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61. 发明授权

US4746752A Preparation of hydrogenosilanes by redistribution 失效
标题翻译：通过再分配制备氢硅烷
公开(公告)号：US4746752A
公开(公告)日：1988-05-24
申请号：US837053
申请日：1986-03-06
申请人： Jean-Luc Lepage , Gerard Soula
发明人： Jean-Luc Lepage , Gerard Soula
IPC分类号： C01B33/04 , B01J20/26 , B01J31/00 , C01B33/107 , C07F7/12 , C09K3/00 , C07F7/08 , C07F7/18
CPC分类号： C07F7/125
摘要： Hydrogenated silanes are facilely prepared by redistribution, by reacting (1) a silane having the formula H.sub.m SiX.sub.4-m in which X is halogen or an alkoxy group and m is an integer equal to 0, 1, 2 or 3, with (2) an alkyl or aryl hydrosilane having the formula R.sub.n H.sub.p SiX'.sub.4-(n+p) in which X' is halogen or an alkoxy group, R is an alkyl or aryl group and n and p, which may be identical or different, are integers equal to 1, 2 or 3, with the proviso that n+p.ltoreq.4, in the presence of (3) a catalytically effective amount of a catalyst comprising (i) a quaternary ammonium salt having the formula R'.sub.4 NY or a quaternary phosphonium salt having the formula R'.sub.4 PY, in which formulae R', which may be identical or different, are each a monovalent hydrocarbon radical and Y is halogen, (ii) a tertiary amine of the general formula NR'R"R"', in which R', R" and R"', which may be identical or different, are monovalent hydrocarbon radicals, or (iii) an ion exchange resin comprising tertiary amine or quaternary ammonium groups.
摘要翻译：氢化硅烷通过重新分布，通过使（1）具有式HmSiX4-m的硅烷（其中X是卤素或烷氧基，m是等于0,1,2或3的整数）与（2）具有式RnHpSiX'4-（n + p）的烷基或芳基氢硅烷，其中X'为卤素或烷氧基，R为烷基或芳基，n和p可相同或不同，为等于 1，2或3，条件是在（3）催化有效量的催化剂存在下，n + p = 4，其包含（i）具有式R'4NY的季铵盐或季鏻具有式R'4PY的盐，其中可以相同或不同的式R'各自为一价烃基，Y为卤素，（ii）通式NR'R''R“'的叔胺 '，其中可以相同或不同的R'，R“和R”'是一价烃基，或（iii）包含叔胺或四氢呋喃的离子交换树脂铵基团。

62. 发明授权

US4504682A Novel polyoxaalkyl aminoalcohols 失效
标题翻译：新型聚氧杂烷基氨基醇
公开(公告)号：US4504682A
公开(公告)日：1985-03-12
申请号：US455898
申请日：1983-01-05
申请人： Louis Linguenheld , Gerard Soula
发明人： Louis Linguenheld , Gerard Soula
IPC分类号： C09K3/00 , B01F1/00 , B01J25/00 , B01J25/02 , C07B61/00 , C07C67/00 , C07C213/00 , C07C217/08 , C07C85/06
CPC分类号： C07C213/02
摘要： Novel polyoxaalkyl aminoalcohols, well adapted for the complexation/solubilization of a wide variety of cations, have the structural formula: ##STR1##
摘要翻译：新的聚氧杂烷基氨基醇，适用于各种阳离子的络合/溶解，具有以下结构式：

