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61. 发明授权

US5486623A Cysteine protease inhibitors containing heterocyclic leaving groups 失效
公开(公告)号：US5486623A
公开(公告)日：1996-01-23
申请号：US164031
申请日：1993-12-08
申请人： Mary P. Zimmerman , Robert E. Smith
发明人： Mary P. Zimmerman , Robert E. Smith
IPC分类号： A61K31/34 , A61K31/35 , A61K31/365 , A61K31/40 , A61K31/44 , A61K31/4406 , A61K31/443 , A61K31/505 , A61K31/5375 , A61K38/00 , A61K47/48 , A61P1/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/02 , A61P25/28 , A61P27/02 , A61P27/12 , A61P27/14 , A61P29/00 , A61P31/12 , A61P33/02 , A61P35/00 , A61P37/08 , A61P43/00 , C07D207/16 , C07D213/64 , C07D213/65 , C07D213/80 , C07D239/34 , C07D295/215 , C07D307/58 , C07D307/60 , C07D307/62 , C07D309/32 , C07D309/38 , C07D405/12 , C07K14/81 , C07D315/00 , C07D307/02 , C07D207/00
CPC分类号： C07D213/64 , A61K31/34 , A61K31/35 , A61K31/40 , A61K31/44 , A61K31/443 , A61K31/505 , A61K31/5375 , A61K47/48238 , C07D207/16 , C07D213/80 , C07D239/34 , C07D295/215 , C07D307/58 , C07D307/60 , C07D307/62 , C07D309/38 , C07D405/12
摘要： A class of cysteine protease inhibitors which inactivate a cysteine protease by covalently bonding to the protease and releasing a heterocyclic leaving group is presented. The cysteine protease inhibitors of the present invention comprise a first portion which targets a desired cysteine protease and positions the inhibitor near the thiolate anion portion of the active site of the protease, and a second portion which covalently bonds to the cysteine protease and irreversibly deactivates that protease by providing a carbonyl or carbonyl-equivalent which is attacked by the thiolate anion of the active site of the cysteine protease to sequentially cleave a heterocyclic leaving group. The heterocyclic leaving group of the protease inhibitor is of the formula: --O-- Het, where Het is a heterocycle having 4-7 atoms in the ring, with at least one of the heterocycle atoms being N, O or S.

62. 发明授权

US5441589A Flat bed daisy wheel hot debossing stamper 失效
标题翻译：平床菊花轮热压缩压模
公开(公告)号：US5441589A
公开(公告)日：1995-08-15
申请号：US78792
申请日：1993-06-17
申请人： Charles T. Groswith, III , William A. Banks , Eugene F. Duval , Roger M. Gray , Raymond D. Heistand, II , Barry C. Kockler , Warren K. Shannon , Robert E. Smith , William J. Usitale
发明人： Charles T. Groswith, III , William A. Banks , Eugene F. Duval , Roger M. Gray , Raymond D. Heistand, II , Barry C. Kockler , Warren K. Shannon , Robert E. Smith , William J. Usitale
IPC分类号： B41F19/06 , B41J1/00 , B41J1/24 , B41J1/30 , B41J3/28
CPC分类号： B41J1/00 , B41F19/068 , B41J1/24 , B41J1/30 , B41P2219/20 , B41P2219/434 , Y10T156/171
摘要： A dual station hot debossing stamper for a report or book cover includes a print engine having a character finger daisy wheel forcer and a logo die forcer which are actuatable independently by a common servo motor through respective gear trains. The print engine moves line-by-line and a platen moves character-by-character. A print wheel is inserted and locked into the engine in a character debossment operation with a motor driving the print wheel. When using a logo die, the print wheel and casing is removed and using a loader-unloader tool the die is articulated under the logo die forcer. Insertion of a logo transfer tape cartridge shifts the gears in the print engine. A second character tape cartridge is used with the print wheel. A dedicated personal computer and associated software and firmware programs control the stamping apparatus.
摘要翻译：用于报告或书籍封面的双站热压缩压模包括具有字符指状菊花轮锻造和标志模具的打印引擎，该打印引擎可以通过相应的齿轮系通过公共伺服电动机独立地致动。打印引擎逐行移动，压板逐个移动。打印轮被插入并锁定到发动机中，并以驱动打印轮的马达进行字符压缩操作。当使用标志模具时，打印轮和外壳被移除，并使用装载机卸载工具将模具铰接在标志模具下。插入标志转移盒式磁带可以移动打印引擎中的齿轮。打印轮使用第二个字符的磁带盒。专用的个人计算机和相关的软件和固件程序控制冲压装置。

