohua Chen , Robert Wade Worsham
发明人： Parminder Singh , Danir Bairamov , Guohua Chen , Robert Wade Worsham
IPC分类号： A61M5/00
CPC分类号： A61K9/0021 , A61K38/29 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/36 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要： A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
摘要翻译：提供了以脉动方式经皮给药甲状旁腺激素（PTH）的方法和药物递送系统，其中药物递送系统包括每个包含PTH的微阵列阵列。

10. 发明申请

US20100297209A1 SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES 审中-公开
标题翻译：溶剂/聚合物溶液作为悬浮液
公开(公告)号：US20100297209A1
公开(公告)日：2010-11-25
申请号：US12827265
申请日：2010-06-30
申请人： Catherine M. ROHLOFF , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. ROHLOFF , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
IPC分类号： A61F2/00 , A61K38/21 , A61P31/14 , A61P3/10 , A61P35/00 , A61P1/16 , A61P13/12
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/095 , A61K38/105 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
摘要翻译：能够悬浮活性剂的非水性单相载体。非水性单相载体包含至少一种溶剂和至少一种聚合物，并配制成在与水性环境接触时显示相分离。所述至少一种溶剂可以选自苯甲酸苄酯，癸醇，乳酸乙基己酯及其混合物，并且所述至少一种聚合物可以选自聚酯，吡咯烷酮，不饱和醇的酯，不饱和醇的醚，聚氧乙烯聚氧丙烯嵌段共聚物及其混合物。在一个实施方案中，所述至少一种溶剂是苯甲酸苄酯，并且所述至少一种聚合物是聚乙烯吡咯烷酮。还公开了包含非水单相载体和活性剂的稳定的非水悬浮液制剂及其形成方法。

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