63. 发明授权

US4467055A Filled polymeric compositions comprising novel polymer/filler interfacing additive 失效
标题翻译：包含新型聚合物/填料界面添加剂的填充聚合物组合物
公开(公告)号：US4467055A
公开(公告)日：1984-08-21
申请号：US423264
申请日：1982-09-24
申请人： Jean Machurat , Jean-Claude Morawski , Gerard Soula
发明人： Jean Machurat , Jean-Claude Morawski , Gerard Soula
IPC分类号： C08K3/00 , C08K5/00 , C08K5/16 , C08K5/20 , C08K5/34 , C08K5/3462 , C08K9/00 , C08K9/04 , C08K9/06 , C08K3/36
CPC分类号： C08K5/20 , C08K5/16 , C08K5/3462
摘要： Polymeric, advantageously elastomeric, e.g., natural or synthetic rubber, matrices including a reinforcing amount of a filler therefor, e.g., inorganic particulates, further comprise, as an interfacing additive between the matrix and the reinforcing filler, the condensation product of at least one polyamine with at least one carboxylic acid.
摘要翻译：聚合物，有利的是弹性体，例如天然或合成橡胶，包括增强量的填料，例如无机颗粒的基质，还包含作为基质和增强填料之间的界面添加剂的至少一种多胺的缩合产物与至少一种羧酸。

64. 发明授权

US4429160A Polyoxaalkyl aminoalcohols 失效
标题翻译：聚氧杂烷基氨基醇
公开(公告)号：US4429160A
公开(公告)日：1984-01-31
申请号：US296214
申请日：1981-08-25
申请人： Louis Linguenheld , Gerard Soula
发明人： Louis Linguenheld , Gerard Soula
IPC分类号： C09K3/00 , B01F1/00 , B01J25/00 , B01J25/02 , C07B61/00 , C07C67/00 , C07C213/00 , C07C217/08 , C07C93/04
CPC分类号： C07C213/02
摘要： Novel polyoxaalkyl aminoalcohols, well adapted for the complexation/solubilization of a wide variety of cations, have the structural formula: ##STR1##
摘要翻译：新的聚氧杂烷基氨基醇，适用于各种阳离子的络合/溶解，具有以下结构式：

65. 发明授权

US4322369A Preparation of alkyl cyanoacetates 失效
标题翻译：氰基乙酸烷基酯的制备
公开(公告)号：US4322369A
公开(公告)日：1982-03-30
申请号：US216363
申请日：1980-12-15
申请人： Michel Desbois , Gerard Soula
发明人： Michel Desbois , Gerard Soula
IPC分类号： C07C255/19 , C07C67/00 , C07C253/00 , C07C120/04
CPC分类号： C07C255/00 , C07C253/14
摘要： The alkyl cyanoacetates are prepared by reacting an alkyl chloracetate with an excess of an alkali metal cyanide, in an inert solvent and in the presence of at least one tertiary amine sequestering agent having the formula:N--CHR.sub.1 --CHR.sub.2 --O--CHR.sub.3 --CHR.sub.4 --O.sub.n R.sub.5 ].sub.3 (I).
摘要翻译：氰基乙酸烷基酯通过使氯代乙酸烷基酯与过量的碱金属氰化物在惰性溶剂中并在至少一种具有下式的叔胺螯合剂的存在下反应制备：N-CHR1-CHR2-O-CHR3-CHR4 -OnR5] 3（I）。

66. 发明授权

US4094802A Novel lubricant additives 失效
标题翻译：新型润滑剂添加剂
公开(公告)号：US4094802A
公开(公告)日：1978-06-13
申请号：US782881
申请日：1977-03-30
申请人： Gerard Soula , Philippe Duteurtre
发明人： Gerard Soula , Philippe Duteurtre
IPC分类号： B01D19/04 , C07D207/40 , C07D207/412 , C10M133/16 , C10M133/56 , C10N30/04 , C10N30/12 , C10N30/18 , C10N40/25 , C10M1/32 , C10M3/26 , C10M5/20 , C10M7/30
CPC分类号： C07D207/412 , C10M133/16 , C10M133/56 , C10M2203/02 , C10M2203/022 , C10M2203/024 , C10M2203/04 , C10M2203/06 , C10M2205/02 , C10M2207/028 , C10M2207/04 , C10M2207/282 , C10M2207/34 , C10M2209/00 , C10M2209/02 , C10M2209/10 , C10M2209/103 , C10M2209/108 , C10M2209/109 , C10M2215/04 , C10M2215/26 , C10M2217/046 , C10M2217/06 , C10M2219/044 , C10M2223/04 , C10M2223/042 , C10M2223/045 , C10M2229/02 , C10M2229/05 , C10N2210/02 , C10N2230/12
摘要： Novel lubricant additives are provided comprising compositions based on alkenylsuccinimides containing at least one alkenylsuccinimide of the formula: ##STR1## WHERE R is an alkenyl group of about C.sub.20 to C.sub.200, m is an integer equal to 0, 1 or 2, and n is an integer equal to 0 or 1. These compositions can be prepared by condensation of an alkenylsuccinic anhydride with N,N,N',N'-tetrakis-(3-aminopropyl)-ethylenediamine.
摘要翻译：提供新的润滑剂添加剂，其包含基于含有至少一个下式的链烯基琥珀酰亚胺的烯基琥珀酰亚胺的组合物：其中R为约C20至C200的烯基，m为等于0,1或2的整数，n是等于0或1的整数。这些组合物可以通过烯基琥珀酸酐与N，N，N'，N'-四（3-氨基丙基） - 乙二胺缩合来制备。