63. 发明授权

US5360035A Pressure balanced poppet valve for hydraulic couplings 失效
标题翻译：压力平衡液压联轴器提升阀
公开(公告)号：US5360035A
公开(公告)日：1994-11-01
申请号：US82767
申请日：1993-06-25
申请人： Robert E. Smith
发明人： Robert E. Smith
IPC分类号： F16L37/30 , F16L37/28
CPC分类号： E21B33/038 , F16L37/30 , Y10T137/87925 , Y10T137/87957
摘要： An undersea hydraulic coupling having a poppet valve movable between an open and a closed position is disclosed. The poppet valve operates without substantial fluid pressure exerted axially against the face of the poppet valve. When the poppet valve is opened, radial passages are interconnected through an annular cavity between the poppet valve body and the valve bore.
摘要翻译：公开了一种具有可在打开和关闭位置之间移动的提升阀的海底液压联轴器。提升阀在没有实质的流体压力的作用下轴向地抵靠提升阀的表面进行操作。当提升阀打开时，径向通道通过提升阀阀体和阀孔之间的环形空腔相互连接。

64. 发明授权

US5277225A Undersea hydraulic coupling with pressure-energized seals 失效
标题翻译：带压力密封件的海底液压联轴器
公开(公告)号：US5277225A
公开(公告)日：1994-01-11
申请号：US920802
申请日：1992-07-28
申请人： Robert E. Smith
发明人： Robert E. Smith
IPC分类号： E21B33/035 , E21B33/038 , F16L17/035 , F16L29/04 , F16L29/00 , F16L37/22
CPC分类号： F16L17/035 , E21B33/0355 , E21B33/038 , F16L29/04 , Y10S285/917 , Y10T137/87957
摘要： An undersea hydraulic coupling having a pair of flexible, pressure-energized seals is disclosed. The seals are configured to seal radially between the male and female members of the coupling so that hydraulic fluid does not leak from the annular space between the receiving chamber and outer surface of the male member. The coupling is pressure-balanced for fluid communication through mating radial passages and the annular space between the members.
摘要翻译：公开了一种具有一对柔性的，带通电的密封件的海底液压联轴器。密封件构造成在联接器的阳构件和阴构件之间径向密封，使得液压流体不会从接收室和阳构件的外表面之间的环形空间泄漏。联接器通过配合的径向通道和构件之间的环形空间进行压力平衡。

65. 发明授权

US5029613A Hydraulic coupler with radial metal seal 失效
标题翻译：液压联轴器带径向金属密封
公开(公告)号：US5029613A
公开(公告)日：1991-07-09
申请号：US589767
申请日：1990-09-28
申请人： Robert E. Smith, III
发明人： Robert E. Smith, III
IPC分类号： F16L37/32 , F16L37/58
CPC分类号： F16L37/32 , F16L1/26 , F16L37/58 , Y10S285/917 , Y10T137/87957
摘要： A coupling having a seal member with an annular flexible metal seal surface for sealing with a male member or probe. The metal seal surface is integral with the seal member and extends into the bore of the female member. The metal seal surface is urged radially inwardly against the male member in response to internal fluid pressure in the coupling.
摘要翻译：一种联接器，其具有密封构件，该密封构件具有用于与阳构件或探针密封的环形柔性金属密封表面。金属密封表面与密封构件成一体并延伸到阴构件的孔中。响应于联接器中的内部流体压力，金属密封表面径向向内抵靠阳构件。

66. 发明授权

US5015016A Internal pressure loaded V-seal connector 失效
标题翻译：内部加压V型密封连接器
公开(公告)号：US5015016A
公开(公告)日：1991-05-14
申请号：US332545
申请日：1989-04-03
申请人： Robert E. Smith, III
发明人： Robert E. Smith, III
IPC分类号： F16L17/08 , F16L29/04 , F16L37/32 , F16L39/00
CPC分类号： F16L17/08 , F16L29/04 , F16L37/32 , F16L39/00 , Y10T137/87957
摘要： A coupling having an internal pressure-loaded V-seal between a male member and a female member incudes a sleeve member insertable into the female member bore. The V-seal is repeatably positionable in the sleeve member such that insertion of the male member serves to slightly compress the V-seal and thereby preload the seal before pressurization. Upon pressurization of the coupling, the lips of the V-seal are urged to expand longitudinally against the leading face of the male member and an internal shoulder in the sleeve member. The pressurization of the coupling also tends to urge the sleeve member toward the male member, to enhance the seal and to compensate for any tolerances between the coupling halves.
摘要翻译：在阳构件和阴构件之间具有内部加压的V形密封件的联接器包括可插入到阴构件孔中的套筒构件。 V形密封件可重复地定位在套筒构件中，使得阳构件的插入用于稍微压缩V形密封件，从而在加压之前预加载密封件。当联接器加压时，V形密封件的唇缘被推动以纵向地伸展到阳构件的前表面和套筒构件中的内肩部。联接器的加压也趋向于朝向阳构件推动套筒构件，以增强密封并补偿联接器半部之间的任何公差。