67. 发明授权

US08629124B2 Dextran functionalized by hydrophobic amino acids 有权
标题翻译：疏水性氨基酸功能化的葡聚糖
公开(公告)号：US08629124B2
公开(公告)日：2014-01-14
申请号：US12078441
申请日：2008-03-31
申请人： Gerard Soula , Olivier Soula , Remi Soula
发明人： Gerard Soula , Olivier Soula , Remi Soula
IPC分类号： A01N43/04 , A01N61/00 , A61K31/715 , A61K31/00
CPC分类号： A61K31/721 , C08B37/0021
摘要： The invention relates to a dextran functionalized by at least one hydrophobic alpha-amino acid radical, said alpha-amino acid being grafted or bonded to the dextran by a bonding arm and a functional group. A hydrophobic amino acid radical is understood as being the product of coupling between the amine of the amino acid and an acid carried by the bonding arm, said dextran being amphiphilic at neutral pH. In an embodiment, the hydrophobic amino acid is selected from tryptophan derivatives, such as tryptophan, tryptophanol, tryptophanamide, 2-indole ethyl-amine and their alkaline cation salts. The present invention relates also to a pharmaceutical composition comprising one of the dextrans according to the invention.
摘要翻译：本发明涉及由至少一个疏水性α-氨基酸官能化的葡聚糖，所述α-氨基酸通过键合臂和官能团接枝或结合到葡聚糖上。疏水性氨基酸被理解为是氨基酸的胺和由结合臂携带的酸之间的偶联的产物，所述葡聚糖在中性pH下是两亲性的。在一个实施方案中，疏水性氨基酸选自色氨酸衍生物，例如色氨酸，色氨酸，色氨酰胺，2-吲哚乙基胺及其碱性阳离子盐。本发明还涉及包含根据本发明的葡聚糖之一的药物组合物。

68. 发明授权

US08367640B2 Complex consisted of a polysaccharide and an HBP 有权
标题翻译：复合物由多糖和HBP组成
公开(公告)号：US08367640B2
公开(公告)日：2013-02-05
申请号：US12585886
申请日：2009-09-28
申请人： Olivier Soula , Remi Soula , Martin Gaudier , Gerard Soula
发明人： Olivier Soula , Remi Soula , Martin Gaudier , Gerard Soula
IPC分类号： A01N43/04 , A01N61/00 , A61K31/715 , A61K31/00
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/1825 , A61K38/185 , A61K38/1866 , A61K38/27 , A61K38/29 , A61K47/42 , A61K47/61
摘要： The invention relates to a complex consisted of a polysaccharide and an HBP, said polysaccharide being consisted from glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative. The invention also relates to a pharmaceutical composition comprising a complex according to the invention and to the use of a polysaccharide consisted of glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative, for the preparation of a pharmaceutical formulation of stable HBPs.
摘要翻译：本发明涉及由多糖和HBP组成的复合物，所述多糖由（1,6）和/或（1,4）和/或（1,3）和/或（1,2）的糖苷键组成）类型并用至少一种可成盐或盐化的色氨酸衍生物官能化。本发明还涉及包含根据本发明的复合物和由（1,6）和/或（1,4）和/或（1,3）和/或（1,3）的糖苷键组成的多糖和/ 或（1,2）型，并用至少一种可成盐或盐化的色氨酸衍生物官能化，用于制备稳定HBP的药物制剂。