67. 发明授权

US4915419A Sliding lock plate for hydraulic connectors 失效
标题翻译：液压连接器滑动锁板
公开(公告)号：US4915419A
公开(公告)日：1990-04-10
申请号：US264160
申请日：1988-10-28
申请人： Robert E. Smith, III
发明人： Robert E. Smith, III
IPC分类号： F16L39/02
CPC分类号： F16L1/26 , E21B41/0007 , F16L37/56 , Y10S285/92
摘要： An apparatus for locking together simultaneously one or more male and female coupling members is disclosed, primarily for use in undersea hydraulic applications. The apparatus comprises a sliding lock plate supported by a first junction plate, the plate being slideable perpendicular to the coupling axis between an unlocked position and a locked position. The sliding lock plate has a number of passages configured to receive each coupling member therethrough in the unlocked position. In the locked position, the passages are configured to engage the circumference of the male and female coupling members and restrict axial movement of the members.
摘要翻译：公开了一种用于同时锁定一个或多个阳联接构件和阴联接构件的装置，主要用于海底液压应用中。该装置包括由第一接合板支撑的滑动锁定板，该板可在解锁位置和锁定位置之间垂直于联接轴线滑动。滑动锁定板具有多个通道，其构造成在解锁位置中容纳穿过其中的每个联接构件。在锁定位置，通道构造成接合阳联接构件和阴联接构件的圆周并限制构件的轴向移动。

68. 发明授权

US4892101A Method and apparatus for offsetting baseline portion of oximeter signal 失效
标题翻译：用于抵消血氧计信号基线部分的方法和装置
公开(公告)号：US4892101A
公开(公告)日：1990-01-09
申请号：US315330
申请日：1989-02-24
申请人： Peter W. Cheung , Karl F. Gauglitz , Lee R. Mason , Stephen J. Prosser , Robert E. Smith , Darrell O. Wagner , Scott W. Hunsaker
发明人： Peter W. Cheung , Karl F. Gauglitz , Lee R. Mason , Stephen J. Prosser , Robert E. Smith , Darrell O. Wagner , Scott W. Hunsaker
IPC分类号： A61B5/00
CPC分类号： A61B5/14551
摘要： A feedback control system is disclosed for use in processing signals employed in pulse transmittance oximetry. The signals are produced in response to light transmitted through, for example, a finger at two different wavelengths. Each signal includes a slowly varying baseline component representing the relatively fixed attenuation of light produced by bone, tissue, skin, and hair. The signals also include pulsatile components representing the attenuation produced by the changing blood volume and oxygen saturation within the finger. The signals are processed by the feedback control system before being converted by an analog-to-digital (A/D) converter (72) for subsequent analysis by a microcomputer (16). The feedback control system includes a controllable offset subtractor (66), a programmable gain amplifier (68), controllable drivers (44) for the light sources (40, 42), and the microcomputer (16). The microcomputer (16) receives signals from the offset subtractor (66), gain amplifier (68), drivers (44) and A/D converter (72) to produce signals that control the function of the subtractor (66) and drivers (44) in the following manner. Normally, the drivers ( 44) are maintained within a predetermined current range. In the event the microcomputer (16) senses an output from the converter (72) that is not within a predetermined range, the drive signal is adjusted to produce an acceptable signal. The magnitude of the offset removed by the subtractor (66), as controlled by the microcomputer (16), is maintained at a constant level when the converter (72) output is within a first predetermined range and is a predetermined function of the converter (72) output when that output falls within a second predetermined range.
摘要翻译：公开了一种反馈控制系统，用于处理脉冲透射比率测定中使用的信号。信号是响应于透过例如两个不同波长的手指的光产生的。每个信号包括缓慢变化的基线分量，其表示由骨，组织，皮肤和头发产生的光的相对固定的衰减。信号还包括表示由手指内的血液体积变化和氧饱和度产生的衰减的脉动成分。这些信号由模拟数字（A / D）转换器（72）转换之前由反馈控制系统处理，用于微计算机（16）的后续分析。反馈控制系统包括可控偏移减法器（66），可编程增益放大器（68），用于光源（40,42）的可控驱动器（44）和微计算机（16）。微型计算机（16）从偏移减法器（66），增益放大器（68），驱动器（44）和A / D转换器（72）接收信号，以产生控制减法器（66）和驱动器（44）的功能的信号）。通常，驱动器（44）保持在预定的电流范围内。在微计算机（16）感测到转换器（72）的输出不在预定范围内的情况下，调节驱动信号以产生可接受的信号。当转换器（72）输出在第一预定范围内并且是转换器的预定功能时，被微计算机（16）控制的减法器（66）去除的偏移量的幅度保持在恒定水平 72）当该输出处于第二预定范围内时输出。