69. 发明申请

US20100249020A1 Fast-acting insulin formulation 有权
标题翻译：速效胰岛素制剂
公开(公告)号：US20100249020A1
公开(公告)日：2010-09-30
申请号：US12662036
申请日：2010-03-29
申请人： Remi Soula , Gerard Soula , Olivier Soula
发明人： Remi Soula , Gerard Soula , Olivier Soula
IPC分类号： A61K38/28 , C07K17/10 , A61P3/10
CPC分类号： A61K38/28 , A61K9/0019
摘要： The invention relates to a complex between an insulin and a polysaccharide comprising carboxyl functional groups, said polysaccharide being chosen from polysaccharides functionalized with at least one phenylalanine derivative, noted Phe, said phenylalanine derivative being chosen from the group consisting of phenylalanine and its alkali metal cation salts, phenylalaninol, phenylalaninamide and ethylbenzylamine or from phenylalanine esters, and said insulin being either a human insulin or an insulin analog. The invention also relates to a pharmaceutical composition comprising at least one complex according to the invention, especially in the form of an injectable solution.
摘要翻译：本发明涉及胰岛素和包含羧基官能团的多糖之间的复合物，所述多糖选自用至少一种苯丙氨酸衍生物（所述Phe）官能化的多糖，所述苯丙氨酸衍生物选自苯丙氨酸及其碱金属阳离子盐，苯丙氨酸，苯丙氨酰胺和乙基苄胺或苯丙氨酸酯，所述胰岛素是人胰岛素或胰岛素类似物。本发明还涉及包含至少一种根据本发明的复合物，特别是可注射溶液形式的药物组合物。

70. 发明申请

US20100167984A1 Complex between human insulin and an amphiphilic polymer and use of this complex in the preparation of a fast-acting human insulin formulation 审中-公开
标题翻译：人胰岛素与两亲性聚合物之间的复合物，以及该配合物在制备快速作用的人胰岛素制剂中的用途
公开(公告)号：US20100167984A1
公开(公告)日：2010-07-01
申请号：US12588349
申请日：2009-10-13
申请人： Olivier Soula , Remi Soula , Gerard Soula
发明人： Olivier Soula , Remi Soula , Gerard Soula
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： A61K38/28 , A61K9/0019 , C07K14/62
摘要： The invention relates to a complex between human insulin and an amphiphilic polymer comprising carboxyl functional groups, said amphiphilic polymer being chosen from functionalized polysaccharides predominantly composed of glycoside monomers bonded via glycoside bonds of (1,6) type which are functionalized by at least one tryptophan derivative.It also relates to a pharmaceutical composition comprising at least one complex according to the invention, it being possible for said formulation to be in the form of an injectable solution.It more particularly relates to the use of a complex according to the invention in the preparation of a human insulin formulation at a concentration of approximately 600 μM (100 IU/ml), the onset of action of which is less than 30 minutes, preferably less than 20 minutes and more preferably less than 15 minutes and/or the glycemic nadir of which is at less than 120 minutes, preferably less than 105 minutes and more preferably less than 90 minutes.
摘要翻译：本发明涉及人胰岛素与包含羧基官能团的两亲聚合物之间的复合物，所述两亲性聚合物选自主要由通过（1,6）型糖苷键键合的糖苷单体组成的官能化多糖，其由至少一种色氨酸官能化衍生物。它还涉及包含至少一种根据本发明的复合物的药物组合物，所述制剂可以是可注射溶液的形式。更具体地涉及根据本发明的复合物在制备浓度为约600μM（100IU / ml）的人胰岛素制剂时的用途，其作用开始小于30分钟，优选较少 20分钟以上，更优选小于15分钟，和/或血糖最低值低于120分钟，优选小于105分钟，更优选小于90分钟。

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