69. 发明授权

US4832080A Pressure balanced hydraulic coupling with metal seals 失效
标题翻译：压力平衡液压联轴器与金属密封
公开(公告)号：US4832080A
公开(公告)日：1989-05-23
申请号：US146319
申请日：1988-01-21
申请人： Robert E. Smith, III
发明人： Robert E. Smith, III
IPC分类号： F16L29/04 , F16L37/35
CPC分类号： F16L1/26 , F16L29/04 , F16L37/35 , Y10S251/90 , Y10S285/917 , Y10T137/87957
摘要： A pressure-balanced hydraulic coupling for use in undersea drilling and production operations, the coupling having radial passageways communicating between the male and female members such that substantial fluid pressure is not exerted against the face of either member during coupling or uncoupling or during the coupled state. Check valves in both the male and female members are opened when the male member probe is fully inserted into the receiving chamber of the female member. Mutually opposed valve stems extending from each check valve contact one another to effectuate the simultaneous opening of each check valve, and allow fluid to flow through a valve port and then radially through matching fluid passageways in the male and female members. The radial passageways of the male and female members match up at their longitudinal surfaces so that fluid pressure between the male and female members is in a substantially radial direction and is not exerted at the face of either member. Metal seals may be used to seal the annulus formed between the male and female members when they are coupled. The metal seals may be pressure-energized in response to fluid pressure in the coupling to enhance the sealing effect.
摘要翻译：一种用于海底钻井和生产操作的压力平衡液压联接器，该联接器具有在阳构件和阴构件之间连通的径向通道，使得在联接或非耦合期间或在耦合状态期间不会对任一构件的表面施加相当大的流体压力。当阳构件探针完全插入阴构件的容纳室中时，阳构件和阴构件中的止回阀都打开。从每个单向阀延伸的相互相对的阀杆彼此接触以实现每个止回阀的同时打开，并且允许流体流过阀口，然后径向地流过男性和女性构件中的匹配流体通道。阳和阴构件的径向通道在其纵向表面处相匹配，使得阳构件和阴构件之间的流体压力处于基本上径向的方向上，并且不施加在任一构件的表面上。金属密封件可以用于密封当雄构件和阴构件联接时形成的环形空间。金属密封件可以响应于联接器中的流体压力而被加压，以增强密封效果。

70. 发明授权

US4813454A Undersea coupling with pressure balancing ports 失效
标题翻译：与压力平衡端口的海底联轴器
公开(公告)号：US4813454A
公开(公告)日：1989-03-21
申请号：US85931
申请日：1987-08-17
申请人： Robert E. Smith, III
发明人： Robert E. Smith, III
IPC分类号： F16L37/32 , F16L37/28
CPC分类号： F16L37/32 , F16L1/26 , Y10T137/402 , Y10T137/87925 , Y10T137/87957
摘要： A pressure-balanced hydraulic coupling having a male and female member wherein the male member includes at least one balancing port communicating between the leading face and outer side wall. When the male member is sealed in relation to the annular elastomeric seal in the receiving chamber of the female member, and the poppet valves of each member are closed, the balancing port is used to bleed seawater into or out from the annulus between the coupling members.
摘要翻译：一种具有阳和阴构件的压力平衡液压联接器，其中所述阳构件包括在所述前表面和外侧壁之间连通的至少一个平衡端口。当阳构件相对于阴构件的接收室中的环形弹性体密封件密封并且每个构件的提升阀关闭时，平衡端口用于将海水排出到耦合构件之间的环空中。

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